Electroacupuncture regulates ferroptosis to improve postoperative cognitive dysfunction in mice through mediating GRX1/GSK-3β/Nrf2 axis by Xiaqing Zhang, Afen Zhang, Rui Li, Mingna Jiao, Rou Wen, Rongzhi Zheng

“…Background: The incidence of postoperative cognitive dysfunction (POCD) is higher happening in the elderly. …”
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VGLL4 Protects against Oxidized-LDL-Induced Endothelial Cell Dysfunction and Inflammation by Activating Hippo-YAP/TEAD1 Signaling Pathway by Kaicheng Xu, Haomin Zhao, Xiaolei Qiu, Xiwen Liu, Fucheng Zhao, Yue Zhao

“…The aim of this study was to investigate the effect of VGLL4 on the dysfunction and inflammatory response of Ox-LDL-induced human umbilical vein endothelial cells (HUVECs) and its mechanism, so as to provide a new theoretical basis for the diagnosis and treatment of atherosclerosis. …”
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A novel peptide from yak ameliorates hypoxia-induced cardiac dysfunction via targeting gut microbiota and HIF-1α pathway by Feiyan Yang, Guangfan Qu, Yuchi Wu, Pingsheng Zhong, Zhongxing Chu, Zeyu He, Yuyan Wang, Yiping Tang, Shuguo Sun, Feijun Luo

“…Our previous investigations showed that peptide from yak milk residue exhibits notable antioxidant, anti-inflammatory, and anti-apoptotic properties that may have a good regulatory effect on hypoxic cardiac dysfunction. In this study, our results suggest that oral administration of yak milk peptide T3 improves the cardiac dysfunction of mice by the hypoxia-inducible factor 1α (HIF-1α) pathway, and these results may be related to the regulation of T3 on the gut microbiota of mice. …”
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Influence of levothyroxine replacement on metabolic dysfunction-associated steatotic liver disease and dyslipidemia in subclinical hypothyroidism: insights from a randomized contro... by Zainab Gaber Mahran, Salma Mokhtar Osman, Amira Abdelmawgod, Nahed A. Makhlouf, Elham Ahmed Hassan, Ehab F. Moustafa

“…Abstract Background In recent years, there has been growing awareness of metabolic dysfunction-associated steatotic liver disease (MASLD) linked to hypothyroidism. …”
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Comparison of Male and Female Sexual Dysfunction between Hemodialysis and Peritoneal Dialysis in Patients with End-Stage Renal Disease: An Analytical Cross-Sectional Study by Shahryar Zeighami, Saeid Dehghankhalili, Khadije Heiran, Seyede Pegah Azarchehry, Alireza Heiran, Mehrab Sayadi, Fatemeh Azadian

“…One of the most ignored but important health issue among dialysis patients is sexual dysfunction, which interferes with quality of life (QoL). …”
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Serum insulin-like growth factor binding protein 2 is associated with hepatic steatosis in adults with metabolic dysfunction-associated steatotic liver disease by Ziwei Wang, Hongyan Wu, Hsiuying Fu, Yingying Xue, Lixuan Shen, Jingyu Zhu, Ziwei Zhu, Xizhong Yu, Ruonan Zhou, Wenbin Shang

“…Methods: A total of 347 patients with metabolic dysfunction-associated steatotic liver disease (MASLD) were enrolled, adhering to the inclusion criteria. …”
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Centella asiatica extract improves senescence-associated metabolic dysfunction by targeting inflammation in adipose tissue and macrophage in obesity-induced insulin resistance mice by Agian Jeffilano Barinda, Agian Jeffilano Barinda, Wawaimuli Arozal, Wawaimuli Arozal, Nounik Cheri Dwita, Muhamad Sadam Safutra, Ippei Shimizu, Yung Ting Hsiao, Normalina Sandora, Rani Wardani Hakim, Rani Wardani Hakim, Nurul Gusti Khatimah, Harri Hardi

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High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction by Niyousha Ghazbani, Arezoo Razmdideh, Amin Alimohammadi, Danial Bagherzadeh, Ehsan Rezaee Moeini, Mohammad Reza Mozaffari, Mohammad Sadra Roshani Koosha

“…Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction. High-intensity interval training (HIIT) improves cardiometabolic health, but its effects on hemostatic markers in MetS remain underexplored. …”
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The association between inflammatory, metabolic, and hepatic fibrosis-related biomarkers and atrial fibrillation in older patients with metabolic dysfunction-associated steatotic l... by Shuai Zhang, Hao Liang, Jun Liu, Zhipeng Huang, Xijing Shi, Ye Zhu

“…Subgroup analysis revealed significant interaction effects between diabetes and the AF risk associated with NFS, ALBI, and FIB-4, as well as between sex and the AF risk associated with MHR(P for interaction < 0.05). …”
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Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 by Xiaodie Wei, Xiaohui Liu, Jinhan Zhao, Jinhan Zhao, Yang Zhang, Lixia Qiu, Jing Zhang

