High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…Abstract Introduction Rheumatoid factor (RF) plays an important role in rheumatoid arthritis (RA) pathophysiology, yet the differential effects of varying RF titers remain understudied. …”
Get full text

Optimization and Stability Evaluation of Simulating Milk Fat Globule Membrane Delivery Systems for DHA-rich Algal Oil by Bo WANG, Shiwei LIU, Jianfeng SUN, Shenglin DUAN, Youqiang YU, Xishan MA, Jia LIU, Peng YUAN, Wenxin WANG, Yuanyuan LIU, Xiaoyang ZHENG

“…Objective: To enhance the bioavailability of functional substances and the stability of reprocessed products, the development of different algal oil product forms and the application of simulated milk fat globule membrane (MFGM) embedding systems in food research and development were investigated. …”
Get full text

Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4 by Aizhong Xu, Jianjun Liu, Li Tong, Tingting Shen, Songlin Xing, Yujie Xia, Bosen Zhang, Zihao Wu, Wenkang Yuan, Anhai Yu, Zijie Kan, Wenqi Yang, Chao Zhang, Chong Zhang

“…Mfuzz expression pattern clustering and functional enrichment were applied to genes with BEX4 as the core to explore their regulatory mechanisms. …”
Get full text

Disability in childhood and the equity of health services: a cross-sectional comparison of mass drug administration strategies for soil-transmitted helminths in southern Malawi by Hannah Kuper, Calum Davey, Judd Walson, Robin L Bailey, Sean Galagan, Khumbo Kalua, James Simwanza, Rachel Pullan, Lazarus Juziwelo, Hugo Legge, Stefan Witek-McManus, Rejoice Msiska, Hastings Mangawah, William Oswald, Joseph Timothy, Emily Pearman, Mariyam Shaikh

“…Community-based ‘door to door’ approaches may provide a more equitable strategy to ensure that children with disabilities are reached, but disability is rarely assessed rigorously in the evaluation of health interventions.Objectives To describe the prevalence and factors associated with disability among children aged 5–17 years and to assess the relative effectiveness of routine school-based deworming (SBD) compared with a novel intervention of community-based deworming (CBD) in treating children with disabilities for soil-transmitted helminths.Setting DeWorm3 Malawi Site (DMS), Mangochi district, Malawi.Participants All 44 574 children aged 5–17 years residing within the DMS.Primary and secondary outcome measures Disability was defined as a functional limitation in one or more domains of the Washington Group/UNICEF Child Functioning Module administered as part of a community-based census. …”
Get full text

Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy by Kang Zhu, Zhanyuan Li, Jingjing Cao, Yixi Cao, Jimei Wang, Shiyu Wang, Ling Chen, Huiqin Zhou, Wei Huang, Hanxun Zou, Qunsheng Li, Jing Mu, Jibin Song

“…Furthermore, the fluorescence “OFF‐ON” mechanism, triggered by H2O2‐induced etching of silver allows real‐time monitoring of H2O2 levels via the second near‐infrared window (NIR‐II) fluorescence (FL) imaging “Turn On”, which delineates tumor boundaries for precise RT and reduce side effects to normal tissue. This dual‐functional platform not only enables real‐time tracking but also enhances therapeutic outcomes, offering a promising approach to precision cancer treatment.…”
Get full text

Preserving Paratenon in Acute Achilles Tendon Repair: A 5-Year Follow-Up by Mohammad Hossein Chegini Kord MD, Alireza Ebrahimi MD, Gregory R. Waryasz MD, Soheil Ashkani-Esfahani MD, Mohammad Razi MD

“…Conclusion: Preserving the Paratenon during AT repair showed satisfactory functional and clinical outcomes without any case of the wound complications that are common after open repairs. …”
Get full text

The impact of changing exposure to PM2.5 on mortality for US diplomats with multiple international relocations: a modelling study by Leslie Edwards, James Milner, Paul Wilkinson, Ai Milojevic

“…Sensitivity analysis of baseline mortality, exposure level, C-R functions and lags was conducted. The effect of mitigation measures, including the addition of air purifiers, was examined. …”
Get full text

ALKBH5 Promotes Breast Cancer Stemness Through Regulating Wnt/β-Catenin Signaling by Wang K, Wang K

“…Spheroid formation and in vitro extreme limiting dilution analysis (ELDA) were performed to elucidate the effect of ALKBH5 deficiency on stemness of MCF-7 cells. …”
Get full text

Different management methods for tunnel abscess in tunneled cuffed catheters with catheter-related bloodstream infections and central venous stenosis: two case reports by Yafei Bai, Chunli Wang, Mingzhi Xu, Hong Li, Na An, Ruman Chen

“…Both patients achieved infection control and preserved functional vascular access. Conclusions Both patients achieved infection control and preserved functional vascular access. …”
Get full text

Сlinical features of changes in the microcirculation system among children with allergic rhinitis, depending on the severity of dysfunction of the autonomic nervous system by N. S. Tataurschikova, P. V. Berezhansky

“…Microcirculatory mechanisms are of great pathogenetic significance in the development of allergic inflammation, including in AR.Depending on the leading pathognomonic trait, it is now customary to distinguish individual phenotypes and endotypes of AR.The phenotype covers the clinically significant properties of AR, but does not reveal the detailed mechanisms of its development, on the basis of which a personalized algorithm for prevention, treatment and prognosis can be created.And the autonomic nervous system is responsible for setting links between the body, ambient and internal environment through the regulation of metabolism, functioning of organs and tissues based on changes in this environment; it also provides the integration of all organs into a single whole acting as one of the main body’s adaptive systems.Since the autonomic nervous system governs the body and homeostasis uniting separate pathogenetic links of disease progression and sets the basis for structural and functional unity. …”
Get full text

