Melatonin protects rats against bisphenol A-induced testicular dysfunction through the upregulation of α-smooth muscle actin, vimentin, and S-100 proteins by Olumide Samuel Ajani, Samuel Gbadebo Olukole, Matthew Olugbenga Oyeyemi, Ekundayo Stephen Samuel

“…This study investigated how melatonin protects against BPA-induced testicular dysfunction in rats. Forty male Wistar rats were grouped randomly into four. …”
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Sulforaphane from Brassica Oleracea Induces Apoptosis in Oral Squamous Carcinoma Cells via p53 Activation and Mitochondrial Membrane Potential Dysfunction by Pooja Narain Adtani, Sura Ali Ahmed Fuoad Al-Bayati, Walid Shaaban Elsayed

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The diagnostic value of MRI-PDFF in hepatic steatosis of patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis by Yue-Xia Zhang, Yan-Ping Feng, Cong-Lei You, Ling-Yun Zhang

“…Abstract Objective To evaluate the diagnostic efficacy of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in assessing hepatic steatosis among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) through systematic review and meta-analysis approaches. …”
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Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities... by Laura Comi, Claudia Giglione, Fationa Tolaj Klinaku, Federico Pialorsi, Valentina Tollemeto, Maria Zurlo, Antonio Seneci, Paolo Magni

“…By integrating scientific research, sustainable agricultural practices, and innovative extraction methods, we can develop effective strategies to combat these pervasive health issues. …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Nevertheless, to date, no cure or effective therapy is available, and thus attempts to find a potential drug target, have received increasing attention. …”
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Impact of cardiosphere-derived cells on the maladapted right ventricular muscle in a rat sugen/hypoxia model of pulmonary hypertension with right ventricular dysfunction. by Ryan C Middleton, Oleg A Karpov, Mario Fournier, Simion Kreimer, Mitra Mastali, Weixin Liu, Liang Li, Norbert F Voelkel, Jennifer E Van Eyk, Eduardo Marbán, Michael I Lewis

“…Such adjunctive therapy, in addition to those employed to reduce pulmonary vascular resistance, would be a great advance in managing RV failure, for which no effective current approved therapies exist.…”
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Prevalence of metabolic dysfunction‐associated steatotic liver disease in people living with HIV and on antiretroviral treatment: A systematic review and meta‐analysis protocol by Amogelang Sedibe, Khanyisa Maswanganyi, Nomusa C. Mzimela, Mlindeli Gamede

“…Abstract Introduction Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become the most common hepatic condition globally. …”
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Associations of anti-inflammatory diet with cognitive impairment, physical dysfunction, depressive symptoms, and Multimorbidity in Chinese elderly: a national community-based study by Deng Huang, Pan Ding, Rongxiu Ding, Chao Lin

“…Conclusions Regular anti-inflammatory diets may have potential benefits in protecting against cognitive impairment, physical dysfunction, depressive symptoms, and multimorbidity, and rational dietary modification may be an effective strategy for preventing aging-related health problems in older adults.…”
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Interleukin 24 Promotes Mitochondrial Dysfunction, Glucose Regulation, and Apoptosis by Inactivating Glycogen Synthase Kinase 3 Beta in Human Prostate Cancer Cells by Anastassiya Kim, Sual Lopez, Simira Smith, Alphons Sony, Jennifer Abreu, Columba de la Parra, Moira Sauane

“…Notably, the expression of a constitutively active form of GSK3β abolishes the effect of IL-24. These results demonstrate a previously unrecognized role of IL-24 in apoptosis mediated through GSK3β regulation and its possible implications for metabolic stress, mitochondria dysfunction, and apoptosis. …”
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CARDIAC MAGNETIC RESONANCE IMAGING AND POSITRON EMISSION TOMOGRAPHY IN THE PREDICTION OF LEFT VENTRICULAR DYSFUNCTION REVERSIBILITY IN PATIENTS WITH CHRONIC TOTALLY OCCLUDED CORONA... by D. V. Ryzhkova, I. S. Kostina

