Peritoneal Catheters Malposition/Dysfunction and Their Approach with Catheterography and Radiologic Manipulation in Peritoneal Dialysis: A Minireview and Case Series by Martina Cacciapuoti, Anna Basso, Lucia Federica Stefanelli, Federico Nalesso, Lorenzo A. Calò

“…Peritoneal catheter dysfunction is one of the most frequent complications of peritoneal dialysis. …”
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Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19: A randomized placebo-controlled trial by Iman Shamohammadi, Seyedmohammad Kazemeyni, Mohammadali Sadighi, Tara Hasanzadeh, Alireza Dizavi

“…Conclusion: Daily administration of tadalafil 5 mg seems to be effective and safe for improvement of erectile dysfunction caused by COVID-19.…”
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Point of care creatinine testing for early detection of renal dysfunction in Tanzanian HIV patients: a study protocol by Daniel Msilanga, Anthony Muiru, Emmanuel Balandya, Kathleen Liu

“…The diagnostic performance and agreement to diagnose renal dysfunction will be assessed using a standardized statistical approach: Bland-Altman analysis and linear mixed-effects models to test agreement between creatinine dipstick tests with serum creatinine. …”
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Low-Intensity Extracorporeal Shockwave Therapy – A New Approach in the Treatment of Erectile Dysfunction after Radical Prostatectomy by Boyan Stoykov, Nikolay Kolev, Rumen P.Kotsev, Fahd Al-Shargabi, Pencho Genov, Aleksandar Vanov

“…The experience accumulated with low-intensity extracorporeal shock wave therapy (LI-ESWT) from international clinical trials has demonstrated its safety, efficacy and good tolerance in treatment of erectile dysfunction (ED). The aim of this retrospective study was to investigate the effect of LI-ESWT in patients with ED after bilateral nerve sparing radical surgery for prostate cancer. …”
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A comparative study of the anti-ischemic activity of trimetazidine and the compound ALM-802 under conditions of endothelial dysfunction by V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii

“…Conclusion. Endothelial dysfunction prevents the implementation of the trimetazidine anti-ischemic action, but does not affect on the compound ALM-802 effect. …”
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Non-coding RNA-mediated granulosa cell dysfunction during ovarian aging: From mechanisms to potential interventions by Li Dong, Haicui Wu, Fanghua Qi, Yuan Xu, Wen Chen, Yuqi Wang, Pingping Cai

“…The exact pathogenesis of ovarian aging (OA) remains incompletely understood, with granulosa cells (GCs) dysfunction playing a significant role in this process. …”
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Zinner syndrome unveiled: Ectopic ureter and seminal vesicle cyst leading to urinary dysfunction: A case report by Zaid Sawaftah, Khaled Sawafta, Moath Hattab, Adel Abu Al Rub, Omar Sawafta, Jehad Khamaysa, Humam Emad Rajha, Jana Dibas, Muath Daraghmeh, Yazan Dibas

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Unveiling Therapeutic Potential of Yoga Mitigating Oxidative Stress and Mitochondrial Dysfunction in PCOS: A Randomized Controlled Trial by Deepika Kumari, Manoj Kumar, Ashish Datt Upadhyay, Neena Malhotra, Reeta Mahey, Vatsala Dadhwal, Tushar Sehgal, Richa Mishra, Rima Dada

“…Background: Hormonal imbalance, mitochondrial dysfunctions, and oxidative stress (OS) have been implicated in the pathogenesis of polycystic ovarian syndrome (PCOS) and its associated clinical features. …”
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A Mitochondria‐Targeted Biomimetic Nanomedicine Capable of Reversing Drug Resistance in Colorectal Cancer Through Mitochondrial Dysfunction by Xiaohui Wang, Zhiyuan Xu, Jian Wang, Chunrong Wu, Lin Zhang, Chengyuan Qian, Yang Luo, Yanjuan Gu, Wing‐Tak Wong, Debing Xiang

“…Abstract Chemoresistance and metastasis are the main obstacles to the clinical success of anticancer treatment and are responsible for most cancer deaths. Developing effective approaches to reverse chemoresistance and inhibit metastasis is essential for efficient chemotherapy. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Evolving Insights into Pathogenesis, Progression, and Personalized Treatment Approaches by Paweł Kukiełka, Katarzyna Moliszewska, Joanna Kośka, Kacper Dywan, Michał Błaszkiewicz, Julia Mazurek, Julia Załęcka, Alicja Nowik, Martyna Musiorska, Gabriela Łocik

