Endothelial Microvascular Dysfunction and Its Relationship with Haptoglobin Levels in Patients with Different Phenotypes of Chronic Heart Failure by V. I. Podzolkov, N. A. Dragomiretskaya, I. G. Beliaev, Ju. S. Kucherova, A. V. Kazadaeva

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Electrical Muscle Stimulation for the Conservative Management of Female Pelvic Floor Muscle Dysfunction: A Scoping Review by Nicole A. Guitar, Priyanshi S Akbari, Christina Dzieduszycki, Kristi Konduros, Hessa Asmani, Sinéad Dufour

“…EMS demonstrates a positive effect for improving outcomes related to PFDs in adult women. …”
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Resmetirom and Thyroid Hormone Receptor‐Targeted Treatment for Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) by Chang‐Hai Liu, Qing‐Min Zeng, Teng‐Yue Hu, Yu Huang, Yongfeng Song, Haixia Guan, Don C. Rockey, Hong Tang, Sheyu Li

“…Its severe form, metabolic dysfunction‐associated steatohepatitis (MASH), is also on the rise. …”
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PACAP/PAC1 regulation in cystitis rats: induction of bladder inflammation cascade leading to bladder dysfunction by Hanwei Ke, Hanwei Ke, Lin Zhu, Weiyu Zhang, Weiyu Zhang, Huanrui Wang, Huanrui Wang, Zehua Ding, Zehua Ding, Dongyu Su, Dongyu Su, Qi Wang, Qi Wang, Kexin Xu, Kexin Xu

“…Transcriptomic analysis, immunohistochemistry, and bladder function assays were employed to assess the correlation between PACAP/PAC1 activation, bladder inflammation, and sensory dysfunction. Additionally, modulation of the PACAP/PAC1 pathway was tested in rats to determine its effects on bladder inflammation and function.ResultsOur results demonstrate significant upregulation of PACAP and PAC1 in both human bladder tissues from IC/BPS patients and in the rat cystitis model. …”
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Sex and region-specific disruption of autophagy and mitophagy in Alzheimer’s disease: linking cellular dysfunction to cognitive decline by Aida Adlimoghaddam, Fariba Fayazbakhsh, Mohsen Mohammadi, Zeinab Babaei, Amir Barzegar Behrooz, Farhad Tabasi, Teng Guan, Iman Beheshti, Mahmoud Aghaei, Daniel J. Klionsky, Benedict C. Albensi, Saeid Ghavami

“…Cognitive deficits in females correlated with mitochondrial dysfunction in the cortex, while in males, higher LC3B-II levels associated positively with cognitive performance, suggesting protective autophagy effects. …”
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Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease by Buket Yigit, Ekin Ozgonul, Omer Yaman, Tarik Sipahioglu, Burge Ulukan, Yagmur Cetin Tas, Berna Morova, Musa Aydin, Yigit Uysalli, Elif Demirtas, Mert Erkan, Gurkan Tellioglu, Dila Atak, Yasemin Gursoy Ozdemir, Sercin Karahuseyinoglu, Cihan Yurdaydin, Murat Akyildiz, Abhishek Sheth, Guruprasad Padur Aithal, Hale Kirimlioglu, Murat Dayangac, Onur Ferhanoglu, Alper Kiraz, Müjdat Zeybel

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Using the grip strength effort task to measure reward processing dysfunction in schizophrenia and major depressive disorder by Asad Malik, Shannon N. Millard, Ailidh Finlayson, Amy Beckenstrom, Abigail Abrahams, Dennis Hernaus, Stella D. Voulgaropoulou, Therese van Amelsvoort, Daniel Umbricht, William J. Martin, Darrel J. Pemberton, Jane Tiller, Anke Sambeth, Oliver Grimm, Michael M. Plichta, Andreas Reif, Charis Styliadis, Athanasia Liozidou, Georgios Papazisis, Victor Pérez, Matilde Elices, Karla V. Allebrandt, Stephane Pollentier, Gerard R. Dawson

“…Forty-three participants performed the GSET again after 3–5 weeks and moderate-to-high test-retest reliability was observed. Minimal site effects confirmed operational feasibility of the task in multi-site studies. …”
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Prolonged In Vivo Chemogenetic Generation of Hydrogen Peroxide by Endothelial Cells Induces Cardiac Remodelling and Vascular Dysfunction by Melina Lopez, Niklas Herrle, Bardia Amirmiran, Pedro F. Malacarne, Julia Werkhäuser, Souradeep Chatterjee, Carine Kader, Victoria Jurisch, Xin Wen, Maedeh Gheisari, Katrin Schäfer, Christian Münch, Florian Leuschner, Ralf Gilsbach, Flávia Rezende, Ralf P. Brandes

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Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation by Yanjun Zheng, Jingrong Lin, Guoqing Wan, Xuefeng Gu, Jian Ma

“…Moreover, LPS induced mitophagy, an effect that was further enhanced by Notch1 knockout. …”
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Low-intensive Laser Therapy for Management of Cerebral Dysfunction in Patients with Obstructive Jaundice of Non-tumor Origin by A. P. Vlasov, I. A. Chigakova, D. E. Timoshkin, M. A. Spirina, V. S. Kuznetsov, N. S. Sheyranov, A. V. Rubtsov

