A Moderate Intake of Beer Improves Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in a High-Fat Diet (HFD)-Induced Mouse Model by Andrea Vornoli, Aymen Souid, Barbara Lazzari, Federica Turri, Flavia Pizzi, Emilia Bramanti, Beatrice Campanella, Cheherazade Trouki, Andrea Raffaelli, Marta Wójcik, Clara Maria Della Croce, Lucia Giorgetti, Vincenzo Longo, Emanuele Capra, Luisa Pozzo

“…This study aimed to evaluate beer’s anti-steatotic effects in a high-fat diet (HFD)-induced mouse model of Metabolic dysfunction-Associated Liver Disease (MASLD) and to explore the underlying mechanisms. …”
Get full text

Triglycerides/high-density lipoprotein-cholesterol ratio outperforms traditional lipid indicators in predicting metabolic dysfunction-associated steatotic liver disease among U.S.... by Jin Yuan, Xuequan He, Yan Lu, Xuehua Pu, Lihe Liu, Xuejun Zhang, Jinping Liao, Guiling Li, Ying Luo, Tianwu Zhang

“…ObjectiveTriglycerides (TG), high-density lipoprotein cholesterol (HDL-c), and their ratio (TG/HDL-c) are key lipid markers associated with metabolic dysfunction. This study aims to investigate the association of TG, HDL-c, and TG/HDL-c ratio with metabolic dysfunction-associated steatotic liver disease (MASLD) and to assess whether TG/HDL-c ratio provides superior predictive ability for MASLD compared to TG or HDL-c alone.ImportanceAlthough previous research has explored the relationship between TG/HDL-c and MASLD, the applicability of these findings across different ethnicities and populations remains uncertain. …”
Get full text

Infusion of Human Umbilical Cord Blood Cells Ameliorates Hind Limb Dysfunction in Experimental Spinal Cord Injury through Anti-inflammatory, Vasculogenic and Neurotrophic Mechanism... by Chun-Ta Chen, Ning-Hui Foo, Won-Shiung Liu, Sheng-Hsien Chen

“…Human umbilical cord blood cells (HUCBCs) were used to investigate the mechanisms underlying the beneficial effects of cord blood cells in spinal cord injury (SCI). …”
Get full text

Construction of a deep - learning - based rehabilitation prediction model for lower-limb motor dysfunction after stroke using synchronous EEG-EMG and fMRI by Jiaqi Shi, Hongyu Wang, Haiyan Gou, Yan Chen, Jia He, Youyang Qu, Xinya Wei, Mingyue Fan, Yanlong Wang, Yanmei Zhu, Yulan Zhu

Get full text

Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway... by Bai Gao, Yuchen Jing, Xi Li, Shuyan Cong

“…We demonstrated that USP11 downregulation promoted ubiquitination modification of PTEN and activated the AKT pathway, and PTEN overexpression reversed the effects of USP11 knockdown. Conclusions Collectively, USP11 knockdown protects R6/1 mouse neurons from oxidative stress by alleviating mitochondrial dysfunction, thereby preventing the HD progression. …”
Get full text

Obesity-induced arterial redox imbalance involving mitochondrial NOX4, endothelial dysfunction, and ER stress underlie kidney injury compensated by enhanced mitochondrial bioenerge... by Cristina Contreras, Mercedes Muñoz, Óscar Freire-Agulleiro, Ánxela Estévez, María Pilar Martínez, Lucia Olmos, Alfonso Gómez del Val, Claudia Rodríguez, Ramona A. Silvestre, Ana Sánchez, Sara Benedito, Luis Rivera, Javier Sáenz-Medina, Miguel López, María Elvira López-Oliva, Dolores Prieto

“…Mitochondrial reactive oxygen species (mtROS) are key pathogenic factors in the microvascular complications of metabolic disorders including nephropathy. However, the effects of obesity on kidney vascular mitochondria and endothelial function remain unclear. …”
Get full text

CD36 promotes iron accumulation and dysfunction in CD8 T cells via the p38-CEBPB-TfR1 axis in earlystage hepatocellular carcinoma by Yifei Qin, Fei Huo, Zhuan Feng, Jialu Hou, Yaxin Ding, Quancheng Wang, Yu Gui, Ziwei Yang, Jiali Yang, Gang Zhou, Ling Li, Jianli Jiang, Lingmin Kong, Shijie Wang, Gang Nan, Dingqiao Xu, Xiaohang Xie, Lijuan Wang, Qian He, Ruibin Yang, Peng Lin, Huijie Bian, Zhi-Nan Chen, Jiao Wu

“…Background/Aims The identification of factors that lead to CD8+ T cell dysfunction within the tumor microenvironment (TME) holds great promise for the development of innovative immunotherapies. …”
Get full text

Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population by Hongyu Tan, Tingting Hu, Yunhui Pan, Yiting Xu, Yufei Wang, Xiaojing Ma, Yuqian Bao

