Alterations in blood pressure dependent activation of leg muscles during standing following bed rest mimic those observed with ageing by Malcom Tremblay, Da Xu, Ajay K. Verma, Nandu Goswami, Nandu Goswami, Andrew P. Blaber

“…Since inactivity and ageing are common causes of orthostatic intolerance, the HDBR results were compared with those from young and older individuals in a previously published study to investigate the similarities in their effects on muscle-pump baroreflex.ResultsDuring standing, FTA reduced for all muscles except MG following HDBR and was lower in older compared to younger participants. …”
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Short-term consequences of daily consumption of the quinoa (Chenopodium quinoa Willd.) diet in normal and diabetic rats by Murali Adiga, S. D. Manjula, Dhiren Punja, Chakravarthy Marx Sadacharan, Dinesh Upadhya, K. Vasanthalaxmi, Nanda Acharya, Chinmay Suryavanshi

“…The findings support quinoa’s potential as a safe dietary adjunct in managing diabetes-related metabolic dysfunctions.…”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Background Tumor-infiltrating T cells enter an exhausted or dysfunctional state, which limits antitumor immunity. …”
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Exploring the hepatic-ophthalmic axis through immune modulation and cellular dynamics in diabetic retinopathy and non-alcoholic fatty liver disease by Shuyan Zhang, Jiajun Wu, Leilei Wang, Cheng Zhang, Yinjian Zhang, Yibin Feng

“…Abstract Background Dysfunctions within the liver system are intricately linked to the progression of diabetic retinopathy (DR) and non-alcoholic fatty liver disease (NAFLD). …”
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Ecocritical Study of the Chornobyl Disaster (Based on Materials of Contemporary Literature of Fact) by Nataliia Rozinkevych

“…The effects of humankind during the Capitalocene period caused planetary changes that resulted in the devastation and destruction of the Earth. …”
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Restoration of the functional state of military personnel after gunshot wounds to the upper limb using physical therapy measures based on the principles of neuroplasticity by Nataliia Shestopal, Helen Bismak, Olena Lazarieva

“…MG patients experienced significantly fewer limitations associated with upper limb dysfunctions compared to CG, which had a positive effect on the ability to perform exercises related to professional activity according to the results of the military questionnaire. …”
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Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial by CLÁUDIO DE NOVAES SOARES, NINA ROSA MUSOLINO, MALEBRANCHE CUNHA NETO, MARIA ADELAIDE CAIRES, MARIA CRISTINA ROSENTHAL, CANDIDA PIRES CAMARGO, MARCELLO D. BRONSTEIN

“…BACKGROUND: Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during stress, depressive symptoms) that may cause deleterious effects on quality of life, and may be positively influenced by recombinant human growth hormone (rh-GH) therapy. …”
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Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2 by Walter Witke, Marina Di Domenico, Laura Maggi, Alessia Di Nardo, Valentin Stein, Pietro Pilo Boyl

“…Consequently, lack of PFN2 caused seizures behavior and age-dependent loss of cerebellar Purkinje cells, comorbidities observed in a subset of autistic patients, which can be attributed to the effect of excessive glutamatergic neurotransmission.DiscussionOur data directly link altered pre-synaptic actin dynamics to autism spectrum disorder in the mouse model and support the hypothesis that synaptic dysfunctions that asymmetrically increase the excitatory drive in neuronal circuits can lead to autistic-like phenotypes. …”
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A framework of composite factors for assessing ecosystem service supply drivers: A sustainable socio-ecological perspective by Chang You, Hongjiao Qu, Luo Guo

“…In this study, we constructed a sustainable framework for composite factors to analyze their effects on the ecosystem services supply (ESS). This framework emphasizes the positive roles assessment indicators such as water, forests, lakes, grasslands, and governance have on ESS, which are directly linked to the objectives of Sustainable Development Goal (SDG) 15, which include forest conservation, biodiversity maintenance, and water resource management. …”
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Long-Term Clinical and Imaging Findings in Patients with Lower Extremity Varicose Veins Treated with Endovenous Laser Treatment: A Follow-Up Study of up to 12 Years by Hossein Ghanaati, Amir Hossein Jalali, Madjid Shakiba, Diana Zarei, Nafiseh Ghavami, Kavous Firouznia

