The Impact of Kefir Consumption on Inflammation, Oxidative Stress Status, and Metabolic-Syndrome-Related Parameters in Animal Models: A Systematic Review and Meta-Analysis by Zahid Naeem Qaisrani, Wai Phyo Lin, Bo Bo Lay, Khin Yadanar Phyo, Myat Mon San, Nurulhusna Awaeloh, Sasithon Aunsorn, Rinrada Pattanayaiying, Susakul Palakawong Na Ayudthaya, Choosit Hongkulsup, Nirunya Buntin, Sasitorn Chusri

“…Kefir, a fermented beverage rich in probiotics and beneficial compounds, has emerged as a functional food that may offer metabolic advantages. …”
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Actionable Wearables Data for the Neurology Clinic: A Proof‐of‐Concept Tool by Nicolette Miller, Ebenezer Chinedu‐Eneh, Jaeleene Wijangco, Kyra Henderson, Nikki Sisodia, Narender Sara, Jennifer Reihm, Shane Poole, Jim Rowson, Chu‐Yueh Guo, Jeffrey M. Gelfand, Valerie J. Block, Riley Bove

“…In multiple sclerosis (MS), monitoring step count and sleep is feasible, valid, and offers a holistic glimpse of patient functioning and worsening. However, data generated from wearables are typically unavailable at the point of care. …”
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Evaluation of Hippocampal Microanatomy and Neuro-Biomarkers Following Administration of Silver Nanoparticles Conjugated with Tenofovir Disoproxil Fumarate in Experimental Diabetic... by Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Babatunde Adebola Alabi, Kafalotse Sylvia Dithole, Samuel Thopho Matula, Edwin Coleridge Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu

“…This study shows that AgNPs-TDF restores various alterations in the hippocampus and improves cognitive functions in diabetic rats.…”
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Intravenous tirofiban in acute ischemic stroke patients not receiving reperfusion treatments: a systematic review and meta-analysis of randomized controlled trials by Shatha Alqurashi, Shatha Alqurashi, Mohammed S Alqahtani, Mohammed S Alqahtani, Shahad Mohammed Albeladi, Shahad Mohammed Albeladi, Saleha Almahdawi, Saleha Almahdawi, Hala Danish, Hala Danish, Hatoon Alshaikh, Hatoon Alshaikh, Ahmed Alkhiri, Ahmed Alkhiri, Ammar Alkawi, Fahad S Al-Ajlan, Fahad S Al-Ajlan, Adel Alhazzani, Adel Alhazzani

“…Efficacy endpoints included excellent (modified Rankin scale of 0–1) and good (modified Rankin scale of 0–2) functional outcomes at 90 days. Safety outcomes included symptomatic intracerebral hemorrhage (sICH), any ICH, and 90-day mortality.ResultsFour randomized clinical trials, including a total of 1,199 patients, were included. …”
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Multilayer Double Emulsion Encapsulation of <i>Limosilactobacillus reuteri</i> Using Pectin-Protein Systems by Kattya Rodríguez, Diego Catalán, Tatiana Beldarraín-Iznaga, Juan Esteban Reyes-Parra, Keyla Tortoló Cabañas, Marbelis Valdés Veliz, Ricardo Villalobos-Carvajal

“…The development of bakeable foods supplemented with probiotics requires novel strategies to preserve the functionality of probiotic cells during thermal and gastrointestinal stress conditions. …”
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Revealing genes related teat number traits via genetic variation in Yorkshire pigs based on whole-genome sequencing by Jialin Wei, Jingchun Sun, Yi Pan, Minghao Cao, Yulong Wang, Tiantian Yuan, Ao Guo, Ruihua Han, Xiangdong Ding, Gongshe Yang, Taiyong Yu, Rongrong Ding

“…In this study, we detected Single Nucleotide Ploymorphism (SNP), Insertion-Deletion (InDel) and Structural variant (SV) by high-coverage whole-genome resequencing data, and selected teat number at birth and functional teat number as two types of teat number traits for genome-wide association study (GWAS) to reveal candidate genes associated with pig teat number traits. …”
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Association of CYP2D6*4 Polymorphism With Response to Atorvastatin in Patients With High Low-Density Lipoprotein Level in Northern Iran, Guilan Provice by Raziyeh Asadollahpour, Faeze Khaghani, Fardin Mirbolouk, Anvarsadat Kianmehr, Omid Goodarzvand, Sara Dabirian, Mohammad Sadegh Alipour, Ehsan Zamani, Mehdi Evazalipour

