The use of ultrasonography in the diagnosis and management of Acute Kidney Injury and other forms renal dysfunction in the paediatric population: Systematic review protocol. by Gontse Leballo, Nabeela Arbee-Kalidas, Moses Mogakolodi Kebalepile, Palesa Motshabi Chakane

“…<h4>Conclusion</h4>This protocol outlines a systematic review designed to evaluate the application of ultrasonography in identifying paediatric patients at risk of developing acute kidney injury and other forms of renal dysfunction. The review will critically assess the effectiveness of ultrasound techniques, including point-of-care ultrasound, in identifying acute kidney injury in children, with a particular emphasis on early detection. …”
Get full text

Prevalence of Sexual Dysfunction with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS): An Updated Systematic Review and Meta-Analysis by Saad Alshahrani, Basem A. Fathi, Tamer A. Abouelgreed, Ashraf El-Metwally

“…<i>Background and Objectives</i>: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common condition linked to substantial urogenital symptoms, notably sexual dysfunction. This meta-analysis sought to determine the overall prevalence of sexual dysfunction in men with CP/CPPS, considering the four primary categories: desire, arousal, orgasm, and pain disorders. …”
Get full text

E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis by Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lu

“…Genetic or pharmacological activation of Nrf2 effectively activates E2F2 to attenuate the MASH progression. …”
Get full text

Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China by Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Yun Chang, Yun Chang, Yun Chang, Yun Chang, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao

“…Interaction analysis identified marital status (p = 0.035) and education level (p = 0.034) as significant effect modifiers, where subgroup differences notably altered the AIP-dysfunction association, warranting further study.ConclusionElevated AIP is significantly associated with increased physical dysfunction risk, highlighting its potential as a simple, predictive biomarker.…”
Get full text

Protective Action of 3,5-Diiodo-L-Thyronine on Cigarette Smoke-Induced Mitochondrial Dysfunction in Human Alveolar Epithelial Cells by Francesca Panico, Davida Mirra, Giuseppe Petito, Giuseppe Spaziano, Vitale Del Vecchio, Renata Esposito, Rosalba Senese, Vincenzo Desiderio, Antonia Lanni, Bruno D’Agostino

“…Oxidative stress and mitochondrial dysfunction play a crucial role in CS-induced pulmonary injury. 3,5-Diiodothyronine (T2) affects energy metabolism, having mitochondria as a major target. …”
Get full text

Evaluation of magnetic stimulation as a non-invasive technique in treating different causes of erectile dysfunction: a prospective cohort study by Hasan El-Fakahany, Haythem Bassyouni, Sameh Fayek GamalEl Din, Mahmoud H. A. Montaser

“…Abstract Background Elaboration of alternative therapeutic modality is needed, which should be safer, less costly and with no side effects. Functional Magnetic Stimulator (FMS) is a technique that was approved by the US Food and Drug Administration in 1998. …”
Get full text

Polyunsaturated Fatty Acids Improved Long Term Prognosis by Reducing Oxidative Stress, Inflammation, and Endothelial Dysfunction in Acute Coronary Syndromes by Alexandru Covaciu, Theodora Benedek, Elena Bobescu, Horatiu Rus, Valentina Benza, Luigi Geo Marceanu, Simona Grigorescu, Christian Gabriel Strempel

“…The study was divided into four groups related to the type of ACS and treatment with Omega-3 PUFAs added to the optimal medical therapy (OMT). The effect of Omega-3 PUFAs therapy associated with the OMT was determined by measuring the dynamics of the following parameters: (a) oxidative stress—total antioxidant status (TAS), oxidated low density lipoprotein cholesterol antibodies (Ab anti-ox-LDL), IgG anti-Myeloperoxidase antibodies (IgG type Ab anti-MPO); (b) inflammatory syndrome—C-reactive protein and fibrinogen; (c) endothelial dysfunction—flow mediated dilation (FMD) and von Willebrand factor (vWf) activity, from baseline to 6 months of follow-up. …”
Get full text

Impact of renal dysfunction on mid-term outcome after transcatheter aortic valve implantation: a systematic review and meta-analysis. by Chi Chen, Zhen-Gang Zhao, Yan-Biao Liao, Yong Peng, Qing-Tao Meng, Hua Chai, Qiao Li, Xiao-Lin Luo, Wei Liu, Chen Zhang, Mao Chen, De-Jia Huang

“…<h4>Background</h4>There is conflicting evidence regarding the impact of preexisting renal dysfunction (RD) on mid-term outcomes after transcatheter aortic valve implantation (TAVI) in patients with symptomatic aortic stenosis (AS).…”
Get full text

Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes by James Goodman, Martin Schain, Giovanni Di Stefano, Victoria Lupson, Tracy Horn, Marion Hill, Roie Manavaki, Timothy D. Fryer, Elaine Bumanlag-Amis, Navazh Jalaludeen, Lutz Jermutus, Edvin Johansson, Kerstin Heurling, Henrik Haraldsson, Mark Evans, Joseph Cheriyan, Lars Johansson, Philip Ambery, Ian B. Wilkinson

