Impact of Implementing Structured Compensatory Methods on Knowledge and Awareness of Cognitive Dysfunction Management Among Neurological Disorder Patients in Vijayapur Hospitals by Nelson Vijaykumar, Aleyamma Varghese

Get full text

Mitochondrial FIS1 As a Novel Drug Target for the Treatment of Erectile Dysfunction: A Multi-Omic and Epigenomic Association Study by Tianle Zhu, Pan Gao, Yukuai Ma, Peng Yang, Zhi Cao, Jingjing Gao, Junhua Du, Hui Jiang, Xiansheng Zhang

“…Purpose: Mitochondrial dysfunction may impact male erectile function, but the underlying genetic mechanisms remain unclear. …”

Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomic... by Jinliang Liang, Huanyi Liu, Guo Lv, Xiaotong Chen, Zhaoshou Yang, Kunhua Hu, Hongyan Sun

“…Abstract Clinical studies have suggested that tirzepatide may also possess hepatoprotective effects; however, the molecular mechanisms underlying this association remain unclear. …”
Get full text

Cognitive Slowing, Dysfunction in Verbal Working Memory, Divided Attention and Response Inhibition in Post COVID-19 Condition in Young Adults by Johanna Takács, Darina Deák, Beáta Seregély, Akos Koller

“…One of the most reported symptoms in PCC is cognitive dysfunction, yet there are only a few studies investigating long-term effects on different domains of cognitive function. …”
Get full text

The roles of negative mood, impulsivity, and executive dysfunction in non-suicidal self-injury behaviors among Chinese middle school students by Juanjuan Guo, Lijuan Shi, Jieyu Xiao, Ling He, Saijun Zeng, Jingbo Gong

“…However, the interplay of these factors and their gender-specific effects on NSSI remain unclear. Methods In 2023, a sample of 1084 middle school students (Mage = 13.33; Nboy=574, Ngirl=510) completed psychological assessments measuring negative mood, impulsivity, executive dysfunction, and NSSI thoughts and behaviors over the past year. …”
Get full text

Neurodevelopmental defects in Dravet syndrome Scn1a+/− mice: Targeting GABA-switch rescues behavioral dysfunctions but not seizures and mortality by Lara Pizzamiglio, Fabrizio Capitano, Evgeniia Rusina, Giuliana Fossati, Elisabetta Menna, Isabelle Léna, Flavia Antonucci, Massimo Mantegazza

“…Our work provides further evidence that seizures and neuropsychiatric dysfunctions in DEEs can be uncoupled and can have differential pathological mechanisms. …”
Get full text

Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes by Figarella K, Marsiccobetre S, Arocha I, Colina W, Hasegawa M, Rodriguez M, Rodriguez-Acosta A, Duszenko M, Benaim G, Uzcategui NL

Get full text

Impact of mHealth on Postoperative Quality of Life, Self-Management, and Dysfunction in Patients With Oral and Maxillofacial Tumors: Nonrandomized Controlled Trial by Yufei Li, Yueping Wang, Yifan Wu, Hong Yu, Hua Yao, Yuqun Wang, Yulan Yin, Lan Wang, Lili Hou

“…The generalized estimating equation results showed that after adjusting for age, sex, pathological histology, cancer stage, and primary site, the intervention group had a significantly higher improvement in quality of life than the control group at the T2 (regression coefficient, β=−68.020, 95 % CI −116.639 to −19.412; PPP ConclusionsThe Intelligent Home Rehabilitation Care Platform interventions can effectively enhance patients’ self-management efficacy, improving quality of life and facilitate recovery from dysfunctions. …”
Get full text

Hypertension may lead to cognitive dysfunction in older adults via methylmalonic acid: evidence from NHANES 2011–2014 population by Ying Xu, Rucheng Chen, Paulus Torkki, Weijun Zheng, An Chen

“…Results After adjusting for potential confounding factors, we observed a significant mediating effect of the sMMA level in the hypertension-cognition link, accounting for 11.14% (95% CI 4.09%-14.00%, p < 0.001) of the relationship in older adults. …”
Get full text

Acupuncture Alters Brain’s Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial by Yahui Wang, Mengxin Lu, Ruoyi Liu, Liping Wang, Yue Wang, Lingling Xu, Kang Wu, Chen Chen, Tianzhu Chen, Xinyue Shi, Kuangshi Li, Yihuai Zou

“…Neuroimaging studies have confirmed that acupuncture can promote static functional reorganization in poststroke patients with motor dysfunction. But its effect on dynamic brain networks remains unclear. …”
Get full text

