Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha by Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou

“…This study integrates mechanistic and functional analyses to evaluate ALA's neuroprotective effects. Isoflurane‐exposed neonatal mice exhibited hippocampal metabolic dysregulation, with altered lactate, pyruvate, and adenosine triphosphate (ATP) levels, leading to cognitive dysfunction. …”
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A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model by Abraham Tettey-Matey, Viola Donati, Chiara Cimmino, Chiara Di Pietro, Damiano Buratto, Mariateresa Panarelli, Alberto Reale, Arianna Calistri, Maria Vittoria Fornaini, Ruhong Zhou, Guang Yang, Francesco Zonta, Daniela Marazziti, Fabio Mammano

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Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

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Stroke attributed to kidney dysfunction from 1990 to 2021 and the prediction for 2040: an analysis of national data in China based on the Global Burden of Disease 2021 database by Na Guo, Shen Teng, Shuyuan Chen, Jiawen Bi, Xiaolin Xu, Hongming Wang, Weiyu Teng, Weishuang Xue

“…The downward trends suggested that the current prevention for stroke related to kidney dysfunction were effective. However, the ASMRs of IS associated with kidney dysfunction is expected to exceed that for ICH, highlighting further interventions to reduce the burden of IS in vulnerable populations. …”
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Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptot... by Shouqing Zhang, Jiajia Yu, Sule Bai, Shuhan Li, Quanyuan Qiu, Xiangshun Kong, Cen Xiang, Zhen Liu, Peng Yu, Yuou Teng

“…<b>Objectives:</b> Metabolic dysfunction-associated steatohepatitis (MASH) lacks effective therapies. …”
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Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion by Yunhan Zou, Jiaoxiang Wu, Sheng Cheng, Daqing Cheng, Taoying Chen, Xirong Guo, Li Tang, Xianbin Su, Man Zhang, Xin Zhang, Ying Liu, Jin Zhang, Qun Bao, Shangwei Hou, Peng Sun, Yong Li, Bo Han

“…Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with limited effective treatments. …”
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A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome by Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard, Tao Jia

“…In vivo studies show Pt-ttpy’s efficient anti-tumor effects, disrupting mt genome function with fewer side effects than cisplatin. …”
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Chronic administration of a cannabis-derived mixture at an antihyperalgesic dose does not significantly enhance hepatotoxicity or the development of metabolic dysfunction-associate... by Kim B. Pedersen, Tomislav Jelesijevic, Tamara M. Morris, Sarah M. Melton, Ashley S. Henderson, John F. Glenn, Gregory J. Davenport, Martin J. J. Ronis, Peter J. Winsauer

“…The latter properties have led to the suggestion that these products could have therapeutic effects on the development of metabolic dysfunction-associated steatohepatitis (MASH) - a severe type of liver pathology in obese and diabetic patients. …”
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Optimization of electrical stimulation for the treatment of lower limb dysfunction after stroke: A systematic review and Bayesian network meta-analysis of randomized controlled tri... by Yu Fang, Jiang Li, Shanyu Liu, Yan Wang, Jiaming Li, Dongdong Yang, Qiaoling Wang

“…<h4>Objective</h4>To compare the treatment effect of five electrical stimulation methods commonly used in the treatment of stroke patients with lower limb dysfunction.…”
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Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation by Jianjun Zhao, Zhiyun Shu, Xiangjun Li, Wenqing Zhang, Mengze Sun, Wenxiao Song, Hongyuan Cheng, Shaomin Shi

“…Follow-up experiments revealed that Deh significantly inhibited PA-induced mitochondrial dysfunction in VSMCs by suppressing acetylation and expression of Drp1 and reducing mitochondrial ectasia, an effect that was achieved by regulating SIRT1. …”
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Omentin-1 protects against endothelial dysfunction through the AMPK/KLF2/eNOS pathway in adult rat offspring exposed to maternal diabetes by ChunXiang Wang, QingHua Wang, HaoShan Mai

“…Abstract Objective Exposure to gestational diabetes mellitus appears to produce several effects on offspring, including increased rates of early-onset cardiovascular disease from childhood to early adulthood. …”
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Prevalence of Erectile Dysfunction in Patients with Diabetes Mellitus and Its Association with Body Mass Index and Glycated Hemoglobin in Africa: A Systematic Review and Meta-Analy... by Wondimeneh Shibabaw Shiferaw, Tadesse Yirga Akalu, Yared Asmare Aynalem

“…DerSimonian and Laird random-effects model was applied to estimate the pooled effect size. …”
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3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis by Mingzhi Yang, Zipeng Jiang, Lutong Zhou, Nana Chen, Huan He, Wentao Li, Zhixin Yu, Siming Jiao, Deguang Song, Yizhen Wang, Mingliang Jin, Zeqing Lu

“…This study systematically evaluates the prebiotic effects of 3'-SL and its therapeutic potential in combination with Bifidobacterium infantis (B. infantis) for UC. …”
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Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway by Donghua Huang, Yizhong Peng, Kaige Ma, Xiangcheng Qing, Xiangyu Deng, Zhiliang Li, Zengwu Shao

“…Puerarin (PUR), an 8-C-glucoside of daidzein extracted from Pueraria plants, is closely related to autophagy, reduced reactive oxygen species (ROS) production, and anti-inflammatory effects, but its effects on human nucleus pulposus mesenchymal stem cells (NPMSCs) have not yet been identified. …”
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A New Way to Treat Central Nervous System Dysfunction Caused by Musculoskeletal Injuries Using Transcranial Direct Current Stimulation: A Narrative Review by Stéphane Perrey

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Mdivi-1 alleviates nicotine-induced human periodontal ligament cells injury by inhibiting mitochondrial fission and dysfunction through the JNK/Drp1 pathway by Leihua Cui, Meiqiao Chen, Yihong Jin, Huining Wang, Yubo Hou

“…However, the exact mechanisms through which nicotine exerts its harmful effects remain incompletely understood. This study investigates the impact of nicotine-induced mitochondrial fission on human periodontal ligament cells (hPDLCs). …”
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Ulinastatin inhibits macrophage M1 polarization to improve acute pancreatitis-associated intestinal barrier dysfunction by promoting Nrf2 signaling pathway activation by Qi Wang, Jiahui Fang, Siqi Zhang, Ming Gao

“…Results Ulinastatin treatment effectively improved both AP and AP-associated intestinal barrier dysfunction. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…The overexpression of PINK1 induced Prdx2 expression and effectively attenuated palmitic acid‐induced apoptosis through the c‐Jun amino‐terminal kinase (JNK) and mitogen‐activated protein kinase (p38) pathways, whereas siRNA‐mediated Prdx2 knockdown abolished the protective effect of PINK1. …”
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The Upregulation of L1CAM by SVHRSP Mitigates Neuron Damage, Spontaneous Seizures, and Cognitive Dysfunction in a Kainic Acid-Induced Rat Model of Epilepsy by Zhen Li, Biying Ge, Haoqi Li, Chunyao Huang, Yunhan Ji, Melitta Schachner, Shengming Yin, Sheng Li, Jie Zhao

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Evaluation of Standard Market Preparation Tablet (Tentex Forte) and Vrishya Gutika in the Management of Klaibya (Erectile Dysfunction): Research Protocol for a Randomised Controlle... by Abhishek Patil, Sourabh Deshmukh, Trupti Thakre

“…Introduction: Klaibya is a sexual dysfunction characterised by various symptoms, including Ling Shaithilya (penis shrinkage) and Mlan Shishna (penis weakening). …”
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