Tapping natures rhythm: the role of season in mitochondrial function and genetics in the UK biobank by Anastasios Papadam, Mihail Mihov, Adriana Koller, Hansi Weissensteiner, Klaus Stark, Felix Grassmann

“…Methods We leveraged data from individuals participating in the UK Biobank study and computed their mitochondrial abundance from Exome sequencing reads mapping to the mitochondrial genome. The seasonal effect was modelled as a sine-cosine function across the year and changes in amplitude, acrophase and displacement of mitochondrial abundance due to various demographic, lifestyle, genetic, proteomic, and metabolomic markers were investigated with multivariate regression. …”
Get full text

Large-scale examination of hot and cool executive function in children born preterm by Iris Menu, Mark Duffy, Tanya Bhatia, Sofia Trapaga, Jenna John, Selma Music, Daelah Nicholas, Seyeon Yim, Moriah E. Thomason

“…Linear mixed models showed varying effects of preterm birth across the different EF tasks. …”
Get full text

Plateau zokor disturbances transform the stability and functional characteristics of soil fungal communities by Xiaojuan Zhang, Zhuangsheng Tang, Jie Yang, Saman Herath, Zhiwen Wang, Yiming Wang, Guangjun Chen, Lei Yue

“…These disturbances not only threaten biodiversity but also affect the healthy functioning of ecosystems. Effects of plateau zokor (Eospalax baileyi) disturbances on the complexity, stability and assembly processes of belowground microbial networks remain unclear. …”
Get full text

Physical Activity and Renal Function: Results of the Entry Phase of the Fasa Cohort Study by M Rostami Chijan, A Dehghan, M Kazemi, MM Naghizadeh, M Emkani, M Bijani, M Farjam, R Homayounfar, N Samimi, M Sedigh Rahimabadi, A Ghaemi

“…In order to measure the level of physical activity, a standard questionnaire was used in three levels of low, moderate and intense physical activity. Also, renal function was evaluated in three levels: normal, mild insufficiency, and severe insufficiency based on milliliters per minute. …”
Get full text

Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages by Daniel E. Paparini, Esteban Grasso, Franco Aguilera, M. Agustina Arslanian, Victoria Lella, Brenda Lara, Ana Schafir, Soledad Gori, Fátima Merech, Vanesa Hauk, Claudio Schuster, Marcelo Martí, Cesar Meller, Rosanna Ramhorst, Daiana Vota, Claudia Pérez Leirós

“…Moreover, differential sex-associated pathways accompanying the phenotypic and functional profiles of HBC appeared related to the placental villi environment. …”
Get full text

p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment by Xiaojuan Han, Danni Jiang, Qianni Li, Pengfei Li, Lan Chao, Yang Yang

Get full text

Genomic and functional analysis of isochorismate synthase genes in sugarcane and their roles in disease resistance by Zhen Zeng, Xinyu Zhu, Jiaoyun Chen, Shilong Zhang, Sisi Zhou, Kailin Li, Wankuan Shen

“…This study establishes the groundwork for functional studies of sugarcane ICS genes and enhances our understanding of the mechanisms of disease resistance in sugarcane.…”
Get full text

The prevalence of respiratory symptoms and diseases and declined lung function among foundry workers by Kirsi Koskela, Lauri Lehtimäki, Jukka Uitti, Panu Oksa, Antti Tikkakoski, Riitta Sauni

“…Research on respiratory symptoms, diseases, and lung function in foundry workers over the past few decades has been limited. …”
Get full text

Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells by Alexander V. Maltsev, Valeria Ventura Subirachs, Oliver Monfredi, Magdalena Juhaszova, Pooja Ajay Warrier, Shardul Rakshit, Syevda Tagirova, Anna V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev

“…Furthermore, neighboring CRUs exhibited repulsive behavior. Functional properties of the CRU network were further examined in a novel numerical SANC model developed using our experimental data. …”
Get full text

Soluble immune checkpoint molecules: mechanism of formation, function, role in malignant neoplasms by T. V. Glazanova, I. E. Pavlova, E. V. Kuzmich, L. N. Bubnova

“…Normally, sICs exert both stimulatory and inhibitory effects on the immune system, and their balance may be disturbed in many malignant neoplasms, COVID-19, HIV infection. …”
Get full text

Evaluating handgrip strength and functional tests as indicators of gait speed in older females by Valentina Muollo, Samuel D’Emanuele, Laura Ghiotto, Doriana Rudi, Federico Schena, Cantor Tarperi

