Prescription patterns demonstrate high demand for treating erectile dysfunction following radical prostatectomy by Signe Benzon Larsen, Annika von Heymann, Hein V. Stroomberg, Anne Sofie Friberg, Klaus Brasso, Andreas Røder, Susanne Oksbjerg Dalton, Randi Karlsen, Pernille Envold Bidstrup, Annamaria Giraldi, Christoffer Johansen

Get full text

Thyroid Dysfunction as a Predictive Indicator in Camrelizumab of Advanced Esophageal Squamous Cell Carcinoma by Ying Chen, Lei Zhuang, Danhong Zhang, Xianghui Du, Liming Sheng

“…Thyroid dysfunction (TD) induced by programmed death-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) has been widely reported. …”
Get full text

Efficacy of angiotensin receptor blockers for erectile dysfunction in hypertensive men: A systematic review by Swati Sucharita Dash, Harshita K Kothari, Shashwati Pankaj, Lakshmi Venkatachalam, Jignesh Bhate, Guruprasad K S Rao

“…Erectile dysfunction (ED) is a condition that affects many men, especially as they age, and is an indicator of an underlying health condition and is a risk factor for cardiovascular disease. …”
Get full text

Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice by Vanessa Kristina Wazny, Aparna Mahadevan, Nhi Nguyen, Hannah Wee, Ashwati Vipin, Tammy Lam, Kai Yi Tay, Jia-Xiang See, Gurveen Sandhu, Yi Jin Leow, Giuseppe D’Agostino, Martin Graf, Aravind Sivakumar, Sichen Lin, Nguyen Cao Thien Phuc, James Xiao Yuan Chen, Sarah R. Langley, Lay Teng Ang, Kyle M. Loh, Nagaendran Kandiah, George J. Augustine, Christine Cheung

Get full text

Postoperative cognitive dysfunction in elderly postcardiac surgery patients: progress in rehabilitation application research by Zhen-Rong Zhang, Yang-Zheng Li, Xiao-Qing Wu, Wen-Jun Chen, Jian Xu, Wei-Hua Zhao, Xiao-Yan Gong

“…A comprehensive rehabilitation strategy can more effectively address postoperative cognitive dysfunction in patients.…”
Get full text

Application Prescription of Brain-Computer Interface Based on Motor Imagery in Post-Stroke Dysfunction by JIANG Shanshan, QIU Zhiqing, YOU Tingting, FU Xinyu, CHEN Guanzhou, LI Haoda, LIANG Boyuan, YU Jiani, OU Haining

“…Particularly, motor imagery-based BCI (MI-BCI) has demonstrated therapeutic potential in post-stroke rehabilitation targeting motor dysfunction, cognitive impairment, and swallowing disorders. …”
Get full text

Arterial hypertension and obstructive sleep apnoea syndrome: treatment resistance and the role of autonomic dysfunction by V. V. Rostorotskaya, I. A. Elgardt, A. P. Ivanov, N. S. Sdobnyakova

“…To study the role of obstructive sleep apnoea syndrome (OSAS) in the development of treatment resistance in patients with arterial hypertension (AH). To assess the effects of autonomic nervous system (ANS) dysfunction, as one of the potential pathophysiological mechanisms of inadequate blood pressure (BP) reduction in patients with AH and OSAS. …”
Get full text

Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats by Tatyana Y. Postnikova, Alexandra V. Griflyuk, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Anastasia V. Mikhel, Dmitriy S. Vasilev, Aleksey V. Zaitsev

“…This study examines the effects of moderate maternal HCY on excitatory synaptic transmission in the CA1 region of the dorsal hippocampus in rat offspring at juvenile (P21) and adult (P90) stages. …”
Get full text

Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age. by Yujie Tang, Xueqin Wang, Shuibing Zhang, Shangchun Duan, Wenxiang Qing, Gong Chen, Feng Ye, Yuan Le, Wen Ouyang

“…Occurrence of postoperative cognitive dysfunction (POCD) is age-dependent and heterogenous. …”
Get full text

