Evaluation of cognitive and mobility function in geriatric dogs following treatment with stem cell and stem cell extracellular vesicles derived from embryonic stem cells: a pilot s... by Tae-Yoon Kim, Nam-Hee Kim, Jin-A Chae, Hyun-Keun Oh, Seonghyun Yang, Jae-Bong Moon, Seon Mi Wi, Ju-Hyun An, Ji Min Yu

“…Additionally, safety assessments were conducted through blood tests such as complete blood count and serum chemistry.ResultsFollowing an assessment of clinical symptoms and blood tests in both the groups receiving ES-MSC and ES-MSC-EVs treatments, no notable side effects were detected. Moreover, the questionnaire survey revealed that both groups showed alleviation in CCDR and LOAD scores following administration.DiscussionThese findings suggest that ES-MSC and ES-MSC-EV treatments have the potential to be used as a therapeutic option for improving clinical symptoms of degenerative diseases such as canine cognitive dysfunction and degenerativemusculoskeletal diseases in elderly dogs.…”
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Influence of insulin resistance on renal function in patients with abdominal obesity. by T. O. Pertseva, M. K. Rokutova

“…In regression analysis predictive role of insulin resistance in the formation of renal dysfunction in patients with abdominal obesity was established. …”
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Metacognitive deficits drive depression through a network of subjective and objective cognitive functions by Yuting Zhan, Xu Ding

“…These findings provide compelling evidence for the metacognitive model of depression and suggest that interventions targeting maladaptive metacognitive beliefs may effectively address both mood symptoms and subjective cognitive dysfunction, even in the absence of objective cognitive impairment.…”
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Age- and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder by Fatma Aydinoglu, Tugba Toyran, Nuran Ogulener

“…H2S- and urothelium-related molecular and biological changes may be responsible for bladder dysfunctions by aging. Understanding the mechanisms involved in chemical and mechanical signaling of the H2S pathway may provide important insights into the development of novel targets for the clinical management of age-related bladder dysfunctions in human such as overactive bladder, lower urinary tract symptoms, and other urological diseases. …”
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A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin by Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang

“…This work finds high‐fat status in complex diabetes risk factors majorly contributes most to cardiomyocyte death and contractile dysfunction. Notably, PA induced early electrophysiological abnormalities, and lately is associated with cardiac fibrosis, mitochondrial fission, and systolic and diastolic dysfunction at tissue level. …”
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The introduction of a new mobile lifestyle tool in the battle against hypothalamic obesity; the “HAPPYthalamus” application by I.M.A.A. van Roessel, M.J. de Koning, M.V. Birk, J. Blom, J. Dekker, E.J.M. Feskens, J.P. de Graaf, Y. Lu, D.A. Lucassen, E. Pondaag, W.J.E. Tissing, H.M. van Santen

“…Background: Children with hypothalamic dysfunction may experience hypothalamic weight gain, marked by severe hyperphagia, low energy expenditure, and reduced initiative. …”
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Left atrial appendage emptying velocity and left ventricular function as predictors of inotropic support in patients undergoing elective off-pump coronary artery bypass grafting by Varun Arora, Srikanth Gujja, Rajesh Thosani, Kamal Sharma, Himani Pandya

“…There is a paucity of data on the effect of left ventricular (LV) dysfunction on left atrial appendage (LAA) emptying velocity. …”
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Prevention and treatment of CCV in patients undergoing cataract phacoemulsification by E. Yu. Yazykova, L. Sh. Ramazanova

“…Systane Balance had been chosen as an artificial tears as its composition is very close to the natural tear film, compensates the deficiency of the lipid layer that is broken when meibomean gland dysfunction (MGD) thus it prevents from increasing tear film osmolarity and its rupture.Results: In 60% (36 people) SSG was due to dysfunction of the meibomian glands, and 40% (24 people) had a different genesis (endocrine pathology, receiving β-blockers for local and systemic effects, long-term use of drugs containing the preservative benzalkonium chloride, menopause). …”
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Redox Imbalance Is Associated with Neuronal Apoptosis in the Cortex of Neonates Gestated Under Chronic Hypoxia by Esteban G. Figueroa, Rodrigo L. Castillo, Adolfo A. Paz, Matías Monsalves-Alvarez, Francisca Salas-Pérez, Ximena Calle, Tamara A. Jiménez, Emilio A. Herrera, Alejandro Gonzaléz-Candia

“…Postnatal hypoxia in the cerebral tissue can induce a redox imbalance and mitochondrial dysfunction, consequently increasing neuronal death. …”
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Impact of medication use on olfactory performance in older adults by Maite Izco-Cubero, Maite Izco-Cubero, Fabiola Zambom-Ferraresi, Fabiola Zambom-Ferraresi, Fabiola Zambom-Ferraresi, Fabiola Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Fabricio Zambom-Ferraresi, María Luisa Fernández González de la Riva, María Luisa Fernández González de la Riva, Enrique Santamaría, Enrique Santamaría, Enrique Santamaría, Enrique Santamaría, Joaquín Fernandez-Irigoyen, Joaquín Fernandez-Irigoyen, Joaquín Fernandez-Irigoyen, Joaquín Fernandez-Irigoyen, Mercedes Lachén-Montes, Juan Jose Lasarte, Juan Jose Lasarte, Juan Jose Lasarte, Maria Uzcanga-Lacabe, Maria Uzcanga-Lacabe, Secundino Fernandez, Gloria Sanjurjo San Martin, Enrique Maraví-Aznar, Enrique Maraví-Aznar, Nicolas Martinez-Velilla, Nicolas Martinez-Velilla, Nicolas Martinez-Velilla, Nicolas Martinez-Velilla, Nicolas Martinez-Velilla, Nicolas Martinez-Velilla