“…IntroductionWith aging, females often experience greater declines in functional capacity [e.g., gait speed (GS)] compared to males, highlighting the need for sex-difference considered in screening and intervention planning. …”
Get full text

Novel Noninvasive Assessment of Pulmonary Arterial Stiffness Using Velocity Transfer Function by Ankur Gupta, Oleg F. Sharifov, Steven G. Lloyd, Jose A. Tallaj, Inmaculada Aban, Louis J. Dell'italia, Thomas S. Denney, Himanshu Gupta

“…We hypothesized that PA stiffness and impedance could be evaluated noninvasively by PA velocity transfer function (VTF), calculated as a ratio of the frequency spectra of output/input mean velocity profiles in PAs. …”
Get full text

The influence of drying methods on the physicochemical, functional, and antioxidant properties of passion fruit peel by LIU Zhaohan, YANG Tongxiang, XU Hanshan, LI Xuejing, CHEN Junliang, REN Guangyue, DUAN Xu

“…<b>Objective:</b> This study aimed to investigate the effects of drying methods on passion fruit peels. …”
Get full text

Functional and relaxing properties of coffee leaf tea: An integrative food cognition approach by Kiki Fibrianto, Igoy Arya Bimo, Eka Shinta Wulandari, Yusuf Hendrawan

“…Coffee leaf tea, rich in bioactive compounds such as phenolic and gamma-aminobutyric acid (GABA), demonstrates potential as a relaxing and functional beverage. This study optimized total phenolic content (TPC) using Response Surface Methodology (RSM), varying brewing temperature (74–81 °C) and duration (4–12 min). …”
Get full text

Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions by Alex Hopke, Adam L. Viens, Natalie J. Alexander, Seok Joon Mun, Michael K. Mansour, Daniel Irimia

“…We also found that treating human neutrophils with GCSF and GM-CSF rescues some neutrophil antifungal function during SYK inhibition. These findings advance our understanding of swarming biology in humans while laying the foundation for developing therapeutics that enhance neutrophil function during immunosuppression.…”
Get full text

The influence of vaginal microbiota on ewe fertility: a metagenomic and functional genomic approach by Edgar L. Reinoso-Peláez, María Saura, Carmen González, Manuel Ramón, Jorge H. Calvo, Magdalena Serrano

“…This research explores the relationship between ovine vaginal microbiota, associated functional pathways, and fertility using advanced nanopore long-reading metagenomic sequencing on 297 ewes from three Spanish breeds across four herds. …”
Get full text

Resting-state functional connectivity changes following audio-tactile speech training by Katarzyna Cieśla, Katarzyna Cieśla, Katarzyna Cieśla, Tomasz Wolak, Amir Amedi, Amir Amedi

“…In this study, we used resting-state functional magnetic resonance imaging (rsfMRI) to measure spontaneous low-frequency oscillations in the brain while at rest to assess training-induced changes in functional connectivity. …”
Get full text

The function of a spindle checkpoint gene bub-1 in C. elegans development. by Xiangming Wang, Min Liu, Weida Li, Christopher D Suh, Zuoyan Zhu, Yishi Jin, Qichang Fan

“…Also, the decrease of neurons in the ventral cord phenotype could not be suppressed by a caspase-3 loss-of-function mutant. In addition, bub-1(fw5 and fw8) mutants showed widespread effects on postembryonic development in many cell lineages. …”
Get full text

Multi-scale machine learning model predicts muscle and functional disease progression by Silvia S. Blemker, Lara Riem, Olivia DuCharme, Megan Pinette, Kathryn Eve Costanzo, Emma Weatherley, Jeff Statland, Stephen J. Tapscott, Leo H. Wang, Dennis W. W. Shaw, Xing Song, Doris Leung, Seth D. Friedman

“…This study demonstrates the machine learning models incorporating individual muscle and performance data can effectively predict MRI disease progression and functional performance of complex tasks, addressing the heterogeneity and nonlinearity inherent in FSHD. …”
Get full text

D-ribose-5-phosphate inactivates YAP and functions as a metabolic checkpoint by Cheng-E Tu, Yong-Feng Liu, Hong-Wei Liu, Chun-Mei Jiao, Quentin Liu, Mien-Chie Hung, Peng Li, Xiang-Bo Wan, Xin-Juan Fan, Yun-Long Wang

“…Importantly, D5P synergistically enhances the tumor-suppressive effect of GLUT inhibitors and inhibits cancer progression in mice. …”
Get full text