Relationship between electrocardiographic characteristics and subclinical left ventricular systolic dysfunction in isolated left bundle branch block patients by Guangyuan Li, Yonghuai Wang, Bo Pang, Jun Yang, Chunyan Ma

“…Abstract Background Early identification of subclinical left ventricular (LV) systolic dysfunction (LVSD) in patients with isolated left bundle branch block (LBBB) and preserved LV ejection fraction (LVEF), termed LBBBpEF, is clinically important. …”
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Analysis of pelvic floor anatomy in pelvic floor dysfunction syndrome based on four-dimensional ultrasonography of the perineum dynamic examination by Mu Liang, Xu Jiaojiao, Chen Hao, Nan Shuliang, Liu Wei, Xue Yuhong, Liu Li

“…[Conclusion] Four-dimensional ultrasonography of the perineum dynamic examination during the Valsalva maneuver can clearly show the anatomical characteristics of reduced levator ani relaxation function and decreased ARA in female patients with pelvic floor dysfunction syndrome. It can be used as a simple and effective imaging method for pelvic floor dysfunction syndrome.…”
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Noninvasive assessment of hepatic steatosis grades by ultrasound derived fat fraction in metabolic dysfunction associated steatotic liver disease by Meng Sun, Mingwei Zhong, Fangqiong Luo, Meng Lan, Xinru Zhang, Wei Nie, Zhe Ma

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Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study by Xin Qiu, Xin Qiu, Shuang Shen, Nizhen Jiang, Donghong Lu, Yifei Feng, Guodong Yang, Bangde Xiang, Bangde Xiang, Bangde Xiang

“…However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. …”
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Resting-state connectivity and task-based cortical response in post-stroke executive dysfunction: A fNIRS study by Kayee Chong, Songmei Chen, Xixi Chen, Xiaolin Zhang, Deng Liu, Zhiqing Zhou, Xiaowen Wang, Jingjing Zhang, Chunlei Shan

“…Objective: This study attempted to investigate the frontoparietal cortical reorganization associated with executive function (EF) in post-stroke executive dysfunction (PSED) patients, focusing on resting-state, Stroop and 1-back task-based functional connectivity (FC) using functional near-infrared spectroscopy (fNIRS). …”
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Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a by Mengyuan Dai, Jing Shi, Tao Wang, Sha Wan, Chen Fan, Siyu Wang, Siyuan Chen, Jiaojiao Shang, Qingquan Kong, Qingquan Kong

“…Identifying molecular targets involved in chondrocyte (responsible for ECM homeostasis in OA) dysfunction is therefore essential for developing effective OA treatments. …”
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Xietu Hemu Prescription Improves Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Cohort Study by Xiang LL, Cao YT, Wang XX, Wang GX, Zhang YJ, Li RH, Qi F, Huai JX, Sun J, He XJ, Zhou XQ

“…After controlling confounding by IPTW, log-binomial analysis revealed that XHP administration was significantly more effective for MASLD in the exposure cohort than in the referent cohort (weighted risk ratio=2.99, 95% CI=1.86 to 4.89, p< 0.001). …”
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PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT by Zejin Zhang, Zejin Zhang, Zhenzhen Yan, Zhenzhen Yan, Tao Yuan, Tao Yuan, Xiaona Zhao, Xiaona Zhao, Minghui Wang, Minghui Wang, Guoqing Liu, Guoqing Liu, Lijun Gan, Wei Qin, Wei Qin, Wei Qin

“…NAC supplementation could be an effective clinical strategy to mitigate PD-1 inhibitor-induced imbalanced collagen distribution and cardiac dysfunction.…”
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Ergothioneine ameliorates metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation by Xiaoyu Lv, Chenyu Nie, Yihan Shi, Qincheng Qiao, Jing Gao, Ying Zou, Jingwen Yang, Li Chen, Xinguo Hou

“…In contrast, intervention with 3-MA abrogated these effects, suggesting that ergothioneine ameliorated effects by promoting autophagy. …”
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Inhibition of Sodium/Hydrogen Exchanger‐1 in the Right Ventricle and Lung Dysfunction Induced by Experimental Pulmonary Arterial Hypertension in Rats by Giuseppina Milano, Melanie Reinero, Julien Puyal, Piergiorgio Tozzi, Michele Samaja, Florence Porte‐Thomé, Maurice Beghetti

