Emerging Role of Microtubule-Associated Protein 2 as a Prognostic Factor for Renal Dysfunction by Fatima Ghazi Talab, Hind Shakir Ahmed

“…This study aims to analyze the effectiveness of these parameters in evaluating CKD and its associated mechanisms in Iraqi patients. …”
Get full text

Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives by Olabimpe Caroline Badejogbin, Oyedayo Phillips Akano, Oluwafisayo Elizabeth Boluwatife Julius, Mary Olaoluwa Agunloye, Makinde Vincent Olubiyi, Ojichukwuka Ebere Chijioke‐Agu, Matthew Agene Obekpa, Adesina Paul Arikawe, Kehinde Samuel Olaniyi

“…Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction. Methods A systematic review of PubMed, Web of Science, Scopus, and Google Scholar was conducted to identify peer‐reviewed studies, both preclinical and clinical, that explored CREM's role in diabetes‐induced testicular dysfunction. …”
Get full text

CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC COR PULMONALE BY ANGIOTENSIN II RECEPTORS ANTAGONISTS by V. S. Zadionchenko, N. B. Holodkova, O. I. Nesterenko, I. V. Pogonchenkova, A. M. Shchikota, Y. V. Ignatova, I. Y. Malyshev, E. B. Manukhina, S. V. Kruglov, D. A. Pokidyshev, O. A. Zemnina

“…Significant increase in intensity of endothelial dysfunction and activation of apoptosis processes were registered according to growth of CCP severity. …”
Get full text

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction by Cathrin E. Hansen, Davide Vacondio, Lennart van der Molen, Annika A. Jüttner, Wing Ka Fung, Manon Karsten, Bert van het Hof, Ruud D. Fontijn, Gijs Kooij, Maarten E. Witte, Anton J. M. Roks, Helga E. de Vries, Inge Mulder, Nienke M. de Wit

Get full text

Brain structural alterations and cognitive dysfunction in lung cancer patients without brain metastasis by Da-Fu Zhang, Huan Ma, Zhi-Ping Zhang, Jing Ai, Zong-Sheng Pu, Yi-Fan Liu, Wen-Ting Cao, Zhen-Hui Li

“…Structural brain changes and cognitive dysfunction are evident in aLC patients, independent of metastasis. …”
Get full text

Myocardial contractility dysfunction in patients with chronic lymphocytic leukemia receiving chemotherapy and their treatment with enalapril by I. L. Davydkin, T. P. Kuzmina, I. A. Zolotovskaya, O. V. Tereshina, O. E. Danilova, R. K. Khairetdinov, L. A. Rogozina

“…To assess eft ventricular (LV) contractility dysfunction in patients with chronic lymphocytic leukemia (CLL) receiving chemotherapy with fludarabine, cyclophosphamide, and rituximab (FCR), and to determine the enalapril.effectiveness for their treatment.Material and methods. …”
Get full text

Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis by Likai Yu, Zishan Su, Di Tian, Shangqi Liu, Li Zhang, Zeen Wang, Shaobo Guo, Wenhui Zhu, Peimin Wang, Nongshan Zhang

“…Methods In this study, we employed various techniques to assess the effects of mechanical stress on knee joint cartilage in vivo and in vitro experiments. …”
Get full text

Efficacy and putative mechanisms of action of nutraceuticals in the management of erectile dysfunction: a narrative review by Lorenzo Romano, Michele Musone, Luigi Napolitano, Lorenzo Spirito, Celeste Manfredi, Davide Arcaniolo, Ferdinando Fusco, Biagio Barone, Antonio Tufano, Pier Paolo Prontera, Ugo Amicuzi, Antonio Cioffi, Ciro Imbimbo, Marco De Sio, Carmine Sciorio, Felice Crocetto

“…Erectile dysfunction (ED) is a common condition in the male population and isinfluenced by numerous pathophysiological factors. …”
Get full text

Asthma and cognitive dysfunction in older adults: the mediating role of systemic immune-inflammation index by Jianqin Hu, Honggang Ma, Zhiyuan Ning, Qi Xu, Ji Luo, Xuanfei Jiang, Bing Zhang, Ying Liu

“…Mediation analysis indicated SII was a mediator of asthma-induced cognitive impairment, a notable Average Causal Mediated Effect (ACME) (P = 0.004) between SII and cognitive dysfunction. …”
Get full text

