Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction by Huihui Zhang, Zi Yan, Junyou Zhu, Ziyue Li, Lianglong Chen, Weihan Zheng, Zhenning Dai, Jiaxin Yang, Xinyi Yun, Yilin Wang, Hai Zhou, Ziwei Jiang, Qiuyi Yu, Shiyu Li, Wenhua Huang, Lei Yang

“…In vivo experiments also showed that MDV drops hindered wound healing in diabetic mice; however, this effect is rescued by SNX9 inhibitors, restoring mitochondrial dynamics and balance. …”
Get full text

Cognitive Dysfunction in Patients Treated with Androgen Deprivation Therapy: A Multimodality Functional Imaging Study to Evaluate Neuroinflammation by Azeem Saleem, Syed Imran Ali Shah, Stephen A. Mangar, Christopher Coello, Matthew B. Wall, Gaia Rizzo, Terry Jones, Patricia M. Price

Get full text

Association between periodontitis and mortality in participants with metabolic dysfunction-associated steatotic liver disease: results from NHANES by Zhaofu Zhang, Qiuyun Zheng, Yiheng Liu, Guanhui Chen, Yiming Li

“…Abstract Background It has been reported that periodontitis was a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD). …”
Get full text

Platelet-rich plasma: A promising therapy for mitigating sperm oxidative stress and mitochondrial dysfunction in subfertile men. by Rim Kooli, Manel Boussabbeh, Dhekra Chebil, Abderraouf Kenani, Linda Khefacha, Meriem Mehdi, Amira Sallem

“…This study aims to investigate the effect of autologous PRP supplementation on oxidative stress levels and mitochondrial activity in human sperm. …”
Get full text

Sleep Quality as a Mediator of Internet Gaming Disorder and Executive Dysfunction in Adolescents: Cross-Sectional Questionnaire Study by Michoel L Moshel, Wayne Warburton, Rainer Thomasius, Kerstin Paschke

“…MethodsA representative sample of 1000 adolescents (539/1000, 53.9% males), aged between 12 and 17 years (mean 14.52, SD 1.64), completed validated self-report measures of IGD symptoms, executive dysfunction, and sleep quality. Structural equation modeling was used to test direct and indirect effects with age and gender included as covariates. …”
Get full text

Pathogenic aspects of fructose consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): A narrative review by Katharina Burger, Michael Trauner, Ina Bergheim

“…Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to non-alcoholic fatty liver disease (NAFLD), has become a global health concern with a still increasing prevalence. …”
Get full text

THE ROLE OF LACTASE INSUFFICIENCY AND INTESTINAL MICROFLORA IN DEVELOPMENT OF GASTROINTESTINAL DYSFUNCTIONS IN INFANTS AGED 0–6 MONTHS OLD by E. A. Kornienko, S. S. Kubalova

“…Correction of GIF should be performed in accordance with LI. Lactase enzyme effectively eliminates both LI symptoms and inflammation signs.…”
Get full text

Metabolic dysfunction-associated steatotic liver disease (MASLD): emerging insights into gut microbiota interactions and therapeutic perspectives by Wenchu Qian, Ling He, Chenxue Fu, Tiantian Zeng, Hanyu Wang, Haifang Li

“…As the most prevalent hepatic disorder worldwide, metabolic dysfunction-associated steatotic liver disease (MASLD) afflicts over one-third of the global population, representing a significant public health challenge. …”
Get full text

Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice by Rodrigo Araujo Fraga-Silva, Fabiana Pereira Costa-Fraga, Fabrizio Montecucco, Younouss Faye, Silvia Quintao Savergnini, Sébastien Lenglet, François Mach, Sabine Steffens, Nikolaos Stergiopulos, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

“…Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. …”
Get full text

HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury by Yunwen Yang, Peipei Wang, Kaiqian Zhou, Wen Zhang, Suwen Liu, Jing Ouyang, Mi Bai, Guixia Ding, Songming Huang, Zhanjun Jia, Aihua Zhang

“…Importantly, the overexpression of type 2 MUTYH (nuclear) significantly ameliorates cisplatin‐induced apoptosis, oxidative stress, mitochondrial dysfunction, and DNA damage in vivo and in vitro. In contrast, overexpression of type 1 MUTYH (mitochondrial) shows a marginal effect against cisplatin‐induced injury, indicating the chief role of type 2 MUTYH in antagonizing AKI. …”
Get full text

