Occupational Dysfunction as a Mediator between Recovery Process and Difficulties in Daily Life in Severe and Persistent Mental Illness: A Bayesian Structural Equation Modeling Appr... by Aki Watanabe, Takayuki Kawaguchi, Mai Sakimoto, Yuya Oikawa, Keiichiro Furuya, Taichi Matsuoka

“…If the mediation model was significant, the path coefficient from difficulty in daily life to recovery and the multiplication of the path coefficients mediated by occupational dysfunction were considered as each the direct effect and the indirect effect. …”
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Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway by Hui Chen, Hui Chen, Hui Chen, Hui Chen, Hui Chen, Ting Cao, Ting Cao, Ting Cao, Ting Cao, ChenQuan Lin, ChenQuan Lin, ChenQuan Lin, ShiMeng Jiao, ShiMeng Jiao, ShiMeng Jiao, YiFang He, YiFang He, YiFang He, ZhenYu Zhu, ZhenYu Zhu, ZhenYu Zhu, QiuJin Guo, QiuJin Guo, QiuJin Guo, RenRong Wu, HuaLin Cai, HuaLin Cai, HuaLin Cai, HuaLin Cai, BiKui Zhang, BiKui Zhang, BiKui Zhang

“…In this study, we investigated the therapeutic potential of AKK to counteract metabolic dysfunctions induced by Olanzapine (OLZ), a first-class antipsychotic known for its high therapeutic efficacy but also its association with metabolic disturbances, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). …”
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Astragaloside IV Alleviates H2O2-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway by Miaomiao Qi, Qiongying Wang, Runmin Sun, Zeyi Cheng, Mingze Li, Xin Fan, Feng Bai, Jing Yu

“…This study is aimed at evaluating the protective effects and mechanism of As-IV against H2O2-induced mitochondrial dysfunction in H9c2 cells. …”
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MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy by Yuxiao Zhang, Xiaoran Huang, Tucheng Sun, Linli Shi, Baojuan Liu, Yimei Hong, Qing-Ling Fu, Yuelin Zhang, Xin Li

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice by Mengjie He, Mengying Hu, Tingqiao Wang, Zeping Zuo, Hongkai Li, Zhiwei Zhao, Yunwen Hao, Xueling Dai, Jianfang Wang, Yaxuan Sun

“…The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. …”
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Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI S... by Zhiwei Guo, Yu Jin, Haitao Peng, Guoqiang Xing, Xiang Liao, Yunfeng Wang, Huaping Chen, Bin He, Morgan A. McClure, Qiwen Mu

“…The aim of this study was to evaluate the effects of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on stroke patients with motor dysfunction and to investigate the underlying neural mechanism. …”
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Frequency of thyroid dysfunctions during interferon alpha treatment of single and combination therapy in hepatitis C virus-infected patients: a systematic review based analysis. by Chandrasekharan Nair Kesavachandran, Frank Haamann, Albert Nienhaus

“…Variations in IFN dosage, treatment duration of IFN, definition/criteria followed in each study for thyroid dysfunction and irregular thyroid function testing during treatment in different studies influence the outcome of the single studies and jeopardise the validity of a pooled risk estimate of side effects of thyroid dysfunction. …”
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Low-Intensity Pulsed Ultrasound Enhanced Adipose-Derived Stem Cell-Mediated Angiogenesis in the Treatment of Diabetic Erectile Dysfunction through the Piezo-ERK-VEGF Axis by Shiyun Liu, Chenyi Jiang, Jianlin Hu, Huixing Chen, Bangmin Han, Shujie Xia

“…LIPUS enhanced the curative effects of ADSCs on diabetic erectile dysfunction through the activation of the Piezo-ERK-VEGF pathway. …”
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Targeting gut microbiota and metabolism profiles with coated sodium butyrate to ameliorate high-energy and low-protein diet-induced intestinal barrier dysfunction in laying hens by Sasa Miao, Jiankui Li, Ying Chen, Wenyan Zhao, Mengru Xu, Fang Liu, Xiaoting Zou, Xinyang Dong

“…Butyrate, a major energy source for intestinal epithelial cells, has been shown to improve barrier dysfunction and modulate the gut microbiota. In this trial, we examined the preventative effect of coated sodium butyrate (CSB) on high-energy and low-protein (HELP)-induced intestinal barrier injury in laying hens, and also worked to determine the underlying mechanisms by an integrative analysis of gut microbiota and the metabolome. …”
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Association of triglyceride glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis. by Yasaman Ghodsi Boushehri, Zahra Meymanatabadi, Ali Ezzatollahi Tanha, Pouria Azami, Maryam Alaei, Amir Ali Alamdari, Hooman Momtazi, Nasrin Deilami Moezzi, Amirhossein Habibzadeh, Shaghayegh Khanmohammadi