Randomized, Placebo‐Controlled, Triple‐Blind Clinical Trial of Ivabradine for the Prevention of Cardiac Dysfunction During Anthracycline‐Based Cancer Therapy by Stephanie Itala Rizk, Isabela Bispo Santos da Silva Costa, Cecília Beatriz Bittencourt Viana Cruz, Brunna Pileggi, Fernanda Thereza de Almeida Andrade, Thalita Barbosa Gonzalez, Cristina Salvadori Bittar, Julia Tizue Fukushima, Vinicius Caldeira Quintao, Eduardo Atsushi Osawa, Juliana Barbosa Sobral Alves, Silvia Moulin Ribeiro Fonseca, Diego Ribeiro Garcia, Juliana Pereira, Valeria Buccheri, Juliana Avila, Lucas Tokio Kawahara, Cecilia Chie Sakaguchi Barros, Lucas Takeshi Ikeoka, Letícia Naomi Nakada, Mariella Fellini, Vanderson Geraldo Rocha, Eduardo Magalhães Rego, Paulo Marcelo Gehm Hoff, Roberto Kalil Filho, Giovanni Landoni, Ludhmila Abrahão Hajjar

“…Ivabradine reduces heart rate without affecting contractility and showed anti‐inflammatory, antioxidant, and antiapoptotic effects in experimental cardiotoxicity models. This study aims to evaluate the effect of ivabradine on cancer therapy–related cardiac dysfunction in patients with lymphoma or sarcoma treated with anthracycline. …”
Get full text

Hydrochlorothiazide combined with exercise training attenuates blood pressure variability and renal dysfunctions in an experimental model of hypertension and ovarian hormone depriv... by Pietra Petrica Neves, Maycon Junior Ferreira, Tânia Plens Shecaira, Marina Rascio Henriques Dutra, Débora Conte Kimura, Guiomar Nascimento Gomes, Kátia De Angelis

Get full text

Gut microbial dysbiosis exacerbates long-term cognitive impairments by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxia-ischemia by Andi Chen, Chengqian Teng, Jianjie Wei, Xuyang Wu, Honghong Zhang, Pinzhong Chen, Dingliang Cai, Haitao Qian, Hui Zhu, Xiaochun Zheng, Xiaohui Chen

“…Additionally, the interventions such as TLR4 inhibitor TLR4-IN-C34 administration, FMT, and oral DEX were demonstrated to modulate intestinal function by inhibiting the LPS/TLR4 signaling pathway, thereby exerting neuroprotective effects. Collectively, these findings underscore the contribution of gut microbial dysbiosis post HI insult in activating the LPS/TLR4 signaling pathway, triggering intestinal inflammation and dysfunction, exacerbating systemic inflammation, and consequently worsening synaptic and cognitive impairments in neonatal HIBD rats. …”
Get full text

Changing patterns of cardiovascular diseases and subtypes induced by kidney dysfunction among 25–64 years in China from 1992 to 2021 by Guoqiang Zeng, Hongliang Wang, Pinghui Cao, Jinyang Zhao, Lingyun Liu, Hui Guo

“…Additionally, an age-period-cohort (APC) model was employed to estimate the overall annual percentage change in mortality (net drift), the annual percentage change for specific age groups (local drift), the relative risks of period and cohort effects, and the age-specific rates adjusted for period bias (age effect). …”
Get full text

CORRELATION BETWEEN THE LENGTH OF THE DENTAL ROWS AND THE TOPOGRAPHOANATOMIC INDICATORS OF THE ARTICULAR DISK (MENISCUS) IN THE PATIENTS WITH DYSFUNCTIONAL CONDITIONS ACCORDING TO... by Y.S. Lunkova, O.B. Tumakova, V.M. Novikov

Get full text

Neural stem cell-specific deletion of Atg7 alleviates hippocampal dysfunction and neuronal alterations induced by chronic restraint stress by Hyeonjeong Jeong, Seongwon Choe, Seonghee Jung, Seong-Woon Yu

Get full text

Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial by Andrea Scaramuzza, Elisa Giani, Francesca Redaelli, Saverio Ungheri, Maddalena Macedoni, Valentina Giudici, Alessandra Bosetti, Matteo Ferrari, Gian Vincenzo Zuccotti

“…After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. …”
Get full text

Long-Term Impact of Cyclosporin Reduction with MMF Treatment in Chronic Allograft Dysfunction: REFERENECE Study 3-Year Follow Up by L. Frimat, E. Cassuto-Viguier, F. Provôt, L. Rostaing, B. Charpentier, K. Akposso, M. C. Moal, P. Lang, D. Glotz, S. Caillard, D. Ducloux, C. Pouteil-Noble, S. Girardot-Seguin, M. Kessler

Get full text

ACE inhibitor lisinopril influence on left ventricular diastolic dysfunction and endothelial response in hypertensive patients with or without chronic heart failure by A. D. Kuimov, O. N. Belyaeva, I. I. Volkova, O. N. Novikova, G. R. Musina, O. G. Kukushkina

Get full text

The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction by Matthew H. Doran, Michael J. Rynkiewicz, Evan Despond, Meera C. Viswanathan, Aditi Madan, Kripa Chitre, Axel J. Fenwick, Duncan Sousa, William Lehman, John F. Dawson, Anthony Cammarato

Get full text