Cemiplimab and diabetic ketoacidosis: a case report of a rare endocrinopathy associated with immune checkpoint inhibitors by Anna Arecco, Cristian Petolicchio, Alessandro Pastorino, Enrica Teresa Tanda, Enrica Teresa Tanda, Lara Vera, Mara Boschetti, Mara Boschetti, Francesco Cocchiara, Davide Carlo Maggi, Davide Carlo Maggi, Diego Ferone, Diego Ferone, Federico Gatto, Federico Gatto

“…However, the activation of immune response can cause a broad range of side effects, called immune-related adverse events (irAEs). …”
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Study on bioactivities of Morinda citrifolia L. fruit hydroalcoholic extracts and detection of novel phytoconstituents by UPLC-Q-exactive orbitrap-tandem mass spectrum analysis by Aslee Tailulu, Hanyue Cui, Liren Wu, Yuhu Shen, Ping Shi

“…In dual ion-scan mode UPLC analysis, 17 distinct phytoconstituents were identified, including 2-Hydroxycinnamic acid, 4-Hydroxycinnamic acid, and riboflavin, known for treating cancer, metabolic dysfunctions, and COVID-19. The 14 constituents were discovered in noni fruit for the first time. …”
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Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study by Meng Qi, Yiting Huang, Runru Mai, Zhaoxian Yan, Biyun Xu, Bo Liu, Yue Zhang

“…Abstract Background Dysfunctional basal forebrain (BF) connectivity contributes to primary insomnia (PI). …”
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N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Conclusions The study highlights that the effects of N88S seipin mutation extend beyond protein misfolding, with significant disruptions in lipid metabolism and iron homeostasis. …”
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EFFICIENCY OF TREATMENT OF HARD TISSUES DEFECTS OF LATERAL TEETH WITH DIRECT AND INDIRECT RESTORATIONS MADE OF COMPOSITE MATERIALS: COMPARATIVE CLINICAL EVALUATION by N.I. Mykyievych

“…The study is aimed at raising the effectiveness of dental treatment by clinical evaluation of the quality of direct and indirect restorations made from composite materials. …”
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Qualitative Analysis of Valeriana officinalis leaf by Thin-Layer Chromatography by A. Yu. Fisiuk, O. V. Mushkina, N. S. Golyak, O. A. Yorshyk

“…., family Valerianaceae) have sedative, antiarrhythmic, antispasmodic, anticonvulsant, anxiolytic effects and are widely used in psychoemotional and cognitive disorders, for the treatment of dysfunctions of the autonomic nervous system, including children, also for menopausal disorders. …”
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Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice by Samantha K. Bartholomew, Wendy Winslow, Ritin Sharma, Khyatiben V. Pathak, Savannah Tallino, Jessica M. Judd, Hector Leon, Julie Turk, Patrick Pirrotte, Ramon Velazquez

“…As glyphosate use continues to rise, more research is needed to elucidate the impact of this herbicide and its metabolites on the human brain, and their potential to contribute to dysfunctions observed in neurodegenerative diseases.…”
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Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents: an observational prospective study by Eva S.L. Pedersen, Sarah Glick, Carmen C.M. de Jong, Cristina Ardura-Garcia, Anja Jochmann, Carmen Casaulta, Katharina Hartog, Diana Marangu-Boore, Dominik Mueller-Suter, Nicolas Regamey, Florian Singer, Alexander Moeller, Claudia E. Kuehni

“…Previous bronchodilator use (94%) and its effect on exercise-induced respiratory symptoms (88%) were consistently documented by physicians. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Ccr8 is also expressed by dysfunctional CD4+ and CD8+ T cells, but the CCR8 protein was only prominent on the highly activated and strongly T-cell suppressive ti-Treg subpopulation of mouse and human tumors, with no major CCR8-positivity found on peripheral Tregs. …”
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Applying bioinformatic analysis for prognostic assessment of the <i>HS3ST6</i> missense mutations clinical significance in the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. R. Denisova, N. S. Podchernyaeva, A. A. Totolian

“…The majority of HAE cases are associated with decreased levels of C1 (C1-esterase inhibitor), there are also descriptions of HAE with dysfunctional C1 inhibitor and HAE with normal C1 inhibitor. …”
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Association between vitamin D, vitamin D supplementation and benign paroxysmal positional vertigo: a systematic review and meta-analysis by Yanyan Li, Peng Gao, Rui Ding, Ying Xu, Zhicheng Wang, Xiaorui Pei, Lianhe Li

“…BackgroundBenign paroxysmal positional vertigo (BPPV) is one of the most prevalent peripheral vestibular dysfunctions encountered in clinical practice, including dizziness and vertigo, which has a significant impact on people’s everyday lives and affects their quality of life in many ways. …”
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1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells by Peng Li, Hua Zhang, Xiao Wang, Biyun Chen, Ke Li, Zhinan Yin, Xinhai Zhu, Guangchao Cao, Ruan Wu, Wenhui Yuan, Guodong Sun, Xichun Xia, Ligong Lu, Yunfei Gao

“…Background Epidemiological surveys have revealed that low serum vitamin D level was correlated with increased risk of tumors. Dysfunctional T cells in patients with tumor are characterized as exhausted with high levels of immune checkpoint receptors (ICRs). …”
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Anogeissus leiocarpus (DC.) Guill. &amp; Perr. extract-protected rats against CCl4-induced liver fibrosis by Omokolade O. Alejolowo, MSc, Olarewaju M. Oluba, PhD, Oluyomi S. Adeyemi, PhD

“…Conclusion: Collectively, AL exhibited anti-inflammatory, hepatoprotective, and antifibrotic effects and thus has prospects for further exploration as a potential therapy in liver diseases.…”
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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…The findings suggest that, under extreme conditions, individuals may adapt and find ways to mitigate the effects of a challenging society and other disadvantages. …”
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Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…While stress might be triggered by, for instance, social phenomena, its physiological effects are profound. It is not always possible to treat the latter without addressing the former. …”
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Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…While stress might be triggered by, for instance, social phenomena, its physiological effects are profound. It is not always possible to treat the latter without addressing the former. …”
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The Female Athlete Triad: A Metabolic Phenomenon by Anne B. Loucks

“…The specific kind of reproductive dysfunctions caused by low energy availability are functional hypothalamic menstrual disorders.  …”
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