“…BackgroundSarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Ellagic Acid Alleviates Imidacloprid-Induced Thyroid Dysfunction via <i>PI3K/Akt/mTOR</i>-Mediated Autophagy by Amina A. Farag, Mahmoud Mostafa, Reham M. Abdelfatah, Alshimaa Ezzat ELdahshan, Samar Fawzy Gad, Shimaa K. Mohamed, Mona K. Alawam, Aya Aly Elzeer, Nesma S. Ismail, Sally Elsharkawey, Haneen A. Al-Mazroua, Hatun A. Alomar, Wedad S. Sarawi, Heba S. Youssef

“…This study aimed to evaluate the therapeutic effects of EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction and to investigate the underlying mechanisms. …”
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Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin‐Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Path... by Yi Zhong, Di Fan, Peiyi Zhang, Xiaoxiang Mao, Baoqing Liu, Cheng Wang, Qiubai Li

“…Previous studies have demonstrated that mitochondrial dysfunction and oxidative stress are crucial in DIC and are promoted by RNF2 overexpression and impeded by RNF2 knockout. …”
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Human umbilical cord-derived mesenchymal stromal cell exosomes ameliorate aging-associated skeletal muscle atrophy and dysfunction in SAMP10 mice by Zhe Huang, Limei Piao, Xiangkun Meng, Aiko Inoue, Kazuhiro Hitomi, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

“…Because exosomes of human umbilical cord-derived mesenchymal stem cells (hucMSC-Exos) have been widely used to treat various human diseases, we examined their effects on aging-associated muscle atrophy and dysfunction in senescence-accelerated mouse prone 10 (SAMP10) mice, an animal model of human Sarcopenia. …”
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Association between oxidative balance score and prevalence rates of thyroid dysfunction and autoimmune thyroiditis among U.S. adults: evidence from epidemiological studies by Jie Wu, Xuqin Dong, Qingkai Yang, Junxian Niu, Chuyu Jia, Xin Li, Zhuyan Li

“…This study aimed to explore the relationship between OBS and the prevalence of thyroid dysfunction.MethodsThis study investigated the relationship between OBS and the prevalence of thyroid dysfunction using data from 6,268 participants in the 2007–2012 National Health and Nutrition Examination Survey (NHANES). …”
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A novel calreticulin of Psoroptes ovis regulated keratinocyte function resulting in host skin barrier dysfunction: implications for involvement in the pathogenesis of psoroptic man... by Yane Li, Guiying Hao, Je Fan, Fangyan Wu, Xiangyue Yao, Youping Liang, Jing Xu, Ran He, Hui Wang, Yue Xie, Xiaobin Gu

“…To investigate the functional impact of recombinant PsoCRT (rPsoCRT), we conducted in vitro studies assessing its effects on keratinocyte proliferation, migration, differentiation, and the expression of immune regulatory factors. …”
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Which treatment works better for Meibomian Gland Dysfunction: LipiFlow or intense pulsed light? A systematic review and network meta-analysis by Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

“…Background: Meibomian Gland Dysfunction (MGD) is a common cause of evaporative dry eye disease. …”
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Bone morphogenetic protein 10 serves as a biomarker and a potential therapeutic target for endothelial dysfunction in endotoxin-induced acute lung injury by Wen-Kuang Yu, Wei-Chih Chen, Hsiao-Chin Shen, Chuan-Yen Sun, Hui-Jung Yu, Vincent Yi-Fong Su, Kuang-Yao Yang

“…Additionally, LPS stimulation increased the levels of ICAM-1, VCAM-1, and angiopoietin-2, highlighting evidence of endothelial dysfunction. BMP10 treatment reversed these effects. …”
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Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease by Zixuan Wang, Zixuan Wang, Ge Chen, Xutong Sun, Jia Xiao, Lingling Kong, Shunshun Jiang, Tingting Xu, Meijiao Wang, Meijiao Wang, Hong Zhao

“…ObjectiveTo investigate the effects of the Mediterranean diet (MD) on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).MethodsC57BL/6 mice were fed a high-fat diet for 12 weeks to induce MASLD, with normal chow (NC)-fed mice as controls. …”
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MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients by Ye R, Wei Y, Li J, Xu M, Xie H, Huang J, Deng L, Li C

“…Finally, we found that plasma-EVs from sepsis patients exert an inhibitory effect on PMNs autophagy, which can be reversed by EV inhibitors such as GW4869 and enoxaparin.Conclusion: These findings suggest that miRNAs and PMN-related membrane proteins from plasma-EVs could be valuable diagnostic tools for identifying sepsis-induced organ dysfunction and predicting prognosis, enabling proactive management of sepsis by physicians and improving the prognosis of sepsis patients.Keywords: extracellular vesicles, MicroRNAs, membrane proteins, sepsis-induced organ dysfunction, neutrophils, autophagy…”
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Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection by Lakmini S. Premadasa, Marina McDew-White, Luis Romero, Beverly Gondo, Jade A. Drawec, Binhua Ling, Chioma M. Okeoma, Mahesh Mohan

“…Although epigenetic mechanisms are predicted to drive GI dysfunction, they remain unknown and unaddressed in HIV/SIV infection. …”
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