“…   Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously classified under non-alcoholic fatty liver disease (NAFLD), is an increasingly prevalent chronic liver disorder tightly linked to obesity, insulin resistance, and systemic metabolic dysfunction. …”
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Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction by Xuemei Shi, Zhonghan Yan, Ruilin Ding, Fenfen Xia, Yan Du, Xiaojie Wang, Qing Peng

“…The lack of early, specific biomarkers and effective treatments necessitates exploration of novel mechanisms. …”
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Angiotensin II Induces Vascular Endothelial Dysfunction by Promoting Lipid Peroxidation-Mediated Ferroptosis via CD36 by Qian Zhou, Ying Zhang, Wei Shi, Lu Lu, Jianglan Wei, Jinhan Wang, Hu Zhang, Yuepu Pu, Lihong Yin

“…Angiotensin II (Ang II) is an effective vasoconstriction peptide, a major effector molecule of the renin–angiotensin–aldosterone system (RAAS) and one of the important causes of endothelial dysfunction. …”
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Using Radial Shock Wave Therapy to Control Cerebral Palsy-Related Dysfunctions: A Randomized Controlled Trial by Hussein HM, Gabr AM, Aldhahi MI, Alshammari AA, Alshammari HZ, Altamimi KK, Alqahtani AM, Dewir IM, El-Shamy SM, Ibrahim AA

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Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure by Chiara Verra, Maria Kerstin Paulmann, Maria Kerstin Paulmann, Jamila Wegener, Jamila Wegener, Enrica Marzani, Gustavo Ferreira Alves, Massimo Collino, Sina Maren Coldewey, Sina Maren Coldewey, Christoph Thiemermann

“…Thus, we investigated the effects of the highly selective SYK inhibitor PRT062607 (15mg/kg; i.p.) on sepsis-induced cardiac dysfunction and MOF in a clinically-relevant, murine model of sepsis. …”
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Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia by Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo

“…In this study, using flow cytometry (FCM), proteomics, and single‐cell RNA sequencing of samples from patients with ITP, it is shown that exosome‐mediated lectin complement pathway is involved in the pathogenesis of ITP, which triggers and enlarges the complement activation cascade without effective regulation because of downregulated CD55. …”
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A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide by Zhiyan Wang, Nore Ojogun, Yiling Liu, Lu Gan, Zeling Xiao, Jintao Feng, Wei Jiang, Yeying Chen, Benkun Zou, ChengYun Yu, Changshun Li, Asha Ashuo, Xiaobo Li, Mingsheng Fu, Jian Wu, Yiwei Chu, Robert S Munford, Mingfang Lu

“…The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasing worldwide. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…This genetic and epigenetic crosstalk mechanism provides insights for advancing our understanding of motor neuron disease and developing effective treatments.…”
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Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction by Giuseppina Basta, Serena Babboni, Daniele Pezzati, Serena Del Turco, Emanuele Balzano, Gabriele Catalano, Lara Russo, Giovanni Tincani, Paola Carrai, Stefania Petruccelli, Jessica Bronzoni, Caterina Martinelli, Simona Palladino, Arianna Trizzino, Lorenzo Petagna, Renato Romagnoli, Damiano Patrono, Giandomenico Biancofiore, Adriano Peris, Chiara Lazzeri, Davide Ghinolfi

“…Biomarkers linked with oxidative stress, hepatic injury, mitochondrial dysfunction, inflammation, regeneration, and autophagy were measured during NRP, end-ischemic MP, and one week post-transplant. …”
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Oral azithromycin versus doxycycline in meibomian gland dysfunction: A hospital-based study at Nepal eye hospital by Sabita Dhakal, Sabina Shrestha, Pooja Karki, Sujata Dhakal

“…Background: Meibomian gland dysfunction (MGD) involves posterior blepharitis, which includes a disruption of the tear and meibum lipids and thereby produces an evaporative dry eye. …”
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l-carnitine protects against bile acid-induced mitochondrial dysfunction and IGF-1 impairment in hepatocyte cultures by Wafa'a Alqabandi, Maira Alsaeid, Gursev Dhaunsi

“…Conclusions: GCDC-induced hepatotoxic effects could be triggered by mitochondrial dysfunction and impairment of IGF-1 activity. …”
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