Application of Meldonium for the Treatment of Patients with Diabetic Nephropathy by Topchii І.

“…Medications of the basic treatment (ACE inhibitors and CCB) have a positive effect both on endothelial dysfunction and on structural changes of the myocardium, protecting it from the further remodeling. …”
Get full text

Features of ionic transport processes in a model of arterial hypertension by A. V. Nosarev, Yu. G. Birulina, I. V. Petrova, I. V. Kovalev, S. V. Gusakova, L. V. Smagliy, E. S. Teslya, A. Yu. Shamanaev, E. V. Pushkina, M. A. Medvedev

Get full text

Prospects for using a perindopril/amlodipine combination in patients with hypertension and/or coronary artery disease and COVID-19: focus on the endothelium by O. A. Polyakova, A. I. Kochetkov, O. D. Ostroumova

“…A strong theoretical justification for the multisystem effect of COVID-19 is the close relationship between it and endothelial dysfunction, which, according to expert consensus, is crucial for the pathogenesis and severity of the disease. …”
Get full text

Lead affects the proliferation and apoptosis of chicken embryo fibroblasts by disrupting intracellular calcium homeostasis and mitochondrial function by Zheng Liu, Budan Liu, Weijun Guan, Hui Wang

“…This study investigated the effects of Pb on CEF proliferation and apoptosis, and the underlying molecular mechanisms in vitro. …”
Get full text

Vliyanie sulodeksida na funktsional'noe sostoyanie endoteliya u bol'nykh s sakharnym diabetom i diabeticheskoyretinopatiey by Natalya Alexandrovna Gavrilova, Olga Evgen'evna Tishchenko

Get full text

Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma by Evangelia E. Tsakiridis, Elham Ahmadi, Jaya Gautam, Yi Ran Hannah She, Russta Fayyazi, James S.V. Lally, Simon Wang, Fiorella Di Pastena, Celina M. Valvano, Daniel Del Rosso, Olga-Demetra Biziotis, Brandon Meyers, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg

“…The complex microenvironment of these tumors, characterized by metabolic dysfunction, hypoxia, steatosis, and fibrosis, limits the effectiveness of standard-of-care therapies, such as the multi-tyrosine kinase inhibitor lenvatinib (LEN). …”
Get full text

Natriuretic peptides and chronic heart failure in arterial hypertension patients by Yu. A. Vasuyk, A. B. Khadzegova, S. V. Ivanova, I. M. Amirbegishvili, N. I. Gerasimova, E. N. Yushchuk, O. V. Krikunova, V. G. Bitsuev

“…The data describing possible antihypertensive therapy effects on brain natriuretic peptide level in AH patients are presented.…”
Get full text

Non-infectious chronic blepharitis pharmacotherapy by S. N. Sakhnov, S. V. Yanchenko, A. S. Rudashova, A. V. Malyshev

“…Purpose: To evaluate the effectiveness of complex treatment included the eyelid hygiene in non-infectious chronic blepharitis patients.Methods: 50 non-infectious chronic blepharitis, meibomian gland dysfunction and dry eye patients (18‑46 years) were examined before and after the treatment (eyelid hygiene using Blepharoshampoo, Blepharolotion or Blepharosalfetka, Blepharogel-1; anti-inflammatory therapy; artificial tears). …”
Get full text

Clinical and Economic Evaluation of the Blood Purification with Selective Sorption Techniques in ICU Patients by Yu. S. Polushin, D. V. Sokolov, R. O. Dreval, A. N. Zabotina

Subjects: Get full text

Somatoform disorders in the family doctor's practice by Prykhodko V., Mikropulo I., Oleinik M., Kononenko E., Moreva D., Gogol O., Kashkovskiy D., Lisnyak O., Lisnyak A.

“…Somatoform disorders include somatization disorder, undifferentiated somatoform disorder, hypocho¬n¬driacal disorder, somatoform dysfunction of the autonomic nervous system and stable somatoform pain disorder. …”
Get full text

A method for assessing changes in mandibular biomechanics using a software-hardware system by T. G. Makichyan, E. V. Gusakova, Z. S. Khabadze, A. S. Sulimov

“…Ninety patients aged 19 to 61 years with TMJ dysfunction and extra-occlusal disorders were enrolled. …”
Get full text

Translation, Cultural Adaptation and Content Validity of the Persian Version of the Structured Cognitive Training Program “NEUROvitalis” by Milad Karimi, Amin Modarres Zadeh, Payam Kabiri, Hasan Ashayeri, Ahmad Rreza Khatoonabadi, Elke Kalbe

Get full text

Evaluating Frequency and Yield of Echocardiography in a Pediatric Intensive Care Unit by Shafee Salloum, MD, Andrew J. Lautz, MD, Christopher Statile, MD

“…Low ventricular function, defined as moderate or severe systolic dysfunction, was found in 6% of all TTEs, whereas 94% showed hyperdynamic, normal, or mildly diminished ventricular function. …”
Get full text

Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis by Zenghui Li, Xinghui Li, Hui Jiang, Jingdong Li, Bin Xiao, Yong Chen, Shunhai Jian, Mei Zeng, Xiaoming Zhang

“…The products of lipid metabolism, ROS, contribute to mitochondrial ultrastructural alterations and mitochondrial dysfunction. These changes act as sentinel events that regulate acute pancreatitis.…”
Get full text

Clinical, Echocardiographic and Laboratory Cardiac Monitoring in Breast Cancer Patients Undergoing Chemotherapy with Anthracycline Agents: A Pilot Study on Cardioprotective Algorit... by Indah Puspita

“…There was low incidence of cardiovascular risk factors in this population, indicated stronger isolated effect of chemotherapy agent for cardiac dysfunction progression. …”
Get full text

Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…Altered CD73-adenosine signaling likely plays a substantial role in immune dysfunction in CKD. Keywords: adenosine, CD73, hemodialysis, infection, T cell dysfunction…”
Get full text

Economic impact of reduced postoperative visits after inflatable penile prosthesis implantation by Bradley Gill, Young Eun Shin, Kathryn Durand, Andrew Sun, Paurush Babbar, Sirikan Rojanasarot

Prevalence and determinants of erectile dysfunction among type 2 diabetes mellitus patients at selected government hospitals in gurage zone: A cross-sectional study. by Seid Abrar Abdlshikure, Aklilu Getachew Mamo, Bisrat Fikadu, Abdulber Seid

“…<h4>Background</h4>Erectile dysfunction (ED) is often not recognized in men with type 2 diabetes mellitus (T2DM), despite the prevalence of the disease. …”
Get full text

ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS

“…This study investigated astrocyte dysfunction in ADLD through two complementary approaches. …”
Get full text

Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson’s disease through inhibition of H3K4me3 demethylation by Xiaoyuan Zhang, Fali Zhang, Yue Zeng, Aiying Li, Jiamao Yan, Pei Li, Kexin Qin, Teng Zhang, Jiaojiao Huang, Minghui Zhao, Massimo De Felici, Yang Zhou, Wei Shen

“…Here, we report that impaired mitochondrial quality control (MQC) system is a molecular basis of the mitochondrial dysfunction in PD and that tricarboxylic acid cycle (TCA cycle) disorder is the main feature of such mitochondrial dysfunction. …”
Get full text