Endo-lysosomal dysfunction in human proximal tubular epithelial cells deficient for lysosomal cystine transporter cystinosin. by Ekaterina A Ivanova, Maria Giovanna De Leo, Lambertus Van Den Heuvel, Anna Pastore, Henry Dijkman, Maria Antonietta De Matteis, Elena N Levtchenko

“…Treatment with cysteamine improved surface expression and lysosomal cargo processing but did not lead to a complete restoration and had no effect on the abnormal morphology of endo-lysosomal compartments. …”
Get full text

Upfront Low-Dose Cytarabine with Prednisolone for Langerhans Cell Histiocytosis with Liver Dysfunction: A Ray of Hope by Niranjan Gurunath Hegde, Meena S. Sivasankaran, Vimal Kumar G., Deenadayalan Munirathnam

“…In conclusion, a modified, less toxic low-dose cytarabine-based chemotherapy effectively managed LCH with liver dysfunction, with liver transplantation as a postremission treatment option.…”
Get full text

Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival by Wenjia Yuan, Hedong Zhang, Longkai Peng, Chao Chen, Chen Feng, Zhouqi Tang, Pengcheng Cui, Yaguang Li, Tengfang Li, Xia Qiu, Yan Cui, Yinqi Zeng, Jiadi Luo, Xubiao Xie, Yong Guo, Xin Jiang, Helong Dai, Sihan Zhou, Xiuyuan Hao

“…In vitro, blockade of IRF4 in T cells effectively inhibited T cell proliferation, increased apoptosis, and significantly upregulated the expression of programmed cell death protein 1 (PD-1), Helios, CD160, and cytotoxic T lymphocyte-associated antigen (CTLA-4), markers of T cell dysfunction. …”
Get full text

Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. by Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, Koichi Iijima

“…Importantly, perturbations in mitochondrial transport in neurons were sufficient to disrupt PKA signaling and induce late-onset behavioral deficits, suggesting a mechanism whereby mitochondrial mislocalization contributes to Abeta42-induced neuronal dysfunction. These results demonstrate that mislocalization of mitochondria underlies the pathogenic effects of Abeta42 in vivo.…”
Get full text

Metabolic Dysfunction-Associated Steatotic Liver Disease: From a Very Low-Density Lipoprotein Perspective by Yan Chen, Kaiwen Lei, Yanglong Liu, Jianshen Liu, Kunhua Wei, Jiao Guo, Zhengquan Su

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive accumulation of triglycerides and other lipids within liver cells and is closely associated with cardiovascular disease and metabolic syndrome. …”
Get full text

Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice by Yuncong Xu, Yuhui Yang, Yonghui Shi, Bowen Li, Yanli Xie, Guowei Le

“…Abstract To explore the effects of methionine (Met) supplementation on cognitive dysfunction and the associated mechanisms in aging mice. …”
Get full text

Fatigue and cognitive dysfunction in previously hospitalized patients with COVID-19: A 1-year follow-up. by Ingrid Andreasson, Hanna C Persson, Ann Björkdahl

Get full text

Breathing therapy for patients with medically unexplained physical symptoms and dysfunctional breathing: A pilot and feasibility trial. by Hege Svenningsen, Trine Stub, Rosalba Courtney, Tor-Ivar Karlsen

“…Fifteen participants with MUPS and dysfunctional breathing (assessed by the Nijmegen Questionnaire) were recruited from two general practitioner offices. …”
Get full text

MANAGEMENT OF ERECTILE DYSFUNCTION IN CARDIOVASCULAR PATIENTS WITH COMORBIDITIES: REVIEW OF THE TRIALS ON CONTINUING THERAPY WITH PHOSPHODIESTERASE-5 MEDICATIONS by G. G. Sharvadze, R. R. Dalari, B. U. Mardanov, M. N. Mamedov

“…The review is focused on the issues of erectile dysfunction (ED) management by long term courses of continuous intake of the phosphodiesteraze-5 type (PDE5) inhibitors. …”
Get full text

C-phycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells. by Shukkur M Farooq, Nithin B Boppana, Asokan Devarajan, Shamala D Sekaran, Esaki M Shankar, Chunying Li, Kaliappan Gopal, Sazaly A Bakar, Harve S Karthik, Abdul S Ebrahim

