Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1 by M. Smimmo, V. Casale, D. D'Andrea, I. Bello, N. Iaccarino, F. Romano, V. Brancaleone, E. Panza, R. d’Emmanuele di Villa Bianca, A. Katsouda, E. Mitidieri, I. Antoniadou, A. Papapetropoulos, F. Maione, S. Castaldo, M. Friuli, A. Romano, S. Gaetani, R. Sorrentino, A. Randazzo, G. Cirino, M. Bucci, M. Filipovic, V. Vellecco

“…Exogenous H2S exerts beneficial effects recovering SIRT-1 persulfidation/activity. …”
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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension. by Lin Chen, Jiayao Chen, Jindong Wan, Muqing Shao, Caiyu Chen, Shuo Zheng, Fuwei Zhang, Jian Yang

“…Similarly, the phosphorylation of renal Mas receptor was increased and its-induced renal effects were decreased in human (h) GRK4γ 142V transgenic mice relative to wild-type littermates. …”
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Redox Imbalance and Antioxidant Defenses Dysfunction: Key Contributors to Early Aging in Childhood Cancer Survivors by Vanessa Cossu, Nadia Bertola, Chiara Fresia, Federica Sabatini, Silvia Ravera

“…Survival rates for childhood cancer survivors (CCS) have improved, although they display a risk for early frailty due to the long-term effects of chemo/radiotherapy, including early aging. …”
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An assessment of erectile dysfunction among male diabetics attending Temba Community Health Centre, Pretoria by T. Bongongo, J. V. Ndimande, J. Tumbo

“…Introduction: Erectile dysfunction is common among men with diabetic mellitus and has a negative effect on their quality of life. …”
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Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis by Lei Wu, Hengheng Zhang, Yongwen Li, Jinxin Tang, Dengwen wang, Linrong Zhu

“…Observational studies have suggested that insomnia may lead to thyroid dysfunction, which in turn contributes to osteoporosis. …”
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Binding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models by Jie Jiao, Ge Gao, Junge Zhu, Chaodong Wang, Lei Liu, Hui Yang

“…The overexpression of ACO2 and the addition of isocitrate, a downstream metabolite of ACO2, were observed to alleviate hα-syn-induced mitochondrial dysfunction and cytotoxicity. Furthermore, we designed an interfering peptide to block the interaction between ACO2 and hα-syn, which showed therapeutic effects in reducing hα-syn toxicity in vitro and in vivo. …”
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HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis by Lei Zhang, Ying Yu, Peng Yu, Jian Wu, Aijun Sun, Yunzeng Zou, Yangang Su, Hong Jiang, Junbo Ge

“…Fibrosis had important effects on pressure overload-induced left ventricular (LV) dysfunction. …”
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Fecal metabolomics to understand intestinal dysfunction in male dairy beef calves at arrival to the rearing farm by Anna Bassols, Núria Amigó, Marc Pérez-Rodado, Yolanda Saco, Raquel Peña, Raquel Pato, Lucia Pisoni, Maria Devant, Sònia Marti

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A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest by Yingxue Liu, Guanghui Yuan, Yameng Hui, Xiaoxiao Wang, Jiashan Li, Jiao Zhuang, Huaiqian Dou, Linfang Han, Duan Li, Cuifang Hao

“…Abstract Background Ovulatory dysfunction and oocyte maturation arrest are among the common causes of female infertility, but the genetic etiology of these phenotypes is not well understood. …”
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COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment by Cameron D. Owens, Camila B. Pinto, Zsofia Szarvas, Mihaly Muranyi, Ana Clara da C. Pinaffi-Langley, Anna Peterfi, Peter Mukli, Sam Detwiler, Lauren Olay, Zalan Kaposzta, Kenneth Smith, Angelia C. Kirkpatrick, Faddi Saleh Velez, Stefano Tarantini, Anna Csiszar, Zoltan I. Ungvari, Calin I. Prodan, Andriy Yabluchanskiy

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Associated Clinical Factors for Coagulation Dysfunction due to Trimeresurus stejnegeri: A Retrospective Observational Study by Run-Hua Xie, Xiao-Lu Ye, Cong-Yao Tang, Yu-Huai Wang, Long-Xin Zhong

“…Trimeresurus stejnegeri (T.s) accounts for most snakebites in southern China, which always leads to coagulation dysfunction. Coagulopathy due to venom is widely considered to be a characteristic phenomenon of the DIC-like syndrome. …”
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A systematic review on renal and bladder dysfunction after endoscopic treatment of infravesical obstruction in boys. by Pauline M L Hennus, Geert J M G van der Heijden, J L H Ruud Bosch, Tom P V M de Jong, Laetitia M O de Kort

“…Moreover, the risk of bias is rather high, and therefore we put little confidence in the reported estimates of effect. We found elevated nadir serum creatinine as a predictor for renal dysfunction. …”
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Causal role of endothelial dysfunction in ischemic stroke and its subtypes: A two-stage analysis by Qian Wu, Jiabo Cui, Yao Jiang, Xiaoxin Li, Chongge You

“…Subsequent MR was applied to discern the causal effects of the endothelial dysfunction proteins on IS and its subtypes, utilizing genetically instrumental variants. …”
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Hashimoto’s Thyroiditis and Graves’ Disease in One Patient: The Extremes of Thyroid Dysfunction Associated with Interferon Treatment by R. H. Bishay, R. C. Y. Chen

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Endothelial dysfunction in patients with obesity and type 2 diabetes mellitus or normoglycemia: assessment of specific markers by E. V. Pokrovskaya, E. A. Shestakova, M. V. Shestakova

“…There was also no effect of cardioprotective drugs (SGLT-2 and / or GPP-1) on any of endothelial dysfunction markers in individuals with T2DM.CONCLUSION: We suggest that an increase in sE-selectin may be an early marker of endothelial dysfunction in obese individuals and T2DM.…”
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Prevalence and Risk Factors of Erectile Dysfunction in Patients with Type 2 Diabetes Mellitus in Erbil-Iraq by Yahya Kamal MohammedAli, Yousif Baha'addin Ahmed

“… Background and Objectives: Erectile dysfunction is a highly prevalent disease. It affects multiple aspects of health and can have a serious adverse effect on both the patients and their partners. …”
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation by Pei Zhou, Feng Jin, Shenshen Yao, Ben Sun, Ni Sun, Hongbo Guan, Xiaomei Liu

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HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition by Guochun Liu, Binyi Zhao, Qinglong Chen, Xiang Li, Xuejiao Zhu, Maowei Duan, Mengdie Zhang, Zhuohan Liu, Xuan Wen, Jia Guo, Man Zheng, Ruiyu Wang, Minghao Luo

“…Abstract Atherosclerosis (AS), driven by vascular endothelial dysfunction and poses a global health threat. This study compared the therapeutic effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial function in early-stage AS mice, specifically investigating PCSK9 modulation and the TRX/TXNIP/NLRP3/GSDMD-N pathway. …”
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Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis by Andrea Sansone, Angelo Cignarelli, Massimiliano Sansone, Francesco Romanelli, Giovanni Corona, Daniele Gianfrilli, Andrea Isidori, Francesco Giorgino, Andrea Lenzi

“…Elevated levels of serum homocysteine (Hcy) have been associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). …”
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The relationship of body image with sexual dysfunction and dyadic adjustment in individuals diagnosed with bipolar disorder in Türkiye by Emine Reyhan Yazar, Filiz İzci

“…IntroductionThe objective of this study is to evaluate the relationship of body image (BI) with sexual dysfunction (SD) and dyadic adjustment (DA) in individuals diagnosed with Bipolar Disorder (BD). …”
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