Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction by Qing Wang, Wen He, Yufeng Zhou, Rui Feng, Yingwen Wang, Lijuan Liu, Yuan Yuan, Jiajia Dai, Yun Liu, Xiaobo Zhang

“…The activation of the epidermal growth factor receptor (EGFR) pathway and its downstream extracellular regulating kinase (ERK) was investigated using transcriptomic sequencing to elucidate the effects of PS-NPs exposure on lung epithelial barrier dysfunction. …”
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Cycling training for endothelial dysfunction correction and atherosclerotic risk factor modification in young males (data from Tomsk City university students’ survey) by G. B. Krivulina, V. N. Kim, R. S. Karpov, V. M. Shevelev

“…To assess physical training (PT) effect on NO-dependent vascular and autonomous tonus disturbances in male students with atherosclerosis risk factors (ARF) and endothelial dysfunction (ED), as well as to develop the optimal PT protocol. …”
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Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey by Shaojie Liu, Shaojie Liu, Weibin Huang, Yaming Lin, Yifei Wang, Hongjin Li, Xiaojuan Chen, Yijia Zou, Bo Chen, Baochang He, Zhiping Yang, Jing Fan

“…ObjectivesThe associations between various minerals' intake and thyroid dysfunction (TD), including hyperthyroidism and hypothyroidism, are still inconclusive, which may be attributed to the potential synergistic effects among various minerals.MethodsThe data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2002 and 2007–2012 databases. …”
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EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells by Weike Hu

“…Furthermore, MTHFD2 overexpress and EP300 ablation counteracted each other’s effect in LPS-exposed NRK-52E cells. EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction of tubular epithelial cells in SI-AKI.…”
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Maternal Low-Protein Diet During Nursing Leads to Glucose–Insulin Dyshomeostasis and Pancreatic-Islet Dysfunction by Disrupting Glucocorticoid Responsiveness in Male Rats by Paulo Cezar de Freitas Mathias, Aline Milena Dantas Rodrigues, Patrícia Cristina Lisboa, Rosiane Aparecida Miranda, Ananda Malta, Tatiane Aparecida Ribeiro, Luiz Felipe Barella, Ginislene Dias, Thalyne Aparecida Leite Lima, Rodrigo Mello Gomes, Egberto Gaspar de Moura, Júlio Cezar de Oliveira

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Compound Xuanju capsules combined with phosphodiesterase-5 inhibitors as a new strategy for erectile dysfunction: a meta-analysis and trial sequential analysis by Ronghui Li, Min Liao, Yunfeng Yu, Bing Guo, Rong Yu, Qinghu He, Qinghu He, Guomin Zhang

“…Trial sequential analysis confirmed that the meta-analysis results for IIEF-5, clinical effectiveness rate, penile cavernous blood flow, and serum testosterone levels were conclusive. …”
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Economic evaluation of non-invasive test pathways for high-risk metabolic dysfunction-associated steatotic liver disease (MASLD) in the United Kingdom (UK) by Zobair M. Younossi, James M. Paik, Linda Henry, Richard F. Pollock, Maria Stepanova, Fatema Nader

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BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1/Smad2/3 Signaling Pathways by Zhigui Wu, Wenxian Yin, Mengqi Sun, Yuankai Si, Xiaoxiao Wu, Meijuan Chen

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The Complex Treatment Algorithm for Dry Eye Syndrome with Meibomian Gland Dysfunction. Combination of Intense Pulsed Light (IPL) with Eyelid Hygiene and Artificial Tears by D. Yu. Maуchuk, A. O. Loshkareva, T. V. Tsvetkova

“…Nowadays, Meibomian gland dysfunction is considered as the leading cause of dry eye syndrome. …”
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Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage by Xue Li, Yao Zhuang, Ya Ru Zhang, Ke Ke Fan, Xin Xin Chen, Xin Xing Chen, Xuan Yi Liu, Jing Sun, Li Liu

“…IntroductionDopamine system dysfunction is closely associated with nervous system diseases such as Parkinson’s disease and psychiatric disorder. …”
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From adiposity to steatosis: metabolic dysfunction-associated steatotic liver disease, a hepatic expression of metabolic syndrome – current insights and future directions by Bruno Basil, Blessing K. Myke-Mbata, Onyinye E. Eze, Augustine U. Akubue

