Telomerase RNA component knockout exacerbates Staphylococcus aureus pneumonia by extensive inflammation and dysfunction of T cells by Yasmina Reisser, Franziska Hornung, Antje Häder, Thurid Lauf, Sandor Nietzsche, Bettina Löffler, Stefanie Deinhardt-Emmer

Get full text

A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma by Byung-Kwan Jeong, Won-Il Choi, Wonsuk Choi, Jieun Moon, Won Hee Lee, Chan Choi, In Young Choi, Sang-Hyun Lee, Jung Kuk Kim, Young Seok Ju, Pilhan Kim, Young-Ah Moon, Jun Yong Park, Hail Kim

“…Abstract The lack of an appropriate preclinical model of metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole disease spectrum impedes exploration of disease pathophysiology and the development of effective treatment strategies. …”
Get full text

Use of Impella RP Flex in Post-Heart Transplant Patients with RV Primary Graft Dysfunction by Ioana Dumitru, Jonathan DeWolf, Maria Sevillano, Leeandra Schnell, Hiram Bezerra, Debbie Rinde-Hoffman

“…<b>Background</b>: Right ventricular primary graft dysfunction (RV-PGD) is a rare but serious complication following heart transplantation, associated with a high morbidity and mortality. …”
Get full text

Efficacy of Omega-3 supplementation in olfactory dysfunction: a systematic review of randomized controlled trials by Raghad S. Alzahrani, Taif F. Alkhatabi, Abdulaziz F. Bokhari, Wed M. Ismail, Abdullah S. Alyamani, Ali S. Alsudais, Bassam AlRajhi, Dakheelallah M. Almutairi

“…Abstract Background Olfactory dysfunction (OD) significantly impacts patients’ quality of life, yet effective treatments are limited. …”
Get full text

Implantable Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction: A Single-Institution Retrospective Study by Karis Buford, Haley Eisner, Annah Vollstedt, Brett Friedman, Jason Gilleran, Bernadette M.M. Zwaans, Kenneth M. Peters, Priya Padmanabhan

“…Purpose Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent among patients with neurologic disorders. …”
Get full text

DYNAMICS OF CARDIOVASCULAR STATUS AND SERUM MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS, TREATED WITH INFLIXIMAB by S. P. Oranskyi, L. N. Eliseeva, N. A. Samorodskaya, I. G. Malkhasyan

“…In RA patients, infliximab was highly effective for the functional cytokine dysbalance correction, also demonstrating pleiotropic effects, such as correction of microvascular and endothelial dysfunction.…”
Get full text

Cancer Therapy-Related Cardiac Dysfunction: A Review of Current Trends in Epidemiology, Diagnosis, and Treatment by Panagiotis Theofilis, Panayotis K. Vlachakis, Evangelos Oikonomou, Maria Drakopoulou, Paschalis Karakasis, Anastasios Apostolos, Konstantinos Pamporis, Konstantinos Tsioufis, Dimitris Tousoulis

“…Cancer therapy-related cardiac dysfunction (CTRCD) has emerged as a significant concern with the rise of effective cancer treatments like anthracyclines and targeted therapies such as trastuzumab. …”
Get full text

The Emerging Role of Anti-Hyperglycemic Agents for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease by Pieralice S, Amendolara R, Berna V, Manganaro G, Zurru A, D'Onofrio L, Risi R, Alfonsi M, Maddaloni E, Buzzetti R

“…The variety of MASLD includes steatosis, metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), fibrosis, cirrhosis and MASH-related hepatocellular carcinoma (HCC). …”
Get full text

Pathogenetic basis of treating endothelial dysfunction with metformin in patients with diabetes (literature review and own data) by A.M. Sokolova, V.V. Pushkarev, L.K. Sokolova, V.M. Pushkarev, M.D. Tronko

“…Primary is the effect of MF on endothelial dysfunction, as endothelial integrity is a critical long-term determinant of vascular health and, therefore, the occurrence of cardiovascular disease. …”
Get full text

Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Julia Markowska, Kamila Kasprzak-Drozd, Przemysław Niziński, Magdalena Dragan, Adrianna Kondracka, Ewa Gondek, Tomasz Oniszczuk, Anna Oniszczuk

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic liver disease. …”
Get full text

Catheter ablation of atrial fibrillation versus antiarrhythmic therapy in patients with left ventricular systolic dysfunction by D. F. Ardus, T. M. Uskach, O. V. Sapelnikov, M. I. Makeev, S. N. Tereschenko, R. S. Akchurin

“…To evaluate the efficacy of catheter ablation (CA) of atrial fibrillation (AF) in patients with left ventricular systolic dysfunction and the effect of the procedure on the course of chronic heart failure (CHF) compared with the use of antiarrhythmic therapy (AAT).Materials and methods. …”
Get full text

Dosing of Antimycotic Treatment in Sepsis–Induced Liver Dysfunction by Functional Liver Testing with LiMAx® by Carmen Kirchner, Jasmin Sibai, Elke Schwier, Dietrich Henzler, Claas Eickmeyer, Günther Winde, Thomas Köhler

Get full text

The influence of alterations in the composition of intestinal microbiota on neurovascular coupling and cognitive dysfunction in individuals afflicted with CSVD by Wei Zhang, Xianfeng Yu, Min Wei, Jie Zhou, Yajun Zhou, Xia Zhou, Kai Zhao, Xiaoqun Zhu

