Controlled release of hydrogel-encapsulated mesenchymal stem cells-conditioned medium promotes functional liver regeneration after hepatectomy in metabolic dysfunction-associated s... by Naoya Kasahara, Takumi Teratani, Junshi Doi, Shinichiro Yokota, Kentaro Shimodaira, Yuki Kaneko, Hideyuki Ohzawa, Yasunaru Sakuma, Hideki Sasanuma, Yasuhiro Fujimoto, Taizen Urahashi, Hideyuki Yoshitomi, Hironori Yamaguchi, Joji Kitayama, Naohiro Sata

“…Abstract Background Globally, prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing, and there is an urgent need to develop innovative therapies that promote liver regeneration following hepatectomy for this disease. …”
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Statins: Evidence for effectiveness by K. Outhoff

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The Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms by Chongshan Dai, Daowen Li, Tony Velkov, Jianzhong Shen, Zhihui Hao

“…Recent research has shown that melatonin supplementation can effectively mitigate AFB1-induced multiple toxic effects. …”
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Hypertension and Headache: the Effect of Antihypertensive Drugs by V. A. Parfenov, T. M. Ostroumova, O. D. Ostroumova

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Angioprotection role in arterial hypertension treatment: focus on olmesartan by D. V. Nebieridze, A. S. Safaryan, T. V. Ivanishina, N. L. Vinnitskaya

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Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure by Umesh Bhattarai, Xiaochen He, Ziru Niu, Lihong Pan, Dongzhi Wang, Hao Wang, Heng Zeng, Jian-Xiong Chen, Joshua S. Speed, John S. Clemmer, Yingjie Chen

“…IL12β is a subunit for proinflammatory cytokines IL12 and IL23. However, the effect of IL12β inhibition on HF development and the underlying mechanism is not understood.MethodsWe determined the effect of pharmacological inhibition of IL12β using IL12β blocking antibody on transverse aortic constriction (TAC)-induced left ventricular (LV) inflammation and HF development.ResultsIL12β blocking antibody significantly attenuated TAC-induced LV immune cell infiltration, hypertrophy, fibrosis, dysfunction, and the consequent pulmonary inflammation and remodeling. …”
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A modern conception of postcholecystectomy syndrome (based on the materials of the Advisory Board held on May 4, 2019 in Almaty, Kazakhstan) by A. V. Nersesov, D. A. Kaibullaeva, O. S. Vasnev, L. K. Tashenova, M. M. Sakhipov, G. T. Berestimov, G. A. Akhmetzhanova, O. T. Ibekenov, M. O. Doskhanov, N. M. Zhumazhanov, Zh. M. Balzhanov, B. A. Aitmoldin, E. A. Toleubaev, E. M. Laryushina, K. N. Zhumagulov, G. N. Sobirova, S. I. Umarova, Yu. O. Shulpekova, A. V. Okhlobystin

“…Papillosphincterotomy is not effective in relieving biliary pain in cases of the sphincter of Oddi dysfunction. …”
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Conservative Management of Thrombotic Microangiopathy in a Renal Transplant Recipient: The Importance of Early Recognition by Ahmad S. Matarneh, Sundus Sardar, Abdel‐rauof Akkari, Pankhuri Mohan, Naman Trivedi, Gurwant Kaur, Nasrollah Ghahramani

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Ocular rosacea: Update on diagnosis and new therapeutic options by Camila Del Castillo, Guillermo Raul Vera-Duarte, Naomi Carolina Zatarain-Barrón, Nicolás Kahuam-López, Alejandro Navas, Enrique O. Graue-Hernandez, Arturo Ramirez-Miranda

“…Its pathophysiology involves genetic predisposition, immune dysfunction, neurovascular alterations, and microbiome dysregulation, leading to chronic ocular surface inflammation and epithelial barrier disruption. …”
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Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy for Demodex-Associated Blepharitis by Farrant S, Giannaccare G, Lim CHL, Coco G

