Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes. by Fabiana Ariemma, Vittoria D'Esposito, Domenico Liguoro, Francesco Oriente, Serena Cabaro, Antonietta Liotti, Ilaria Cimmino, Michele Longo, Francesco Beguinot, Pietro Formisano, Rossella Valentino

“…Therefore, 3T3-L1 pre-adipocytes were cultured for three weeks with BPA 1 nM to mimic human environmental exposure. We evaluated BPA effect on cell proliferation, differentiation, gene expression and adipocyte metabolic function. …”
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Associations between sleep duration trajectories and physical dysfunction among middle-aged and older Chinese adults by Xiaojiang Zhao, Laiguo Han, Hong Ding, Changqing Li

“…Abstract Background The relationship between a single time-point measurement of sleep duration and physical dysfunction has been extensively investigated. However, few researches has concentrated on the effects of sleep duration trajectories. …”
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Microglial clock dysfunction during neuroinflammation impairs oligodendrocyte progenitor cell recruitment and disrupts neuroimmune homeostasis by Qingqing Lu, Qingqing Lu, Jin Young Kim, Jin Young Kim

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Subclinical Myocardial Dysfunction in Pediatric and Adolescent Celiac Disease Patients: A Systematic Review and Meta-Analysis by Elpida Emmanouilidou-Fotoulaki, Maria Kavga, Michail Delis, Evangelia Farmaki, Charalampos Agakidis, Kyriaki Papadopoulou-Legbelou

“…<b>Background/Objectives:</b> This is the first systematic review and meta-analysis investigating early myocardial dysfunction in children/adolescents with celiac disease and the effect of a gluten-free diet by comparing early echocardiographic markers between patients and healthy individuals and between compliant and non-compliant celiac disease patients (based on serum antibody titers). …”
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The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction by Nana Chen, Yushan Yang, Limin Fan, Yanni Cai, Weimin Yin, Zichen Yang, Yuge Zhao, Shiyu Chen, Hui Zhi, Liangyi Xue, Xiaoyou Zhang, Lulu An, Yongyong Li, Tianbin Ren

“…Abstract Manganese-based STING-activating tumor immunotherapy faces limitations due to T cell exhaustion. Mitochondrial dysfunction is a key factor contributing to T cell exhaustion. …”
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Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic by Agnieszka Żak‐Bochenek, Zuzana Drábková, Vaiva Sergedaite, Natalia Siwińska, Joanna Bajzert, Dominika Pasak, Anna Chełmońska‐Soyta

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HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction by Mei-Ling Le, Yi-Qi Wan, Jia-Yu Xue, Shi-Yi Deng, Bin-Hui Wang, Li-Hai Wu, Hou-Peng Wang, Yang-Yang Yuan, Xiao-Dong Kuang, Tao Luo, Da-Lei Zhang

“…In our study, the mouse model was used to investigate the toxic effects of HFPOs on male reproductive function and their underlying mechanisms. …”
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An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome by Pratibha Thakur, Martin Lackinger, Anastasia Diamantopoulou, Sneha Rao, Yijing Chen, Khakima Khalizova, Annie Ferng, Curt Mazur, Holly Kordasiewicz, Robert J Shprintzen, Sander Markx, Bin Xu, Joseph A Gogos

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Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia by M. V. Sokolova, Ye. Ye. Starostina, T. N. Krasnova, L. M. Samokhodskaya, T. P. Rozina, V. G. Avdeyev, M. G. Artemova, Ye. B. Yarovaya, N. A. Mukhin

“…Aim of investigation. To estimate the effect of carriage of endothelial dysfunction and hemostasis gene allelic variants on development of cryoglobulinemic vasculitis (CryoVas) and its clinical symptoms in patients with chronic hepatitis C (CHC). …”
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Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques by Jennifer Tisoncik-Go, Jennifer Tisoncik-Go, Jennifer Tisoncik-Go, Thomas B. Lewis, Thomas B. Lewis, Leanne S. Whitmore, Kathleen Voss, Skyler Niemeyer, Jin Dai, Paul Kim, Kai Hubbell, Naoto Iwayama, Chul Ahrens, Solomon Wangari, Robert Murnane, Paul T. Edlefsen, Kathryn A. Guerriero, Michael Gale, Michael Gale, Michael Gale, Michael Gale, Deborah H. Fuller, Deborah H. Fuller, Megan A. O’Connor, Megan A. O’Connor

