Regional insights into the relationship between metabolic associated steatotic liver disease and chronic kidney disease: a socioeconomic perspective on disease correlation by Jiang Bai, Lijuan Zhang, Mingyan Zhang, Yifan Hao, Zhen Yi, Yun Zhou

Subjects: “…Metabolic Dysfunction-Associated Steatotic Liver Disease…”
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Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. by Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi

“…This "genomic storm" can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a high mortality and morbidity rate and adversely affects long-term health outcomes. …”
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Role of renin-angiotensin-aldosterone system gene polymorphisms in the development of diastolic dysfunction in female patients with hypertension by Mariya A. Grenaderova, Nadezhda V. Izmozherova, Elena V. Kudryavtseva, Muraz A. Shambatov, Danila L. Zornikov, Artem A. Popov, Anna A Vikhareva, Daniil O. Kornilov, Mikhail A. Tryapitsyn, Veronika M. Simarzina, Aleksey A. Bekhter

“…Renin-angiotensin-aldosterone system-related gene polymorphisms were evaluated in patients with and without diastolic dysfunction, as assessed by transthoracic echocardiography. …”
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Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model by Hui Bang Cho, Hye‐Ryoung Kim, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Hye Jin Kim, Keun‐Hong Park

“…These findings suggest that NIR‐mediated NADH delivery is an effective strategy for improving mitochondrial function, and has the potential to lead to novel treatments for mitochondrial disorders and muscle degeneration.…”
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Withaferin A Rescues Brain Network Dysfunction and Cognitive Deficits in a Mouse Model of Alzheimer’s Disease by Linhan Yang, Yang Zou, Jihua Fan, Pu Yin, Han Qin, Zhen Li, Fengjuan Wu, Xingyi Li, Huaijin Teng, Yun Zhang, Xiaowei Chen, Sunny C. Li

“…<b>Background:</b> Alzheimer’s disease (AD) is the most common dementia, characterized by significant cognitive impairments and neural network dysfunction. Currently, multiple therapeutic strategies are being developed to design effective anti-AD drugs. …”
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Metabolomic Insights into Smoking-Induced Metabolic Dysfunctions: A Comprehensive Analysis of Lipid and Amino Acid Metabolomes by Muhammad Amtiaz Aslam, Hajra Iqbal, Kainat Ilyas, Kanwal Rehman, Amjad Hussain, Muhammad Sajid Hamid Akash, Mudassar Shahid, Shuqing Chen

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KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer’s disease by Bolivar Arcos-Encarnación, Eladio Cortes-Flores, Isabel Barón-Mendoza, Jorge Luis Almazán, David Valle-García, Sol Díaz de León-Guerrero, Ladislav Hovan, Karla F. Meza-Sosa, Nohemi Camacho-Concha, Jeovanis Gil, Marieke Lydia Kuijjer, Aliesha González-Arenas, Sergio Encarnación-Guevara, Gustavo Pedraza-Alva, Leonor Pérez-Martínez

“…Despite extensive research, effective treatments remain elusive. Here, we identify potassium channel-interacting protein 3 (KChIP3) as a key driver of AD pathology using the 5XFAD mouse model. …”
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Prevalence of thyroid dysfunction among pregnant women in the horn of Africa: A systematic review and Meta-analysis by Marye Nigatie, Getinet Kumie, Abdu Jemal, Solomon Gedfie, Woldeteklehaymanot Kassahun, Muluken Gashaw, Agenagnew Ashagre, Tadesse Misganaw, Wagaw Abebe, Ermias Getachew, Selamyhun Tadesse, Zelalem Dejazmach, Sisay Ayana, Yalewayker Gashaw, Zelalem Asmare, Assefa Sisay, Atitegeb Abera, Biruk Beletew Abate, Melese Abate Reta

“…Background: Thyroid dysfunction ranks among the most prevalent endocrine disorders. …”
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Prediction of Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease by Type IV Collagen 7S by Hiroshi Ishiba, Yoshio Sumida, Yoshihiro Kamada, Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Atsushi Nakajima, Takeshi Okanoue

“…However, whether COL4-7S can detect advanced fibrosis (AF) and predict the prognosis of metabolic dysfunction–associated steatotic liver disease (MASLD) is unclear. …”
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Impact of TNF inhibitors on inflammation-associated cognitive dysfunction in patients with rheumatoid arthritis: a prospective analysis by Natalia Mena-Vázquez, Natalia Mena-Vázquez, Fernando Ortiz-Márquez, Fernando Ortiz-Márquez, Fernando Ortiz-Márquez, Teresa Ramirez-García, Teresa Ramirez-García, Celia Gillis-Onieva, Pablo Cabezudo-García, Pablo Cabezudo-García, Aimara García-Studer, Aimara García-Studer, Aimara García-Studer, Arkaitz Mucientes, Arkaitz Mucientes, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Paula Borregón-Garrido, Paula Borregón-Garrido, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Laura Cano-García, Laura Cano-García, Pedro Jesús Serrano-Castro, Pedro Jesús Serrano-Castro, Pedro Jesús Serrano-Castro, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

