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Diagnostic performance of point shear wave elastography and vibration-controlled transient elastography in paediatric metabolic dysfunction-associated steatotic liver disease: a sy...
Published 2025-06-01“…Objective This study aimed to comprehensively assess the diagnostic accuracy of point shear wave elastography (pSWE) and vibration-controlled transient elastography (VCTE) in paediatric metabolic dysfunction-associated steatotic liver disease (MASLD).Design Systematic review and meta-analysis of diagnostic test accuracy using the Grading of Recommendations Assessment, Development and Evaluation approach with random-effects models.Data sources PubMed, Embase, Web of Science, Ovid (Medline), Cochrane, China National Knowledge Infrastructure, Wan Fang and OpenGrey were searched for publications from April 1989 to July 2024.Eligibility criteria The study included relevant records on the application of pSWE and VCTE in diagnosing MASLD in children (<19 years). …”
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A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models
Published 2025-03-01“…Studies investigating the effect of NAD+ precursors on cognitive impairments in rodent models were included. …”
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Initial experience of a single center with the use of ZSI 475 penile prosthesis
Published 2021-04-01“…The lower cost of ZSI 475 may add to the chances of the product to become a cost-effective alternative to treat those patient who need a IPP.…”
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Association between erectile dysfunction and the predicted 10-year risk for atherosclerosis cardiovascular disease among U.S. men: a population-based study from the NHANES 2001-200...
Published 2024-12-01“…BackgroundErectile dysfunction (ED) is considered the tip of the iceberg for cardiovascular disease (CVD). …”
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CORRECTION OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PREECLAMPSY BY COMBINED USE OF TRIMETAZIDINE AND PURIFIED MICRONIZED FLAVONOID FRACTION AS WELL AS THEIR COMBINATIONS WITH...
Published 2021-03-01“…An integrated/multimethodology approach is the most effective way of treatment for preeclampsia. Therefore, an urgent task of modern pharmacology is to study the effectiveness of new drugs when used in combinations, as well as the drugs included in the standards for treatment.Materials and methods. …”
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The impact of rehabilitation on the recovery of executive functions in stroke patients with different location of the ischemic focus
Published 2024-10-01“…Objectives Cognitive dysfunction is part of the clinical picture of stroke. …”
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Cognitive impairment in chronic heart failure. How new therapeutic options for the treatment of chronic heart failure affect cognitive function?
Published 2024-03-01“…Understanding the pathophysiology of diseases will allow the effective evaluation of health status and development of suitable treatments. …”
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Guilingji capsules enhances erectile function by promoting testosterone-dependent angiogenesis in the corpus cavernosum
Published 2025-03-01“…Background and aim: Guilingji capsules (GLJC) have the effect of treating erectile dysfunction (ED). This study aims to explore the potential mechanisms of GLJC in treating ED. …”
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Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-...
Published 2025-07-01“…Given ambroxol’s potential neuroprotective effects, we explore the underlying molecular mechanisms, explicitly examining its role in attenuating scopolamine-induced oxidative stress-mediated activation of the c-Jun N-terminal kinase (JNK) pathway, as well as its modulation of Akt and glycogen synthase kinase-3 beta (GSK-3β) signaling, which is a key contributor to neuroinflammation, synaptic dysfunction and neurodegeneration. …”
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Is there a link between heart rate variability and cognitive decline? A cross-sectional study on patients with mild cognitive impairment and cognitively healthy controls
Published 2023-01-01“…Conclusion The results support the presence of autonomic dysfunction at the early stage of cognitive impairment. …”
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Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Bra...
Published 2025-03-01“…Keywords: liposomes, hydrogen sulphide, AP39, reactive oxygen species, mitochondrial-targeted compounds, mitochondrial dysfunction…”
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Ganoapplanilactone C from <i>Ganoderma applanatum</i> Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish
Published 2025-05-01“…Histopathological analysis confirmed GATC’s protective effects on the liver against high-fat diet-induced damage. …”
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Active Vitamin D Ameliorates Arsenite-Induced Thyroid Dysfunction in Sprague–Dawley Rats by Inhibiting the Toll-like Receptor 4/NF-KappaB-Mediated Inflammatory Response
Published 2024-12-01“…This study aimed to investigate the intervention effect of VD on NaAsO<sub>2</sub>-induced thyroid dysfunction in SD rats. …”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi...
Published 2025-02-01“…In vivo experiments demonstrated that QAFF effectively ameliorated colitis symptoms, reduced IL-6, IL-1β, and TNF-α levels, enhanced intestinal barrier integrity, and downregulated PI3K/AKT pathway activation. …”
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