Implantable bone conduction devices enhance functional ear reconstruction in patients with pediatric microtia by Ying Chen, Ying Chen, Chen-long Li, Chen-long Li, Liu-Jie Ren, Liu-Jie Ren, Xu Wu, Na Gao, Na Gao, Ai-juan He, Yao-yao Fu, Yao-yao Fu, Ya-ying Zhu, Ya-ying Zhu, Tian-yu Zhang, Tian-yu Zhang, Tian-yu Zhang

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Bridging the gap: enhancing blood regulatory functions in African contexts through comparative analysis by Washington T. Samukange, Washington T. Samukange, Washington T. Samukange, Verena Kluempers, Chancelar Kafere, Kristina Heinrich, Joanna Atemnkeng, Alireza Khadem Broojerdi, Florence Tirane, Edwin Nkansah, Shani Maboko, Linda Nhukarume, Khamusi Mutoti, Noel Aineplan, Helga Gardasdottir, Helga Gardasdottir, Helga Gardasdottir, Aukje K. Mantel-Teeuwisse, Jens Reinhardt

“…The aim of this study was to assess and compare the status of implementation and performance of the regulatory functions for registration and marketing authorization as well as the system for approval of blood, blood components and plasma for fractionation or processes.MethodsWe did this by conducting assisted self-benchmarking in 12 African countries using the GBT plus Blood (registration and marketing authorization function, 34 sub-indicators and approval of blood, blood components, and plasma for fractionation or processes function, 24 sub-indicators). …”
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Gut microbiome and metabolome profiling in coal workers’ pneumoconiosis: potential links to pulmonary function by Xiao Yu, Tao Xiong, Lu Yu, Gaisheng Liu, Fan Yang, Xueqin Li, Yangyang Wei, Xiaojing Wang, Shuting Wei, Yi Jiang, Xiaomei Kong, Shouan Ren, Yiwei Shi

“…However, its pathogenesis remains elusive, compounded by a lack of early detection markers and effective treatments. Although the impact of gut microbiota on lung diseases is acknowledged, its specific role in CWP is unclear. …”
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Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro by H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén

“…However, a major challenge is the effective delivery of these nucleic acid-based therapeutics. …”
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Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging by Zehong Zhang, Qianyi Wan, Yuedan Zhu, Jinbao Ye, Fang Fu, Xinxin Fan, Haiou Chen, Gang Ren, Wei Jiang, Xiaoxin Guo, Juanyu Zhou, La Yan, Jinhua Yan, Xingzhu Liu, Yu Yuan, Yi Chen, Haiyang Chen

“…Abstract Intestinal stem cell (ISC) aging diminishes the regenerative capacity of the intestinal epithelia, but effective therapeutic strategies to counteract human ISC aging remain elusive. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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Spectral tuning and after-effects in neural entrainment by Maëlan Q. Menétrey, David Pascucci

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Principles for determining effective parameters for organizing train traffic in suburban-urban traffic, taking into account the differentiation of service classes by A. F. Borodin, I. F. Mustafin, K. Yu. Nikolaev

“…Problem of determining the effective parameters of the route network of suburban-urban railway communication in order to achieve acceptable financial results for the owners of infrastructure and carriers is considered. …”
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Precision measurement for effective pollution mitigation by evaluating air quality monitoring systems in linguistic Pythagorean fuzzy dombi environment by Hanan Alolaiyan, Umme Kalsoom, Umer Shuaib, Abdul Razaq, Abdul Wakil Baidar, Qin Xin

“…Furthermore, we develop a novel scoring function for multiple attribute decision-making (MADM) issues within the context of linguistic Pythagorean fuzzy knowledge. …”
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Effective NSGA-II Algorithm for a Limited AGV Scheduling Problem in Matrix Manufacturing Workshops with Undirected Material Flow by Xuewu Wang, Jianing Zhang, Yi Hua, Rui Yu

“…In addition, to enhance the quality of initial population, a minimum cost function strategy based on load balancing is adopted. …”
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Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack by Bingxun Wang, Yongqing Liu, Wenya Han, Bing Li, Pang Jie, Wenwen Yang, Zengcai Ma, Zesheng Xu

“…Conclusions: Colchicine adjuvant therapy improves the efficacy of CHD patients with acute gout attacks, helps improve cardiac function and vascular endothelial function, reduces serum levels of NALP3, sICAM-1, MMP-9, and MMP-13, enhances patient immunity, and controls disease progression.…”
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Unconventional strategies to break through the efficiency of light‐driven water splitting: A review by Kang Wang, Dingwang Huang, Xiaowei Li, Kuang Feng, Ming Shao, Jiabao Yi, Weidong He, Liang Qiao

