TNF-ɑ induces mitochondrial dysfunction to drive NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells by Kexin Gao, Yancui Liu, Cheng Sun, Ying Wang, Hongrong Bao, Guoyang Liu, Jinrui Ou, Ping Sun

“…Tumor necrosis factor-ɑ (TNF-ɑ) is an inflammatory cytokine, and some studies have shown that TNF-ɑ can cause pyroptosis of cells and exert anti-tumor effects. However, whether TNF-ɑ exerts anti-tumor effects on breast cancer cells by inducing pyroptosis has not been reported. …”
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Еndothelial dysfunction in patients with chronic obstructive pulmonary disease: feasibility of non-medicamental treatment (literature review and personal experience) by N. V. Vantiukh, O. I. Lemko

“…The aim of the work was to study the feasibility of the use of non-medicamental factors for the correction of endothelial dysfunction in patients with chronic obstructive pulmonary disease. …”
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Scutellarin Alleviates Cuprizone-Induced Demyelination by Improving Mitochondrial Dysfunction, Reducing Lipid Oxidation and Inhibiting the p38 MAPK Pathway by Qiting Zhao, Yantuanjin Ma, Shufen Wang

“…In conclusion, our findings demonstrate that scutellarin exerts significant neuroprotective effects on Cuprizone-induced mice by improving mitochondrial dysfunction in microglia, thereby reducing inflammatory responses. …”
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Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis by Xinfeng Yu, Quanbin Zhang, Wentong Cui, Zheng Zeng, Wenzhe Yang, Chao Zhang, Hongwei Zhao, Weidong Gao, Xiaomin Wang, Dali Luo

“…This study was intended to evaluate the protective effect of low molecular weight fucoidan (LMWF) against cardiac dysfunction in diabetic rats. …”
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The influence of sodium-glucose co-transporter-2 inhibitors on the risk of cancer therapy-related cardiac dysfunction: A meta-analysis by Zhitao Yan, Xiaona Xing, Jinmei Huang

“… Cancer therapy-related cardiac dysfunction (CTRCD) is a major concern for patients undergoing cardiotoxic cancer treatments. …”
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Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor. by Dharmani Murugan, Yeh Siang Lau, Chi Wai Lau, Mohd Rais Mustafa, Yu Huang

“…The present study investigated the protective effect of Ang 1-7 against Ang II-induced endoplasmic reticulum (ER) stress and endothelial dysfunction. …”
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Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways by Xueyan Li, Yunan Chen, Lei Su, Jialin He

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DNMT3a-Mediated Enterocyte Barrier Dysfunction Contributes to Ulcerative Colitis via Facilitating the Interaction of Enterocytes and B Cells by Bo Cheng, Ai-mei Rong, Wenlu Li, Xiuqian Bi, Xinguang Qiu

“…Further in vitro results revealed that DNMT3a silencing or TNFSF13 overexpression in IECs partly abolished the result of LPS-induced epithelial barrier dysfunction, as well as abrogated the effect of IEC-regulated B cell differentiation, while si-TACI transfection reversed these effects. …”
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

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Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism by Han F, Wang H, Wang L, Fan L, Peng S, Hou X, Shu X, Sun B, Liu Y

“…Mechanistic investigations further showed that SIL-SOR-MPs more effectively down-regulated lipid synthesis genes and up-regulated genes involved in lipid oxidation.Discussion: In summary, our study highlights that carrier-free SIL-SOR-MPs demonstrate the ability to reverse the progression of MASLD and present a promising therapeutic strategy.Keywords: metabolic dysfunction-associated steatotic liver disease, silibinin, sorafenib, self-assembled carrier-free microparticles, fatty acid metabolism…”
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Dietary and exercise intervention for patients with metabolic dysfunction associated steatotic liver disease (MASLD): a systematic review and meta-analysis. by Binika Gurung, Sujita Gurung, Nwe Ni (Sophia) Than