The role of glucagon-like peptide-1 receptor agonists in the correction of immune and metabolic disorders in women with reproductive dysfunction by N. D. Kozhukhov, A. R. Karpova, A. A. Sadretdinova, D. G. Kodoeva, A. S. Kardanova, A. S. Proshina, A. S. Avbakirova, D. R. Kilichev, I. Sh. Metov, L. M. Magomedov, D. K. Gatsaev, M. E. Balabanova, Kh. B. Mutalieva, Z. M. Alibekova

Get full text

Myo‐inositol oxygenase (MIOX) accelerated inflammation in the model of infection‐induced cardiac dysfunction by NLRP3 inflammasome by Wenjun Zhou, Congyi Yu, Yiwen Long

“…The inhibition of MIOX reversed the effects of NLRP3 in the in vitro model of cardiac dysfunction. …”
Get full text

The implications of surgery on sexual dysfunction in patients with lumbar disc herniation with cauda equina syndrome: a systematic review by Zahra Moradi, Shadab Shahali, Fazlollah Ahmadi, Ali Montazeri

“…The findings were narratively synthesized to effectively describe, compare, and combine the study results. …”
Get full text

Endothelin-B Receptors and Left Ventricular Dysfunction after Regional versus Global Ischaemia-Reperfusion in Rat Hearts by Sofia-Iris Bibli, Eleni V. Toli, Agapi D. Vilaeti, Varnavas C. Varnavas, Giannis G. Baltogiannis, Apostolos Papalois, Zenon S. Kyriakides, Theofilos M. Kolettis

“…Results. Left ventricular dysfunction was more prominent in ETB-deficient rats, particularly after regional ischaemia. …”
Get full text

Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction. by Hirotada Akiho, Yohei Tokita, Kazuhiko Nakamura, Kazuko Satoh, Mitsue Nishiyama, Naoko Tsuchiya, Kazuaki Tsuchiya, Katsuya Ohbuchi, Yoichiro Iwakura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto

“…<h4>Background and aim</h4>The etiology of post-inflammatory gastrointestinal (GI) motility dysfunction, after resolution of acute symptoms of inflammatory bowel diseases (IBD) and intestinal infection, is largely unknown, however, a possible involvement of T cells is suggested.…”
Get full text

CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid—Maintaining Health and Preventing Thyroid Dysfunction in Aging by Jennifer Nhieu, Fatimah Najjar, Li-Na Wei

“…Retinoic acid (RA) exerts biological effects through RA receptors (RARs) to regulate transcription. …”
Get full text

Schizophrenia-associated alterations in fecal mycobiota and systemic immune dysfunction: a cohort study of elderly Chinese patients by Zongxin Ling, Yiwen Cheng, Xia Liu, Xiaocui Xu, Lingbin Wu, Li Shao, Zhangcheng Zhu, Wenwen Ding, Qinghai Song, Longyou Zhao, Guolin Jin

“…Notably, key fungal species, such as S. cerevisiae and P. lilacinum, were correlated with systemic immune dysfunction. Our receiver operating characteristic (ROC) analysis indicated that these fungal species could effectively distinguish SZ patients from HCs, suggesting their potential as non-invasive biomarkers for SZ diagnosis. …”
Get full text

Neurological mechanism of the dietary supplementations of lycopene on chemotherapy-induced cognitive dysfunction/chemobrain and hippocampal toxicity in the rat model by Sunday Aderemi Adelakun, Jacob Adewale Siyanbade, Akwu Bala Peter, Mistura Abisola Salami, Bisade Esther Adeyeluwa, Opeyemi Zainab Kaka

“…This study investigates the effect of Lycopene on Chemotherapy-induced cognitive dysfunction and hippocampal toxicity in rat models. …”
Get full text

Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction by Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy

“…Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. …”
Get full text

Exploring the impact of sleep duration and sleep disorders on metabolic dysfunction-associated steatotic liver disease in older adults by Fan Zhang, Yuan Xue, Wenjian Li

“…Abstract Objective This study investigated the effects of sleep duration and sleep disorders on metabolic dysfunction-associated steatotic liver disease (MASLD) in older adults and provided a scientific basis for the development of targeted health management strategies. …”
Get full text