Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Abstract Background Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered by stress, with endothelial dysfunction being one of its pathophysiological mechanisms. …”
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PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial–Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway by Yue Wang, Bowen Zheng, Panhui Xiong, Yijun Liu, Longlan Shu, Yang Shen, Tao Lu, Yucheng Yang

“…Methods included IHC, qRT-PCR, and WB under PM2.5 exposure, with further investigation into downstream effects on CYP1B1 and epithelial–mesenchymal transition (EMT). …”
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Isoespintanol Isolated from <i>Oxandra</i> cf. <i>xylopioides</i> (Annonaceae) Leaves Ameliorates Pancreatic Dysfunction and Improves Insulin Sensitivity in Murine Model of Fructos... by Sherley Catherine Farromeque Vásquez, Luisa González Arbeláez, Benjamín Rojano, Guillermo Schinella, Bárbara Maiztegui, Flavio Francini

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Incorporation of Metabolic Dysfunction‐Associated Steatotic Liver Disease in the Health Stage of Cardiovascular‐Kidney‐Metabolic Syndrome Improves Predictive Ability for Coronary A... by Wataru Kawaharata, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Hiroki Aida, Rie Matsumori, Kei Nakata, Keitaro Nishizawa, Toru Suzuki, Hidemichi Kouzu, Nagisa Hanawa, Masato Furuhashi

“…Background Cardiovascular‐kidney‐metabolic (CKM) syndrome is a recently proposed condition encompassing metabolic dysfunction, chronic kidney disease, and cardiovascular diseases including coronary artery disease (CAD). …”
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Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high... by Oluwatosin O. Omodara, Mohammed U. Kawu, Ibrahim G. Bako, Daniel H. Mhya, Theophilus T. Dawus

“…The present study aimed to elucidate the molecular mechanisms underlying the preventive effects of dietary UA supplementation on obesity-related metabolic disorders and inflammation in male Wistar rats fed with HCHFD. …”
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Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgeni... by Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu

“…However, the FOXO1 antagonist AS1842856 invalidated the positive effects of quercetin in APP/PS1 transgenic mice (ac‐FOXO1: Quercetin‐treated APP/PS1 mice vs. …”
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Endothelial protective effect of pitavastatin by A. S. Berns, V. V. Kashtalap

“…Modern potential of anti-aging therapy aimed at slowing the progression of vascular aging and endothelial dysfunction are reflected. A descriptive literature review was carried out based on the analysis of sources from the PubMed, eLibrary databases for the following keywords: endothelium, aging, pitavastatin, anti-aging effect (endothelium, aging, pitavastatin, anti-aging effect). …”
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The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol by Christine M. Liu, Jakob L. Fischer, Edith T. Zemanick, Jason C. Woods, Karolin K. Markarian, Sean B. Fain, Deborah Froh, Sonya L. Heltshe, Lucas R. Hoffman, Stephen M. Humphries, Elizabeth L. Kramer, Katie Larson Ode, Michael Lewis, Douglas A. Li, Jaime Mata, Sarah S. Milla, Peter J. Niedbalski, Benjamin D. Sawatzky, Myung-Shin Sim, Jillian S. Sullivan, Andrew T. Trout, Christopher H. Goss, Jennifer L. Taylor-Cousar, Daniel M. Beswick

“…Background Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are prevalent disease complications in people with cystic fibrosis. …”
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Innovative diagnostic framework for shoulder instability: a narrative review on machine learning-enhanced scapular dyskinesis assessment in sports injuries by Yahui Fu, Shuai Ma, Benxu Ma, Meng Han, Dongxue Zhao, Ziteng Li

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PROTECTIVE EFFECT OF MITOTEMPO IN STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL: EFFECTS ON CORPUS CAVERNOSUM AND AORTA by Eser Yıldız, Pınar Ayvat, Ayşe Saide Şahin, Mehmet Mesut Pişkin, Burak Cem Soner

“…Objective: In this study we aimed to evaluate the effect of mitotempo, a mitochondria-specific antioxidant, on endothelial and erectile dysfunction in a Streptozotocin-induced rat diabetes model. …”
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HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications by Sivasankar Chandran, Morgan Adler, Ling Chen, Sandeep Kaur, Navneet K. Dhillon

“…This review focuses on the role and the underlying mechanisms of HIV-Tat in promoting endothelial dysfunction across the cardiovascular, pulmonary, and brain vasculature. …”
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Lysosome targeted therapies in hematological malignancies by Madhumita S. Manivannan, Anthea Peters, Spencer B. Gibson

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Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support in New Era of Heart Transplant by Lorenzo Giovannico, Giuseppe Fischetti, Domenico Parigino, Luca Savino, Nicola Di Bari, Aldo Domenico Milano, Massimo Padalino, Tomaso Bottio

“…Heart failure is a serious and challenging medical condition characterized by the inability of the heart to pump blood effectively, leading to reduced blood flow to organs and tissues. …”
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The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective by Haoran Xiang, Haoran Xiang

“…This review aims to provide a new perspective on the pathogenesis of PD and to identify avenues for the development of more effective therapeutic strategies.…”
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Choline alphoscerate: insights between acquired certainties and future perspectives by Giovanni Biggio, Giovanni Biggio, Claudio Mencacci

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Сontribution of circadian rhythms to the development of neurological disorders after prolonged anesthesia by Nikita A. Mazurov, Oksana A. Kicherova, Tatyana E. Verbakh, Lyudmila I. Reichert, Yulia I. Doyan, Valentina A. Saltanova

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Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases by Meng Zhang, Jin Wei, Chang He, Liutao Sui, Chucheng Jiao, Xiaoyan Zhu, Xudong Pan

“…During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle. …”
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Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice by Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai

“…These findings suggest that there is a possibility that amyloban may improve social deficits by suppressing the hyperactivation of the dopaminergic system. Amyloban may be an effective treatment for social dysfunctions associated with various psychiatric disorders.…”
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Infravesical Obstruction in a Boy with Orthotopic Ureterocele: Clinical Case by Anastasia A. Bebenina, Olga G. Mokrushina, Marina V. Levitskaya, Vasiliy S. Shumikhin, Nadezhda N. Erokhina

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Rope skipping or badminton? exercise reduced sleep onset latency in university students by Zixin Ye, Shuyue Tan, Shuyue Tan, Yingyuan Zhu, Jialin Fan, Jialin Fan

“…Badminton has a greater effect on improving daytime dysfunction than rope skipping. …”
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