“…Recently, unconventional enhancement strategies based on surface plasmonic effects, piezoelectric effects, thermoelectric effects, and magnetic effects have provided unique pathways for improving the solar‐to‐hydrogen efficiency of photo(electro)catalysts. …”
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Transforming technical assistance for more effective health services delivery in Africa: the WHO multi-country assignment teams experience by Ndoungou Salla Ba, Abdulmumini Usman, Alex Gasasira, Patrick Kabore, Bei Achu, Hyelni Kulausa, Emmanuel Chanda, Olushayo Oluseun Olu, Joseph Cabore, Matshidiso Moeti

“…Additionally, many of the approach’s activities were non-related to its core function which hampered the effective and timely delivery of their support. …”
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Paradoxes in pediatric rehabilitation: building an interdisciplinary, total-child framework to promote effective interventions and life course well-being by Sharon Landesman Ramey, Michael E. Msall, Craig T. Ramey

“…The paradoxes support a major revision in hypotheses about how effective interventions can alter a child's functioning and life course. …”
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Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group r... by Tim Theologis, Daniel C. Perry, Ines Rombach, David J. Keene, Ioana R. Marian, Morag Andrew, Catherine Barry, Loretta Davis, Gregory Firth, Heidi Fletcher, Beth Fordham, Vivi Gregory Osborne, Helen Gregory Osborne, Lesley Katchburian, Joanna O'Mahoney, Jeremy R. Parr, Rachel Rapson, Jennifer Ryan, Fema Er, Megan Stone, Helen Wood, Sally Hopewell

“…However, there is wide variability in the exercise regimes used and limited evidence of their effectiveness. The SPELL trial will assess the clinical effectiveness of an individually tailored dynamic stretching programme, compared to usual care for ambulant children with spastic CP. …”
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A novel, rapid, and effective technique for whole lung lavage in patients with pulmonary alveolar proteinosis and silicosis: retrospective study by Eviatar Naamany, Karam Azem, Shai M. Amor, Safo Awad, Lev Freidkin, Dror Rosengarten, Shimon Izhakian, Mordechai R. Kramer

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The impact of supplementation with highland barley in different nutrients on weight loss: The nutrients and function relationship by Fan Xie, Yuting Yan, Xin Gao, Haocheng She, Jingyi Wang, Jie Li, Yi Zhang, Jun Zhang, Zhou Zhang, Lianzhong Ai

“…The dietary fiber in highland barley (HB) may be a key nutrient in exerting its physiological functions. How about the effects of other nutrients? …”
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Microbial functional diversity indicators in vineyard soils under organic and biodynamic land management by Tábata A. Bublitz, Heberto Rodas-Gaitan, Rainer Georg Joergensen, Vincent Masson, Juergen Fritz

“…Abstract Background An on-vineyard approach was used to investigate the effects of biodynamic (BD) preparations on microbial functional diversity and extracellular polymeric substances (EPS) in four vineyards on different bedrocks under organic management. …”
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Formation pathways, ecosystem functions, and the impacts of land use and environmental stressors on soil aggregates by Patience Ponyane, Ferdinand J. Dina Ebouel, Peter N. Eze, Peter N. Eze

“…Subsequently, the effects of land use and/or changes in land use in the delivery of these functions were examined. …”
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Functional Bracing After Anterior Cruciate Ligament Reconstructions: A Review of the Current Literature by Charles R. Heyworth, Lauren E. Berube, PA-C, Emma C. Gossman, BS, Matthew D. Milewski, MD, Elise C. Bixby, MD

“…Key Concepts: (1) Functional knee braces have been shown to reduce anterior tibial translation in controlled conditions but show inconsistent effects on rotational forces and valgus stability during dynamic activities. (2) Clinical studies offer conflicting evidence on the effectiveness of functional bracing in reducing ACL re-tear rates, with no consensus on routine use. (3) Patient-specific factors, including graft type, compliance, and baseline knee stability, may influence the effectiveness of functional bracing. (4) Psychological benefits, such as reduced fear of reinjury, may contribute to the value of bracing, though effects on proprioception and muscle strength are mixed. (5) Further research is needed, particularly with dynamic, sport-specific testing, to determine the true efficacy of functional bracing in ACL reconstruction recovery.…”
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