Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore by Bolun Zhao, Fazhan Ban, Yuehua Li, Qiong Shi, Sen Guo, Xiuli Yi, Huina Wang, Tianwen Gao, Chunying Li, Guannan Zhu

“…This study investigates whether mitochondrial dysfunction induced by the copper ionophore disulfiram (DSF) can effectively counteract resistance to BRAF inhibitors. …”
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Correction of Endothelial Dysfunction in Patients with Essential Hypertension when Using a Combination of Olmesartan/Lercanidipine and Zofenopril/Lercanidipine by O. V. Zimnitskaya, M. M. Petrova

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Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress by Lei Zhang, Guangyuan Zhang, Weipu Mao, Si Sun, Shuchun Tao, Yue Gao, Nieke Zhang, Guiya Jiang, Ming Chen, Xun Lu, Shuqiu Chen

“…Background Xuebijing (XBJ) injection has been used to treat sepsis. However, the effect and mechanism of XBJ injection in the treatment of septic acute kidney injury (AKI) is unknown. …”
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Baduanjin exercise combined with moxibustion box for gastrointestinal dysfunction in the elderly: a protocol of prospective, randomized controlled trial by Jing Zhu, Jing Zhu, Dongxia Zhang, Lu Yang, Lu Yang, Hong Liang, Hong Liang, Qingyan Liu, Qingyan Liu, Jinyan Liang, Jinyan Liang, Zunjiang Li, Zunjiang Li, Banghan Ding, Banghan Ding, Danwen Zheng, Danwen Zheng

“…However, the therapeutic effect of WDT during enteral nutrition in critically ill patients is unsatisfactory. …”
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Tear Film Instability and Meibomian Gland Dysfunction Correlate with the Pterygium Size and Thickness Pre- and Postexcision in Patients with Pterygium by Ning Li, Tao Wang, Ruixue Wang, Xuanchu Duan

“…This study aimed to evaluate the effects of excision on dry eye and meibomian gland dysfunction (MGD) in individuals with pterygium, before and after surgery. …”
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ACAA2 Protects Against Cardiac Dysfunction and Lipid Peroxidation in Renal Insufficiency with the Treatment of S-Nitroso-L-Cysteine by Zhengqi Xu, Feng Jiang, Xiaofan Wu, Bowen Ren, Cuntai Zhang, Li Lin, Sheng Li

“…The key fatty acid β-oxidation protein acetyl-CoA acyltransferase 2 (ACAA2) plays a significant role in myocardial lipid peroxidation and cardiac dysfunction induced by renal insufficiency. However, the mechanisms of lipid metabolism related to renal insufficiency-associated cardiac dysfunction remain poorly understood, and current clinical treatments have been largely ineffective. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…Abstract Background Postoperative cognitive dysfunction (POCD) represents a post-surgical complication that features progressive cognitive impairment and memory loss, often occurring in elderly patients. …”
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Impact of perioperative esketamine on the perioperative neurocognitive dysfunction: a systematic review and meta-analysis of randomised controlled studies by Lu Chen, Chao Li, Xin Yuan, Yanan Zhao, Shufang Liu, Jiayu Zhu, Xuesen Su, Zixuan Wang, Yihe Tian, Shouyuan Tian

“…Objectives The effect of esketamine on perioperative neurocognitive dysfunction (PND) remains controversial. …”
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PERPHERAL BLOOD CELL MITOCHONDRIAL DYSFUNCTION IN MYELODYSPLASTIC SYNDROMECAN BE IMPROVED BY A COMBINATION OF COENZYME Q10 AND CARNITINE by Kalman Filanovsky, Michal Haran, Vita Mirkin, Andrei Braester, Olga Shevetz, Anfisa Stanevsky, Erica Sigler, Ekaterina Votinov, Yehudit Zalzman-Amir, Alain Berrebi, Atan Gross, Lev Shvidel

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Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats by Peng Li, Geng-Rong Chen, Fu Wang, Ping Xu, Li-Ying Liu, Ya-Ling Yin, Shuang-Xi Wang

“…The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown. …”
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Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction by Angel Lopez-Candales, Talal Asif, Khalid Sawalha, Nicholas B. Norgard