Mitochondrial Dysfunction and Reduced TCA Cycle Metabolite Levels in Inflammatory Bowel Disease Patients by Dudzińska E, Madro A, Sauer AK, Grabrucker AM, Strachecka A

Get full text

Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions by Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Raul Diaz-Pedrero, Laura Lopez-Gonzalez, Jorge Monserrat, Silvestra Barrena-Blázquez, Miguel Angel Alvarez-Mon, Guillermo Lahera, Melchor Alvarez-Mon

“…In this sense, this review aims to delve into the relationship between immune dysfunction and mood disorders and their integration in the complex context of PNIE. …”
Get full text

Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice by Baoxing Gan, Xufei Zhang, Jinge Xin, Lixiao Duan, Ning Sun, Yu Chen, Junqi Zeng, Yueying Lian, Hao Li, Hesong Wang, Xueqin Ni, Hailin Ma

“…Administration of HL79 alleviated these burdens, including memory dysfunction and tissue damage, though complete reversal was not achieved. …”
Get full text

Factors Influencing Continued Usage of Intracavernosal Injections for Erectile Dysfunction: A Retrospective Analysis by Braian Rene Ledesma, Jason Codrington, David Velasquez, Alexandra Aponte Varnum, Joshua White, Greeshma Venigalla, Farah Rahman, Katherine Campbell, Alexander Weber, Max Sandler, Ranjith Ramasamy

“…Purpose: Intracavernosal injections are used to treat erectile dysfunction. Patient compliance with intracavernosal injections is required for success, though factors influencing compliance are unknown. …”

Correction of mitochondrial dysfunction with trimethoxy-substituted monocarbonyl curcumin analogues in experimental Alzheimer’s disease by D. I. Pozdnyakov, A. A. Vikhor, V. M. Rukovitsina, E. T. Oganesyan

“…The treatment of AD usually involves symptomatic therapy, but the research field for new medicines to correct AD focus on the pathogenetic keys of the disease, i.e., a mitochondrial dysfunction.The aim of the work was to evaluate the effect of trimethoxy-substituted monocarbonyl curcumin analogues on changes in the mitochondrial function of the hippocampus in AD rats.Materials and methods. …”
Get full text

Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling by Sona Cacanyiova, Andrea Berenyiova, Hana Malinska, Martina Huttl, Irena Markova, Basak G. Aydemir, Veronika Garaiova, Martina Cebova

Get full text

A modified liver retraction method decreases liver dysfunction after laparoscopic gastrectomy by Hao-Jie Li, Lang Zhou, Wei-Han Zhang, Kai Liu, Kun Yang, Jian-Kun Hu, Xiao-Long Chen

“…However, postoperative liver dysfunction is frequently encountered after liver retraction. …”
Get full text

The influence of the chosen method of anesthesia on the severity of postoperative cognitive dysfunction in patients with ophthalmic surgery by G.S. Dorofeeva

“…Dexmedetomidine was used (the selective agonist of α-adrenoreceptors) as one of the components of multimodal anaesthetization. The sedative effect of this drug is explained by inhibition of neural activity in the blue spot of the brain stem. …”
Get full text

Targeting endoplasmic reticulum stress‐induced lymphatic dysfunction for mitigating bisphosphonate‐related osteonecrosis by Ziyue Qin, Hanyu Xie, Pengcheng Su, Zesheng Song, Rongyao Xu, Songsong Guo, Yu Fu, Ping Zhang, Hongbing Jiang

Get full text

Age features of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction by D. A. Lashkul

“…When comparing the groups of middle-aged and elderly it was found that normal renal function was in 45 (27.1%) and 13 (11.7%) persons, respectively (χ2=11,2; p=0.0008), light kidney dysfunction was in 108 (65.1%) and 74 (66.7%) persons, respectively (χ2=0,8; p=0.78), moderate dysfunction was in 13 (7.8%) and 24 (21.6%) people, respectively (χ2=10,9; p=0.0009). …”
Get full text

Effects of aerobic training on brachial artery flow-mediated dilation in healthy adults: a meta-analysis of inter-individual response differences in randomized controlled trials by Armin H. Paravlic, Kristina Drole

Get full text