Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease by Guo-Lin Miao, Wen-Xi Zhang, Yi-Tong Xu, Yi-Ran Liu, Ping-Ping Lai, Jia-Bao Guo, Gong-Lie Chen, Jing-Xuan Chen, Zi-Hao Zhou, Yan-Wei Li, Chong Zhang, Yang Ding, Lian-Xin Zhang, Yu-Fei Han, Jin-Xuan Chen, Jing-Dong Wu, Yin-Qi Zhao, Si Mei, Yang Zhao, Yuan-Wu Ma, Ling Zhang, Wei Huang, Dong-Yu Zhao, Er-Dan Dong, Yu-Hui Wang, Xun-De Xian

“…Overexpression of human KIF13B by lentivirus effectively prevented metabolic dysfunction-associated steatohepatitis (MASH) in methionine-choline-deficient diet (MCD)-fed mice. …”
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IgA Dysfunction Induced by Early-Lifetime Low-Dose Antibiotics Exposure Aggravates Diet–Induced Metabolic Syndrome by Xue Han, Yue Qin, Jielong Guo, Weidong Huang, Yilin You, Jicheng Zhan, Yue Yin

“…This highlights a critical mechanism linking early-life antibiotic exposure, gut immune dysfunction, and long-term metabolic health, with significant implications for food safety.…”
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Yes-Associated Protein Promotes Endothelial-Mesenchymal Transition to Mediate Diabetes Mellitus Erectile Dysfunction by Phosphorylating Smad3 by Ming Xiao, Xiaoli Tan, Huanqin Zeng, Biao Liu, Xiaopeng Tang, Yanghua Xu, Yinghao Yin, Jiarong Xu, Zhitao Han, Zitaiyu Li, Yuxin Tang, Liangyu Zhao

“…Purpose: The main objective of this study is to elucidate the role of endothelial-mesenchymal transition (EndMT) regulated by yes-associated protein (YAP) on diabetes mellitus erectile dysfunction (DMED). Materials and Methods: High concentrations of glucose and palmitic acid (HGP) culturing simulated a diabetic condition in vitro. …”

Coronary microvascular dysfunction in post-PCI target vessels: a systematic review and meta-analysis of prevalence and associated outcomes by Yunze Li, Yunze Li, Jinlan Duan, Hongxu Liu, Sheng Lin, Sheng Lin, Hongkun Xu, Hongkun Xu, Xiang Li

“…BackgroundCoronary microvascular dysfunction (CMD) in post-percutaneous coronary intervention (PCI) target vessels is increasingly recognized as a critical determinant of adverse cardiovascular outcomes, yet its prevalence and prognostic implications remain poorly characterized. …”
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Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial by Run-Nan Xu, Run-Nan Xu, Jun Guo, Chun-He Zhang, Qing Zhou, Qiang Gen, Qiang Gen, Fu Wang, Yu Zhao, Yu Zhao, Xin-Yun Luo, Yan-Feng Li, Yi-Jia Fu, Yi-Jia Fu, Xin Zhang, Xin Zhang, Wen-Zhi Wang, Jian-Xiong Ma, Jian Wang, Jian Wang, Xiao-Jun Huang, Wen-Jie Huang, Bo-Dong Lv, Bo-Dong Lv

“…We conducted a multi-center, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of the Chinese Herbal Medicine, Hongjing I granule (HJIG), in patients with mild to moderate erectile dysfunction (ED).MethodsThis study is structured as a randomized, double-blind, placebo-controlled trial, executed across multiple centers. …”
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Association between alcohol consumption and hepatic fibrosis in Chinese adult males with metabolic dysfunction-associated steatotic liver disease by Mao Li, Bin Yu, Xiaoli Zhang, Jia Pan, Lei Tang, Yi Zhang, Ruixin Wang, Honglian Zeng, Shujuan Yang

“…Logistic regression models were used to assess the association between alcohol consumption and hepatic fibrosis, and analyze the modification effect of body mass index (BMI) and waist-to-hip ratio (WHR) on the association. …”
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Neurological and Olfactory Disturbances After General Anesthesia by Antonino Maniaci, Mario Lentini, Rosario Trombadore, Loris Gruppuso, Santo Milardi, Rosario Scrofani, Giuseppe Cuttone, Massimiliano Sorbello, Rodolfo Modica, Jerome R. Lechien, Paolo Boscolo-Rizzo, Daniele Salvatore Paternò, Luigi La Via