“…Future research should focus on precision medicine and innovative therapies to effectively address the disease and its consequences.…”
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Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice by Jiacheng Fang, Jiacheng Fang, Xiaochen Zhang, Zhongshi Qi, Zhongshi Qi, Liying Zhou, Yuntiao Chen, Qingxin Li, Run Liu, Hongzhuan Yu

“…IntroductionDiabetic cognitive dysfunction (DCD) refers to the impairment of cognitive function resulting from diabetes. …”
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Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling by Sha Li, Hongyan Wang, Mingzhe Qin, Wei Huang, Huifang Gao, Xiaoyang Song, Xiaolong Chen, Bixi Li

“…Notably, RAGE overexpression negates the beneficial effects of EE, emphasizing the key role of this receptor in SI-induced susceptibility to POCD. …”
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Comparative efficacy of amiodarone with ivabradin combination or amiodarone with bisoprolol combination in the prevention of atrial fibrillation recurrence in pa- tients with left... by K. G. Adamyan, L. G. Tunyan, A. L. Chilingaryan

“…The incidence of side effects in group 1 was significantly less than that in group 2 and was not different compared with control group. …”
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Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis by Andrea Costamagna, Eleonora Balzani, Matteo Marro, Erika Simonato, Alessandro Burello, Mauro Rinaldi, Luca Brazzi, Massimo Boffini, Vito Fanelli

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Decreased vasoregulatory dysfunction associated with intra-operative hemoadsorption treatment is related to mitigated post-transplant procalcitonin rather than cytokine or compleme... by Hajna Katona, Hajna Katona, Adam Soltesz, Adam Soltesz, Eniko Kovacs, Eniko Kovacs, Zsofia Szakal-Toth, Eszter Tamaska, Eszter Tamaska, Kristof Racz, Kristof Racz, Tamás Radovits, Attila Fintha, Krisztián Kovács, Lisa Hurler, Zoltán Prohászka, Bela Merkely, Endre Nemeth, Endre Nemeth

“…The 24-h inflammatory profile of HA and control groups remained unchanged in the cluster of severe vasoregulatory dysfunction. There was a moderate positive correlation between the vasopressor score and the PCT concentration in the control group (rS: 0.605, p = 0.002) which was not identified in the HA group.DiscussionIntraoperative HA treatment exerts a beneficial modulatory effect on the postoperative PCT response in OHT recipients, which is directly associated with significantly lower rates of post-transplant severe vasoregulatory dysfunction compared to controls.…”
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The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction by Shan Liu, BSc, Ze-Lang Cai, MS, Jingcheng Liu, Si-Yi Que, BSc, Wan-Zhen Hu, MS, Liang Chen, MS, Jia-Jie Chen, PhD, Kunmei Ji, PhD

“…Our aim was to investigate the effects of Der p 39 on AD-like inflammation and associated mechanisms. …”
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Pelvic dysfunction in women as a consequence of anatomical and functional changes of the pelvic floor during pregnancy and a reflection of adaptation to childbirth: A review by Aleksandr A. Bezmenko, Anna S. Staroverova

“…It has been shown that the onset of pelvic dysfunctions during pregnancy is a reflection of the stages of connective tissue remodeling. …”
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Association between non-skimmed milk consumption and metabolic dysfunction-associated fatty liver disease in US adults: insights from NHANES data by Futao Wu, Fuying Zheng, Xue Li, Danzhu Wu, Honghao Li, Yingyi Zeng, Yan Tang, Side Liu, Aimin Li

“…Abstract Purpose Previous studies on the association between non-skimmed milk consumption and non-alcoholic fatty liver disease (NAFLD) have reported inconsistent findings, with some suggesting an increased risk and others indicating a protective effect. Moreover, as the research focus has shifted globally from NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD), there remains limited evidence on the relationship between non-skimmed milk consumption and MAFLD. …”
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Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells by Ye Yeong Jeong, Jieon Hwang, Areum Park, Sungmin Cho, Inyoung Cho, Soseul Won, You Me Shin, Sung Eun Kim, Chan Hoon Maeng, Jaemoon Yang, Minhee Ku, Hyuk Lee, Sang Joon Shin

“…This combined therapeutic effects of IRP2 inhibition and radiation treatment were observed in parental and radioresistant cancer cells, significantly enhancing the proportion of cell death. …”
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