“…Recognizing poor metabolizers may help prevent adverse effects of drugs.  Objective: This study aims to assess the association of CYP2D6*4, as the most frequent non-functional allele of CYP2D6 gene, and response to atorvastatin in patients with high low-density lipoprotein (LDL) level in northern Iran. …”
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Results of using L-ornitin-L-aspartate in the treatment of hepatic encephalopathy in liver transplantation by S. E. Voskanyan, E. V. Naydenov, A. I. Artemev, D. A. Zabezhinskiy, K. K. Gubarev, V. S. Rudakov, M. V. Shabalin, D. S. Svetlakova, A. P. Maltseva, Yu. V. Voskanyan, A. G. Naydenova, M. Muktarzhan, Z. Sadykhov

“…The aim was to study the results of using various treatment regimens for hepatic encephalopathy for patients with liver cirrhosis before and after liver transplantation and the effect on the incidence and severity of hepatic encephalopathy in the perioperative period, and on the posttransplantation course.Material and methods. …”
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Using individualised bowel care plans to improve clinical outcomes in specialist intellectual disability mental health units in England and Wales: quality improvement project by Alexandra Gabrielsson, Richard Laugharne, Jon Painter, Harriet Slater, Catherine Bright, Andrew Dossett, Romanie Dekker, Alex Bordessa-Kelly, Kloe Edwards, Jarod Newbury, Salman Azfar, Paul Bassett, Samuel Tromans, Indermeet Sawhney, Phil Elliot, Mahesh Odiyoor, Kiran Purandare, Rohit Shankar

“…HoNOS-LD item 12 for physical functioning showed significant improvement for PwID with constipation compared with those without, between baseline and 6 months. …”
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Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment by Camille Chatelain, Laurine Berland, Marion Grard, Nicolas Jouand, Judith Fresquet, Joëlle Nader, Ugo Hirigoyen, Tacien Petithomme, Chantal Combredet, Elvire Pons-Tostivint, Delphine Fradin, Lucas Treps, Christophe Blanquart, Nicolas Boisgerault, Frédéric Tangy, Jean-François Fonteneau

“…These macrophages inhibit GFP expression in tumor cells harboring a defect in IFN-I production and a functional signaling downstream of the IFN-I receptor, while having minimal effects on GFP expression in tumor cells with defect of responsiveness to IFN-I. …”
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The Impact of Environmental Factors on Skin and Tissue Ageing by Aleksandra Dorosz, Agnieszka Skoczeń, Michał Kulesza, Weronika Wawrzynów, Magdalena Maria Jakubowska, Adrian Kruk, Natalia Rutecka, Martyna Miłoś, Agata Kuśnierz-Gibała, Błażej Kaczmarek

“…With the passing of years, due to both internal and external factors, the skin's functions gradually weaken, and its regenerative processes slow down. …”
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Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients by Mabel Hernández-Cedeño, Arielis Rodríguez-Ulloa, Yassel Ramos, Luis J. González, Anabel Serrano-Díaz, Katharina Zettl, Jacek R. Wiśniewski, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Vladimir Besada, María del Carmen Domínguez-Horta

“…The proteomic profile regulated by Jusvinza is characterized by the presence of proteins related to RNA splicing, phagocytosis, endocytosis, and immune functions. In response to Jusvinza treatment, several proteins that regulate the NF-κB signaling pathway were differentially modulated, supporting the peptide’s anti-inflammatory effect. …”
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Spatially and temporally mismatched blood flow and neuronal activity by high-intensity intracortical microstimulation by Alexandra Katherine Isis Yonza, Lechan Tao, Xiao Zhang, Dmitry Postnov, Krzysztof Kucharz, Barbara Lind, Antonios Asiminas, Anpan Han, Victor Sonego, Kayeon Kim, Changsi Cai

