Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial by Hua Wu, Hua Wu, Hao-Ling Xu, Xia-Hua Liu, Arif Sikandar, Wei Lin, Mao-Lin Cui, Ming-Xia Kang, Ming-Xia Kang, Yi-Ru Zheng, Yi-Ru Zheng, Shi-Rui Gan, Shi-Rui Gan, Liang-Liang Qiu, Liang-Liang Qiu

“…IntroductionSpinocerebellar ataxia type 3 (SCA3) poses challenges for patients due to motor dysfunctions and non-motor symptoms (NMS), such as sleep disorders, cognitive deficits, and mood disturbances. …”
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The importance of measuring the levels of ionized magnesium in the blood in critically ill patients by Stanojević Marija B., Parezanovic Miro, Biorac Marko, Spasić Svetolik, Kovačević Sanjin, Lopičić Srđan, Nešović Ostojić Jelena

“…Background: Critical illnesses imply vital organ dysfunctions with high risk of imminent death. Magnesium is a bioessential element with multiple physiological effects relevant for vital body functions. …”
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Chemogenetic tools for modulation of spatial learning in dopamine transporter deficient rats by Arina A. Gromova, Arina A. Gromova, Taisiia S. Shemiakova, Mikhail G. Khotin, Evgeniia N. Petrunina, Anastasia D. Belskaya, Raul R. Gainetdinov, Raul R. Gainetdinov, Natalia P. Kurzina, Anna B. Volnova, Anna B. Volnova

“…The objective of this study was to evaluate the effect of chemogenetic activation of NE release in the PFC on the performance of a spatial behavior task by DAT-KO rats. …”
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Walking gait biomechanics in individuals with quadriceps tendon autograft anterior cruciate ligament reconstruction by Kate Pfile, Bennett Prosser, Harris Slone, Michelle McLeod, Chris Gregory, Jennifer Hunnicutt

“…All significant findings had large effect sizes (d > 0.8).DiscussionThree-dimensional biomechanical gait alterations are present at the knee and hip following QT-ACLR when comparing between limbs. …”
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Reliability and Validity Study of the <italic>International Classification of Functioning</italic>，<italic>Disability and Health Rehabilitation Set</italic> in Rehabilitation of Kn... by LEI Lei, PENG Zhizhou, GAO Mingyue, LI Fei, MAO Ningning, WU Xi, XIAO Chengcheng, XUN Yajing, ZHAO Suchen, FAN Xiaojun

“…The Cronbach's α coefficients for the remaining items of the ICF-RS decreased except for deleting b620 urinary function, b730 muscle strength function, d710 basic interpersonal interactions and d850 remunerative employment. 70.00% (21/30) of the items showed significantly differences in distinguishing between mild and severe dysfunctions, in which items with |<italic>r</italic>|&gt;0.8 could effectively distinguish KOA patients with high and low score function, including d420 changing body position, d510 washing oneself, d640 doing household chores and d470 using transportation.ConclusionICF-RS could be used to assess the functional status of KOA patients with good reliability, validity and criterion-related validity.…”
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Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice by Onno Kranenburg, Hergen Spits, Julien Villaudy, Madalina Cercel, Miriam Koopman, Cornelis J A Punt, Jamila Laoukili, Andre Verheem, Inne H M Borel Rinkes, Emre Küçükköse, Balthasar A Heesters, Susan van Hal, Sylvia F Boj, Jeanine M L Roodhart

“…ICB completely cleared liver metastases and reduced primary tumor mass but had no effect on peritoneal metastases. This mimics clinical observations. …”
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Maternal milk fat globule membrane enriched gut L. murinus and circulating SCFAs to improve placental efficiency and fetal development in intrauterine growth restricted mice model by Cuiping Feng, Yujun Wu, Xiangyu Zhang, Shuxian Wang, Junjun Wang, Huixia Yang

“…Intrauterine growth restriction (IUGR) caused by placental dysfunctions leads to fetal growth defects. Maternal microbiome and its metabolites have been reported to promote placental development. …”
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Evaluation of Neurovascular Coupling Behaviors for FES-Induced Wrist Movements Based on Synchronized EEG-fNIRS Signals by He Mao, Haotian Meng, Qiyun Tan, Oluwarotimi Williams Samuel, Guanglin Li, Peng Fang

“…This mechanism is strongly associated with the brain state and alters with the pathological conditions such as motor dysfunctions. Clinically, functional electrical stimulation (FES) is being increasingly used for motor function restoration, but the impact of FES on NC behaviors is still lack of study, which would prevent the understanding of FES in improving neurorehabilitation performance. …”
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Detecting the contribution of V5/MT in reading, reading-related tasks, eye-movements and EEG-oscillations in children and adolescents with developmental dyslexia via high-definitio... by Federica Somma, Giulia Lazzaro, Samy Rima, Kristina Rainich, Christa Müller-Axt, Michael Christoph Schmid, Stefano Vicari, Katharina von Kriegstein, Deny Menghini

“…Abstract Background Neuroscientific theories of Developmental Dyslexia (DD) primarily focus on language-related dysfunctions and their associated brain networks. However, DD is also associated with alterations in sensory pathways. …”
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Study on Large‐Scale Brain Network Abnormalities in Patients With Beta‐Thalassemia by Mingrui Yang, Guowei Chen, Peng Peng, Cheng Tang, Chaotian Luo, Fei Peng, Rong Kong, Chunxia Zhu, Jiatong Liang

