Metformin may alter the course of Leber’s hereditary optic neuropathy: a case report by Shenoda Abd Elmaseh, Danielle A. Gauthier, Danielle A. Gauthier, Maryam Golmohammadi, Maryam Golmohammadi, Nutsa Pargalava, Valerio Carelli, Valerio Carelli, Alfredo A. Sadun, Alfredo A. Sadun

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The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19 by Yu. Р. Orlov, V. V. Afanasyev, I. A. Khilenko

“…A number of experimental and clinical studies (on a fairly large number of patients) reflect the positive effect of tissue hypoxia correction using succinates, both in adult patients and in children with a different spectrum of pathology associated with acute respiratory failure syndrome. …”
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Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies by Yehua Li, Siying Ren, Shen’ao Zhou

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Nanoplastics exposure exacerbates Aβ plaque deposition in Alzheimer’s disease mice by inducing microglia pyroptosis by Hongxiang Yu, Zongbo Zhao, Hui Li, Yingying Han, Hongxia Li, Can Cui, Yongbo Hu, Bei Zhang

“…Our study addresses the critical issue of environmental relevant dose nanoplastics (NPs) exposure and their neurotoxic effects, highlighting a significant environmental health concern. …”
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Transforming Screening, Risk Stratification, and Treatment Optimization in Chronic Liver Disease Through Data Science and translational Innovation by Tamer A. Addissouky

“…Analyses revealing IL21R as a PBC susceptibility gene and implicating dysfunctional VWF processing in portal hypertension deliver mechanistic insights. …”
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Impact of blood pressure variability on arteriovenous graft function during hemodialysis by Quan Zi-lin, Song Li, Sun Chun-yan, Cui Dong-mei, Zhao Li-yan, Zhong Mi, Zhou Li-fang, Chen Ying-gui, Fu Xia

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Moexipril in postmenopausal women with arterial hypertension by M. G. Glezer, E. B. Tkhostova, M. A. Demidova, Yu. B. Belousov

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The impact of perioperative hyperglycemia on postoperative cognitive function: A comprehensive review by Jiale Song, Shuqin Li, Heng Zhao, Qian Hao, Hongyuan Sui, Hongmei Zhou, Jian Lu

“…Hyperglycemia, commonly triggered by the physiological stress of surgery, is exacerbated by counter-regulatory hormonal responses and can lead to significant complications including Postoperative Cognitive Dysfunction (POCD) and delirium. These conditions not only extend hospitalization and increase healthcare costs but also negatively impact long-term patient well-being. …”
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Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis by Qianhua Yuan, Wanhan Song, Ya Wang, Yutong Xie, Dazhang Deng, Nageena Qayyum, Huawen Li, Honghui Guo

“…These findings supported that Nano-RAE alleviates WD-induced metabolic dysfunction and aging by enhancing mitochondrial biogenesis, highlighting its potential as a dietary intervention for obesity and age-related disorders.…”
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Medin induces pro‐inflammatory activation of human brain vascular smooth muscle cells by Nina Karamanova, Kaleb T. Morrow, Alana Maerivoet, Jillian Madine, Ming Li, Raymond Q. Migrino

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Target organs in patients with post-infarction chronic heart failure: dynamics during complex therapy including beta-adrenoblockers by I. P. Rubesh, L. A. Nekrutenko, A. V. Tuev, Yu. V. Larina, A. V. Agafonov

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Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment by Makhloufi Zoulikha, Jiahui Zou, Pei Yang, Jun Wu, Wei Wu, Kun Hao, Wei He

“…The developed rod-shaped nanococrystals effectively target the pulmonary endothelium and relieve experimental PH.…”
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Loneliness during the COVID-19 pandemic: A potential risk factor for post-pandemic cognitive decline in older adults without dementia by Alaa Harb, Juliana Nery Souza-Talarico, Grace Willey, Fernanda Carini da Silva, Maria Clara Ferreira de Jesus, Jennifer Deberg

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Game-based visual feedback-guided dynamic balance training versus conventional training in patients with hemiplegia: a pilot randomized controlled trial by Yan Xu, Jiadong Ni, Yajing Yang, Jiajia Yao, Lianhui Fu, Cong Xu

“…Conclusion: Our results indicate that game-based visual feedback with dynamic balance training has effects comparable to those of conventional balance training in patients with hemiplegia. …”
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KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients by Cairui Xu, Kangli Cao, Along Ma, Meijuan Zheng, Yuanhong Xu, Ling Tang

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Efficiency of L-arginine and L-carnitine in the Complex Treatment of Patients With Acute Myocardial Infarction and Comorbid Metabolic Syndrome by Shved M., Pelo M.

“…According to the results of numerous studies, synergistic effects of various components of the metabolic syndrome (MS) play a major role in the development of atherosclerosis, coronary artery disease and myocardial infarction (MI), due to the formation of numerous hemodynamic, neurohumoral, immuno-inflammatory, procoagulant reactions, leading to metabolic disorders in the cardiac muscle and vascular endothelial dysfunction. …”
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Influence of endothelial NO synthase gene polymorphisms on development and prognosis of chronic heart failure by N. F. Yakovleva, S. D. Mayanskaya, A. V. Yakovlev, M. L. Filipenko, E. N. Voronina, E. N. Berezikova, S. N. Shilov, T. I. Zakharova

“…Aim. To study the effects of eNOS gene polymorphisms (Glu298Asp and VNTR intron 4) on endothelial dysfunction (ED) development, chronic heart failure (CHF) severity and progression in patients with coronary heart disease (CHD) and arterial hypertension (AH).Material and methods. …”
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THYROID STATUS COMPENSATION AND CARDIOVASCULAR PARAMETERS IN PATIENTS WITH PRIMARY HYPOTHYREOSIS by E. S. Mazur, D. V. Kileynikov, V. V. Mazur, D. G. Semenychev

“…Aim. To investigate the effects of primary hypothyreosis (PHT) compensation on cardiac remodelling, aortic elasticity, and vasomotor endothelial function. …”
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CURRENT IDEAS ABOUT THE PATHOGENETIC MECHANISMS OF PAIN IN OSTEOARTHROSIS by E. F. Turovskaya, L. I. Alekseeva, E. G. Filatova

“…Experimental and clinical studies of the mechanism of chronic pain in osteoarthrosis (OA), which show that dysfunction of pain systems themselves (the so-called dysfunctional pain) along with the nociceptive mechanisms caused by chronic inflammation and degenerative changes in the joint area plays an important role in the chronization of pain syndrome, are considered in detail. …”
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Diaphragm Assessment by Multimodal Ultrasound Imaging in Patients with Chronic Obstructive Pulmonary Disease: A Prospective Observational Study by Zhang T, Liu Y, Wang M, He M, Yu M, Li Y, Song Y

“…Tianjie Zhang,1 Yan Liu,1 Mengmei Wang,2 Miao He,1 Min Yu,1 Yi Li,1 Ye Song1 1Department of Ultrasonography, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China; 2Department of Respiratory Diseases, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, People’s Republic of ChinaCorrespondence: Ye Song, Email songy_18@sumhs.edu.cnBackground: Chronic obstructive pulmonary disease (COPD) patients often exhibit diaphragmatic dysfunction which can be effectively assessed using ultrasonography. …”
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