“…Introduction: Intracortial microstimulation (ICMS) is widely used in neuroprosthetic brain-machine interfacing, particularly in restoring lost sensory and motor functions. Spiking neuronal activity requires increased cerebral blood flow to meet local metabolic demands, a process conventionally denoted as neurovascular coupling (NVC). …”
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Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes by Luca Di Nunno, Luca Di Nunno, Veronica Pagani, Elena Canciani, Gerardina Ruocco, Gerardina Ruocco, Mattia Spedicati, Mattia Spedicati, Maria Talmon, Luca Fusaro, Dalila Di Francesco, Dalila Di Francesco, Simona Casarella, Manuela Rizzi, Francesca Boccafoschi, Francesca Boccafoschi

“…Functional bleeding control could allow time for further treatment and decrease mortality rates. …”
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Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics by Soji Soman, Sanjay Kulkarni, Jeena John, Milan Paul, Krishnadas Nandakumar, Swati Biswas, Sajan D. George, Srinivas Mutalik

“…The exfoliated BPNSs were surface loaded with an anticancer drug, doxorubicin (DOX), functionalized with a photo-responsive polymer, polydopamine (PDA), and conjugated with a protein-based ligand, transferrin (TF). …”
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Identification, Characterization, and Ultrastructure Analysis of the Phenol-Degrading <i>Rhodococcus erythropolis</i> 7Ba and Its Viable but Nonculturable Forms by Valentina N. Polivtseva, Anton N. Zvonarev, Olesya I. Sazonova, Yanina A. Delegan, Yulia N. Kocharovskaya, Alexander G. Bogun, Nataliya E. Suzina

“…Minor biostimulation will allow the strain to recover its metabolic activity and effectively degrade pollution.…”
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Genome‐wide identification of bZIP transcription factors in 12 Rosaceae species and modeling of novel mechanisms of EjbZIPs response to salt stress by Ling Zhu, Mengjie Zhang, Xiuyao Yang, Yinqiang Zi, Tuo Yin, Xulin Li, Ke Wen, Ke Zhao, Jiaqiong Wan, Huiyun Zhang, Xinping Luo, Hanyao Zhang

“…However, it has not been extensively studied in Rosaceae, and the functional effects of bZIP on Eriobotrya japonica under salt stress are still unknown. …”
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The Influence of a Low-Frequency Musical Fragment on the Neural Oscillations by Kateryna Drozdenko, Sergey Naida, Oleksandr Drozdenko, Anastasiia Damarad, Dmytro Pareniuk, Liudmyla Vakulenko, Zhanna Adaricheva

“…Study of musical-acoustic influences, which are used to improve the functional state of a person, as well as her/his neurophysiological or psychological rehabilitation, is very relevant nowadays. …”
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Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids by Federica Papaccio, Manuel Cabeza-Segura, Blanca García-Micó, Francisco Gimeno-Valiente, Sheila Zúñiga-Trejos, Valentina Gambardella, María Fernanda Gutiérrez‐Bravo, Carolina Martinez‐Ciarpaglini, Pilar Rentero‐Garrido, Tania Fleitas, Susana Roselló, Juan Antonio Carbonell-Asins, Marisol Huerta, David Moro-Valdezate, Desamparados Roda, Noelia Tarazona, Manuel M. Sánchez del Pino, Andrés Cervantes, Josefa Castillo

“…We integrated the RNA-seq and mass spectrometry-based proteomics data from PDOs in a functional interaction network to identify the significantly dysregulated processes in CIN. …”
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Exosomal miR-93-3p targets EIF4EBP1 to regulate macrophage polarization and accelerate wound healing post-anal fistula surgery by Wei Zhang, Wenzhe Feng, Junhong Chen, Ruoxi Cao, Xi Chen

“…The direct interplay between miRNA and its target gene was verified through a dual-luciferase reporter (DLR) assay.ResultsMicroarray analysis and qPCR validation identified miR-93-3p as the most significantly DEMs. miR-93-3p overexpression markedly downregulated M1 macrophage marker CD86 and pro-inflammation cytokines IL-1β, IL-6, and TNF-α, while upregulating M2 markers Arg-1, CD206, and anti-inflammation cytokines IL-10 and TGF-β in functional assays. Conversely, miR-93-3p suppression exhibited the opposite effect. …”
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