Ulinastatin modulates TRPM4 expression and apoptosis to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder rats by Xiaohui Xia, Jiayi Li, Mengmeng Zhang, Chunyan Zhang, Keliang Lu, Huirong han

“…However, the underlying mechanisms of this effect remain unclear. Transient receptor potential melastatin 4 (TRPM4) is a Ca2 + -activated, monovalent cation channel associated with many neurological diseases. …”
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Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial by Bas Groenewegen, Merel M. Ruissen, Emily Crossette, Rajita Menon, Amanda L. Prince, Jason M. Norman, Bart E. P. B. Ballieux, Hildo J. Lamb, Elisabeth M. Terveer, Josbert J. Keller, Maarten E. Tushuizen

“…The gut microbiota is increasingly considered a contributory factor in metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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AIBP Protects Müller Glial Cells Against Oxidative Stress-Induced Mitochondrial Dysfunction and Reduces Retinal Neuroinflammation by Seunghwan Choi, Soo-Ho Choi, Tonking Bastola, Keun-Young Kim, Sungsik Park, Robert N. Weinreb, Yury I. Miller, Won-Kyu Ju

“…Oxidative stress and mitochondrial dysfunction have a significant role in triggering glia-driven neuroinflammation and subsequent glaucomatous RGC degeneration in the context of glaucoma. …”
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Energy drinks exacerbate high-fat diet-induced metabolic and hepatic dysfunction in male and female Wistar rats by Worship Odosa Agbonifo, Joseph Chimezie, Mercy Oluwaseun Awoleye, Hope Oluwabukola Francis, Temitope Gabriel Adedeji

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CCN5 Drives Leydig Cell Aging and Testicular Dysfunction: Insights into Fibrosis, Lipid Dysregulation, and Therapeutic Potential by Xiaoli Tan, Yanghua Xu, Ningjing Ou, Yuzhuo Chen, Wanyi Xia, Emily Xing, Ren Mo, Hao Bo, Zhitao Han, Jiarong Xu, Zepeng Dong, Yingbo Dai, Yuxin Tang, Liangyu Zhao

“…In summary, CCN5 drives LCs’ aging and testicular dysfunction maybe via promoting fibrosis and lipid droplet loss. …”
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Association between polycyclic aromatic hydrocarbons exposure and metabolic dysfunction-associated steatotic liver disease in US adults by Jiajun Wu, Shaoqian Cui, Xuekui Li, Xiaofei Zhang, Siqi Yang, Junhao Sun, Xiubo Jiang

“…ObjectiveTo investigate the individual or combined effects of polycyclic aromatic hydrocarbons (PAHs) on metabolic dysfunction-associated steatotic liver disease (MASLD) in U.S. adults.MethodsWe enrolled 3,130 participants aged 20 and over from the 2007–2016 National Health and Nutrition Examination Survey (NHANES) and analyzed six urinary PAH metabolites. …”
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Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. by Lucy J Garvey, Nicola Pavese, Anil Ramlackhansingh, Emma Thomson, Joanna M Allsop, Marios Politis, Ranjababu Kulasegaram, Janice Main, David J Brooks, Simon D Taylor-Robinson, Alan Winston

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Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence from 18F-FDG-PET by Maria Arioli, Irene Bossert, Daniela D’Ambrosio, Marina Manera, Elena Maria Andreolli, Nicola Canessa, Nicola Canessa, Giuseppe Trifirò

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TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson’s disease by Baoyu Zhu, Jiezhu Feng, Xiaomei Liang, Zhongling Fu, Mengshi Liao, Tongtong Deng, Kaicheng Wang, Jianwei Xie, Jieshan Chi, Lu Yang, Yuyuan Gao, Kun Nie, Lijuan Wang, Piao Zhang, Yuhu Zhang

“…In these mice, exacerbated cognitive impairment, neurodegeneration, disruption of synaptic plasticity, and accumulation of pathological α-Synuclein (α-Syn) in the hippocampus were observed, without any detected motor dysfunction. Despite increased infiltration of activated microglia surrounding α-Syn aggregates, lysosomal dysfunction in microglia was aggravated in the TREM2-/-/A53T mice. …”
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Prevalence of Menstrual Dysfunction and Hormonal Contraceptive Use Among Elite Female Athletes from Different Sports in Germany by Elisabeth M. Kirschbaum, Katharina Fischer, Dorothee Speiser, Franziska Lautenbach, Friedemann Schwenkreis, Anne Dathan-Stumpf, Kirsten Legerlotz

“…Abstract Background While a regular menstrual cycle is an indicator of good health, menstrual dysfunction (MD) and wrong beliefs regarding hormonal contraceptives (HC) are quite common among elite female athletes and threaten their health. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Cognitive dysfunction has become the second leading cause of death among the diabetic patients. …”
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Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study by Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang

