ScreenSafeFuture: A parent-empathetic and pragmatic mhealth application for toddlers' brain development addressing screen-addiction challenges by Nafisa Anjum, Md. Mehedi Hasan, Syeda Umme Salma, Liang Zhao, Maria Valero de Clemente, Nazmus Sakib

“…This paper presents a functional ScreenSafeFuture iOS prototype, that will undergo parent usability testing, followed by continuous advancements based on user feedback. …”
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Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways by Yu Yuefeng, Lin Zhiqi, Chen Yi, Zhu Keyu, Wan Heng, Wang Yuying, Wang Ningjian, Yu Yuetian, Gu Xinjie, Zhang Yihao, Lu Yingli, Xia Fangzhen

“…Moreover, the androgen receptor (AR) antagonist flutamide mimicked the effects of testosterone deficiency on PCSK9 and LDLR indicating the role of AR as a mediator in triggering attenuating liver cholesterol uptake in which testosterone instead of dihydrotestosterone (DHT) is the major functional form of androgen. …”
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HL-TRP channel is required for various repellents for the parthenogenetic Haemaphysalis longicornis by Ceyan Kuang, Jie Cao, Yongzhi Zhou, Houshuang Zhang, Yanan Wang, Jinlin Zhou

“…Conclusions This exploration of ticks and repellents found that HL-TRP channel functions as a chemosensory receptor for repellents and, thereby, mediates avoidance behavior. …”
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Role of interleukin-16 in human diseases: a novel potential therapeutic target by Timothy B. Niewold, Julia S. Lehman, Iva Gunnarsson, Iva Gunnarsson, Alexander Meves, Vilija Oke, Vilija Oke

“…Blockade of IL-16 showed positive therapeutic effects in several animal models of human disease with low rate of side effects. …”
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Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies by Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li

“…Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). …”
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Fesibility Study on Increasing Water Use Efficiecy in (Thymus vulgaris L.) in Different Planting Pattern and Partial with Using Biochar by Kiomars Fakhri, Saeed Sayfzadeh, Mansour Sarajooghi, Seyed Alireza Valad Abadi, Ismail Hadidi Masouleh

“…Biochar treatment also had a positive effect on all vegetative and functional traits of thyme.…”
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Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI by Yongzhen Tan, Xunlong Zhong, Xiangping He, Yuying Yuan, Yunfeng Deng, Jingjie Huang, Yao Zhou, Chuhai Xie, Huaidong Peng

“…This study aimed to investigate the effect of β-Sitosterol on the biological functions of FLSs. …”
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Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight by Md Nurul Islam, Hiroki Nabekura, Hiroaki Ueno, Takahiro Nishida, Atsushi Nanashima, Hideyuki Sakoda, Weidong Zhang, Masamitsu Nakazato

“…Here, we investigated the effects of VSG in both chow diet (CD)-fed and high-fat diet (HFD)-fed mice. …”
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Localized delivery and retention of hydrogen sulfide causing regional lipid accumulation in mouse adipose tissues in vivo by Richa Verma, Ming Fu, Hassan M. Arif, Guangdong Yang, Ishani Sarkar, Kuljeet Kaur, John B. Matson, Lingyun Wu, Rui Wang

“…This study confirms the feasibility of selectively delivering H2S via injectable hydrogels and their effectiveness in regulating targeted tissue functions. …”
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Insights into the combined toxicity of copper and cadmium in zebrafish (Danio rerio) embryos and adults by Sanah Majid, Karen Smeets, Lucia Vergauwen, Ali Pilehvar, Dries Knapen, Ronny Blust

“…Key morphological and functional endpoints were assessed in embryos at 96 hours post-fertilisation (hpf) and in adults after seven days of exposure. …”
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Exploring the Determinants of Spatial Vitality in High-Speed Rail Station Areas in China: A Multi-Source Data Analysis Using LightGBM by Pengpeng Liang, Xu Cui, Jiexi Ma, Wen Song, Yao Xu

