Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in... by Chi Zhang, Daosheng Luo, Tingting Li, Qiyun Yang, Yun Xie, Haicheng Chen, Linyan Lv, Jiahui Yao, Cuncan Deng, Xiaoyan Liang, Rongpei Wu, Xiangzhou Sun, Yuanyuan Zhang, Chunhua Deng, Guihua Liu

“…The present study is aimed at determining the contribution of autophagy in cavernosal endothelial dysfunction of DED rats and explaining the therapeutic effect of urine-derived stem cells (USCs). …”
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Dragon Fruit Peel (<i>Hylocereus undatus</i>) Modulates Hepatic Lipid Metabolism and Inflammation in a Rat Model of High-Fat, High-Fructose-Induced Metabolic Dysfunction by Siriwan Chumroenvidhayakul, Thavaree Thilavech, Mahinda Yapa Abeywardena, Michael Conlon, Julie Dallimore, Michael Adams, Beverly Muhlhausler, Sirichai Adisakwattana

“…This study investigated the effects of dragon fruit peel powder (DFP) on metabolic dysfunction and hepatic abnormalities induced by a HFHFr diet in rats. …”
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Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus stru... by Kyosuke Kobayashi, Yuri Imai, Yuka Shimizu, Isamu Ogawa, Isamu Ogawa, Takaaki Nakai, Yuri Mizuno, Yoshika Kaneda, Yumiko Watanabe-Yasuoka, Fuka Yamazaki, Junko Mochizuki, Toshihiro Sashihara, Tamihide Matsunaga, Tamihide Matsunaga, Takahiro Iwao, Takahiro Iwao

“…Finally, transcriptome analysis suggested that they ameliorated the aberration in cytokine-induced cell differentiation via an anti-inflammatory effect on intestinal stem cells.ConclusionsThe results indicate that LAB ameliorate the cytokine-induced dysfunction of intestinal barrier integrity and homeostasis disrupted by cytokines in a co-culture model of hiPSC-SI and LAB.…”
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Machine learning prediction of metabolic dysfunction-associated fatty liver disease risk in American adults using body composition: explainable analysis based on SHapley Additive e... by Yan Hong, Xinrong Chen, Ling Wang, Fan Zhang, ZiYing Zeng, Weining Xie

“…BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent and progressive liver disorder closely linked to obesity and metabolic dysregulation. …”
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Epidemiological transition of metabolic dysfunction-associated steatotic liver disease-related chronic liver disease and cirrhosis: a comparative study between China and the global... by Yi Tang, Yi Tang, Changhao Gu, Changhao Gu

“…ObjectivesThis study systematically evaluates the epidemiological transition of metabolic dysfunction-associated steatotic liver disease (MASLD)-related chronic liver diseases (CLD) and cirrhosis burden in China versus global populations (1990–2021), with emphasis on age-sex stratified disparities in incidence, prevalence, mortality, and disability-adjusted life years (DALYs). …”
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Intraoperative Brief Electrical Stimulation of the Spinal Accessory Nerve (BEST SPIN) for prevention of shoulder dysfunction after oncologic neck dissection: a double-blinded, rand... by Brittany Barber, Hadi Seikaly, K. Ming Chan, Rhys Beaudry, Shannon Rychlik, Jaret Olson, Matthew Curran, Peter Dziegielewski, Vincent Biron, Jeffrey Harris, Margaret McNeely, Daniel O’Connell

“…Abstract Background Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). …”
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The role of plasma glucose in association of food-specific serum immunoglobulin G reactivity with metabolic dysfunction-associated fatty liver disease: a real-world cross-sectional... by Guanchao Sun, Wenjuan Wu, Binbin Su, Ru Zhang, Xiaoyu Dong, Lihui Wang, Shiping Xu, Hui Shi

“…Abstract Background As the immune response product to food antigens, food-specific serum immunoglobulin G reactivity (FSsIgGR) has been reported the clinical relevance to metabolic disorders, but its connections to metabolic dysfunction-associated fatty liver disease (MAFLD) remain underexplored, particularly within Chinese populations. …”
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Sodium-glucose cotransporter-2 inhibitor therapy improves renal and hepatic function in patients with cirrhosis secondary to metabolic dysfunction associated steatotic liver diseas... by Alessandro Colletta, Alessandro Colletta, Katherine M. Cooper, Giuseppe Placentino, Deepika Devuni, Deepika Devuni, Cosimo Colletta