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TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages by Guowei Xu, Haiyang Chen, Zheng Cong, Ling Zhou, Ning Zhao, Yuqing Yang, Ting Li, Xuping Liu, Yi Wang, Bing Li

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Preoperative cognitive training for the prevention of postoperative delirium and cognitive dysfunction: a systematic review and meta-analysis by Ka To Lau, Lok Ching Sandra Chiu, Janet Shuk Yan Fong, Albert Kam Ming Chan, Kwok Ming Ho, Anna Lee

“…Abstract Background Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are associated with major morbidity and mortality after surgery. …”
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Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice. by Giada Lavigna, Anna Grasso, Chiara Pasini, Valentina Grande, Laura Mignogna, Elena Restelli, Antonio Masone, Claudia Fracasso, Jacopo Lucchetti, Marco Gobbi, Roberto Chiesa

“…Pharmacokinetic studies excluded that the lack of effect was due to altered drug metabolism in woozy mice. …”
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The RAGE Inhibitor TTP488 (Azeliragon) Improves Diabetic Bladder Dysfunction in Leptin-Deficient Obese Mice by Akila Lara Oliveira, Matheus Leite Medeiros, Antonio Thiago Pereira Campos, Carlos Lenz Cesar, Fabiola Zakia Mónica, Edson Antunes

“…The advanced glycation end product (AGE)–RAGE axis has been implicated in the pathophysiology of diabetic bladder dysfunction (DBD). However, no previous studies have explored the effects of RAGE blockade on this condition. …”
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Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy by Adam C. Vandergriff, James Bizetto Meira de Andrade, Junnan Tang, M. Taylor Hensley, Jorge A. Piedrahita, Thomas G. Caranasos, Ke Cheng

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Cuscutae Semen in depression-induced ovarian dysfunction: metabolomics with UPLC-QToF-MS in female mice by Ying Xie, Zhaoxiang Zeng, Jinrong Zhang, Qiangqiang Han, Chengwu Song, Chengwu Song, Shuna Jin, Shuna Jin, Min Zhao, Min Zhao

“…Although Cuscutae Semen (CS) is acknowledged for treating reproductive disorders, its pharmacological mechanisms in depression-induced ovarian dysfunction remain insufficiently explored. This study investigated CS’s effects in a chronic unpredictable mild stress (CUMS) mouse model of depression. …”
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Thiacloprid exposure disrupts the gut-liver axis and induces liver dysfunction in the Reeves' turtles (Mauremys reevesii) by Shuqin Lin, Yunjuan Xiao, Siyu Li, Liyan Tang, Haitao Shi, Meiling Hong, Li Ding

“…Our findings demonstrate that THI impairs the intestinal barrier and causes liver dysfunction and damage in turtles, providing new insights into evaluating the toxic effects of thiacloprid on aquatic organisms.…”
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TNF-Like Weak Inducer of Apoptosis Aggravates Left Ventricular Dysfunction after Myocardial Infarction in Mice by Kai-Uwe Jarr, Sabine Eschricht, Linda C. Burkly, Michael Preusch, Hugo A. Katus, Norbert Frey, Emmanuel Chorianopoulos

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DNA-PKcs Dysfunction Enhances the Antitumor Activity of Radioimmunotherapy by Activating the cGAS-STING Pathway in HNSCC by Chen L, Lin J, Wen Y, Guo ZQ, Lan B, Xiong J, Chen CB, Chen Y

“…In vitro, Western blot and PCR confirmed the impact of combining immunotherapy with RT on the cGAS-STING pathway after DNA-PKcs dysfunction.Results: The combination of a DNA-PK inhibitor (NU7441), radiation therapy, and a PD-1 checkpoint inhibitor showed improved antitumor effects and extended survival in mice. …”
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Chronic Oral D-Galactose Induces Oxidative Stress but Not Overt Organ Dysfunction in Male Wistar Rats by Jelena Martinovic, Ivana Gusevac Stojanovic, Sladjan Nesic, Ana Todorovic, Katarina Bobic, Sanja Stankovic, Dunja Drakulic

“…Oral intake of d-gal was found to have milder effects compared to i.p. or s.c. injections, suggesting that this model may induce some features of natural aging but without overt organ dysfunction.…”
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