Compatibility optimization of the traditional Chinese medicines ‘Eczema mixture’ based on back-propagation artificial neural network and non-dominated sorting genetic algorithm by Xin He, Zhijie Song, Yanqun Yang, Siqi Wu, Shuo Meng, Huanyu E, Hongfei Li, Guoyu Ding

“…The 6-n-2 three-layers of back-propagation artificial neural network (BP-ANN) was employed to model the two defined objective functions. With the predictive models, the Pareto front was determined by a variant of non-dominated sorting genetic algorithm II(VNSGAII) to provide the optimal prescription set.ResultsThe 6-n-2 three-layers of artificial neural networks demonstrated a satisfactory fitting effect for the nonlinear activity relationship. …”
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The impact of tolvaptan on the incidence of contrast-induced acute kidney injury and long-term prognosis in high-risk patients after coronary intervention by Chunyang Xu, Gaoliang Yan, Shenghong Ju, Yuancheng Wang, Chengchun Tang

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The impact of deregressed foreign breeding values on national beef cattle single-step genomic evaluation by Damilola Adekale, Zengting Liu, Ross Evans, Thierry Pabiou, Reinhard Reents, Dierck Segelke, Jens Tetens

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Efficacy of RADA16-Based Self-Assembling Peptides on Wound Healing: A Meta-Analysis of Preclinical Animal Studies by Jiaju Lu, Liuting Chen, Zeyue Sun, Zhimou Yang

“…<b>Conclusions</b>: RADA16-based self-assembling peptides, particularly those modified with functional peptide motifs, represent a promising treatment for non-diabetic and diabetic wounds in pre-clinical studies, and translation to the clinical domain appears warranted.…”
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ISO/IEC 25010-based Quality Evaluation of Three Mobile Applications for Reproductive Health Services in Morocco by Karima Moumane, Ali Idri, Fatiha El Aouni, Jihad Laghnimi, Naoual Chaouni Benabdellah, Oussama Hamal

“…Methods: We implemented a three-step analysis process, examining the sub-features and features outlined in the ISO/IEC 25010 standard for software product quality, encompassing functionality, reliability, usability, efficiency, and maintainability. …”
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Iron oxide nanoparticles enhance alkaline stress resilience in bell pepper by modulating photosynthetic capacity, membrane integrity, carbohydrate metabolism, and cellular antioxid... by Raheel Shahzad, Sri Koerniati, Putri Widyanti Harlina, Bernadetta Rina Hastilestari, Ivica Djalovic, P. V. Vara Prasad

“…This study aims to evaluate the role of iron oxide nanoparticles (FeNP) in mitigating AS and enhancing plant growth and metabolic functions by conducting experiments under controlled greenhouse conditions with four main treatments: AS (irrigating plants with alkaline salts mixture solution); FeNP (foliar application of Fe3O4 nanoparticles at 100 mg L−¹); AS + FeNP (integrated treatment of AS and FeNP); and CK (control). …”
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Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels by Ying Yang, Ying Yang, Xuehong Zhu, Dan Sun, Jiangtao Fan

“…This study investigates the role of cuproptosis-related lncRNA (CRL) CNNM3-DT in CC, focusing on its impact on LIAS expression, intracellular copper levels, and tumor progression.MethodsWe analyzed the expression of lnc-CNNM3-DT and LIAS in clinical samples and CC cell lines using Real-time Polymerase Chain Reaction (RT-qPCR), Western blot, and immunohistochemistry (IHC). Functional assays, including CCK-8, wound healing, transwell invasion, and flow cytometry, were used to evaluate the effects of lnc-CNNM3-DT overexpression on cell proliferation, migration, invasion, and apoptosis. …”
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Reusing of intraoperative exfoliated finger epidermis in the treatment of hand scar contracture in patients with RDEB by Chong Wu, Teng Guo, Yuluo Jian, Xinhe Jiao

“…Neither group exhibited contracture recurrence or significant functional improvement. This novel technique repurposes intraoperatively discarded epidermal tissue as biological dressings, effectively minimizing secondary trauma from adherent dressing removal. …”
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FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN CHILDREN WITH SUGAR DIABETES OF THE FIRST TYPE by I. M. Bykov, L. G. Ivchenko, D. A. Domenyuk, N. Yu. Kostyukova, A. P. Storozhuk, D. M. Ilijev

“…Assessment of the state of lipid peroxidation, antioxidant defense and oxidative stress indicators on the model of functional activity of neutrophil granulocytes of blood in children with type 1 diabetes mellitus depending on the stage of endocrinopathy compensation.Materials and methods. …”
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Background for modeling the dynamic characteristics of advanced spacecraft drives considering the operation of oscillators by A. N. Sova, M. I. Stepanov, V. A. Sova, A. I. Bykov