Efficacy of aquatic exercises on balance in children with sickle cell anemia: A randomized controlled trial by Omar Abd El-Hameed Abd El-Fattah Ghetas, Azza Abd El-Aziz Abd El-Hady, El-Sayed Ali Shaheen Ali, Amira El-Sayed El-Bagalaty

“…The aquatic exercise program has a positive effect on improving balance functions in children with sickle cell anemia. …”
Get full text

Introduction to Volume 29, Issue 3 by Pau Pérez-Sales, Chris Dominey

“…The paper by Martin Hill and Mary Lynn Everson, “Indicators likely to contribute to clinical and functional improvement among survivors of politically-sanctioned torture” is unique in the length of post-treatment follow-up, and provides an innovative approach in the measurement of rehabilitation outcomes through a structured measure of functional aspects with an instrument designed at the Kovler Center in Chicago. …”
Get full text

Electroneuromyography: a modern view on the possibilities of application (literature review) by A. M. Morozov, T. V. Sorokovikova, Yu. E. Minakova, M. A. Belyak

“…In turn, needle electroneuromyography is an invasive method, but more accurate and highly informative, allowing to assess the functional state of the peripheral neuromotor apparatus. …”
Get full text

CHEMILUMINESCENT ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN PROGRESSION OF OBSTRUCTIVE JAUNDICE DEPENDING ON ITS ORIGIN AND BILIRUBIN LEVELS by O. V. Smirnova, N. M. Titova, E. W. Kasparov, N. G. Yelmanova

“…In the cases of bilirubin levels of >200 mmol/L, an increased spontaneous and induced activity of granulocytes was registered in these cases, probably, due to development of multi-organ failure and toxic effects of bilirubin. The granulocytes seem to exhibit their maximal activity, until exhaustion of their functional limits.…”
Get full text

Screening of Nutritionally Important Components in Standard and Ancient Cereals by Vesna Dragičević, Milena Simić, Vesna Kandić Raftery, Jelena Vukadinović, Margarita Dodevska, Sanja Đurović, Milan Brankov

“…Sustainable nutrition and food production involve dietary habits and farming systems which are eco-friendly, created to provide highly nutritious staple crops which could serve as a functional food at the same time. This research sought to provide a comprehensive analysis of whole-grain cereals, and some ancient grains toward important macro- (protein), micro-nutrients (mineral elements), and bioactive compounds, such as dietary fiber (arabinoxylan and β-glucan) and antioxidants (phytic acid, total glutathione, yellow pigment, and phenolic compounds) to provide functionality in a sustainable diet. …”
Get full text

Expression of variant isoforms of the tyrosine kinase SYK differentially regulates cervical cancer progression through PI3K/AKT pathway by Bingjie Lin, Qixin Wang, Xin Wang, Hongjian Wei, Xiaojing Nie, Li Li, Yonghua Shi

“…SYK is closely related to tumor development. However, the functions of its two isoforms, SYK (L) or SYK (S), are not fully understood to date. …”
Get full text

Cell-targeted PD-1 agonists are potent NK-cell inhibitors by Harriet C. Pope, Harriet C. Pope, Ana L. Chiodetti, Alice Newey, Guillaume Rieunier, David X. Overton, Eduardo Mateos-Diaz, Tara M. Mahon, Giovanna Bossi, Hussein Al-Mossawi, Charlotte Viant

“…Of note, NK cells can upregulate PD-1 expression upon activation and their effector functions can be modulated by the PD-1 signalling pathway.MethodsWe have generated a novel bispecific inhibitory molecule, comprised of a targeting domain highly specific for a pre-pro-insulin peptide presented by the HLA-A*02 molecules on the cell surface of pancreatic β-cells and a PD-1 agonist effector domain. …”
Get full text

Microbiome matters: how transplantation methods and donor origins shape the successful restoration of the seagrass Posidonia oceanica by Arnaud Boulenger, Tânia Aires, Aschwin H. Engelen, Gerard Muyzer, Michel Marengo, Sylvie Gobert

“…Limited sediment contact in elevated substrates delayed the establishment of key functional bacteria, highlighting the importance of direct interaction with the sediment microbial pool. …”
Get full text

Profile of Chief Medical Officers and performance of health zones in crisis contexts: a cross-sectional study in three provinces of the Eastern Democratic Republic of Congo by Rosine Bigirinama, Jean-Corneille Lembebu, Christian Chiribagula, Pacifique Mwene-Batu, Denis Porignon, Abdon Mukalay, Albert Mwembo, Ghislain Bisimwa

“…Data on CMO profiles and the operational contexts of their health zones were analyzed to identify factors influencing functionality and performance, through multivariate regressions (p < 0.05). …”
Get full text

Frequency and Characteristics of Integrative Oncology Referrals for Patients With Cancer Receiving Inpatient Rehabilitation by Ekta Gupta MD, Gabriel Lopez MD, Santhosshi Narayanan MD, Jegy M. Tennison MD, Imran Elahi BS, Aline Rozman de Moraes MD, Bryan M. Fellman MS, Eduardo Bruera MD

“…Patient demographics and IO consultation details, including patient-reported outcome measures of symptom burden using ESAS-FS and functional status using the Activity Measure for Post-Acute Care “6 clicks,” were extracted. …”
Get full text