“…Objective: This study aimed to explore the relationship between serum fibroblast growth factor 21 (FGF21) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), and further explore the mediation effect of inflammation in their association. …”
Get full text

Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway by Xiaoyan Bi, Xinhui Huang, Chunmei Zhang, Xin Zhao, Junyu Ma, Mengyao Li, Xuexun Li, Bangzhao Zeng, Rong Li, Xian Zhang, Fuli Ya

“…Pharmacological inhibition revealed that the beneficial effects of SFN on platelet function were mediated mechanistically through AR downregulation, which attenuated p53 phosphorylation via Src-dependent ROS generation.ConclusionThese findings suggest that by inhibiting the Src/ROS/p53 signaling pathway and mitigating AR-mediated platelet dysfunction, SFN may confer significant protection against atherothrombosis during hyperglycemia.…”
Get full text

Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease among Chinese children with obesity by Meijuan Liu, Bingyan Cao, Qipeng Luo, Yanning Song, Kai Liu, Di Wu

“…BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent chronic liver diseases worldwide. …”
Get full text

High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation by Jing Chen, Rui Feng, Bin-Bin Gong, Wei-Kang Wu, Bang-Shun Dai, Rui Tan, Wen-Long Xu, Tong Meng, Xiao-Bin Wang, Yun-Zheng Xiao, Cheng Yang, Li Zhang, Chao-Zhao Liang

Get full text

РОЛЬ СОЧЕТАННОГО ТЕЧЕНИЯ ХРОНИЧЕСКОЙ БРОНХООБСТРУКТИВНОЙ ПАТОЛОГИИ И АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ В РАЗВИТИИ ФУНКЦИОНАЛЬНЫХ НАРУШЕНИЙ ПОЧЕК (литературный обзор)... by А. В. Падыганова, Е. Н. Чичерина

“…In this review of literature a question of influence of the combined course of chronic bronchial obstructive pathology and arterial hypertension in the development of renal dysfunction is presented. The main links of a pathogenesis of the combined course of chronic bronchial obstructive pathology and arterial hypertension, bringing to development of renal dysfunction are opened. …”
Get full text

Sexual disorders in a 45 –year-old patient after hysterectomy in the home by Maria Ciechacka, Agnieszka Pawełko

“…Although this procedure is an effective treatment for conditions such as uterine fibroids, uterine prolapse, and chronic bleeding, its consequences for sexual health remain significant and are often insufficiently addressed in postoperative care. …”
Get full text

Efficacy of Whole Body Vibration Training and Yoga along with Resistance Band Exercise for Urinary Incontinence: A Pilot Study by Thirulogachandar Gunasekar, V Ritheeka, D Monesh, V Saravanan, B Shivaranjani, Murali Ravi, K Saraswathi, K Muthulakshmi

Get full text

Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…Establishing corresponding animal models of organ dysfunction syndrome is an essential step in clarifying its pathogenesis, researching potential effective drugs, and evaluating the effectiveness and safety of treatment plans. …”
Get full text

Early Use of Surfactant-BL after Lung Transplantation by M. Sh. Khubutia, A. A. Romanov, O. A. Kurilova, V. Kh. Timerbayev, E. I. Pervakova, I. V., Poplavsky, N. N. Levitskaya, A. M. Gasanov, S. V. Galaiko, D. Kh. Tsurova, S. V. Golovinsky, E. A. Tarabrin

Get full text

MODERN CONCEPTION AS TO THE FUNCTIONAL MORPHOLOGY OF THE OLFACTORY SYSTEM AND ITS CHANGES UNDER THE INFLUENCE OF SOME EXOGENOUS POLLUTANTS by A.D. Shkodina, R.M. Hrinko, I.I. Starchenko

“…In such cases, the olfactory dysfunction can be diagnosed after a long time after the start of the cohort with certain pollutants. …”
Get full text

Impact of gut microbiota on endometriosis: linking physical injury to mental health by Li Yuanyue, Li Yuanyue, Li Yuanyue, Hu Qian, Hu Qian, Liu Ling, Yang Liufeng, Yang Liufeng, Ge Jing, Ge Jing, Wu Xiaomei, Wu Xiaomei

Get full text

Concurrent validity of Thai version of pain assessment in advanced dementia scale versus self reported pain in cognitively impaired and intact geriatric surgical patients by Sahatsa Mandee, Arunotai Siriussawakul, Wannakant Tiraratmetakul, Taechasit Danjittrong

Get full text

Long-term consequences of COVID-19 on sleep, mental health, fatigue, and cognition: a preliminary study by Armin Adibi, Ali Motahharynia, Iman Adibi, Mehdi Sanayei

“…Notably, COVID-19 has been associated with long-term effects on the brain and mental health. This cross-sectional study aims to investigate depression, fatigue, sleep quality, and cognitive dysfunction, particularly working memory, in individuals with PCS compared to a healthy control group. …”
Get full text