TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy by Ruifang Luo, Yuan Miao, Riqiang Hu, Fang Lin, Junyan Yan, Ting Yang, Lu Xiao, Zhujun Sun, Yuting Wang, Jie Chen

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Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation by Asmaa M. Gaber, Adel Abdel-Moneim, Eman S. Abdel-Reheim, Gamal Allam, Manal Abdul-Hamid, Ahmed Hosni, Ahmed Hosni

“…As well, cardiac expression of miRNAs-92a and -499 was elevated while that of miRNA-21 was depleted, reflecting an interdependence between hypothyroidism and the development of cardiac dysfunction. Despite HSD and LT4 effectively alleviating the THs profile, only HSD offered substantial protection from hypothyroidism-associated cardiac inflammation and injury through its potent impact on the transcriptional miRNAs level and Nrf2/NF-κB protein expression (key regulators of the redox biomarkers and the inflammatory mediators).ConclusionHSD provides dual thyroprotective and cardioprotective effects that enhance THs bioavailability and functionality in the cardiovascular system.…”
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Lotus seed (Nelumbo nucifera Gaertn.) extract at low dose ameliorates reproductive dysfunction in l-NAME-induced hypertension and oxidative stress in male rats by Anjaree Inchan, Krongkarn Chootip, Kitiya Kongthong, Tippaporn Bualeong, Wiriyaporn Sumsakul, Phapada Apaikawee, Pakaporn Sa-Nguanpong, Sinlapachai Senarat, Jutamas Wongphoom, Natthawut Charoenphon

“…(Lotus) seeds have been traditionally used to treat hypertension and are reported to have antioxidant effects. The role of lotus seeds in reproductive dysfunction associated with hypertension has not yet been investigated. …”
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DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway by Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu

“…Abstract Background This study aims to elucidate the effect and mechanism of phospholipid transfer protein (PLTP) on vascular dysfunction in DR and explore the molecular mechanism of abnormal PLTP expression based on DNA methylation. …”
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Anesthesia management using remimazolam for coronary artery bypass grafting and aortic valve replacement in a patient with severe cardiac dysfunction: A case report by Tomoki Sagawa, Yusuke Ishida, Tomomi Sasaki, Maiko Hosokawa, Kiyoko Bito, Katsunori Oe

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Associations Between Obstructive Sleep Apnea and Metabolic Dysfunction-Associated Fatty Liver Disease: Insights from Comprehensive Mendelian Randomization and Gene Expression Analy... by Ma T, Liao C, Chen W, Feng J

“…Additionally, three immune cell phenotypes (CD4RA on TD CD4+, HLA DR on CD14+ CD16-monocytes, and HLA DR on CD14+ monocytes) were found to be associated with both OSA and MAFLD.Conclusion: OSA may causally influence MAFLD and mediate the effect of BMI on MAFLD. Four key genes and three immune cell phenotypes play crucial roles in the shared pathogenesis of both diseases.Keywords: obstructive sleep apnea, metabolic dysfunction-associated fatty liver disease, OSA, Mendelian randomization, bioinformatics…”
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Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disea... by Leonard Burg, Heeyong Yoon, Min Peng, Peter Germano, Emily Reesey Gretzmacher, Rui Xiao, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Eiko Nakamaru-Ogiso, Marni J. Falk, Marni J. Falk

“…No morphological or functional toxic effects of zag were observed on larvae viability. …”
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Sevoflurane-induced cognitive dysfunction in aged mice mediated by HDAC8-dependent suppression of adult hippocampal neurogenesis via the pCREB/BDNF pathway by Yingxue He, Yanjing Guo, Xiaowei Li, Jiangnan Wu, Zunsai Feng, Gongming Wang, Mengyuan Zhang

“…Sevoflurane is a widely used anesthetic in elderly patients and has been linked to postoperative cognitive dysfunction; however, its molecular mechanisms remain unclear. …”
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Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction by XiaLing Huang, Fen Yu