Get full text

Total thoracoscopic ablation in patients with atrial fibrillation and left ventricular dysfunctionCentral MessagePerspective by Hye Ree Kim, MD, Dong-Seop Jeong, MD, PhD, Hee-Jin Kwon, MD, Seung-Jung Park, MD, PhD, Kyoung-Min Park, MD, PhD, June Soo Kim, MD, PhD, Young Keun On, MD, PhD

“…Objective: To evaluate the effectiveness and safety of totally thoracoscopic ablation (TTA) in patients with left ventricular (LV) dysfunction for treatment of atrial fibrillation (AF) refractory to antiarrhythmic drug (AAD) therapy. …”
Get full text

Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer’s disease patients by Sarah Mustaly-Kalimi, Wacey Gallegos, Daniel Steinbrenner, Smriti Gupta, Aiden J. Houcek, David A. Bennett, Robert A. Marr, Daniel A. Peterson, Israel Sekler, Grace E. Stutzmann

“…Additionally, pharmacological suppression of RyR-Ca2+ release preserves mitochondrial, ER and lysosomal function, thus providing a novel and effective therapeutic strategy.…”
Get full text

Left atrial dysfunction relates to symptom onset in patients affected by severe degenerative mitral regurgitation by Giacomo Ingallina, Gabriele Paci, Davide Margonato, Leonardo Italia, Francesco Ancona, Stefano Stella, Federico Biondi, Annamaria Tavernese, Martina Belli, Monica Barki, Michele Morosato, Jennifer Wong, Massimo Slavich, Alessandro Castiglioni, Michele De Bonis, Francesco Maisano, Eustachio Agricola

“…Our study aims to evaluate the correlation between left atrial dysfunction and symptoms onset in patients with severe degenerative MR. …”
Get full text

Postoperative Delirium and Cognitive Dysfunction After Cardiac Surgery: The Role of Inflammation and Clinical Risk Factors by Raluca-Elisabeta Staicu, Corina Vernic, Sebastian Ciurescu, Ana Lascu, Oana-Maria Aburel, Petru Deutsch, Elena Cecilia Rosca

“…Postoperative IL-6 and NLR levels, readily measurable and cost-effective markers, may contribute to identifying patients at higher risk. …”
Get full text

vASCULAR AND CARDIAC REMODELLING AND COMbINATION THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC ObSTRUCTIvE PULMONARY DISEASE by L. A. Shpagina, I. S. Shpagin, T. I. Pospelova, O. N. Gerasimenko, N. A. Sukhaterina, Ya. M. Alicheva

Subjects: “…arterial hypertension, chronic obstructive pulmonary disease, cardiac and vascular remodelling, endothelial dysfunction, systemic inflammation, therapy effectiveness.…”
Get full text

Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program by Yuliya S. Nikolova, Yuliya S. Nikolova, Yuliya S. Nikolova, Anthony C. Ruocco, Anthony C. Ruocco, Anthony C. Ruocco, Anthony C. Ruocco, Daniel Felsky, Daniel Felsky, Daniel Felsky, Shannon Lange, Shannon Lange, Shannon Lange, Shannon Lange, Thomas D. Prevot, Thomas D. Prevot, Thomas D. Prevot, Erica Vieira, Erica Vieira, Daphne Voineskos, Daphne Voineskos, Jeffrey D. Wardell, Jeffrey D. Wardell, Jeffrey D. Wardell, Jeffrey D. Wardell, Daniel M. Blumberger, Daniel M. Blumberger, Kevan Clifford, Kevan Clifford, Ravinder Naik Dharavath, Philip Gerretsen, Philip Gerretsen, Ahmed N. Hassan, Ahmed N. Hassan, Ingrid M. Hope, Samantha H. Irwin, Sheila K. Jennings, Sheila K. Jennings, Bernard Le Foll, Bernard Le Foll, Osnat Melamed, Osnat Melamed, Josh Orson, Peter Pangarov, Leanne Quigley, Cayley Russell, Kevin Shield, Kevin Shield, Kevin Shield, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Ashley Smoke, Ashley Smoke, Victor Tang, Victor Tang, Victor Tang, Diana Valdes Cabrera, Diana Valdes Cabrera, Wei Wang, Samantha Wells, Samantha Wells, Samantha Wells, Rajith Wickramatunga, Etienne Sibille, Etienne Sibille, Etienne Sibille, Lena C. Quilty, Lena C. Quilty

“…Through such interdisciplinary research, we can develop policies and interventions that align with biopsychosocial models of addiction, addressing the complex cognitive concerns of people with SUDs in a more holistic and effective way. Here, we introduce the design and procedures underlying Cognitive Dysfunction in the Addictions (CDiA), an integrative research program, which aims to fill these knowledge gaps and facilitate research discoveries to enhance treatments for people living with SUDs. …”
Get full text

Randomized «FARVATER» study. Atorvastatin (10 and 20 mg/d) in treating patients with coronary heart disease and dyslipidemia: effects on lipids, C-reactive protein and fibrinogen l... by A. V. Susekov, M. Yu. Zubareva, M. I. Tripoten’, T. A. Rozhkova, O. A. Pogorelova, T. V. Balakhonova, V. P. Masenko, V. V. Kukharchuk

Get full text