Exploring the nexus between hypothyroidism and metabolic dysfunction-associated steatotic liver disease: a UK biobank cohort study by Haitao Wang, Changlin Zheng, Peisong Wang

“…In recent years, the name NAFLD has been replaced by metabolic dysfunction-associated fatty liver disease (MASLD). …”
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Treadmill Exercise Improves Motor Dysfunction and Hyperactivity of the Corticostriatal Glutamatergic Pathway in Rats with 6-OHDA-Induced Parkinson’s Disease by Wei Chen, Decai Qiao, Xiaoli Liu, Kaixuan Shi

“…Hyperactivity in the corticostriatal glutamatergic pathway (CGP) induces basal ganglia dysfunction, contributing to parkinsonian syndrome (PS). …”
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COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence by C. A. Bousman, M. Cherner, J. H. Atkinson, R. K. Heaton, I. Grant, I. P. Everall, The HNRC Group

“…Main effects for executive dysfunction but not COMT on number of sexual partners were observed. …”
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Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis by Jing Lu, Xiaoxiao Dong, Ziqi Gao, Huizhen Yan, Dilireba Shataer, Liang Wang, Yanan Qin, Minwei Zhang, Jiayi Wang, Jie Cui, Shengyang Zhou

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is recognized as one of the most common chronic liver conditions globally, presenting a significant public health. …”
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An Evaluation a PrEP-Focused HIV Prevention Intervention Tailored for Individuals with Opioid Use Disorder and Cognitive Dysfunction by Mistler CB, Huedo-Medina TB, Shrestha R, Gunstad J, Zelenev A, Copenhaver MM

“…We suggest that future efforts focus on refining and testing additional strategies that can further optimize intervention effects across a broader range of outcomes and MOUD patients.Keywords: cognitive dysfunction, people who inject drugs, pre-exposure prophylaxis, HIV prevention, opioid use disorder, medication for opioid use disorder…”
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Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ by Yuting Bai, Mingjing Jiang, Xiaojie Chen, Gang Zhou

“…The PPARγ inverse agonist T0070907 restored NCOR1-mediated repression, synergistically enhancing the effects of CAV2 knockdown on apoptosis, lipolysis, and mitochondrial dysfunction. …”
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Tannic Acid and Ethacridine Lactate Attenuate Markers of Stress-Induced Intestinal Barrier Dysfunctions in Murine Small Intestinal Organoids by Louisa Filipe Rosa, Steffen Gonda, Nadine Roese, Stephan C. Bischoff

“…TA is thought to modulate gastrointestinal barrier function, but the underlying mechanisms and whether Eta has similar effects remains unclear. (2) Methods: to investigate the effects of TA and Eta on the intestinal barrier, stress responses were induced in murine intestinal organoids by lipopolysaccharide (LPS) exposure or withdrawal of growth factors from cell culture medium (GF_Red). …”
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Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity by Yanyan Deng, Leizhi Xu, Zhengtao Jiang, Lin Chen, Guanghao Zhu, Chuting Xu, Xiayan Chu, Lixin Wang, Xiaoting Niu, Ling Chen, Zhangping Xiao, Jing Hu, Guangbo Ge

“…Cisplatin-induced kidney injury (CIKI) is a major adverse effect of this widely used chemotherapy agent. Targeting key events involved in CIKI, such as inflammation, apoptosis, mitochondrial dysfunction and oxidative stress, holds potential for mitigating CIKI and improving patient outcomes. …”
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Anti-PD-1 Antibody Administration following Hip Fracture Surgery Reverses Immune Dysfunction and Decreases Susceptibility to Infection by Hao Zhang, Chuying Chen, Jiusheng He, Jianzheng Zhang, Zhi Liu, Tiansheng Sun