“…No patient reported TrAEs.Conclusion: Combined light therapy with IPL and LLLT employing blue and red lights is an effective treatment strategy for patients with recalcitrant Demodex-associated blepharitis to reduce mites count and improve main ocular surface parameters along with patients’ symptoms.Keywords: Demodex, dry eye, IPL, LLLT, meibomian gland dysfunction, MGD…”
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COMBINATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE: IS IT POSSIBLE TO FIGHT SYSTEMIC HYPERTENSION AND OBESITY TOGETHER? by Yu. A. Vasyuk, E. Yu. Shupenina, E. A. Nesterova, E. I. Golubkova, V. V. Nesvetov

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Hypoglycemia in type 2 diabetes mellitus patients — cerebral, cognitive, psychosocial and clinical aspects by K. V. Antonova, O. V. Lagoda, M. M. Tanashyan

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Comparative Efficacy of Quadratus Lumborum Muscle Energy Technique with Gluteus Medius Strengthening Versus Gluteus Medius Strengthening Alone in Sacroiliac Joint Dysfunction: A Ra... by Rabail Rani Soomro, Hossein Karimi, Syed Amir Gilani

“…Gluteus medius exercises, along with conventional treatment, are routinely given to patients with sacroiliac joint dysfunction; however, the aim of this study is to explore the additional effects of the muscle energy technique (MET) on the quadratus lumborum along with strengthening of the gluteus medius on pain, disability and quality of life of patients with sacroiliac joint dysfunction. …”
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Analysis of common causes of constipation and fecal incontinence after mixed hemorrhoids surgery and suggestions for prevention and treatment by Zhu Lianjun, Zeng Xinglin, Fan Wenbin, Liu Shan, Yang Xiangdong

“…Identifying the causes of defecatory dysfunction after mixed hemorrhoids surgery, implementing perioperative preventive measures, promptly administering individualized treatment, and conducting effective clinical management are crucial for alleviating symptoms and improving the quality of life of these patients. …”
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Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A by Yun Li, Wencong Sun, Hong Liu, Xiong Z. Ruan

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by excessive hepatic lipid accumulation. …”
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Endurance exercise attenuates Gαq-RNAi induced hereditary obesity and skeletal muscle dysfunction via improving skeletal muscle Srl/MRCC-I pathway in Drosophila by Xin-yuan Yin, Deng-tai Wen, Han-yu Li, Zhao-qing Gao, YuZe Gao, WeiJia Hao

“…Endurance exercise is an effective means of combating acquired obesity and its complications, but the mechanisms by which endurance exercise modulates hereditary obesity and its complications are unknown. …”
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High-activity placenta-derived mesenchymal stem cells combined with low-intensity extracorporeal shock wave therapy for diabetic erectile dysfunction: a prospective randomized cont... by Yun-Hua Ji, Yi-Fan Zhang, Xiao Tan, Hao-Zhong Hou, Zhen Yao, Bo Zhang

“…Conclusion The combination of high-activity hPMSCs and LI-ESWT appears to be a safe and effective strategy for improving erectile function in patients with diabetic ED, demonstrating a synergistic effect in prolonging erection duration and enhancing penile hardness. …”
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The emerging role of exercise preconditioning in preventing skeletal muscle atrophy by Xu Zhou, Xu Zhou, Shiming Li, Shiming Li, Lu Wang, Lu Wang, Jun Wang, Peng Zhang, Xiaoping Chen

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Normative data of the Spanish version of the Montreal Cognitive Assessment (MoCA) in older individuals from Peru by Lucia Bulgarelli, Emilia Gyr, Jose Villanueva, Koni Mejía, Claudia Mejía, Renato Paredes, Sheyla Blumen

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COMPARISON OF CLINICAL EFFICACY OF ORIGINAL BISOPROLOL AND ITS GENERIC DRUG IN PATIENTS WITH STABLE ANGINA AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE by N. Yu. Grigorieva, E. G. Sharabrin, A. N. Kuznetsov

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