Far-infrared radiation alleviates steatohepatitis and fibrosis in metabolic dysfunction-associated fatty liver disease by Tianyi Xu, Haijing Fu, Wumei Zhao, Shijun Shan

“…This study aimed to investigate the potential protective effects of FIR against MAFLD. Mice were fed with a MCD diet to mimic MAFLD progression, and histopathology analysis, biochemical analysis, RT-qPCR, and Western blotting analysis were performed to assess the effect of FIR on MAFLD in vivo. …”
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STOX1: Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation by Marie van Dijk, Cees B. M. Oudejans

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Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome. by Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Haruka Kojima, Misato Kamura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Hirofumi Kai

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The Phosphodiesterase 4 Inhibitor Roflumilast Protects Microvascular Endothelial Cells from Irradiation-Induced Dysfunctions by Nathalie Guitard, Florent Raffin, François-Xavier Boittin

“…As intracellular cyclic AMP (cAMP) levels are known to control intercellular junctions or apoptosis in the endothelium, we investigated here the effect of the Phosphodiesterase 4 inhibitor Roflumilast, a drug increasing cAMP levels, on irradiation-induced endothelial dysfunctions in human pulmonary microvascular endothelial cells (HPMECs). …”
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Mitochondrial Dysfunction as a Problem in Critically Ill Patients. The Role of Succinates: Myth or Tomorrow's Reality? by Yu. P. Orlov

“…In conclusion, it is indicated that succinates should be administered in a timely manner (during the period of early adaptation to hypoxia) and in appropriate doses in order to obtain their maximum positive effect; the conditions should be created for them to accomplish the set task - elimination of mitochondrial dysfunction and restoration of oxidative phosphorylation.…”
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Punicic acid alleviates methylglyoxal-induced oocyte dysfunction during in vitro maturation in mouse species. by Shahrzad Ronasi, Amir Hossein Mahdavi, Shiva Rouhollahi Varnosfaderani, Rasoul Kowsar, Farnoosh Jafarpour, Mohammad Hossein Nasr-Esfahani

“…Interestingly, PA supplementation partially ameliorated these adverse effects of MGO, highlighting its potential as a protective agent against dicarbonyl-induced oocyte dysfunction. …”
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Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway by Yang Wenqin, Nong Weihua, Liu Ke, Lei Xiaocan, Chen Xiaping, Jiang Pei, Tang Jiayi, Hu Cong, Hu Zecheng, Li Meixiang

“…To assess the effects of NMN, single whole-body γ-ray irradiation is used to induce testicular injury and spermatogenic dysfunction in adult male mice. …”
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Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota by Shuqi Cai, Shuqi Cai, Zixuan Li, Zixuan Li, Jie Bai, Jie Bai, Yue Ding, Yue Ding, Ruisang Liu, Liben Fang, Dengyong Hou, Sheng Zhang, Xiaohui Wang, Yujia Wang, Yuyu Jiang, Yuyu Jiang, Yan Xiang, Yan Xiang, Wenhui Wu, Ying He, Ying He, Yunkai Zhang, Yunkai Zhang, Xiaomeng Ren

“…The results revealed that: sleep-deprived mice exhibited weakness, depression-like behaviors, and dysfunction in multiple organs. Pathogenic cardiac hypertrophy and fibrosis occurred in sleep-deprived mice, accompanied by poor ejection fraction and fractional shortening. 16S rRNA sequencing indicated that sleep deprivation induced pathogenic effects on gut microbiota, and similar phenomena were also observed in mice that received fecal microbiota from sleep-deprived mice in the FMT experiments. …”
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Association of pulse pressure with presynaptic dysfunction in older adults with Alzheimer’s disease: a cohort study by Nayeong Kong, Geun Hui Won, Joon Hyung Jung

“…We investigated the associations of PP with CSF GAP-43, a marker of presynaptic dysfunction, and CSF p-tau. The mediation effect of presynaptic dysfunction on the association between PP and CSF p-tau was also examined. …”
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Evaluating the influence of anti-PD-1 immunotherapy combined with IMRT on thyroid dysfunction in nasopharyngeal carcinoma by Liqianqi Chen, Zihuang Li, Xianming Li, Shihai Wu, Long Gong, Gang Xu, Shanyi Chen, Yucong Zhang

“…T-tests, rank-sum tests, multivariate logistic regression analysis, ROC curves, and Cox proportional hazards models were used to evaluate the effects of anti-PD-1 immunotherapy combined with chemoradiotherapy on thyroid function.ResultsPatients with pre-treatment smoking history, thyroid nodules, and cervical lymph node metastasis were more likely to develop thyroid dysfunction (P<0.05). …”
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Exploring the Mediating Role of Student Attitudes in the Relationship between Dysfunctional Teams and Student Team Performance by Amrita Dutt, Vijaishri Tewari, Shashikant Rai, Shardul Shankar

“…This study focuses on the association between dysfunctional teams and student team performance (TP), with the mediating effect of students' attitudes towards team assessment. …”
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An L-shaped association between lymphocyte-to-monocyte ratio and erectile dysfunction in NHANES 2001–2004 by Donggang Shan, Chenze Yan, Zhong Jia

“…Abstract This study aimed to explore the relationship between the lymphocyte/monocyte ratio (LMR) and erectile dysfunction (ED) in adult men in the United States using a comprehensive dataset. …”
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Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest by Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv

“…Cardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available. …”
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Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling by Luca Büschgens, Nina Hempel, Aditi Methi, Andre Fischer, Nele Siering, Lars Piepkorn, Olaf Jahn, Thomas Meyer, Oliver Wirths

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Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals by Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka, Joanna K. Strzelczyk, Aleksander J. Owczarek, Armand Cholewka, Marcin Furmański, Agata Stanek

“…Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. …”
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Modulation of NLRP3 Inflammasome Activation by QYHT Decoction: Implications for the Treatment of Erectile Dysfunction in Hyperuricemia by Pingyu Ge, Yinxue Guo, Bangwei Che, Hang Jin, Lan Chen, Zhichao Chen, Kaifa Tang

“…Hyperuricemia (HUA) causes vascular endothelial dysfunction and oxidative stress, and simultaneously activates the NLRP3 inflammasome, leading to inflammatory reactions and erectile dysfunction (ED). …”
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The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction by Sangavi Eswaran, Roshan Mascarenhas, Shama Prasada Kabekkodu

“…Increased oxidative stress, calcium overload, lipid droplet accumulation, mitochondrial lipotoxicity, and mitophagy suggest that PC can cause mitochondrial dysfunction. N-acetyl cysteine (NAC) treatment reversed the cytotoxic effect of PC, via decreasing lipid peroxidation rate and increasing GSH activity. …”
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Curcumin and omega-3 ameliorate experimental osteoarthritis progression in terms of joint pain and mitochondrial dysfunction by JooYeon Jhun, Donghwan Lee, Hyun Sik Na, Keun-Hyung Cho, Seung Yoon Lee, Jeong Su Lee, Young Joon Lee, Seok Jung Kim, Sung-Hwan Park, Mi-La Cho

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Postpartum administration of eplerenone to mitigate vascular dysfunction in mice following a preeclampsia-like pregnancy by Natalie K. Binder, Natasha de Alwis, Sally Beard, Bianca R. Fato, Anjali Garg, Lydia Baird, Morag J. Young, Natalie J. Hannan

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Cognitive dysfunction in elderly patients with depression based on chronic brain ischemia: vortioxetine (Brintellix) experience by Yu. V. Zhitkova, D. R. Hasanova

“…Vortioxetine eliminated both cognitive dysfunction and symptoms of depression in patients of both age groups. …”
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