“…Studies evaluating the relationship between TyG-BMI and MASLD in adults were included. A random-effects model was employed to pool effect sizes, and subgroup analyses were conducted based on sex, disease definition, and population type.…”
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Poliumoside inhibits apoptosis, oxidative stress and neuro-inflammation to prevent intracerebroventricular streptozotocin-induced cognitive dysfunction in Sprague–Dawley rats: an i... by Yanan Zuo, Bineng Chen, Xiaokun Li, Guocheng Liu

“…The current therapeutic modalities are inefficient in managing the cognitive dysfunction of AD. Therefore, in this study, we aimed to investigate the pharmacological benefit of poliumoside (PMD) in streptozotocin-induced cognitive dysfunction in Sprague–Dawley (SD) rats. …”
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RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells by Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang

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Engeletin Targets Mitochondrial Dysfunction to Attenuate Oxidative Stress and Experimental Colitis in Intestinal Epithelial Cells Through AMPK/SIRT1/PGC-1α Signaling by Jing Li, Zhijun Geng, Lixia Yin, Ju Huang, Minzhu Niu, Keni Zhang, Xue Song, Yueyue Wang, Lugen Zuo, Jianguo Hu

“…This study investigated the therapeutic effects of Engeletin (Eng), a dihydroflavonoid from <i>Smilax glabra</i> Roxb., in dextran sulfate sodium (DSS)-induced colitis mice and colonic organoid models. …”
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Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels. by Ellen J Bennett, Richard J Mead, Mimoun Azzouz, Pamela J Shaw, Andrew J Grierson

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Bone Components Downregulate Expression of Toll-Like Receptor 4 on the Surface of Human Monocytic U937 Cells: A Cell Model for Postfracture Immune Dysfunction by Jui-An Lin, Feng-Yen Lin, Ta-Liang Chen

“…To mimic the immune status of monocyte in the localized fracture region, toll-like receptor 4 (TLR4) surface expression in human monocytic U937 cells was used as the main target to assess immune dysfunction following bone component exposure. We first identified the effects of bone components (including the marrow content) on TLR4 surface expression and then examined the mechanisms underlying the changes. …”
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Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts by Yi Wang, Guihua Chen, Deng Li

“…Abstract Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the therapeutic effects. …”
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Unveiling functionality and conducting two-sample mendelian randomization on WGCNA-identified oxidative stress-related hub genes in metabolic dysfunction-associated fatty liver dis... by Qian Zhu, Jiaqi Liu, Wuxuan Mei, Changchun Zeng

“…Metabolic dysfunction-associated fatty liver disease (MAFLD) shows accelerated development under the impact of oxidative stress (OS). …”
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A1166C POLYMORPHISM OF THE GENE FOR ANGIOTENSIN II RECEPTOR 1ST TYPE AND ENDOTHELIAL DYSFUNCTION IN MEN WITH A HISTORY OF MYOCARDIAL INFARCTION IN YOUNG AGE by O. A. Berkovich, E. A. Bazhenova, E. V. Volkova, M. Z. Alugishvili, N. V. Vahrameeva, I. O. Kiselev, E. V. Shlyahto, E. I. Schwarz

“…The crucial component of the RAAS is angiotensin II and its effects are carried out by angiotensin II receptors 1st type (AT1R).Aim of the study: determine the incidence of the mutant allele of the AT1R gene, estimate possible correlations between AT1R gene polymorphism and the extension of endothelial dysfunction in patients who have suffered MI in the age under 45.Materials and methods: 122 men suffering myocardial infarction under the age of 45 have been examined. …”
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Correlation of sarcopenia with progression of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: a study from two cohorts in China and the Un... by Fan Zhang, Longgen Liu, Wenjian Li

“…Subgroup analysis further corroborated the finding that the harmful effect of sarcopenia on liver fibrosis was consistent across all identified subgroups. …”
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Adaptation using IM Adapt of an evidence-based lifestyle intervention to support the management of metabolic-dysfunction associated steatotic liver disease among Hispanic/Latino ad... by Natalia I. Heredia, Sylvia A. Ayieko, Serena A. Rodriguez, Serena A. Rodriguez, Jessica P. Hwang, Lorna H. McNeill, Maria E. Fernandez, Maria E. Fernandez

“…The high prevalence of metabolic-dysfunction associated steatotic liver disease (MASLD), formerly non-alcoholic fatty liver disease (NAFLD), necessitates the availability of an evidence-based intervention to manage the condition among patients to prevent severe chronic liver disease and other cardiometabolic-related illnesses. …”
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