“…IntroductionOlfactory dysfunction impacts quality of life, safety, and nutrition. …”
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Analysis of complications after living-related kidney transplantation: a single-center experience by F. A. Khadjibaev, V. Kh. Sharipova, P. K. Sultanov

“…The proposed treatment and diagnostic algorithm showed a 95.7% diagnostic value in identifying the complications, and 91.3% of the therapeutic effect in coping with a renal transplant dysfunction.Conclusions. …”
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Burnout Syndrome and Sexual Disorders Among Vietnamese Female Nurses and Midwives at Tu Du Hospital: A Frontline Hospital-Based Cross-Sectional Study by Thanh Hai Pham, Minh Tuan Vo, Phuc Nhon Nguyen

“…It can also lead to a negative effect on quality of work, life, and sexual dysfunction. …”
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Biomediators linked to penile dysfunction was inhibited by roasted cashew nut supplement through NOS/cAMP/PKA dependent inflammatory cascade in hypertensive rats exposed to mixture... by J.K. Akintunde, A.O. Adefuye, O.A. Akinloye, F.C. Thomas, A.D. Folayan

“…This study was conducted to evaluate the effect of roasted cashew nut supplement (RCN) on hypertensive penile dysfunction (HPD) in male Wistar rats on exposure to the mixture of petrol, kerosene and diesel (MPKD). …”
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Impact of surgical and non-surgical weight loss on echocardiographic and strain parameters in Asian patients by Kian Keong Poh, Vinay Bahadur Panday, Asim Shabbir, Jinghao Nicholas Ngiam, Ching-Hui Sia, Siew-Pang Chan, Sik Yin Tan, William K. F. Kong, Arthur Mark Richards, James D. Thomas

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Dry Eye Disease Management Via Technological Methods: A Systematic Review and Network Meta-analysis by Dror Ben Ephraim Noyman, Clara C. Chan, Joshua C. Teichman, Itamar Arbel, Or Yosefi, Ruth Lapid-Gortzak, Michael Mimouni, Margarita Safir

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Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats by Akhigbe RE, Akhigbe TM, Adegbola CA

“…This study evaluated the effects of daflon, a micronized purified flavonoid fraction that contains diosmin and hesperidin, on the NF-kB/NO/cyclic guanosine monophosphate (cGMP) and steroidogenic signaling pathways in cisplatin-induced male sexual dysfunction. …”
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Neuropad Assessment of Sudomotor Function Across Glycemic Levels in Adults by Wang Q, Yang Z, Zhao S, Tian C, Zhang P, Li R

“…With increasing FPG and HbA1c levels, the 10-minute slope decreased progressively (P =0.003, P=0.006). (2) A multivariable linear mixed-effects model adjusted for confounders indicated that previously diagnosed diabetes was an independent predictor of reduced sudomotor function. (3) Adjusting for the same confounders, previously diagnosed diabetes was associated with a 3.480-fold greater risk of incomplete color change than was normoglycemia (OR = 3.480, 95% CI = 1.506– 8.042). (4) Age, BMI, ALB, eGFR, and alcohol consumption history were closely associated with sudomotor function.Conclusion: There is a progressive decline in sudomotor function with increasing blood glucose levels in a physical examination cohort, and previously diagnosed diabetes emerges as an independent risk factor for sudomotor dysfunction.Keywords: neuropad, sudomotor dysfunction, sudomotor function, physical examination cohort, DPN…”
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Intranasal insulin for improving cognitive function in multiple sclerosis by Scott D. Newsome, Kathryn C. Fitzgerald, Abbey Hughes, Meghan Beier, Jacqueline Koshorek, Yujie Wang, Daniela Pimentel Maldonado, Thomas Shoemaker, Taimur Malik, Tarik Bayu, Pablo E. Ravenna, Ama Avornu, Elias S. Sotirchos, Meghan Romba, John Muschelli, Todd T. Brown, Peter A. Calabresi, Ellen M. Mowry

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Tooth Loss Leads to Cognitive Impairment and Mitochondrial Disturbance in Wistar Rats by Shixiang Meng, Yunping Lu, Jiangqi Hu, Bin Luo, Xu Sun, Xiaoyu Wang, Qingsong Jiang

“…Substantial hippocampal mitochondrial dysfunction was observed in the TE group, evidenced by notably decreased ATP production, decreased MMP level, and abnormal mitochondrial morphology in the hippocampus. …”
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Clinical utility of diaphragmatic ultrasound for mechanical ventilator liberation in adults: a systematic review and meta-analysis by Naonori Tashiro, Hiroki Nishiwaki, Takashi Ikeda, William M. M. Levack, Hisashi Noma, Noyuri Yamaji, Erika Ota, Takeshi Hasegawa

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