Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction by Daniyaer Nuerdebieke, Lizhong Yao, Lange Guo, Jiuzhi Li, Hongliang Jia, Yukui Nan

“…BackgroundErectile dysfunction (ED) is a common complication of diabetes mellitus (DM), and because of its complex neurovascular etiology, the associated molecular pathogenic mechanisms are not fully understood. …”
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A Comprehensive Objective Evaluation Method for Handwriting Assistive Devices Using a Tablet and Digital Pen for Individuals with Upper Limb Dysfunction by Qian Li, Rui Gong, Kazunori Hase

“…However, statistical analysis revealed a significant mean difference between the two scoring methods, indicating that the objective method provides a more standardized and quantifiable evaluation, effectively minimizing the influence of personal biases inherent in subjective evaluations. …”
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Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway by Chong Chen, Lixia Lan, Kai Xu

“…Introduction: The effects of remimazolam (Re) in combination with andrographolide (AP) on learning, memory, and motor abilities in rats following cardiopulmonary bypass (CPB) surgery were studied. …”
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Does metabolic dysfunction-associated fatty liver disease increase the risk of chronic kidney disease? A meta-analysis of cohort studies by Wanghao Liu, Xiaoying Sun

“…Abstract Objective Metabolic dysfunction-associated fatty liver disease (MAFLD) has been used to characterize patients with fatty liver and metabolic dysfunction. …”
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Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction‐Associated Steatotic Liver Disease in Perinatal Cadmium‐Exposed Mice by Rebecca Lichtler, Hannah Klossner, Nikia Smith, Cathrine Hoyo, Michael Cowley

“…Another comorbidity of ID and IDA is metabolic dysfunction‐associated steatotic liver disease (MASLD), a liver condition characterized by lipid accumulation and fibrosis. …”
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Potential utility of the triglyceride-glucose index as a predictor of erectile dysfunction and its severity: a cross-sectional, case–control study by Huseyin Aytac Ates, Taha Burak Bulut

“…Abstract The aim of this case–control study was to evaluate the relationship between triglyceride-glucose index (TyG Index) and erectile dysfunction (ED) and its severity. A total of 230 male patients, aged between 18 and 75 years, admitted to the urology outpatient clinic with complaining erectile dysfunction were evaluated. …”
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BMSC-Derived Exosomes Alleviate Sepsis-Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction by Zhenzhen Li, Beijie Zheng, Chenchen Liu, Xiang Zhao, Yupeng Zhao, Xiangrui Wang, Lei Hou, Zhongwei Yang

“…However, the aforementioned BMSC-exo reversal of mitochondrial dysfunction in AECIIs can be blocked by Nrf2 inhibitor ML385. …”
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Association of platelet to albumin ratio with metabolic dysfunction-associated steatotic liver disease based on the National Health and Nutrition Survey 2017–2018 by Jiao Xie, Qingliu He, David Fisher, Khrystyna Pronyuk, Erkin Musabaev, Lei Zhao

“…Abstract The prevalence and incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) are significantly increasing globally, but the index of non-invasive disease is limited. …”
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Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2018 by Bowen Liu, Xiaomei Sun, Xiaobin Li, Fenping Lu, Guangyan Xing, Guiping Ma, Yun Ran, Shi Ping Hu

“…Smoothed curves and threshold effects analyses were fitted to describe nonlinear relationships. …”
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IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice by Mei Ding, Dede Lian, Lirong Zhang, Tiechao Jiang, Wei Wang

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Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis. by Jae Heon Kim, Sung Ryul Shim, Seung Whan Doo, Won Jae Yang, Byung Wook Yoo, Joyce Mary Kim, Young Myoung Ko, Eun Seop Song, Ik Sung Lim, Hong Jun Lee, Yun Seob Song

“…<h4>Background</h4>Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. …”
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An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with rena... by Ryutaro Iwama, Kimie Nishida, Daisuke Ishii, Takeshi Iijima

“…Integrated PopPK analysis of febuxostat used a nonlinear mixed‐effects modeling (NONMEM) program on plasma febuxostat concentration data for 2611 samples from Japanese pediatric patients with hyperuricemia including gout (n = 29) and from adult subjects who are healthy or have renal dysfunction (n = 113). …”
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Peripheral versus central cannulation of VA-ECMO for primary graft dysfunction after heart transplantation: A systematic review and meta-analysis by Eduard Ródenas-Alesina, MD, Aleix Olivella, MD, Ani Orchanian-Cheff, MiST, Farid Foroutan, PhD, Yasbanoo Moayedi, MD, MSc, Vivek Rao, MD, PhD, Filio Billia, MD, PhD, Heather J. Ross, MD, MHSc, Ana Carolina Alba, MD, PhD, Natasha Aleksova, MD, MSc

“…Background: Severe primary graft dysfunction (PGD) after heart transplantation (HT) is a major cause of death and requires veno-arterial extracorporeal membrane oxygenation (VA-ECMO). …”
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Empowering Stroke Survivors: developing a patient version of guidelines to facilitate patient rehabilitation nursing of stroke patients with limb dysfunction in China by Dan Yang, Jingyuan Zhang, Meiqi Meng, Xuejing Li, Lijiao Yan, Jiaxin Fang, Ziyan Wang, Sihan Chen, Xiaoyan Zhang, Yufang Hao, Fang Wang

“…Further research is warranted to evaluate the implementation and effectiveness of this guideline within diverse Chinese healthcare context.…”
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Prophylactic Use of Troxerutin Can Delay the Development of Diabetic Cognitive Dysfunction and Improve the Expression of Nrf2 in the Hippocampus on STZ Diabetic Rats by Songyun Zhang, Lingling Yuan, Lihui Zhang, Caige Li, Jie Li

“…This study was aimed at determining effect of troxerutin on the development of cognitive dysfunction and the expression level of Nrf2 in the hippocampus of streptozotocin (STZ) diabetic rats, when used in the early preventive stage. …”
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Nanoscale therapeutics for erectile dysfunction: a meta-analysis of stem cell-derived extracellular vesicles as natural nanoparticles in diabetic rat models by Kecheng Lou, Junjie Hu, Jiayue Tong, Zhanshi Wang

“…Abstract Background Erectile dysfunction (ED), a prevalent male sexual disorder, severely impacts quality of life. …”
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Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach... by Katayi Mwila-Kazimbaya, Samuel Bosomprah, Obvious Nchimunya Chilyabanyama, Caroline Cleopatra Chisenga, Mwelwa Chibuye, Natasha Makabilo Laban, Michelo Simuyandi, Bert Huffer, Miren Iturriza-Gomara, Robert K M Choy, Roma Chilengi

“…Proposed factors include environmental enteric dysfunction (EED), malnutrition, and immune dysfunction. …”
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Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways by Hsiao-Ya Tsai, Chih-Pei Lin, Po-Hsun Huang, Szu-Yuan Li, Jia-Shiong Chen, Feng-Yen Lin, Jaw-Wen Chen, Shing-Jong Lin

“…Our findings provide a potential treatment strategy targeting dysfunctional EPC in diabetic patients.…”
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Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia by Ruhan Jia, Ying Han, Qinfang Zhu, Jingxuan Zhang, Huan Zhang, Maojia Ka, Yi Ma, Mohammed Gamah, Wei Zhang

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Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C by Tom Ryu, Young Chang, Soung Won Jeong, Jeong-Ju Yoo, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Hong Soo Kim, Seung Up Kim, Jae Young Jang

“…Background/Aims Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus. This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic hepatitis C (CHC). …”
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