“…The DerSimonian and Laird random effects model was used. If meta-analysis was not possible, descriptive methods were utilised. …”
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Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis by Fenfang Wu, Chunhua Xu, Xinlei Si, Fei He, Kang Xu, Yu Zhang, Shan Lin

“…ObjectiveThe effectiveness of using Cordyceps sinensis as an adjuvant therapy for patients with renal dysfunction (RD), especially acute kidney injury (AKI), is still a topic of debate. …”
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Mechanisms of hepatic dysfunction in Nile tilapia (Oreochromis niloticus) fed a high-fava bean (Vicia faba L.) diet by Xinyao Zhang, Ke Cheng, Lixue Dong, Dexing Zhu, Qingyong Li, Zhongbao Guo, Yongju Luo, Apeng Liu, Juan Tian, Di Peng, Jianmin Zhang, Yangyang Liu, Hua Wen, Ming Jiang

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Perioperative Cognitive Dysfunction: Comparative Evaluation of Anesthetic Agents and Neurocognitive Outcomes in Elderly Patients: A Systematic Review and Meta-Analysis by Farah Niaz Awan, Mahmood Ahmad Zahid, Amina Majeed, Muhammad Akram Ramzan

“…This systematic review and meta-analysis aimed to assess the effects of the various types of anesthesia agents and procedures on postoperative cognitive dysfunction among adult surgical patients. …”
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VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1/Parkin-mediated mitophagy pathway by Yang Zhang, Yucheng Gao, Shuanggong Liu, Guowei Yang, Yijun Rong, Dongjin Wu, Zengxin Gao

“…In contrast, VMP1 overexpression enhanced PINK1/Parkin-mediated mitophagy, mitigated mitochondrial dysfunction, and suppressed ferroptosis. Notably, these protective effects were abolished by treatment with CsA. …”
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The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model by Natsuki Nakagoshi, Fabricio M Locatelli, Sonoe Kitamura, Seiji Hirota, Takashi Kawano

“…These findings suggest that managing preoperative stress could mitigate these adverse effects, leading to better postoperative recovery and cognitive health in elderly patients.…”
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An updated narrative review on revolutionizing erectile dysfunction treatment: the crucial role of trophic factors in Adipose-Derived stem cell therapy by Armaghan Ghavam, Farhad Sheikhnia, Mohammad Mahdi Heidari, Mohammad Valilo, Zanyar Mahmoudnejad, Serap Gur

“…Abstract Erectile dysfunction (ED) is a pervasive condition projected to affect some 322 million men worldwide by 2025, profoundly impairing quality of life and psychosocial well‑being. …”
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Total Alkaloids of Rhizoma Corydalis regulates gut microbiota and restores gut immune barrier to ameliorate cognitive dysfunction in diabetic rats by Yazhi Qi, Jun Li, Ya Tang, Rui Cao, Yishu Gao, Qiang Xu, Yusheng Han

“…Background and objectivesGiven the widespread dysbiosis of gut microbiota in patients with T2DM, it has been found that the microbiota-gut-brain axis plays an influential regulatory role in diabetic cognitive dysfunction, and improving gut dysbiosis may be a potential strategy for treating diabetic cognitive dysfunction. …”
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Long-term health outcomes and quality of life in women with untreated pelvic floor dysfunction: a single-center cohort study by Wenchao Chen, Jiang Gong, Mingsheng Liu, Ying Chang Cai

“…Early diagnosis and intervention are critical to mitigating these effects and improving long-term outcomes. These findings highlight the urgent need for targeted public health strategies to address untreated PFD.…”
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Live and heat-killed Leuconostoc mesenteroides counteract the gastrointestinal dysfunction in chronic kidney disease mice through intestinal environment modulation. by Fittree Hayeeawaema, Natthawan Sermwittayawong, Chittipong Tipbunjong, Nawiya Huipao, Paradorn Muangnil, Pissared Khuituan

“…In summary, both live and heat-killed Ln.m effectively alleviated gastrointestinal dysfunction and renal damage in CKD mice, primarily through modulation of the intestinal environment. …”
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