“…Abstract Background Beta‐thalassemia major (β‐TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra‐brain network functional connectivity (FC) and inter‐network functional connectivity (FNC) in β‐TM patients using resting‐state functional magnetic resonance imaging (rs‐fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments. …”
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C-Reactive Protein and Cytokines in Polytrauma by E. K Gumanenko, N. S Nemchenko, V. V. Boyarintsev, S. V. Gavrilin, D. A. Vologzhanin, A. A. Rud

“…When the latter were discontinued, CRP appeared in the quantity reflecting the effect of treatment. In the absence of multiple organ dysfunctions, the level of CRP decreased as the infectious process diminished. …”
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Long-term restraint stress as a predictor of insulin resistance development in experimental rats by K. B. Romanova, O. V. Hancheva, Yu. M. Kolesnyk

“…The environmental space restriction, immobility and complex communication relations gradually induce a range of disorders in animals and change the glycemic response shape to glucose load, impair prandial insulin secretion, augment hyperglycemic effects of counterinsular hormones (corticosterone), and realize dysfunctional manifestations of prandial/postprandial glycemia. 6 weeks of restrictions and challenges shape the hypoinsulinemic-hypoglycemic type of the glycemic curve with high tissue glucose sensitivity, while 15 weeks result in the hypoinsulinemic curve with preserved tissue glucose sensitivity. 21 weeks show the diabetic type of the glycemic curve with impaired tissue glucose sensitivity and the development of insulin resistance.…”
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Markers of cardiovascular risk and their reversibility with acute oxygen therapy in Kyrgyz highlanders with high altitude pulmonary hypertension by M. Furian, T.D. Latshang, S.S. Aeschbacher, U. Sheraliev, N.H. Marazhapov, E. Mirrakhimov, S. Ulrich, T.M. Sooronbaev, K.E. Bloch

“…The lack of a further increase of the elevated SI during hyperoxia in HAPH+ may indicate dysfunctional control of vascular tone and/or remodelling.…”
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PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion by Lei Yu, Yan Wang, Jin Wang, Zhiqiang Liu, Feng Liu, Han Zhao, Yi Tao, Jian-Qing Mi, Nan Xu, Wanyan Ouyang, Shi-Wei Jin, Wei-Yang Liu, Liuqingqing Zhang, Liqing Kang, Yuanfang Liu

“…Background Despite the encouraging outcome of chimeric antigen receptor T cell (CAR-T) targeting B cell maturation antigen (BCMA) in managing relapsed or refractory multiple myeloma (RRMM) patients, the therapeutic side effects and dysfunctions of CAR-T cells have limited the efficacy and clinical application of this promising approach.Methods In this study, we incorporated a short hairpin RNA cassette targeting PD-1 into a BCMA-CAR with an OX-40 costimulatory domain. …”
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Caveolin Scaffolding Domain (CSD) Peptide LTI-2355 Modulates the Phagocytic and Synthetic Activity of Lung-Derived Myeloid Cells in Idiopathic Pulmonary Fibrosis (IPF) and Post-Acu... by Brecht Creyns, BreAnne MacKenzie, Yago Amigo Pinho Jannini Sa, Ana Lucia Coelho, Dale Christensen, Tanyalak Parimon, Brian Windsor, Cory M. Hogaboam

“…<b>Conclusions</b>: Primary myeloid cells from IPF and PASC-F patients exhibit dysfunctional phagocytic and synthetic properties that are modulated by LTI-2355. …”
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AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level by Nádia Conceição-Neto, Wim Pierson, Qinglin Han, Zhiyuan Yao, Qun Wu, Koen Dockx, Liese Aerts, Dries De Maeyer, Matthias Beyens, Koen Van den Berge, Chris Li, George Kukolj, Ren Zhu, Vinod Krishna, Ondřej Podlaha, Isabel Nájera, Ellen Van Gulck

“…IntroductionUnresolved hepatitis B virus (HBV) infection leads to a progressive state of HBV-specific immune dysfunctionality that characterizes chronic infection. …”
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CURRENT POSSIBILITIES OF ANTICOAGULANT THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION by M. Yu. Gilyarov, E. V. Konstantinova, A. I. Trukhin

“…Prognosis and quality of life may be effectively influenced in an AF patient where physicians of all specialties understand each other well and know general approaches to treating these patents. …”
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Adolescenti autistici ad alto funzionamento: un’ipotesi di studio sull’efficacia del trattamento integrato per il disturbo ossessivo compulsivo by Valentina Bellomo

“…Several studies have demonstrated the effectiveness of the integrated treatment of obsessive compulsive disorders in neurotypical subjects. …”
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Does Time and Experience Matter in Pediatric Arterial Ischemic Stroke (AIS) Intervention in Patients with an Initial Clinical Presentation of Mild/Moderate Severity? Long-Term Foll... by Gulten Ozturk, Erhan Biyikli, Olcay Unver, Omer Dogru, Evrim Karadag Saygi, Feyyaz Baltacioglu, Dilsad Turkdogan

“…The affected vascular territory did not have any significant effect on long-term clinical outcomes (<i>p</i> = 0.550). …”
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Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia by Lin Zhang, Li Guo, Xiaohui Liu, Jing Han, Yuanqiang Zhu, Chaozong Ma, Ye Li, Weiliang Ye

“…Repetitive transcranial magnetic stimulation (rTMS), particularly low-frequency rTMS targeting the left temporoparietal junction (TPJ), has shown promise in alleviating AVH symptoms by modulating dysfunctional brain connectivity. However, the network-level effects of rTMS remain incompletely understood, particularly in terms of small-world network properties, which provide insights into local and global network efficiency. …”
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