“…Mechanistically, circ_0020491 binds to and stabilizes IGF2BP2, amplifying its effects. Overexpression of IGF2BP2 counteracted the improvements induced by circ_0020491 knockdown. …”
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Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice by Weilun Miao, Mengli Chen, Minglong Chen, Chang Cui, Yue Zhu, Xinping Luo, Bangwei Wu

“…In vitro, Nr2f2 knockdown ameliorated ferroptosis and mitochondrial dysfunction by negatively regulating PGC-1α, a crucial metabolic regulator. …”
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Sugammadex versus cholinesterase inhibitors to antagonize respiratory dysfunction after neuromuscular blockade in patients undergoing pulmonary surgery: a systematic review and met... by Bo Liu, Keqin Song, Peilin Wang, Fangshuo Li, Qianfeng Guo

“…This study aimed to elucidate the effect of sugammadex in the management of PORC-related respiratory dysfunction following thoracic surgery. …”
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ADSA Foundation Scholar Award: Shakin' off the rust—Oxidative stress and redox status as underlying factors of immune dysfunction in periparturient cows and preweaning calves by Angel Abuelo

“…Although the pathogenesis of these diseases is different, they share the feature that animals exhibit dysfunctional immune responses. A key factor responsible for the development of immune dysfunction in transition cows and newborn calves is oxidative stress (OS), which results from the imbalance between the production of reactive oxygen and nitrogen species (ROS/RNS) during times of high metabolic demands and the availability of antioxidant defenses that are needed to reduce oxidant-induced cellular damage and subsequent loss of function. …”
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Serum uric acid to high-density lipoprotein cholesterol ratio predicts all-cause mortality in adults with metabolic dysfunction associated steatotic liver disease by Yingyong Ou, Zihan Qin, Pinze Wang, Fan Zou

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent chronic metabolic diseases worldwide. …”
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Metabolic Reprogramming in HIV+ CD4⁺ T-Cells: Implications for Immune Dysfunction and Therapeutic Targets in <i>M. tuberculosis</i> Co-Infection by Suheena Ayrga, Gerrit Koorsen

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Inhibition of VDAC1 Rescues Aβ1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways by Xinpei Zhou, Ximin Tang, Tao Li, Dandan Li, Zhiting Gong, Xiujun Zhang, Yanjiao Li, Jianhua Zhu, Yong Wang, Bensi Zhang

“…It has been reported that VDAC1 associated with mitochondrial dysfunction and ferroptosis. However, the mechanism by which VDAC1 regulates mitochondrial dysfunction and ferroptosis of neurons in AD remains unclear. …”
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Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway by Reham H. Mohyeldin, Ehab E. Sharata, Michael Atef Fawzy, Mina Ezzat Attya, Nermeen N. Welson, Remon Roshdy Rofaeil

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Silencing LncRNA HCG27 ameliorates cognitive dysfunction after ischemic stroke via miR-27a-3p regulation by Ting Li, Ying Li, Lin Chen, Chaosheng Zeng, Huaijie Xing, Min Chen, Limin Yan, Xiaopei Zhang

“…Abstract Background We explore the effect of improving cognitive dysfunction after cerebral ischemia–reperfusion (CI/R) by regulating HCG27. …”
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Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells by Yi Chang, Ting-Chen Chang, Jie-Jen Lee, Nen-Chung Chang, Yung-Kai Huang, Cheuk-Sing Choy, Thanasekaran Jayakumar

“…Hyperglycaemia, a characteristic feature of diabetes mellitus, induces endothelial dysfunction and vascular complications by limiting the proliferative potential of these cells. …”
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Renalase Overexpression-Mediated Excessive Metabolism of Peripheral Dopamine, DOPAL Accumulation, and α-Synuclein Aggregation in Baroreflex Afferents Contribute to Neuronal Degener... by Xue Xiong, Yin-Zhi Xu, Yan Zhang, Hong-Fei Zhang, Tian-Min Dou, Xing-Yu Li, Zhao-Yuan Xu, Chang-Peng Cui, Xue-Lian Li, Bai-Yan Li

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Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early adolescen... by Linxi Qian, Linxi Qian, Tao Zheng, Tao Zheng, Bowen Zhao, Weiye Wang, Yifan Wu, Yifan Wu

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