Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction by Aishwarya Raj, Roon Banerjee, Vikram Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Indrani Datta

“…Additionally, we explored the effect of astrocytic secretome on dopaminergic-neuronal survival, neurite collapse and function. …”
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Comparative prospective study of biofeedback therapy and neuromuscular electrical stimulation in rehabilitation of patients with pelvic floor dysfunctions by V. A. Krutova, A. V. Nadtochy

“…Aim. To evaluate the effectiveness of the combined effects of biological feedback (BFB therapy) and electroimpulse stimulation (EIS) in rehabilitation of patients with pelvic floor dysfunctions. …”
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ENDOCRINE ASPECTS OF AMIODARONE THERAPY IN CLINICAL PRACTICE (FOLLOW-UP AND TREATMENT ALGORITHM FOR PATIENTS WITH THYROID DYSFUNCTION) by N. Yu. Sviridenko, N. M. Platonova, N. V. Molashenko, S. P. Golitsyn, S. A. Bakalov, S. E. Serdyuk

“…This review discusses the effects of amiodarone on thyroid function and summarises the results of international studies and the evidence obtained by the researchers from the A.L. …”
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A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease by Michelle Thuy Nguyen, Andrew Lian, Frederick Timothy Guilford, Vishwanath Venketaraman

“…Non-alcoholic fatty liver disease (NAFLD) is a global cause of liver dysfunction. This spectrum of hepatic disorders can progress to severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis, due to oxidative stress and sustained cellular injury. …”
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Iron overload and oxidative stress participated in zinc oxide nanoparticles-induced blood-brain barrier dysfunction by Eun-Hye Kim, Seung Mi Baek, Donghyun Kim, Sungbin Choi, Wondong Kim, Yiying Bian, Soroush Tahmasebi, Ok-Nam Bae

“…Increased oxidative stress led to lysosomal dysfunction and cytotoxicity in bEnd cells treated with ZnO-NPs.3 cells. …”
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Multi-omics reveal the neuroprotective mechanisms of Xinshubao tablet against scopolamine-induced cognitive dysfunction in mice by Zhe Yang, Zhe Yang, Feng-Rong Zhang, Lu Ren, Jia-Ming Bai, Shi-Cong Wang, Xian-Yu Li, Hong-Jun Yang, Hong-He Xiao

“…Transformation of XSB derived fecal microbiota (XSB-FM) effectively alleviated cognitive dysfunction and intestinal barrier injures. …”
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Biological ageing mediates the associations between urinary metals and metabolic dysfunction-associated steatotic liver disease by Yin-Ping Wu, Jin Feng, Yuan-Yuan Zhang, Bai-Yun Wu, Ze-Hua Zhao, Yu-Chen Fan

“…Metabolic dysfunction-associated steatotic liver disease (MASLD), which is associated with exposure to heavy metals in the environment, poses a considerable public health challenge globally. …”
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Thyroid dysfunction as a long-term post-COVID-19 complication in mild-to-moderate COVID-19 by Vesselina Yanachkova, Teodora Stankova, Radiana Staynova

“…The aim of the present study was to assess the post-COVID-19 effects on thyroid function in patients without history of thyroid disease after complete recovery from mild-to-moderate COVID-19. …”
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Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy by Jie‐hong Wu, Ya‐nan Li, An‐qi Chen, Can‐dong Hong, Chun‐lin Zhang, Hai‐ling Wang, Yi‐fan Zhou, Peng‐Cheng Li, Yong Wang, Ling Mao, Yuan‐peng Xia, Quan‐wei He, Hui‐juan Jin, Zhen‐yu Yue, Bo Hu

“…Moreover, anti‐Sema4D had a therapeutic advantage over anti‐VEGF on pericyte dysfunction. Anti‐Sema4D and anti‐VEGF also conferred a synergistic therapeutic effect in two DR models. …”
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Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations by Manaf Al Hashimi, Germar-M Pinggera, Taymour Mostafa, Amarnath Rambhatla, Taha Hamoda, Rupin Shah, Eric Chung, Ahmed Harraz, Mohamed Arafa, Tuncay Toprak, Omer Raheem, Carlo Giulioni, Ponco Birowo, Luca Boeri, Yassir Jassim, Priyank Kothari, Ranjit Vishwakarma, Bahadir Sahin, Widi Atmoko, Safar Gamidov, Cesar Rojas-Cruz, Darren Katz, Adriano Fregonesi, Nazim Gherabi, Armand Zini, Christopher Chee Kong Ho, Mohamed S. Al-Marhoon, Marlon Martinez, Giorgio Ivan Russo, Ayman Rashed, Gian Maria Busetto, Edmund Ko, Hyun Jun Park, Selahittin Cayan, Ramadan Saleh, Osvaldo Rajmil, Dong Suk Kim, Giovanni Colpi, Ryan Smith, Maged Ragab, Ates Kadioglu, Quang Nguyen, Kadir Bocu, Ahmed El-Sakka, Charalampos Thomas, Hussain M Alnajjar, Hiva Alipour, Ashok Agarwal

