Dehydroepiandrosterone Decline in Aging Males as a Predictor of Erectile Dysfunction and Mood Disorders in Patients With Benign Prostate Hyperplasia Undergoing Dutasteride Treatmen... by Maja Sofronievska Glavinov, Senol Tahir, Stefan Arsov

“…DHEA(S) acts as a direct neurosteroid and weak androgen and is the unique steroid unaffected by dutasteride’s inhibitory effect on 5α reductases. This study examined the relationship between dutasteride’s side effects, specifically erectile dysfunction (ED) and mood disorders, and the age-related decline in DHEAS. …”
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miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition by Yude Hong, Zejia Feng, Yunlong Ge, Yuhang Xi, Bowen Zhang, Jianjie Wu, Tian Xia, Bowen Tang, Wei Wang, Jun Chen, Hua Wang, Hengjun Xiao

“…In vitro, CCSMCs were subjected to H2O2-induced oxidative stress, and the protective effects of Exo-145 were evaluated through flow cytometry and Western blot. …”
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From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers by Heather Shaw, Pinkie Chambers, Matthew Watson, Luke Steventon, James Harmsworth King, Angelo Ercia, Noura Al Moubayed

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Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line by Kwang Il Park, Dong Gun Kim, Bo Hyoung Lee, Jin Yeul Ma

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Association between trans-palmitoleic acid and metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma: NHANES 1999–2018 by Qirui Li, Luqi Zhan, Qian Li, Shuai Zhu, Shuaihui Liu, He Jiang, Jinlin Cheng, Lanjuan Li

“…IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a global health burden with an increasing incidence of hepatocellular carcinoma (HCC), yet early risk predictors remain elusive. …”
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D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier by Xuejiao Zhang, Ang Li, Yuanyifei Wang, Jin Wang, Bowei Zhang, Yan Zhang, Jingmin Liu, Shuo Wang

“…Here, we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 mice. …”
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Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues by Ganiyu Oboh, Adedayo O. Ademiluyi, Ayokunle O. Ademosun, Tosin A. Olasehinde, Sunday I. Oyeleye, Aline A. Boligon, Margareth L. Athayde

“…This study was designed to determine the antioxidant properties and inhibitory effects of extract from Moringa oleifera leaves on angiotensin-I-converting enzyme (ACE) and arginase activities in vitro. …”
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Role of Vitamin D and E as Antioxidants Against Cerebral Endothelial Dysfunction: An In Vivo Study in White Rats (Rattus norvegicus) Sepsis Model by Fauzan Fajri, Sukmawan Fajar, Denny Irmawati Hasan, Herlina Dimiati, Eka Yunita Amna, Nora Sovira, Anidar Anidar, Mulya Safri, Aris Gunawan

“…Vitamin D and E are two antioxidants that have been extensively studied for their potential effectiveness. This study aims to evaluate the effectiveness of vitamins D and E in reducing oxidative stress in the cerebral vascular endothelial cells of Wistar mice in a sepsis model. …”
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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease by Susana Bernal, Ignacio Prieto, María Kavanagh, Isabel Herrero del Real, Sara La Manna, Iolanda Lázaro, Hernán Quiceno, Laura López-Sanz, Belén Picatoste, M. Pilar Valdecantos, Sebastián Mas-Fontao, Aleix Sala-Vila, Ángela M. Valverde, Daniela Marasco, Jesús Egido, Carmen Gómez-Guerrero

“…Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disease, encompassing a spectrum from simple steatosis to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma. …”
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Anticancer Potential of <i>Cymbopogon citratus</i> L. Essential Oil: In Vitro and In Silico Insights into Mitochondrial Dysfunction and Cytotoxicity in Cancer Cells by Tamara Maksimović, Daliana Minda, Codruța Șoica, Alexandra Mioc, Marius Mioc, Daiana Colibășanu, Alexandra Teodora Lukinich-Gruia, Maria-Alexandra Pricop, Calin Jianu, Armand Gogulescu

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Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells by Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci

“…This highlights the synergic role of RAB7 and mitochondrial dysfunction, focusing on a cellular mechanism that may boost the effect of mitochondrial dysfunction in the cells, leading to the reduction of the tumorigenic potential.…”
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Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction by Ming Yan, Ming Yan, Ming Yan, Cheng Peng, Cheng Peng, Xueyan Lang, Xueyan Lang, Yilan Li, Yilan Li, Yao Zhang, Yao Zhang