Get full text

Association of the dietary index for gut microbiota and dietary inflammation index with metabolic dysfunction-associated steatotic liver disease and metabolic alcohol-associated li... by Wenhao Wu, Zebin Hou

“…This study investigates the associations of the dietary index for gut microbiota (DI-GM), dietary inflammatory index (DII), and their combined effects with MASLD/MetALD, while exploring the mediating roles of inflammation and metabolic dysfunction.MethodsData from the 2007 to 2018 NHANES included 9,529 participants. …”
Get full text

FACTORS DEFINING CLINICAL OUTCOMES IN THE PATIENTS WITH SEVERE CONCOMITANT TRAUMA COMPLICATED BY DELIRIUM by F. F. Bershadskiy, O. N. Ulitkina, Yu. V. Skripkin, O. A. Grebenchikov, V. V. Likhvantsev

“…Search for most effective way of management of non-specific delirium is an important aspect of treatment of severe concomitant trauma. …”
Get full text

Optimal proprioceptive training combined with rehabilitation regimen for lower limb dysfunction in stroke patients: a systematic review and network meta-analysis by Kaiqi Zheng, Li Li, Yahui Zhou, Xiaokun Gong, Gangbin Zheng, Liang Guo

“…BackgroundThis study aims to evaluate the optimal rehabilitation regimen for lower limb dysfunction in stroke patients by analyzing the effects of proprioceptive training (PT) in combination with different rehabilitation interventions.MethodsRandomized controlled trials (RCTs) published up to April 23, 2024, were searched from PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and SinoMed. …”
Get full text

Sacral Neuromodulation for Refractory Urge Incontinence Is Less Effective Following Spinal Surgery by Angela M. Arlen, Charles R. Powell, Karl J. Kreder

Get full text

Cell-based screening identifies the active ingredients from Traditional Chinese Medicine formula Shixiao San as the inhibitors of atherosclerotic endothelial dysfunction. by Xiaofan Wang, Ruowen Zhang, Liqiang Gu, Yuanyuan Zhang, Xu Zhao, Kaishun Bi, Xiaohui Chen

“…In this study, we performed a phenotypic screening in human endothelial cells exposed to oxidized low density lipoprotein (an in vitro model of atherosclerotic endothelial dysfunction) to identify the effective compounds in Shixiao San. …”
Get full text

Sevoflurane versus propofol on immediate postoperative cognitive dysfunction in patients undergoing cardiac surgery under cardiopulmonary bypass: a comparative analysis by Na Zhao, Rui Qin, Bin Liu, Dongmei Zhang

“…Abstract Objective This study aims to compare the effects of sevoflurane (SEV) and propofol (PRO) on postoperative cognitive dysfunction (POCD) in patients undergoing cardiac surgery (CS) under cardiopulmonary bypass (CPB), with a focus on evaluating the efficacy of these anesthetic agents in preventing POCD. …”
Get full text

Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner by Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui

“…MPP+ accumulation in mitochondria, a key factor in MPTP-induced neurodegeneration, leads to mitochondrial dysfunction, such as respiratory chain inhibition, ultimately leading to neuronal death. …”
Get full text

Blood–brain barrier permeability changes in dogs with suspected canine cognitive dysfunction using magnetic resonance imaging subtraction enhancement analysis by Yael Merbl, Ella Mondrus, Erez Hanael, Merav H. Shamir

“…BackgroundBlood–Brain Barrier (BBB) breakdown/ dysfunction (BBBD) has been recognized as a contributing factor to cognitive decline in degenerative diseases and the normal aging process in the elderly. …”
Get full text

Machine learning for predicting all-cause mortality of metabolic dysfunction-associated fatty liver disease: a longitudinal study based on NHANES by Xueni Wang, Huihui Chen, Luqiao Wang, Wenguang Sun

“…Abstract Background The mortality burden of metabolic dysfunction-associated fatty liver disease (MAFLD) is rising, making it crucial to predict mortality and identify the factors influencing it. …”
Get full text

Successful endovascular treatment of recurrent venocorporeal erectile dysfunction using a liquid non-adhesive embolizing agent "KAP". Case report by D. G. Ioseliani, A. G. Koledinskiy, S. P. Semitko, L. M. Rapoport, D. A. Asadov, N. V. Petrovskii, K. V. Gyulmisaryan, V. V. Fomenko, S. A. Kibets, I. E. Chernysheva, P. V. Glybochko

“…According to the Russian Society of Urologists, almost half of the male population of the country aged 27 to 77 suffers from erectile dysfunction (ED). ED should be considered not only as a serious medical nosology, but also as an important socio-psychological problem of national importance due to its demographic significance. …”
Get full text

Prevalence and characteristics of erectile dysfunction in black and mixed race primary care populations of the Cape Flats and Helderberg Basin area of the Western Cape, South Afric... by H. de Klerk, P.J.T. de Villiers, S. Isaacs

“…There is a growing awareness amongst primary care workers that male erectile dysfunction (ED) may be important in Black and Mixed Race South African populations. …”
Get full text