“…In fact, this heterogeneous clinical entity embodies numerous mechanisms and is linked to multiorgan dysfunction, with hypertension and obesity playing a major role. …”
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The promise of mesenchymal stromal/stem cells in erectile dysfunction treatment: a review of current insights and future directions by Ayyub Ali Patel, Alaa Shafie, Asma’a H. Mohamed, Sana Abdul-Jabbar Ali, Faris J. Tayeb, Hisham Ali Waggiallah, Irfan Ahmad, Salah Ahmed Sheweita, Khursheed Muzammil, Abdullah M. AlShahrani, Waleed Al Abdulmonem

“…In recent years, regenerative medicine, particularly stem cell therapies, has emerged as a promising alternative for managing erectile dysfunction. This review explores the potential of mesenchymal stromal/stem cells (MSCs) and their paracrine effects, including extracellular vesicles (EVs), in the treatment of erectile dysfunction. …”
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CD19+CD24hiCD38hi B Cell Dysfunction in Primary Biliary Cholangitis by Qubo Chen, Lanmin Lai, Xiaoling Chi, Xinyi Lu, Huaxian Wu, Jing Sun, Weilin Wu, Li Cai, Xuan Zeng, Chuyang Wang, WeiCheng Chen, Anping Peng

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Optogenetic inhibition of ventral hippocampal neurons alleviates associative motor learning dysfunction in a rodent model of schizophrenia. by Zheng-Li Fan, Bing Wu, Guang-Yan Wu, Juan Yao, Xuan Li, Ke-Hui Hu, Zhen-Hua Zhou, Jian-Feng Sui

“…Schizophrenia (SZ) is a serious and incurable mental disorder characterized by clinical manifestations of positive and negative symptoms and cognitive dysfunction. High-frequency deep brain stimulation (DBS) of the ventral hippocampus (VHP) has been recently applied as a therapeutic approach for SZ in both experimental and clinical studies. …”
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Natural Killer Cell Dysfunction in Obese Patients with Breast Cancer: A Review of a Triad and Its Implications by Esraa Elaraby, Abdullah Imadeddin Malek, Hanan W. Abdullah, Noha Mousaad Elemam, Maha Saber-Ayad, Iman M. Talaat

“…In this study, we aimed to build a triad of breast cancer, obesity, and NK cell dysfunction to elucidate a link between these pillars on a cellular level. …”
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Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction by Ani Chi, Chao Yang, Jie Liu, Zhichen Zhai, Xuetao Shi

“…Abstract Therapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging males. However, the outcomes of these therapies are not satisfactory. …”
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Exploratory Role of Flavonoids on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in a South Italian Cohort by Caterina Bonfiglio, Rossella Tatoli, Rossella Donghia, Davide Guido, Gianluigi Giannelli

“…Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most recent definition for steatotic liver disease associated with metabolic syndrome. …”
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The relationship between autistic traits and problematic smartphone use in adolescents: The serial mediating role of anxiety and executive dysfunction by Siyuan Zhou, Zongping Chen, Ya Liu

“…Background Based on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study aimed to explore the relationship between autistic traits and problematic smartphone use (PSU) among Chinese adolescents and to examine the serial mediation effect of anxiety and executive dysfunction in the association between autistic traits and PSU. …”
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Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, Mendelian randomization, and molecular docking by Shihan Liu, Lingli Zhang, Wenlong Luo

“…We conducted a cross-sectional analysis of NHANES data (1999–2004) to evaluate the prevalence of vestibular dysfunction among warfarin users. Network pharmacology identified overlapping genes between warfarin targets and vestibular dysfunction-related genes. …”
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TGFβ2‐Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions by Su‐Jeong Oh, Ye Young Shin, Ji‐Su Ahn, Hee‐Jeong Park, Min‐Jung Kang, Tae‐Hoon Shin, Byung‐Chul Lee, Won Kyu Kim, Jung‐Min Oh, Dongjun Lee, Yun Hak Kim, Ji Min Kim, Eui‐Suk Sung, Eun‐Woo Lee, Jee‐Heon Jeong, Byung‐Joo Lee, Yoojin Seo, Hyung‐Sik Kim

“…Using ovariectomized (OVX) mouse models, here this study identifies ferroptosis, an iron‐dependent regulated cell death, as a central mechanism driving postmenopausal salivary gland (SG) dysfunction. In the OVX‐SGs, TGFβ signaling pathway is enhanced with the aberrant TGFβ2 expression in SG mesenchymal cells. …”
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