Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction by Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma

“…Methylglyoxal (MGO), a highly reactive dicarbonyl compound generated during glycolysis, is related to the pathogenesis of cardiovascular diseases and may also promote endothelial dysfunction. Acacetin (ACA) is a naturally occurring flavonoid that can inhibit apoptosis, oxidative stress and inflammation to slow the progression of coronary heart disease; however, its effects on endothelial dysfunction are unknown. …”
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Inhibition of lead acetate-induced testicular dysfunction in male wistar rats: A possible role for combined extracts of Syzygium aromaticum and Xylopia aethiopica seeds by Emmanuel Nnaemeka Uhuo, Paulinus Chinedu Nwuke, Chiemeziem Adnma Obike, Prince Ogochukwu Alaebo, Becky Chinyere Odili

“…Phytoconstituents exhibit antioxidative effects that enhance sperm parameters. This study sought to evaluate the efficacy of a combination extract of Syzygium aromaticum and Xylopia aethiopica seeds (1:1 ratio) in mitigating lead-induced testicular dysfunction in Wistar rats. …”
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Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase by Dongsheng Ni, Zhaolai Qi, Shuang Ma, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen, Kefei Dou, Guoping Li

“…Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as an important public health concern that poses a significant threat to human health and imposes a substantial economic burden. …”
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Inter- and Intraobserver variability of attenuation coefficient measurement in innovative ultrasound diagnosis of metabolic dysfunction-associated steatotic liver disease: a cross-... by Maksym Zhaivoronok, Oleh Dynnyk, Olexandr Livkutnyk, Viktoriia Yerokhovych, Violetta Yuzvenko, Violetta Yuzvenko, Iryna Serednia, Yelizaveta Melnychenko, Nazarii Kobyliak, Nazarii Kobyliak

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Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy‐lysosome degradation of ACSL4 by Xue‐Xue Zhu, Jia‐Bao Su, Fang‐Ming Wang, Xiao‐Ying Chai, Guo Chen, An‐Jing Xu, Xin‐Yu Meng, Hong‐Bo Qiu, Qing‐Yi Sun, Yao Wang, Zhuo‐Lin Lv, Yuan Zhang, Yao Liu, Zhi‐Jun Han, Na Li, Hai‐Jian Sun, Qing‐Bo Lu

“…Induction of ferroptosis and inhibition of the autophagy‐lysosome pathway blocked the protective effects of NKAα1 on EDR. Eventually, we identified Hamaudol as a potent activator of NKAα1 by restraining the phosphorylation and endocytosis of NKAα1, restoring EDR in obese diabetic mice. …”
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EBV Infection in XLP1 Manifested Solely by Behavioral Aggression and Effective Treatment Using Rituximab by Michelle M. Korah-Sedgwick, Luke A. Wall

“…This case also demonstrates the possible effectiveness of rituximab in the treatment of acute EBV infection.…”
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Transanal Irrigation for Refractory Chronic Idiopathic Constipation: Patients Perceive a Safe and Effective Therapy by Kevin J. Etherson, Ian Minty, Iain M. Bain, Jeremy Cundall, Yan Yiannakou

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Unveiling the economic value of equitable care for the traumatically injured: is it cost-effective to decrease trauma disparities? by Rachael A Callcut, Michelle A Price, Vanessa P Ho, Cynthia Lizette Villarreal, Michaela A West, Tanya L Zakrison, Tandis Soltani, Carrie Sims, Arpana Jain, Ashley N Moreno, Susan Cronn, Esther S Tseng, Richard D Betzold, Anamaria J Robles, Bethany Lauren Strong, Kathryn M Stadeli, Sydney Timmer-Murillo, Brianna R Fram, Pamela Bixby, Michelle F Buehner, Lourdes Castañón, Juan C Duchesne, Garrett D Hall, Benjamin Levi, Shayan Rakhit, Shakeva Swain, Marc A de Moya, amir M Fakhry, N Jacob Higgins, arah N Pierrie, L Bethany

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Copper-Based Nanoparticles for Effective Treatment Against Sepsis-Induced Lung Injury in Mice Model by Li JM, Zhang L, Pei SL, Guo L, Shen HL, He J, Guo YY, Zhang WQ, Lin F

“…In vitro experiments were conducted to determine the biologically effective concentration and elucidate the anti-inflammatory mechanism of action. …”
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Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function by Ling-Ling Li, Jie Ma, Jia-Jia Wu, Xin Xue, Mou-Xiong Zheng, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu

“…Moreover, a significant reduction in the along the perivascular space (ALPS) index was observed among aMCI patients, accompanied by a marked increase in PVS volume, indicating significant PVS dysfunction. Further moderation analysis revealed that PVS function moderated the relationship between effective connectivity within the Papez circuit and episodic memory. …”
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Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions by Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian

“…In both the primary cardiac adhesion model and the severe repeated‐injury cardiac adhesion model, the PLEL hydrogel is more effective than commercially available products (including Interceed film and sodium hyaluronate hydrogel) in significantly reducing the incidence and severity of adhesions, without causing any cardiac dysfunction or organ damage. …”
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The Effect of Osteoporosis Risk Factors on Bone Mineral Density by Ebru Umay, Uğur Tamkan, İbrahim Gündoğdu, Serkan Umay, Aytül Çakcı

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Evaluation of the effectiveness of combined treatment of coronary heart disease – coronary artery bypass grafting, transplantation of autologous bone marrow mononuclear cells: a ra... by V. V. Komok, N. S. Bunenkov, S. A. Beliy, V. M. Pizin, V. M. Kondratev, A. V. Dulaev, A. E. Kobak, T. S. Maksimova, I. P. Sergienko, E. V. Parusova, L. A. Smirnova, E. V. Babenko, B. V. Afanasev, A. S. Nemkov, G. G. Khubulava

“…Predictors of overall effectiveness were identified: smoking, initial diastolic myocardial dysfunction, left ventricular ejection fraction. …”
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Implementation of a nurse-delivered, community-based liver screening and assessment program for people with metabolic dysfunction-associated steatotic liver disease (LOCATE-NAFLD t... by Michelle J. Allen, Ruth Tulleners, David Brain, James O’Beirne, Elizabeth E. Powell, Adrian Barnett, Patricia C. Valery, Sanjeewa Kularatna, Ingrid J. Hickman

“…Abstract Background With the high burden of Metabolic dysfunction-associated steatotic liver disease (MASLD), (previously known as Non-Alcoholic Fatty Liver Disease - NAFLD) in the community, current models of care that require specialist review for disease risk stratification overwhelm hospital clinic capacity and create inefficiencies in care. …”
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Early (preclinical) diagnosis of endothelial dysfunction and disturbed vegetative regulation in young men with atherosclerosis risk factors (based upon the examination of male stud... by V. N. Kim

“…Endothelial sensitivity was proved to be effective in early diagnosis of endothelial dysfunction.…”
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Relative fat mass and risk of metabolic dysfunction associated steatotic liver disease and severe hepatic steatosis in U.S. adults: analysis of NHANES 2017–2020 data by Jianjun Wang, Wei He, Xianfu Cai, Zhaohui Hu, Yonghai Peng, Xi Chen, Pei Yang, Xintao Zeng, Sirui Chen, Decai Wang

“…However, its association with metabolic dysfunction associated steatotic liver disease (MASLD) and severe hepatic steatosis (SHS) is underexplored. …”
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Filiform fire needling therapy relieves T cells-mediated melanocyte apoptosis and dysfunction by inhibiting JAK/STAT3 pathway via Mfsd4a in vitiligo by Yue Shi, Dong Chen, Yao Wang, Cong Zhang, Yana Cao, Yan Liu, Ting Song, Cheng Tan, Yongjun Peng

“…Abstract We investigated the molecular mechanism of filiform fire needling therapy (FFN), an effective treatment option for vitiligo, focusing on its role in relieving depigmentation. …”
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Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic... by Han Y, Liu J, Li W, Zhang F, Mao Y

“…RCS analysis revealed that when ΔPBF exceeded 3.2%, ∆METS-IR exhibited an upward trend with further reduction in PBF.Conclusion: The reduction of PBF was closely associated with changes in METS-IR, indicating that fat loss is an effective method for improving insulin resistance in overweight/obese MASLD patients.Keywords: metabolic dysfunction-associated steatotic liver disease, insulin resistance, metabolic score for insulin resistance, triglyceride-glucose index…”
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Pathophysiological mechanisms of integrated regulation of water-sodium homeostasis: from cellular dysfunction of Na-K-ATPase to dysregulation of systemic volume control: a systemat... by Anatoliy Gozhenko, Walery Zukow, Olena Gozhenko, Mykhailo Saensus, Oleksandr Vitiukov

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Myocardial dysfunction caused by MyBPC3 P459fs mutation in hypertrophic cardiomyopathy: evidence from multi-omics approaches and super-resolution imaging by Yupeng Wu, Yupeng Wu, Yuzhu Zhang, Yuzhu Zhang, Qirui Zheng, Qirui Zheng, Qiyuan Wang, Qiyuan Wang, Xingyu Fang, Xingyu Fang, Zaihan Zhu, Zaihan Zhu, Jing Lu, Dandan Sun, Dandan Sun

“…However, there was limited knowledge of the structure–function relationships and potential pathways in clinical HCM with MyBPC3 P459fs mutation.MethodsWe used multi-omics approaches and super-resolution imaging to explore the effects of MyBPC3 P459fs mutation on humans and cells. …”
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