“…The functional, morphological (fibrosis and hypertrophy), and biochemical (inflammation, signaling pathways) dysfunctions caused by PAH were partially reverted by rimeporide in both the lungs and myocardium, where the most striking effects were observed in the right ventricle. …”
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Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats by Charissa E. van den Brom, Christa Boer, Rob F. P. van den Akker, Stephan A. Loer, R. Arthur Bouwman

“…Caloric reduction restored myocardial dysfunction and the protective effect of sevoflurane against ischemia compared to WD-fed rats, whereas the protective effects of WD-feeding persisted. …”
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Methylmalonic acid at the serum level in the elderly contributes to cell growth via mitochondrial dysfunction in colorectal cancer cell spheroids by Arowu R. Tanaka, Chiho Murakami, Hideya Yamamoto

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Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis by Guangjie Wang MD, Chenxiao Hao MD, Sun Yao MD, Yiqin Wang PHD, Zongtao Xu MD, Huiying Zhao MD, Youzhong An MD

“…A significant correlation between DIC and in-hospital mortality persisted (OR 2.15, 95% CI 1.29–3.59, P = 0.003), with nonplt-SOFA scores (OR 1.16, 95% CI 1.05-1.28, P = 0.004) and hemorrhage (OR 2.33, 95% CI 1.08-5.03, P = 0.032) as predictors. The overall effect size was 0.1786 (95% CI 0.0542-0.2886), comprising a direct effect size of 0.1423 (95% CI 0.0153-0.2551) and an indirect effect size of 0.0363 (95% CI 0.0034-0.0739), with approximately 20.3% of effects mediated. …”
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Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction by Li T, Yang B, Liu X, Shi D, Wang Z, Chen Y, Shen C

“…Taixi Li,1,* Boshen Yang,1,* Xijian Liu,2 Dongmei Shi,1 Zhixiang Wang,1 Yizhi Chen,1 Chengxing Shen1 1Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China; 2School of Chemistry and Chemical Engineering, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai University of Engineering Science, Shanghai, 201620, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chengxing Shen, Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China, Email shencx@sjtu.edu.cnPurpose: Myocardial ischemia-reperfusion (IR) injury, a significant challenge in cardiovascular treatment, is primarily driven by ferroptosis and mitochondrial dysfunction. Despite extensive research, no clinical therapies effectively target ferroptosis in IR injury. …”
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Metabolomics and network analysis reveal the mechanism of Salvia miltiorrhiza bunge extract in ameliorating cognitive dysfunction in sleep-deprived rats by Meiya Zhang, Xirui Huang, Mengxiang Dai, Shunbo Zhang, Chao Yin, Qiuyun You

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Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways by Qiyao Xu, Qiyao Xu, Xuan Liu, Xuan Liu, Zhaoyang Chen, Zhaoyang Chen, Can Guo, Can Guo, Pengyu Lu, Pengyu Lu, Sujie Zhang, Xindong Wang, Jianping Shen

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Association Between Daytime Sleepiness and Quality of Life in Chinese Adolescents: A Moderated Mediation of Cognitive Dysfunction and Depressive Symptoms by Li W, Hu N, Yang X, Zheng W, Tong J, Song J, Song Y, Gao X, Wang Z, Liu W, Wang L, Tan Y, Wang C, Deng H

“…Improving depressive symptoms and cognitive dysfunction may be potential strategies to mitigate the adverse effects of daytime sleepiness on adolescents’ quality of life.Keywords: daytime sleepiness, quality of life, cognitive dysfunction, depressive symptoms, adolescents…”
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Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice. by Andrea Leiva, Susana Contreras-Duarte, Ludwig Amigo, Esteban Sepúlveda, Mauricio Boric, Verónica Quiñones, Dolores Busso, Attilio Rigotti

“…In conclusion, our data show important adverse effects of gugulipid intake on HDL metabolism and atherosclerosis in male mice, suggesting potential and unknown deleterious effects on cardiovascular health in humans. …”
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Known-Group Validity and Sensitivity to Change in the Sensory-Motor Dysfunction Questionnaire in Individuals with Neck Pain: A Pilot Study by Ushani Ambalavanar, Megan McIntosh, Heidi Haavik, Bernadette Murphy

“…Background/Objectives: Sensorimotor dysfunction is often reported in individuals experiencing neck pain, irrespective of severity and chronicity. …”
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Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia by Ji-Eun Park, Hye-Bin Lee, Yu Ra Lee, Guijae Yoo, Hee-Kyoung Son, Sang Yoon Choi, Miri Park, Ho-Young Park

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. …”
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