The Role of Benralizumab in Eosinophilic Immune Dysfunctions: A Case Report-Based Literature Review by Margarida Gomes, Ana Mendes, Filipa Ferreira, Joana Branco, Fernanda S. Tonin, M. Elisa Pedro

“…To better illustrate the potential relationship between different eosinophilic immune dysfunctions and the effects of biological therapies in this scenario, here, we present a case of a 63-year-old male first referred to our department in 2018 with a diagnosis of asthma, polyposis, and rhinosinusitis and presenting a suspicion of nonsteroidal anti-inflammatory drugs’ allergy. …”
Get full text

A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction by Ammara Ayub, Ammara Zamir, Muhammad Fawad Rasool, Usman Arshad, Faleh Alqahtani

Get full text

The role of childhood overweight in meibomian gland dysfunction and dry eye disease in Chinese children by Zhen Xu, Lulu Bao, Xiaomin Wang, Haihang Ying, Jianbo Mao

“…Gender had no significant effect on gland dysfunction. The gland meiboscore was significantly correlated with weight, OSDI score, BUT, BMI percentile and BMI percentile ranking. …”
Get full text

Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies by Dalia M. Miller, Stephen L. Archer, Stephen L. Archer, Stephen L. Archer, Kimberly J. Dunham-Snary, Kimberly J. Dunham-Snary

“…Mitochondrial-driven diseases encompass a diverse group of single-gene and complex disorders, all linked to mitochondrial dysfunction, with significant impacts on human health. …”
Get full text

Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer by Ilseok Choi, Kyung-A Kim, Sang Cheol Kim, Donghwan Park, Ki Taek Nam, Jun Hyung Cha, Seungbyn Baek, Junha Cha, Hye-Yeong Jo, Minsun Jung, Melody Y. Zeng, Irina Matei, Susan Bullman, Joong Bae Ahn, Yoon Dae Han, Han Sang Kim, Insuk Lee

Get full text

Macrophage‐Hepatocyte Circuits Mediated by Grancalcin Aggravate the Progression of Metabolic Dysfunction Associated Steatohepatitis by Tian Su, Yue He, Min Wang, Haiyan Zhou, Yan Huang, Mingsheng Ye, Qi Guo, Ye Xiao, Guangping Cai, Mingyang Zhao, Jianping Wang, Xianghang Luo

“…Although numerous endeavors have been made to identify the mediators of metabolic dysfunction associated steatohepatitis (MASH), the molecular underpinnings of MASH progression remain poorly understood, and therapies to arrest MASH progression remain elusive. …”
Get full text

Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality. by Sun Ryoung Choi, Young-Ki Lee, Hayne Cho Park, Do Hyoung Kim, Ajin Cho, Min-Kyung Kang, Seonghoon Choi

“…<h4>Methods</h4>This prospective observational cohort study investigated the effect of LV diastolic dysfunction on CV mortality in the ESKD patients with preserved systolic function using echocardiography. …”
Get full text

Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review by Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina

“…Purpose of Research: This review aims to explore the mechanisms linking liver dysfunction to brain impairment in HE and to summarize recent findings on liver disease's effects on CNS dysfunction. …”
Get full text

Excessive Iron Induces Macrophage Dysfunction in the Liver, Causing Adverse Pregnancy Outcomes in Mice by Sayaka Shimazaki, Ren Ozawa, Akari Isobe, Sohei Kuribayashi, Hisataka Iwata, Koumei Shirasuna

“…The reduction in macrophages also induced higher iron levels and adverse effects during pregnancy, suggesting a vicious cycle between excessive iron and macrophage dysfunction during pregnancy.…”
Get full text

Characterization of polymorphic markers of endothelial dysfunction genes in secondary nephropathies in children with rheumatic diseases by Guzel K. Karymova, Igor V. Zorin

Get full text

Endothelial dysfunction and thrombotic events in patients with severe novel coronavirus infection COVID-19 by A. A. Lebedeva, A. N. Kulikov, I. P. Kovalchuk, M. I. Kadinskaya, A. M. Ginzburg, T. D. Vlasov

“…The same patients have an increased risk of hemorrhagic events as a possible side effect of the therapy.…”
Get full text