“…PurposeMetabolic dysfunction-associated steatotic liver disease (MASLD) increases the risk of chronic kidney disease (CKD), compounding morbidity in patients with cirrhosis. …”
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Carbamazepine in Ventricular Extrasystoles Management: Clinical Case by Leonid S. Gordeev, Ekaterina K. Kulbachinskaya, Vera V. Bereznitskaya

“…The drug’s antiarrhythmic effect was demonstrated previously in a number of experimental and clinical studies. …”
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Impact of Chronic Cold Water Immersion and Vitamin D3 Supplementation on the Hippocampal Metabolism and Oxidative Stress in Rats by Daria Korewo-Labelle, Mateusz Jakub Karnia, Dorota Myślińska, Jan Jacek Kaczor

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Bavachin enhances paclitaxel sensitivity in ovarian cancer cells through modulation of mitochondrial function and ER stress by Sang-Jin Lee, Kee K. Kim, Jin-Young Lee

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Neonicotinoid-Induced Cytotoxicity: Insights into Cellular Mechanisms and Health Risks by Yuqing Ma, Qiangwei Wang

“…The underlying mechanisms involve metabolic disturbances, mitochondrial dysfunction, and oxidative stress. These cellular effects raise serious concerns about the potential risks neonicotinoids pose to both human health and the environment. …”
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Study of acute toxicity, endothelial- and cardioprotective properties of phenolic and thiophenolic derivatives of 2H-imidazoles by O. A. Puchenkova, O. V. Shheblykina, D. A. Kostina, A. A. Bolgov, P. R. Lebedev, V. V. Molchanov, T. G. Pokrovskaya, M. V. Korokin, E. A. Nikiforov, N. F. Vaskina, T. A. Idrisov, T. D. Moseev, V. V. Melekhin, M. V. Varaksin, V. N. Charushin, O. N. Chupakhin

“…To assess the endothelial protective effect, the levels of systolic and diastolic blood pressure were evaluated, as well as the coefficient of endothelial dysfunction; for the cardioprotective effect, the results of stress tests on the myocardium were evaluated.Results. …”
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Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inhibiting ferroptosis in ischemic stroke by Youjie Zeng, Ren Guo, Songhua Chen, Yuxin Lin, Si Cao, Xia Wang, Siyi Zhang, Huilin Xu, Wenxiang Qing, Heng Yang, Wen Ouyang

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Carotid intima–media thickness and endothelial function in adolescents exposed to alcohol consumption and cigarette smoking in utero: a mediation analysis by Tammy Hartel, Aamer Sandoo, André Oelofse, Juléy De Smidt

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Nitazoxanide Modulates Mitochondrial Function and Inflammatory Metabolism in Chondrocytes from Patients with Osteoarthritis via AMPK/mTORC1 Signaling by Ha Eun Kim, Jong Yeong Lee, Ga-Yeon Son, Jun-Young Park, Ki Bum Kim, Chul-Min Choi, Young Jae Moon, Jin Kyeong Choi

“…NTZ can, therefore, effectively inhibit inflammatory metabolic reprogramming and mitochondrial dysfunction in OA chondrocytes through AMPK-dependent mTORC1 signaling inhibition, highlighting its potential as a disease-modifying therapy for OA.…”
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Glucagon in metabolic disease: a mini-review of emerging multi-organ roles beyond glycemic control by Seung Hee Lee, Hyeon Young Park, Ji Ho Yun, Eun Kyoung Do

“…By incorporating recent discoveries, we aim to establish a conceptual basis for future translational research on glucagon’s systemic effects within the framework of diabetic cardiometabolic dysfunction.…”
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From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance by Asar TO, Al-hejaili OD, El-Sawy HS, Abd-Allah FI, Omar AM, Ahmed TA, El-Say KM

“…Keywords: erectile dysfunction, avanafil, inclusion complex, sublingual tablets, pharmacokinetic study…”
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Efficacy and Safety of Chronic Blepharitis Treatment by S. V. Yanchenko, A. V. Malyshev, Sh. Zh. Teshaev, L. M. Petrosyan, Sh. Sh. Ramazonova

“…Methods: 30 posterior or mixed chronic blepharitis (CB), meibomian gland dysfunctions (MGD) and dry eye (DE) patients were examined. …”
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Memantine Exacerbates Trimethyltin‐Induced Neurodegeneration and Delays Cognitive Impairment Recovery by Yusuke Onaka, Taro Yamaguchi, Takumu Yamasaki, Koki Morishige, Masanori Yoneyama

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