Thapsigargin triggers a non-apoptotic, caspase-independent programmed cell death in basophilic leukaemia cells by Philip Steiner, Korollus Melek, Ancuela Andosch, Lena Wiesbauer, Anna Madlmayr, Michelle Duggan, Hubert H. Kerschbaum, Susanna Zierler

“…Here, we investigated the effects of TG on rat basophilic leukaemia (RBL-1) cells using advanced 2D and 3D transmission electron microscopy, confocal laser scanning microscopy, and functional cell death assays. …”
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Traversing Shifting Sands—the Challenges of Caring for Someone With Alzheimer's Disease and the Impact on Care Partners: Social Media Content Analysis by Kristian Steen Frederiksen, Julie Hahn-Pedersen, Rebecca Crawford, Ross Morrison, Rose Jeppesen, Lynda Doward, Wendy Weidner

“…ObjectiveThe objective of this social media review was to gain insight into the impact of caring for someone with AD, focusing particularly on impacts on psychological and emotional well-being, social functioning, daily life and ability to work, health-related quality of life, social functioning, and relationships. …”
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Current Research Status of Digital Technology in the Rehabilitation of Rare Neurological and Muscular Diseases by GUO Yixuan, GAO Yi, YAO Yiyang, QIN Zhuoyue, ZHANG Yaofang, JING Jiaqi, XIE Jing, GUO Jian, ZHANG Shuyang

“…The VR games significantly improved both static/dynamic balance functions and cognitive functions. The intelligent treadmill assistance significantly enhanced gait speed and stride length. …”
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Impact of social-psychological factors on anxiety before gastrointestinal endoscopy and quality of life by Zhen-peng Huang, Kong-jin Quan, Bin-bin Wen, Jia-feng Lin, Tao Liu, Li-ping Yang, Li-ping Meng

“…Patients with anxiety exhibited lower scores in domains of the SF-12, including general health (GH), physical functioning (PF), role-physical (RP), bodily pain (BP), role-emotional (RE), mental health (MH), vitality (VT), and social functioning (SF). …”
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Nutritional Value and Therapeutic Benefits of Dragon Fruit: A Comprehensive Review with Implications for Establishing Australian Industry Standards by Si-Yuan Chen, Cheng-Yuan Xu, Muhammad Sohail Mazhar, Mani Naiker

“…Moreover, investigations of post-harvest handling and processing techniques could optimize the preservation of these valuable compounds, enhancing dragon fruit’s role as a functional food.…”
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Comparison of Vernier Acuity Measured with Three Different Water-induced Blur Simulation Methods by Vivek Suganthan Ramasubramanian, Aiswaryah Radhakrishnan

“…This emphasizes the need to develop a blur metric specific to WIB to objectively quantify its effect on different visual functions. …”
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Enhancing the Total Terminal Galactosylation of CHO Cell-Derived TNF-α Blocker-IgG1 Monoclonal Antibody Using Time-Dependent Galactose Supplementation by Mallikarjuna Pulipeta, Pradeep Kumar Iyer, Rajendra Kumar Palakurthy, Narasimha Pullaguri, Rajasekhar Pinnamaneni, Srinivas Reddy Chilukuri

“…The IgG1 subclass is the most potent among all the immunoglobulin gamma (IgG) antibodies, inducing Fc-related effector functions. N-linked glycan distribution of therapeutic IgG1s affects Fc-related effector functions such as CDC (complement-dependent cytotoxicity) and ADCC (antibody dependent cell-mediated cytotoxicity) biological activities and efficacy in vivo. …”
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Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma by Ruolan Zhang M.M., Jianlin Liu M.M., Hang Yang M.M., Jinsong Tan M.M., Rong Xiong M.M., Yun Liu MM, Gang Feng PhD, Guiqin Song PhD, Kang Liu PhD

“…The circCYP24A1 achieved a perfect area under the curve of 0.94 for the diagnosis of ESCC, and an area under the curve of 0.76 for the prediction of lymph node metastasis. Furthermore, functional loss assays revealed that circCYP24A1 effectively promotes the epithelial-mesenchymal transition and tumor metastasis in vitro. …”
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Tranexamic acid in spontaneous intracerebral hemorrhage: a meta-analysis by Yu Chang, Pei-Chun Lai, Chih-Yuan Huang, Junmin Song, Kuan-Yu Chi, Hsiang-Yi Hung, Yen-Ta Huang

“…Key outcomes analyzed included hematoma expansion, mortality within 90 days, thromboembolic events, and favorable functional outcomes. Data were pooled using a random-effects model and analyzed using the “metafor” package in RStudio. …”
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Resource omnivory in soil food webs and meta-ecosystem connections by Anton M. Potapov