“…DCFDA, a fluorescence-based probe and hexanoyl-lysine adduct (HEL), an oxidative stress marker were used to investigate the effect of CP on oxalate-induced ROS production and membrane lipid peroxidation (LPO). …”
Get full text

Parkinson’s disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction by Xinxin Ma, Yueying Liu, Miaoxian Xie, Chunmei Li, Xinyang Li, Dandan Shang, Min Chen, Haibo Chen, Wen Su

“…In conclusion, PD with possible RBD correlated with more severe glymphatic system dysfunction and non-motor symptoms than those in PD without RBD.…”
Get full text

Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction by Shuwen Qian, Zehua Su, Jiaqi Lin, Qianhao Hou, Xiaomei Wang, Yuling Li, Jieying Wang, Changchun Huang, Zetian Wang, Francisco Javier Cubero, Xiangrui Wang, Lijun Liao

“…Abstract Background and aims Bacterial translocation and intestinal dysbiosis due to gut barrier dysfunction are widely recognized as major causes of the initiation and development of intra-abdominal sepsis. …”
Get full text

Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction by Hua Tong, Xudong Guo, Lili Chen, Honglei Wang, Xuerui Hu, Aijuan He, Chenlong Li, Tianyu Zhang, Jiuhong Kang, Yaoyao Fu

“…Objective: To explore the characteristics of cellular senescence in human auricular chondrocytes during long-term in vitro culture and to evaluate the effects of anti-senescence treatments on enhancing their chondrogenic function. …”
Get full text

Overcoming β-Cell Dysfunction in Type 2 Diabetes Mellitus: CD36 Inhibition and Antioxidant System by Il Rae Park, Yong Geun Chung, Kyu Chang Won

Get full text

Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients: Alteration of the PPARγ-Dependent Pathways by Martine Caron, Corinne Vigouroux, Jean-Philippe Bastard, Jacqueline Capeau

“…Adipose cell function was partially restored by the PPARγ agonists, thiazolidinediones. Adverse effects of PIs and NRTIs have also been reported in macrophages, a cell type that coexists with, and modulates, adipocyte function in fat tissue. …”
Get full text

Global prevalence of female sexual dysfunction based on physical activity: a systematic review and meta-analysis by Nader Salari, Razie Hasheminezhad, Amin Hosseinian-Far, Masoud Mohammadi

“…The aim of this study is to investigate the global prevalence of female sexual dysfunction based on physical activity through a systematic review and meta-analysis. …”
Get full text

Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress by Sarah Viana-Mattioli, Miriam Helena Fonseca-Alaniz, Iguaracy Pinheiro-de-Sousa, Ricardo Rosa Junior, Moises Henrique Mastella, Ricardo de Carvalho Cavalli, Valeria Cristina Sandrim

“…Both PE and GH can induce endothelial dysfunction under atheroprotective LSS, with a more significant effect observed with PE-derived plasma.…”
Get full text

Microplastics induce insulin resistance by causing mitochondrial dysfunction associated with mROS in skeletal muscle in vitro by Yuzhen Tang, Yaxin Suo, Zewen Sun, Xiafang Wu, Qingyang Xing, Yinglong Bai

“…However, studies on the effects of microplastics on glucose metabolism and insulin sensitivity in human skeletal muscle are limited. …”
Get full text

Tangeretin Unravels Metabolic Dysfunction-Associated Fatty Liver Disease in Rats by Enhancing the IRS/Akt Pathway by Ittipon Yuenyong, Prapassorn Potue, Putcharawipa Maneesai, Juthamas Khamseekaew, Apiwan Manimmanakorn, Metee Iampanichakul, Poungrat Pakdeechote

“…Excessive high-fat diet (HFD) intake can precipitate metabolic dysfunction-associated fatty liver disease (MAFLD). …”
Get full text

Efficacy of fish oil supplementation on metabolic dysfunction-associated steatotic liver disease: a meta-analysis by Like Zhou, Dongmei Sun, Houqiao Bai

“…ObjectiveGlobally, the occurrence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is on a steady rise. …”
Get full text