“…On check dates (day 1 and 7), the severity of cerebral dysfunction was assessed in all patients using the psychometric tests (“Point in Circle, “Labyrinth”). …”
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The severity of SLC1A2-associated neurodevelopmental disorders correlates with transporter dysfunctionResearch in context by Peter Kovermann, Allan Bayat, Christina D. Fenger, Lisette Leeuwen, Artem Borovikov, Artem Sharkov, Virginie Levrat, Gaetan Lesca, Laurence Perrin, Jonathan Levy, Christoph Fahlke, Rikke S. Møller, Anders A. Jensen

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Metabolic dysfunction-associated fatty liver disease and risk of nephrolithiasis: a sizeable cross-sectional study by Shengqi Zheng, Tianchi Hua, Guicao Yin, Wei Zhang, Xiaoxiang Wang, Lezhong Qi, Xiayong Jing, Qibing Fan, Xiaoping Yu, Yifan Li

“…ObjectiveMetabolic dysfunction-associated fatty liver disease (MAFLD) and nephrolithiasis are two common metabolic diseases, but their relationship has not yet been thoroughly studied. …”
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Prevalence of renal dysfunction and its influence on functional capacity in elderly patients with stable chronic heart failure by Stanojević Dragana, Apostolović Svetlana, Janković-Tomašević Ružica, Šalinger-Martinović Sonja, Pavlović Milan, Živković Milan, Božinović Nenad, Kutlešić-Kurtović Dušanka

“…In spite of a large number of pharmacological agents that successfully decrease mortality in CHF, the effects on exercise tolerance and quality of life are modest. …”
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Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis by Jie Zhang, Shuangshuang Wang, Ting Zhang, Minghui Zi, Shuxiang Wang, Qiao Zhang

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease, with other fat-liver diseases potentially progressing to cirrhosis and hepatocellular carcinoma. …”
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Correction of renal dysfunction under the influence of dietary management, exercises and lisinopril in patients with abdominal obesity and hypertension. by M. K. Rokutova

“…The purpose of research is to assess the impact of diet therapy, physical activity and an ACE inhibitor (lisinopril) on renal dysfunction in patients with abdominal obesity and hypertension. …”
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Interaction between post-tumor inflammation and vascular smooth muscle cell dysfunction in sepsis-induced cardiomyopathy by Rui Liu, Lina Jia, Lin Yu, Detian Lai, Qingzhu Li, Bingyu Zhang, Enwei Guo, Kailiang Xu, Qiancheng Luo

“…While its clinical relevance is well-documented, the intricate molecular mechanisms that link sepsis, tumor-driven inflammation, and cardiac dysfunction remain inadequately explored. This study aims to elucidate the interaction between post-tumor inflammation, intratumor heterogeneity, and the dysfunction of VSMC in SIC, as well as to evaluate the therapeutic potential of exercise training and specific pharmacological interventions.MethodsTranscriptomic data from NCBI and GEO databases were analyzed to identify differentially expressed genes (DEGs) associated with SIC. …”
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Correction of renal dysfunction under the influence of dietary management, exercises and lisinopril in patients with abdominal obesity and hypertension by Rokutova М.К.

“…The purpose of research is to assess the impact of diet therapy, physical activity and an ACE inhibitor (lisinopril) on renal dysfunction in patients with abdominal obesity and hypertension. …”
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Using a magnetic posture corrector in therapy of somatoform autonomic dysfunction in patients with chronic spinal diseases by R. M. Gafurova, E. R. Makhmudova, R. G. Khabchabov, A. A. Abdullaev, U. A. Islamova, A. A. Anatova, M. A. Dzhanbulatov

“…Somatoform autonomic dysfunction (SAD) can aggravate an existing disease or be combined with other mental disorders (e.g., depression, anxiety, and hypochondria). …”
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Rapid Replenishment of Phylloquinone in the Plasma and Liver Using Hyaluronan-Based Nanocapsules Reverses Endothelial Dysfunction in Mice by Kieronska-Rudek A, Kij A, Bar A, Sternak M, Paterek A, Rolski F, Czyzynska-Cichon I, Fedak FA, Wojnar-Lason K, Bednorz J, Janik-Hazuka M, Kostogrys RB, Franczyk-Zarow M, Czyżowska KZ, Michalkova L, Mączewski M, Zapotoczny S, Kus E, Chlopicki S

“…Importantly, 7-day PK-Oil-HyC12 supplementation restored impaired endothelium-dependent vasodilation in the aorta of PK-deficient mice, while PK-Oil was ineffective.Conclusion: The improved bioavailability of PK, when administered in the form of hyaluronan-based nanocapsules, afforded the rapid replenishment of systemic PK and the reversal of endothelial dysfunction induced by low PK levels. Keywords: Vitamin K1, phylloquinone, hyaluronan-based nanocapsules, endothelial dysfunction, dietary phylloquinone deficiency…”
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Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes by Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey, Ashraf Y. Rangrez

“…Abstract Background Cardiac ischemia, a predominant cause of heart failure, is marked by profound mitochondrial dysfunction, dysregulated ion homeostasis, and maladaptive cellular remodeling, all of which compromise cardiac performance. …”
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