“…Consequent changes of the structure and functioning in the recipient ecosystem requires more attention, especially how biodiversity-ecosystem functioning relationships manifest across ecosystems. …”
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Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target by Jianlei Kang, Yujie Xu, Qitai Zhao, Ying Wang, Zhenyan He, Xin Xu

“…The predictive model showed robust performance in forecasting the survival of glioma patients. Functional analysis identified G0S2 as a key metabolic regulator highly expressed in gliomas. …”
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CD56 and Tim-3 molecule expression in different monocyte subsets in physiological pregnancy by E. G. Orlova, O. A. Loginova

“…It is known that peripheral monocyte functions effectively change at pregnancy to form the immune tolerance at the maternal-fetal interface and the systemic immune defense against pathogens. …”
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Thermo-mechanical-fluid coupled modeling for residual stress prediction in thick plate welding by Yonghui Su, Haitao Xia, Shuo Chen, Chen Wang, Shuaiyu Wu, Wei Lu, Jun Zhu, Hao Wu

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Host-specific adaptation in Fusarium oxysporum correlates with distinct accessory chromosome content in human and plant pathogenic strains by Dilay Hazal Ayhan, Serena Abbondante, Domingo Martínez-Soto, Siyuan Wu, Ricardo Rodriguez-Vargas, Shira Milo, Katherine Rickelton, Vista Sohrab, Shunsuke Kotera, Tsutomu Arie, Michaela Ellen Marshall, Marina Campos Rocha, Sajeet Haridas, Igor V. Grigoriev, Neta Shlezinger, Eric Pearlman, Li-Jun Ma

“…Interestingly, ACs from both genomes also encode proteins with shared functions, such as chromatin remodeling and post-translational protein modifications. …”
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Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages by Rui Ma, Ping Yuan, Xiaolin Wang, Yingjie Li, Meijin Huang, Huichuan Yu, Yanxin Luo, Mingxuan Zhu, Liangliang Bai, Xiaoxia Liu, Shaoyong Peng, Yumo Xie, Hong Bai, Jinxin Lin, Linping Wu

“…CSF1R was reconstructed in CRC cells to identify its biological functions in vitro and in vivo. We compared CSF1R expression and methylation differences between CRC cells and macrophages. …”
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Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study by Antonia Bralić, Sanda Pavelin, Nikolina Pleić, Joško Šoda, Krešimir Dolić, Anita Markotić, Ana Ćurković Katić, Angela Mastelić, Nikolina Režić Mužinić, Jasna Duranović, Zlatko Kljajić, Ivona Stipica Safić, Zoran Đogaš, Maja Rogić Vidaković

“…EDSS scoring included evaluation of the EDSS general score, EDSS functional pyramidal score, and EDSS functional pyramidal score for each extremity. …”
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A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors by Kristin R. Anderson, Wenpeng Cao, Hui Sun Lee, Mark A. Crenshaw, Talulla B. Palumbo, Ethan Fisher-Perez, Amanda DeGraaf, Peter Rogu, Maria A. Beatty, Gabrielle M. Gracias, Gabrielle M. Gracias, Avani V. Pisapati, Katie Hoffman, Krystle J. McLaughlin, Almut Hupbach, Wonpil Im, Wonpil Im, X. Frank Zhang, Julie M. Miwa

“…The murine Lynx2 gene, encoding a protein modulator of nicotinic acetylcholine receptors, is expressed in anxiety-related neural circuitry in rodents and has been functionally associated with anxiety-like behavior.MethodsWe examined variations in the human LYNX2 (LYPD1) gene and their potential effects on anxiety levels in a cohort of 624 participants. …”
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Experience of use of the anti-cytokine drug adalimumab in children with polyarticular seronegative junior arthritis living in the Samara region by S. V. Plakhotnikova, G. V. Santalova, Yu. V. Serezhkina, O. V. Sluzhaeva

“…Polyakov. Analysis of the effectiveness of the therapy was carried out during 6 visits with an interval of 70 days and included an assessment of the functional ability using the CHAQ questionnaire. …”
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In-situ biological regeneration of zeolite to enhance the treatment of high ammonia-nitrogen wastewater by partial nitrification by CHEN Xu, YANG Xiaofan, WANG Chenggang, KUANG Naiqiang, CHEN Chunfu, ZHANG Liqiu

“…High throughput sequencing results showed that Nitrosomonas was the main ammonia-oxidizing functional bacterium genus, with relative abundance varied from 10.3% to 51.7%. …”
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Bacteriostatic activity and mechanism of minerals containing rubidium by Yucui Lu, Xianmei Long, Yuanhui Mao, Lijing Wang, Xiayun Liao, Lichun Zhao

“…This disruption leads to the release of intracellular molecules of various sizes, inhibiting cellular respiration and metabolism, and causing oxidative damage. These combined effects impair cellular functions, affecting cell growth and metabolism, or leading to cell death. …”
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