“…However, its use is restricted by adverse effects, including acute liver injury (ALI). Patients with hepatic insufficiency are often more susceptible to voriconazole-induced liver injury than those with normal hepatic function. …”
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Role of BDNF-TrkB signaling pathway in early-life cadmium exposure induced cognitive dysfunction in mice by Yan SHI, Siqi YANG, Yougang WANG, Qiumei WU, Jinquan LI

“…The behavioral changes associated with cognitive dysfunction were positive in the cadmium exposure group (all P<0.05). …”
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Perfusion mode as a factor of appearance of cognitive dysfunction in patients after on-pump coronary artery bypass grafting by S.M. Sudakevych, О.А. Loskutov, І.P. Shlapak, V.V. Babenko, B.М. Todurov

“…The aim – to evaluate the effect of perfusion pressure during cardiopulmonary bypass on the occurrence of postoperative cognitive dysfunction in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). …”
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Supplementation of Chlorogenic Acid Alleviates the Effects of H₂O₂-Induced Oxidative Stress on Laying Performance, Egg Quality, Antioxidant Capacity, Hepatic Inflammation, Mitochondrial Dysfunction, and Lipid Accumulation in Laying Hens by Haitong Zhao, Zhuang Li, Yue Sun, Ming Yan, Yingjie Wang, Yurong Li, Yeshun Zhang, Mingkun Zhu

“…Furthermore, CGA pretreatment effectively prevented the degeneration in laying performance and egg quality, as well as OS, liver inflammation, pathological damage, and mitochondrial dysfunction induced by H₂O₂. …”
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Effect of early-life exposure to environmental risk factors on adult MASLD: Insights from DOHaD perspective by Zhang Hongchao, Francisco Javier Cubero, Zhao Gang, Xu Jin, Liu Qian, Shao Wentao, Gu Aihua

Subjects: “…metabolic dysfunction-associated steatotic liver disease…”
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Sexual Functions Are Impaired in Males and Females With Chronic Spontaneous and Inducible Urticaria: A Controlled Study by Pelin Kuteyla Can, Utku Can

“… Introduction: Sexual dysfunction (SexD) related to chronic dermatologic diseases in women and men were reported in literature, but there are few reports on effects of chronic urticaria (CU) on male and female sexual functions. …”
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Olfactory and Gustatory Recovery Time Evaluation of COVID-19: A Systematic Review and Meta-Analysis by Mohadeseh Poudineh, Amirhesam Amirbeik, Mohammad Dehghani Firouzabadi, Mahsa Hajizadeh, Farima Kahe, Sepideh Babaniamansour, Amirhossein Poopak, Farbod Zahedi Tajrishi, Niloofar Deravi, Mohammad Rahmanian, Hamidreza Ghasemirad, Mahta Malek, Masoud Noroozi, Mobina Fathi, Kimia Keylani, Ali Dehghani Firouzabadi, Ghader Dargahi Abbasabad, Forough Yazdanian, Sara Ramezanpour, Amirmohammad Babaniamansour, Faryar Zahedi Tajrishi, Soheil Mohammadi, Golnoosh Ansari, Fatemeh Dehghani Firouzabadi, David M Yousem

“… Background: Olfactory dysfunction is a common symptom of Coronavirus disease 2019 (COVID-19). …”
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Isolation and Characterization of Secondary Metabolites from <i>Hydractinia</i>-Associated Fungus, <i>Penicillium brevicompactum</i> MSW10-1, and Their Inhibitory Effects on Hepati... by Hyeon-Jeong Hwang, Hyeokjin Lim, Jae Sik Yu, Eun Seo Jang, Youngsang Nam, Yeo Jin Lee, Eun La Kim, Seonghwan Hwang, Seoung Rak Lee

“…The isolated compounds (<b>1</b>–<b>8</b>) were evaluated for their ability to inhibit hepatic lipogenesis, a key process in lipid metabolism that is dysregulated in metabolic-dysfunction-associated steatotic liver disease. Furthermore, the inhibitory effects of the isolated compounds on lipid accumulation were further evaluated in primary mouse hepatocytes, using Oil Red O staining. …”
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Is Ultrasonography an Effective Method for Diagnosing Degenerative Changes in the Temporomandibular Joint? by Barbara Wojciechowska, Arkadiusz Szarmach, Adam Michcik, Maciej Sikora, Barbara Drogoszewska

“…These conditions, characterized by cartilage degradation, subchondral bone remodeling, and eventual joint dysfunction, necessitate reliable and efficient imaging techniques for early detection and effective management. …”
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