“…The primary indication for RT was the refractory or adverse effects of PDE5 inhibitors, with the best effectiveness reported in middle-aged and mild-to-moderate ED patients. …”

O-prenylchalcones inhibit cell proliferation and activate apoptosis by inducing mitochondrial dysfunction in gastric cancer cells by José C. Espinoza-Hicks, Yarely M. Salinas-Vera, Javier Camarillo-Cisneros, Alejandro A. Camacho-Dávila, Jessica L. Hernández-Rivera, Nadia Flores-Huerta, Eloisa Ibarra-Sierra, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Ángeles C. Tecalco-Cruz, César López-Camarillo

“…Chalcones are favoured molecules from the perspective of chemical medicine, as they exhibit efficient antitumour effects in various human diseases. In the present study, we investigated the anticancer effects of 11 novel synthetic O-prenylchalcones on AGS gastric cancer cells. …”
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Sexual dysfunction among people with mental illness in Africa: A systematic review and meta-analysis study. by Setegn Fentahun, Mamaru Melkam, Gebresilassie Tadesse, Gidey Rtbey, Fantahun Andualem, Yilkal Abebaw Wassie, Gebremariam Wulie Geremew, Tekletsadik Tekleslassie Alemayehu, Tewodros Denekew Haile, Tilahun Nega Godana, Berihun Agegn Mengistie, Mulualem Kelebie, Girum Nakie, Techilo Tinsae, Girmaw Medfu Takelle

“…To estimate the overall prevalence and correlated factors of sexual dysfunction, a random effects model meta-analysis was employed.…”
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Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study by Junhao Chen, Junxian Zhao, Zhi Zhang, Xingcheng Zhu, Jieming Zuo, Zuqing Nie, Yuanzhi Fu, Haifeng Wang, Mengjun Tang, Shi Fu

“…A large-scale two-sample MR analysis, including coloc colocalization analysis and SMR (Summary data-based Mendelian Randomization) analysis, was conducted to evaluate the reliability of proteomic effects on ED outcomes. Additionally, MR mediation analysis involving 1,400 blood metabolites was performed to investigate how these proteins mediate the effect of blood metabolites on ED. …”
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GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis by Pengfei Zhang, Haoxin Zhai, Shuai Zhang, Xiaojie Ma, Ao Gong, Zhaoning Xu, Wei Zhao, Hui Song, Shufeng Li, Tengfei Zheng, Zhendong Ying, Lei Cheng, Yunpeng Zhao, Lei Zhang

“…Furthermore, loss of GDF11 led to NLRP3 inflammasome activation, inflammation, and metabolic dysfunction. In an in vivo surgically induced mouse model, intraarticular administration of recombinant human GDF11 alleviated OA pathogenesis, whereas GDF11 conditional knockout reversed this effect. …”
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Algorithm for Analyzing Computer Images in Radiation Diagnostics of Changes in the Cervical-Cranial Region in Dysfunction of the Temporomandibular Joints by I. U. Samuilau, I. N. Baradina, Yu. F. Vasilyeva, V. Ch. Neden

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The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Anthony O. Boateng, Vinood B. Patel, S. W. Annie Bligh

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease characterised by the accumulation of fat in the liver. …”
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Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats by Liu Xianbao, Zhan Hong, Zeng Xu, Zhang Chunfang, Chen Dunjin

“…In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. …”
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Dose determination of VV116 in COVID-19 patients with severe liver dysfunction: a case report by Jing Yang, Wenwen Jiang, Jianqing Deng, Min Liu, Ya Xue, Jizhang Bao, Tingting Jia, Qi Hu, Lichao Zhang

“…Finally, the patient’s viral load rapidly dropped to an undetected level, and no drug-related adverse effects were observed.…”
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Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice by Lingyan Fei, Honghong Wang, Dongliang Zhao, Xiaohua Wang, Jizhen Ren, Lanyun Liu, Chun Tang, Yan Lei, Qingqing Wang, Yuanpeng Nie, Yang Liu, Na Li, Ming Zhong, Nan Xu, Jin Wei, Pontus B. Persson, Andraes Patzak, Pratik H. Khedkar, Zhihua Zheng, Shan Jiang

“…Furthermore, treatment with Tac led to vascular dysfunction in pancreatic arteries. All of these adverse effects could be partially or fully abrogated by valsartan. …”
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SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation by Wen Zhong, Ruoxue Chen, Jialin Zhao, Yuyu Zhang, Jintao He, Huibin Wang, Feng Zhu, Chunxiang Fan, Xinhua Liu

“…However, its function in the context of diabetic endothelial dysfunction remains poorly understood. This study aims to elucidate the involvement and underlying mechanisms of SETD7 in diabetic endothelial dysfunction. …”
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