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Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis by Zhao–Wei Sun, Zhao–Xin Sun, Yun Zhao, Ling Zhang, Fang Xie, Xue Wang, Jin–Shan Li, Mao–Yang Zhou, Hong Feng, Ling–Jia Qian

“…Methods In a chronic unpredictable mild stress (CUMS) mouse model, a fluorescent dye assay and behavioral tests, including a novel object recognition test and Morris water maze, were performed to evaluate the protective effects of rutin on BBB integrity and cognition. The effects of rutin on BMEC function were also investigated in hCMEC/D3 cells (a human brain microvascular endothelial cell line) in vitro. …”
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Butyric acid ameliorates PCOS-related reproductive dysfunction through gut-brain-ovary axis signaling and ovarian steroidogenic factor activation by Xueping Feng, Xueping Feng, Juan Xiao, Decai Wang, Xianzhao Fu, Jie Gao, Minli Jiang, Jin Li, Lihe Jiang, Xingwei Liang, Yanna Huang, Qinyang Jiang

“…Proteomic analysis and cell experiments suggested that upregulation of Cytochrome P450 1b1 (Cyp1b1) may play a crucial role in regulating E2 metabolism and P4 production, potentially contributing to the pathogenesis of PCOS and ovarian dysfunction.ConclusionThese findings indicate that NaBu may exert its regulatory effects on appetite and hormone levels in the hypothalamus through the gut-brain-ovary axis, modulating the expression of ovarian steroidogenic factors, thereby improving follicular development and granulosa cell function, and enhancing reproductive performance.…”
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Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1 by Sha Xiao, Tianjing Wei, Mingyang Xiao, Mingming Shan, Ziqi An, Na Li, Jing Zhou, Shuang Zhao, Xiaobo Lu

“…This study examined the effects of NAIs against nicotine-induced oxidative damage and vascular endothelial injury in spontaneously hypertensive rats (SHRs). …”
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Apigenin as a therapeutic agent against cigarette smoke-induced cellular dysfunction: A comprehensive study on Beas-2B cells by Nabijan Mohammadtursun, Haibaier Huojiaaihemaiti, Muhammatjan Abduwaki, Alimujiang Paierhati, Jingcheng Dong

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Influencing factors of pulmonary dysfunction among community-based population at high-risk for chronic obstructive pulmonary disease in Putuo District， Shanghai by SONG Rongwei, WU Chunxiang, YU Jie, LU Yuqing, ZHANG Fengying

“…Smoking,insufficient physical activity,recurrent wheezing,post-exercise wheezing or coughing,insensitive to airborne allergens,and history of chronic bronchitis or bronchial asthma are high risk factors for pulmonary dysfunction. The risk assessment model constructed based on these factors has a good predictive effect in screening high-risk population of COPD, but its effectiveness in screening people at general risk needs to be further validated.…”
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AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1 by Yang Ji, Huanzhen Chen, Lihua Pang, Changnong Chen, Sha Wang, Jing Chen, Lei Fang, Benrong Liu, Yongruo Cheng, Shiming Liu, Yun Zhong

“…Compared with BSA-Exos, AGE-Exos significantly impaired endothelial cell proliferation, migration, and tube formation capabilities while increasing monocyte adhesion and proinflammatory cytokine release without affecting cell viability. miR-22-5p was enriched in AGE-Exos, which were subsequently transferred to HUVECs, specifically targeting FOXP1, resulting in endothelial dysfunction. Overexpression of miR-22-5p in HUVECs using lentiviral vectors recapitulated the inflammatory effects observed with AGE-Exos, whereas anti-miR-22-5p conferred protective effects. …”
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Study of efficiency of Likoprofit Potential-Formula biologically active additive (BAA) in the treatment of patients with erectile dysfunction against the background of arterial hyp... by A. I. Neimark, B. A. Neimark, M. A. Melnik, K. A. Sizov, G. S. Tishchenko

“…In patients with erectile dysfunction against the background of arterial hypertension, Likoprofit Potential produces the stimulating effect on CNS, spasmolytic action on penis vessels, and improves hemodynamics in cavernous bodies of penis. …”
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A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction by Jack Sharkey, Lorenzo Ressel, Nathalie Brillant, Lauren Scarfe, Bettina Wilm, B. Kevin Park, Patricia Murray

“…To address these challenges, we have developed an imaging toolbox comprising multispectral optoacoustic tomography and ultrasonography, which allows the degree of kidney, liver, and cardiac injury and the extent of functional recovery to be assessed noninvasively in a mouse model of multiorgan dysfunction. This toolbox allowed us to determine the therapeutic effects of adoptively transferred macrophages. …”
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