“…The analysis of interaction effects highlights strong synergies between urban development and functional configuration, as well as between accessibility and service infrastructure. …”
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Influence of lacquer sanding sealer treatment on the properties of bamboo waste particleboards for sustainable handicrafts by Chris Johnniel France Rana, Aralyn L. Quintos-Cortiguerra, Alexis B. Dorado, Juanito P. Jimenez, Jr

“…Additionally, bio-inspired product prototypes were developed to demonstrate the enhanced particleboard’s aesthetic and functional potential.…”
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A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide by Sarah R Mullinax, Andrea M Darby, Anjali Gupta, Patrick Chan, Brittny R Smith, Robert L Unckless

“…In addition to genotypic effects on gut immunity, we also see strong sex-specific effects that are most prominent in flies without functional diptericin A. …”
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Cardiac history and post-stroke depression association in Chinese stroke survivors: a cross sectional study by Longxiao Liu, Peng Qin, Jing Bai, Yupei Cheng, Jingjie Huang, Zihe Wang, Yuxing Zhang, Bangqi Wu

“…In addition, the data showed that gender, activities of daily living (ADLs), cognitive functioning, and life satisfaction also had an effect on post-stroke depression (PSD). …”
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Reconstruction and Separation Method of Ranging and Communication Phase in Beat-Note for Micro-Radian Phasemeter by Tao Yu, Hongyu Long, Ke Xue, Mingzhong Pan, Zhi Wang, Yunqing Liu

“…The beat-note is processed by complex conjugate rotation, which can effectively eliminate the PRN modulated phase. Simulation and analysis results demonstrate that this method can significantly enhance the purity of the measured phase in the beat-note while maintaining the ranging and communication functions. …”
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Sustainable optimization of high specific surface area Spartina alterniflora biochar for Rhodamine B removal and mechanism by Weiling Yu, Zhouyun Xie, Ni Zhang, Li Tang, Jingfen Xia, Jien Ye, Xuran Liu, Dongbo Wang, Guojing Yang

“…Microscopic analysis validated the presence of an appealing porous structure and surface functionalities that are key for the adsorption of RhB. …”
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Cannabichromene: integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy by Yu-Na Hwang, Ju-Hee Park, Han-Heom Na, Tae-Hyung Kwon, Jin-Sung Park, Sehyun Chae, Young Taek Oh, Keun-Cheol Kim

“…We further confirmed the functional validity of apoptosis and ferroptosis induction after CBC treatment using various molecular assays. …”
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Recent Advances and Prospects of Nucleic Acid Therapeutics for Anti-Cancer Therapy by Minhyuk Lee, Minjae Lee, Youngseo Song, Sungjee Kim, Nokyoung Park

“…In addition, nucleic acids have many advantages as nanomaterials, such as high biocompatibility, design flexibility, low immunogenicity, small size, relatively low price, and easy functionalization. Nucleic acid therapeutics can have a high therapeutic effect by being used in combination with various nucleic acid nanostructures, inorganic nanoparticles, lipid nanoparticles (LNPs), etc. to overcome low physiological stability and cell internalization efficiency. …”
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Amiodarone induced lung toxicity: a radiological overview that simulating COVID19 infection disease by Marco Umberto Scaramozzino, Giovanni Sapone, Ubaldo Romeo Plastina, Guido Levi, Mariacarmela Nucara

“… Amiodarone-induced pulmonary toxicity (AIPT) is among the most serious adverse effects and is one of the leading causes of death associated with its use. …”
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Influence of Prolonged Storage Process, Pasteurization, and Heat Treatment on Biologically-active Human Milk Proteins by Jih-Chin Chang, Chao-Huei Chen, Li-Jung Fang, Chi-Ren Tsai, Yu-Chuan Chang, Teh-Ming Wang

“…Further studies are warranted to evaluate the functional activity of these proteins and their effects on infants' immunological status.…”
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