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Endothelial dysfunction in heart failure with normal systolic function, and its correction with a metabolic agent, mildronate by V. P. Geychenko, A. V. Kuryata, O. V. Muzhchil

“…Basic CHF therapy resulted in disbalanced NO system activation, endothelial hyperstimulation and dysfunction. Adding mildronate to basic therapy resulted in NO system normalization, and endothelial vasoregulatingfunction improvement, that increased treatment effectiveness…”
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Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis by Yihui Lan, Shiquan Wang, Yuan Chu, Yizhi Zhang, Yuan Liu, Fan Yu, Lei Feng, Yifei Zhu

“…Specifically, the deficiency of endothelial TRPC1 exacerbates metabolic dysfunction associated with obesity, whereas its overexpression exerts significant protective effects. …”
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Relationship Between Atrial Dysfunction and Atrial Arrhythmias in Adults With Fontan Palliation: Role of Atrial Strain Imaging by Sara ElZalabany, Amr Moustafa, Ali Ali, Ahmed T. Abdelhalim, Ahmed E. Ali, Malini Madhavan, Abhishek Deshmukh, Alexander C. Egbe

“…Background Atrial dysfunction is a risk factor for atrial arrhythmia and can be detected by atrial strain imaging in patients with biventricular circulation. …”
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Globimetula braunii prevents hyperglycemia, oxidative damage, and hepatorenal dysfunction in dexamethasone-induced insulin-resistant rats by David Miaffo, Kilenma Kolefer, Elizé Dadaya, Barthelemy Maidadi, Abba Talba Mahamad, Albert Kamanyi

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Arterial hypertension as a consequence of endothelial glycocalyx dysfunction: a modern view of the problem of cardiovascular diseases by M. M. Ziganshina, A. R. Ziganshin, E. O. Khalturina, I. I. Baranov

“…The data obtained in the last 10-15 years on endothelial glycocalyx (eGC) studies indicate that endothelial dysfunction is preceded by destabilization and shedding of eGC with the appearance of its soluble components in the blood, which is equivalent to a process that can be designated as eGC dysfunction. …”
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Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep. by Kirsten R Poore, Lisa J Hollis, Robert J S Murray, Anna Warlow, Andrew Brewin, Laurence Fulford, Jane K Cleal, Karen A Lillycrop, Graham C Burdge, Mark A Hanson, Lucy R Green

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Assessing Major Organ Dysfunction in Children With Sickle Cell Disease: Protocol for a Cross‐Sectional Study by Vivian Paintsil, Sandra Kwarteng Owusu, Samuel Blay Nguah, Serwah Bonsu Asafo‐Agyei, Augustina Badu‐Peprah, Lawrence Osei‐Tutu, Christiana Adu‐Takyi, Tony Boakye, Bernice Eklu, Eugenia Osei, Ruth Owusu‐Antwi, George Asafu‐Adjaye Frimpong, Evans Xorse Amuzu, Daniel Ansong

“…With increasing life expectancy, assessment of the effect of progressive organ damage on quality of life becomes essential. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study by Ludovico Abenavoli, Rocco Spagnuolo, Giuseppe Guido Maria Scarlata, Maria Luisa Gambardella, Luigi Boccuto, Nahum Méndez-Sánchez, Francesco Luzza

“…Background: Inflammatory bowel disease (IBD) is characterized by persistent inflammation and is often associated with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Associations of functional and biochemical parameters of endothelial dysfunction in postmenopausal women with a different state of carbohydrate metabolism by Lyudmila Aleksandrovna Ruyatkina, Irina Sergeevna Iskhakova, Konstantin Yuryevich Nikolaev, Dmitriy Sergeevich Ruyatkin

“…We revealed the associations of metabolic, anthropometric, and hemodynamic factors as well as biochemical markers of endothelial dysfunction with microcirculation parameters in various modes of endothelial activity (basal, occlusion, and reperfusion) in postmenopausal women according to their carbohydrate metabolism status; we also describe the effect of age on microvasculature vasomotion.…”
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Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study by Jiali Chen, Jianghao Xiong, Fenfen Zhang, Wanyu Pan, Shaomin Cheng

“…Furthermore, most supplementary MR methods also demonstrated statistically significant differences and exhibited effect sizes consistent with those obtained from IVW. …”
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