“…Recent studies have highlighted the need for tailored anesthetic approaches in these high-risk groups to mitigate potential long-term effects. These disturbances, including postoperative cognitive dysfunction, delirium, and olfactory deficits, often arise from shared pathophysiological mechanisms, such as neuroinflammation, oxidative stress, and disruptions in cerebral perfusion. …”
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Association between circadian syndrome and MASLD risk: evidence from a large cross-sectional study by Jihan Sun, Shuqi Mao, Caide Lu

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition closely associated with metabolic syndrome and linked to circadian disruptions. …”
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The substitution of Phentolamine with an equal amount of Chlopromazine as an alpha-blocker in vasoactive cocktails used for intracavernous injection therapy for the treatment of er... by Reinhard A. Uebel, Abraham Schmidt

“…Introduction: This brief report describes the replacement of phentolamine mesylate with an equal amount of chlorpromazine HCl in vasoactive drug mixtures used as intracavernous (IC) injection therapy for treating erectile dysfunction (ED). Phentolamine, amongst other drugs, had been used in drug injection therapy for the treatment of ED, but was replaced as single drug therapy by more effective drugs, such as alprostadil (prostaglandin E1). …”
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Comparison of the effects of pemafibrate and omega-3 fatty acid ethyl on fatty liver index in patients with dyslipidemia treated with statin: a sub-analysis from the PROUD48 study by Yasutaka Takeda, Masato Furuhashi, Ichiro Sakuma, Shinya Hiramitsu, Mizuho Okada, Shinichiro Ueda, Naoki Kumashiro, Masaru Sakurai

“…BackgroundFatty liver index (FLI) calculated by using body mass index, waist circumference and levels of triglycerides and γ-glutamyl transpeptidase is a noninvasive biomarker for diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD), which is one of the high-risk conditions of atherosclerotic cardiovascular diseases. …”
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REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA by M. V. Pokrovsky, N. G. Filipenko, M. V. Korokin, V. V. Gureyev, T. G. Pokrovsky, A. A. Barsuk, L. V. Korokina, E. V. Proskuryakova, N. V. Maltseva, O. V. Levashova, O. S. Gudyrev, A. S. Belous, O. S. Polyanskaya

“…L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. …”
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CONTEMPORARY SIGHT AT AMLODIPINE AND NEW DRUGS OF S-AMLODIPINE by M. V. Leonova

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Modern views on amlodipine and new S-amlodipine medications by M. V. Leonova

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Interictal hyposexuality in male patients with epilepsy by Silveira Diosely C., Souza Elizabeth A. P. de, Carvalho José F., Guerreiro Carlos A. M.

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Izuchenie vliyaniya sulodeksida na endoteliy-zavisimuyu vazodilatatsiyu mozgovykh sosudov u zhivotnykhso streptozototsin-indutsirovannym sakharnym diabetom by Ivan Nikolaevich Tyurenkov, Andrey Vladislavovich Voronkov, Anna Al'bertovna Slietsans, Evgenia Viktorovna Petrova, Grigoriy Leonidovich Snigur

“…Aim. To analyse effects of sulodexide on endothelium-dependent vasodilation (EDVD) of brain vessels in animals with experimental diabetes mellitus. …”
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An Effective and Fast Model for Characterization of Cardiac Arrhythmia and Congestive Heart Failure by Salim Lahmiri, Stelios Bekiros

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Role and therapeutic perspectives of extracellular vesicles derived from liver and adipose tissue in metabolic dysfunction-associated steatotic liver disease by Wandi Li, Lili Yu

“…The global epidemic of metabolic diseases has led to the emergence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), which pose a significant threat to human health. …”
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Safe and effective antireflux surgery in lung transplant recipients: preliminary results by Maciej Wiewiora, Marek Ochman, Maciej Urlik, Katarzyna Hajduk, Aleksandra Gil, Konrad Karcz, Tomasz Hrapkowicz

“…Conclusions: The study suggests that antireflux surgery in LTRs is a safe and effective approach for GERD management, while improving lung function with minimal adverse effects.…”
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PDH Inhibition in <i>Drosophila</i> Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models by Harim Song, Sohee Kim, Ji Eun Han, Kyong-hwa Kang, Hyongjong Koh

“…<b>Background/Objectives:</b> Chemotherapy-induced peripheral neuropathy (CIPN) is a significant dose-limiting side effect of many effective anticancer agents, including vincristine. …”
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Efficacy of acupuncture on lower limb motor dysfunction following stroke: A systematic review and meta-analysis of randomized controlled trials. by Peng Chen, Xing Jin, Debiao Yu, Xiaoting Chen, Yaoyu Lin, Fuchun Wu, Bin Shao

“…<h4>Background</h4>Acupuncture is widely used for Lower Limb Motor Dysfunction Following Stroke (LLMD) in China, though its effectiveness remains unclear. …”
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