“…PET with F-FDG only is less effective in the prediction of the LV dysfunction reversibility, but can still detect the presence of viable cardiomyocytes in the severely affected myocardial segments.…”
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The efficacy of Chinese herbal medicine on anxiety and depression in patients with chronic prostatitis complicated by sexual dysfunction: a systematic review and meta-analysis prot... by Zhaozhan Xie, Zhaozhan Xie, Xuecheng Zhang, Bai Li, Qi Wang, Zhihui Hou, Hongling Jia, Yongchen Zhang

“…It will focus on identifying randomized controlled trials (RCTs) that examine the effects of CHM interventions for CP complicated by sexual dysfunction and co-occurring anxiety and depression. …”
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The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia by Qian-Qian Wang, Ning Zhang, Xiang Xu, Si-Ang Lv, Zhuo-Deng Huang, Xi-Dai Long, Jun Wu

“…Abstract Background/aims The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals with hyperuricemia is significantly high. …”
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Comparative study of yogic practices and dietary modifications on biochemical variables among middle-aged women on metabolic dysfunction – Associated steatotic liver disease by S. Selva Sundari, C. V. Jayanthy, S. Natarajan

“…These results suggest the combined intervention may be effective in improving metabolic health, with potential for greater impact over longer durations or in larger cohorts.…”
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Studying associative relations between left ventricular dysfunction and heart failure development in patients with acute coronary syndrome and clinical manifestation of COVID-19 by D. V. Bondarets, K. V. Rudenko

“…The aim of the work: to determine associative relations between left ventricular dysfunction and heart failure development in patients with acute coronary syndrome and COVID-19. …”
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Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Patients with Allergic Conjunctivitis and Tear Film Dysfunction: A Randomized Controlled Trial by Mario Troisi, Salvatore Troisi, Diego Strianese, Michele Rinaldi, Maria Vittoria Turco, Ciro Costagliola

“…Its frequent overlap with dry eye disease (DED) complicates diagnosis and management, as both conditions share inflammation and tear film dysfunction as underlying mechanisms. Effective treatments must address both the inflammatory and tear film aspects of these conditions. …”
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Development and validation of a nomogram for predicting the risk of intestinal barrier dysfunction in patients after major abdominal surgery: a prospective cohort study by Qinghua Zou, Ruotian Wang, Yunfang Dong, Weiming Li, Guoyun Zhao, Zhaochuan Yin, Manqing Hu, Yijun Li, Qingwen Xu, Lixing Wang, Kaiwen Shi, Hongyuan Liu, Yichen Hu, Yuanpei Zhao

“…BackgroundIntestinal barrier dysfunction (IBDF) can lead to systemic inflammatory response syndrome and multiple organ failure, severely jeopardizing patient health. …”
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Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis by Chenxia Han, Lu Li, Lin Bai, Yaling Wu, Jiawang Li, Yiqin Wang, Wanmeng Li, Xue Ren, Ping Liao, Xiaoting Chen, Yaguang Zhang, Fengzhi Wu, Feng Li, Dan Du, Qing Xia

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ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer by Fangqi Ma, Mingming Ren, Zhongqiu Li, Yujing Tang, Xiaoyu Sun, Yi Wang, Nida Cao, Xiaohong Zhu, Yan Xu, Rui Wang, Yumiao Shen, Ruohan Zhao, Zhaoyan Li, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Aiguang Zhao

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ApTOLL ameliorates cognitive dysfunction and brain injury in ischemic stroke by regulating the miR-335-5p/IRAK1 axis by FengQin Qin, Xiang Feng, HongFu Yang, Hao Liu, Wei Yuan

“…ApTOLL, a promising therapeutic agent, has demonstrated effectiveness in mitigating stroke-induced neurological damage in clinical settings. …”
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Electroacupuncture at ST25 mediated glial cells pruning of pancreatic TRPV1 neural synapse responds to neuropathy-associated beta cell dysfunction by Yun Liu, Jiahui Xie, Zhi Yu, Meirong Gong, Qian Li, Guanhu Yang, Bin Xu, Tiancheng Xu

“…Hence, our study elucidates the EA-mediated glial cell via TRPV1-CGRP pathway regulation of β cell dysfunction after nerve lesion, and the hypoglycemic effect of ST25 is significantly better than that of ST37. …”
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