“…Recommendations to reduce the effect of active oscillators are established. Initial data are selected to determine the dynamics of advanced space vehicles from the point of view of fulfilling their target functions. …”
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Investigating the Soil Hardness on Personal Subsidiary and Individual Peasant Farms by Aleksandr S. Ulanov, Vladimir F. Kupryashkin, Nikolay I. Naumkin, Dmitry A. Naumkin

“…The experience of their use and the research on the effectiveness of their functioning allow identifying ways to improve tillage quality. …”
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Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection by Qi Yan, Nan Duan, Mingqun Lin, Wenqing Zhang, Stephen Denton, Yichen Zhong, Yizhou Dong, Yasuko Rikihisa

“…Abstract Background Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligatory intracellular pathogen. …”
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Phenolic compounds, antioxidant and α-glucosidase inhibitory activities from moringa oleifera seed by-products by Linzhen Li, Xiangjie Dai, Shengjia Xiao, Zhiyi Tang, Yutong Wang, Nian Yu, Ting Xiong, Yongjun Li

“…According to the results, M. oleifera seed husks could be an alternative to develop novel drugs, functional foods and nutritional health products with hypoglycemic effects. …”
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Optimization of Ultrasound-assisted Deep Eutectic Solvent Extraction Process and Biological Activities of Cerasus humilis Proanthocyanidin by Yue ZHAO, Tianxu CHU, Zhe GAO, Wen ZHAO, Yasai SUN

“…The extraction process for ultrasound-assisted deep eutectic solvent extraction of CPC was optimised using single-factor combined response surface methodology, the average degree of polymerisation was determined after purification, and the functional groups and composition of CPC were analysed qualitatively by Fourier infrared spectroscopy and high performance liquid tandem mass spectrometry (UPLC-OE-MS/MS). …”
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Institutional Possibilities and Limits of Professional Self-Realisation of Researchers under the Innovative Restructuring of Russian Science by A. U. Ogorodnikov, E. U. Ruppel

“…The consistency and integrity of functioning of these levels is one of the key conditions for the professional self-realisation of a modern scientist.Methodology and research methods. …”
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Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner by Zhigang Rao, Katharina Lackner, Ilaria Dorigatti, Natascha Brigo, Denise Kummer, Minh Bui Hoang, Christa Pfeifhofer-Obermair, Günter Weiss, Ernst R. Werner, Andreas Koeberle, Katrin Watschinger

“…Lipid mediators are produced by immune and non-immune cells, have diverse homeostatic and immunoregulatory functions and, together with other factors, orchestrate the initiation and resolution of inflammation. …”
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Dentin sialophosphoprotein (DSPP) gene-silencing inhibits key tumorigenic activities in human oral cancer cell line, OSC2. by Rajeshree Joshi, Amany Tawfik, Nneka Edeh, Veronica McCloud, Stephen Looney, Jill Lewis, Stephen Hsu, Kalu U E Ogbureke

“…<h4>Conclusions/significance</h4>DSPP-silencing in OSC2 cell decreased salient hallmarks of oral tumorigenesis and provides the first functional evidence of a potential key role for DSPP in oral cancer biology. …”
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Exploring the therapeutic potential of Emblica officinalis natural compounds against hepatocellular carcinoma (HCC) by Sidra Ilyas, Abdul Manan, Yeojin Choi, Donghun Lee

“…Despite advancements in treatment, drug resistance and adverse side effects have spurred the search for novel therapeutic strategies. …”
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Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes. by Dennis Lal, Eva M Reinthaler, Borislav Dejanovic, Patrick May, Holger Thiele, Anna-Elina Lehesjoki, Günter Schwarz, Erik Riesch, M Arfan Ikram, Cornelia M van Duijn, Andre G Uitterlinden, Albert Hofman, Hannelore Steinböck, Ursula Gruber-Sedlmayr, Birgit Neophytou, Federico Zara, Andreas Hahn, Genetic Commission of the Italian League against Epilepsy, EuroEPINOMICS CoGIE Consortium, Padhraig Gormley, Felicitas Becker, Yvonne G Weber, Maria Roberta Cilio, Wolfram S Kunz, Roland Krause, Fritz Zimprich, Johannes R Lemke, Peter Nürnberg, Thomas Sander, Holger Lerche, Bernd A Neubauer

“…Only the p.T1174S mutation may be considered as a genetic risk factor for epilepsy of small effect size based on the enrichment in patients (P = 6.60 x 10-4; OR = 0.32, fishers exact test), previous functional studies but incomplete penetrance. …”
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The influence of the ionic environment on rheological properties of acidified micellar casein gels by D.J. Wilbanks, S.R. Yazdi, J.A. Lucey

“…Results from this study could help dairy manufacturers to design specialty milk powders that have unique functionality when used for acid milk gels, such as yogurt.…”
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