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Zuojinwan ameliorates depressive-like behavior and gastrointestinal dysfunction in mice by modulating the FXR-bile acid-gut microbiota pathway by Dan Qiao, Dan Qiao, Bo Chen, Yuzhen Huang, Yuzhen Huang, Kunhan Su, Kunhan Su, Hao Wu, Hao Wu, Weiwei Tao, Weiwei Tao, Wanli Liu, Wanli Liu

“…This study investigated the antidepressant and gastrointestinal modulatory effects of ZJW via the bile acid–gut microbiota axis. …”
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Undaria pinnatifida extract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress by Yu Zhen Nan, Fan Yan Jing, Nguyen Thi Van, Piao Chun Hua, Lee Byung-Hoo, Lee So-Young, Shin Hee Soon, Kim Tae-Geum, Song Chang Ho, Chai Ok Hee

“…These results suggest that UPE may treat CARAS by modulating epithelial cell dysfunction and oxidative stress.…”
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2 by Kehinde S. Olaniyi, Stephanie E. Areloegbe

“…However, it is unknown whether acetate would exert a therapeutic effect on ovarian mitochondrial dysfunction in PCOS. …”
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Dynamics of the painful syndrome, cardial dysfunction and cerebral disorders at patients suffering vertebral cardialgies while treatment of intraosteal blockades by V. A. Filimonov, Ye. L. Sokov, L. Ye. Kornilova

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TRIMETAZIDINE INFLUENCE ON FILTRATION AND TUBULOINTERSTITIAL FUNCTION OF KIDNEYS IN ISCHEMIC HEART DISEASE PATIENTS WITH CHRONIC HEART FAILURE AND RENAL DYSFUNCTION by N. A. Koziolova, I. I. Kolegova, M. V. Surovtseva

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Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF-κB Pathway by Xin Xu, Quanli Zhu, Guoliang Li, Junjian Ma, Zhijian Pan, Wei Wu

“…SST, with a protective effect on intestinal barrier dysfunction through suppression of NF-κB, could be a potential therapeutic drug for sepsis-induced intestinal barrier dysfunction.…”
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Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy by Yiting Chen, Xueping Feng, Zeyu Li, Xinrun Wang, Wei Xiong, Jie Liu, Guotao Wang, Wenye Xu, Rui Jin, Lina Zhang, Zhaoxin Qian

“…Methods Through co-immunoprecipitation and molecular biological experiments, the functional interaction relationship between DDIT4 and TXNIP was clarified, and the effect of DDIT4/TXNIP on the progression of SIC was investigated both in vitro/vivo. …”
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Impact of Pathological Grades of Metabolic Dysfunction-Associated Steatotic Liver Disease on Weight Loss Following Laparoscopic Sleeve Gastrectomy by Qu YF, Wang K, Li Y, Cheng YG, Hu SY, Zhong MW

“…This study aimed to evaluate the effect of fatty liver severity on percentage of excess weight loss (%EWL) in patients undergoing laparoscopic sleeve gastrectomy (LSG).Methods: This retrospective cohort study included 226 patients with obesity who underwent LSG. …”
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Prospectively assessed hypothalamic-pituitary dysfunction after proton therapy in adults with head and neck, skull base and brain tumors by Jordan Bouter, Nathan Azemar, Anthony Vela, Pauline Dutheil, Paul Lesueur, Dinu Stefan, Yves Reznik, Juliette Thariat

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Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial. by Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

“…We hypothesized that serelaxin could ameliorate renal vasoconstriction and renal dysfunction in patients with cirrhosis and portal hypertension.…”
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High accumulation of linezolid and its major metabolite in the serum of patients with hepatic and renal dysfunction is significantly associated with thrombocytopenia and anemia by Junqiang Gou, Qian Li, Ning Fan, Chen Zhang, Haiwen Tang, Xiaofeng Wang, Dongfeng Yin

“…It seeks to understand how these levels relate to thrombocytopenia and anemia and to identify concentration thresholds that could cause these adverse effects, thereby aiding in personalized drug dosing. …”
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