“…This study investigates the long-term effectiveness and safety of endovenous laser treatment (EVLT) for chronic venous insufficiency (CVI), a condition commonly caused by dysfunctional valves in the venous circulation system. …”
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Urinary Incontinence after Iatrogenic Bladder Injury during Cesarean Section. A Ten-Year Single-Center Retrospective Analysis and Review of the Literature by Marta Cicuti, Stefano Manodoro, Sara Bosio, Anna Maria Marconi

“…Background: Bladder injuries during caesarean delivery are rare but serious intraoperative complications. Short-term effects of bladder injuries include prolonged catheterization and urinary infections. …”
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Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP) by James Stockley, Brendan Cooper, Eyas Alhuthail, Andrew Coney

“…The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe. The effects on respiratory physiology are not yet fully understood, but evidence is emerging that there is much dysfunctional breathing reported but little information on tidal ventilation from the acute phase of the infection. …”
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Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects by Ling Tian, Qien Zhong, Yubei Yang, Wenmei Wu, Yang Xiao, Sheng Li, Kang Li

“…Conversely, the metabolites accumulated due to dysfunctional autophagy inhibit autophagy occurrence by downregulation of AMPK signaling, thereby forming a regulatory loop in insects. …”
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Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19 by Patrícia Brito Rodrigues, Vinícius de Rezende Rodovalho, Valentin Sencio, Nicolas Benech, Marybeth Creskey, Fabiola Silva Angulo, Lou Delval, Cyril Robil, Philippe Gosset, Arnaud Machelart, Joel Haas, Amandine Descat, Jean François Goosens, Delphine Beury, Florence Maurier, David Hot, Isabelle Wolowczuk, Harry Sokol, Xu Zhang, Marco Aurélio Ramirez Vinolo, François Trottein

“…We show that age-related dysfunctions in the gut microbiota are linked to disease severity and long-term sequelae in older hamsters. …”
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CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation by Jin-Sil Park, Jin-Sil Park, Jin-Sil Park, Hye Yeon Kang, Hye Yeon Kang, Hye Yeon Kang, Ha Yeon Jeong, Ha Yeon Jeong, SeungCheon Yang, JeongWon Choi, JeongWon Choi, JeongWon Choi, Sang Hee Cho, Sang Hee Cho, Sang Hee Cho, Sol Kim, Bo-In Lee, Mi-La Cho, Mi-La Cho, Mi-La Cho

“…Patients with ulcerative colitis exhibited decreased CRIF1 levels with dysfunctional mitochondria in inflamed colonic tissue. …”
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The benefit of inhibitory control training for insomnia with short sleep duration phenotype: a pilot randomized trial by Haobo Zhang, Zhangwei Lv, Hanfei Chen, Zijie Tang, Xu Lei

“…This study investigated the status of impaired response inhibition in these two phenotypes and examined the potential different effect of response inhibition training on these two phenotypes. …”
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A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance by Ping Li, Ping Li, Xin Yin, Xinzhu Wen, Xuyu Li, Yuqing Wang, Hongyan Zhan, Hanqing Che, Chunsuo Yao, Qi Hou, Ziqian Zhang, Ruifang Zheng, Mingbao Lin

“…IntroductionDysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. …”
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CD44 on cancer stem cell is a potential immunological and prognostic pan-cancer biomarker by Ya-Juan Zhu, Si-Ying Li, Shan-Shan Yang, Yang Du, Zhuo-Yuan Zhang, Ji-Yan Liu

“…Furthermore, we verified the effect of CD44 on tumor growth and immune microenvironment in mouse xenografted with shRNA-CD44 MC38. …”
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Relation of Follicular Fluid Soluble Receptor for Advanced Glycation End-Products Concentration and Anti Mullerian Hormone in Polycystic Ovary Syndrome and Non-PCOS Women Referring... by Neda Emami, Ashraf Moini, Samira Vesali

“…Background: Reproductive dysfunctions of polycystic ovary syndrome (PCOS) and blood anti-mullerian hormone(AMH) concentration are significantly influenced by the dietary advanced glycation end products (AGEs). …”
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Genotype‐function‐phenotype correlations for SCN1A variants identified by clinical genetic testing by Andrew T. Knox, Christopher H. Thompson, Dillon Scott, Tatiana V. Abramova, Bethany Stieve, Abigail Freeman, Alfred L. George Jr.

“…Functional data were incorporated into a parvalbumin‐positive (PV+) interneuron computer model to predict variant effects on neuron firing and were compared with longitudinal clinical data describing epilepsy types, neurocognitive outcomes, and medication response. …”
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