A Changepoint Detection-Based General Methodology for Robust Signal Processing: An Application to Understand Preeclampsia’s Mechanisms by Patricio Cumsille, Felipe Troncoso, Hermes Sandoval, Jesenia Acurio, Carlos Escudero

“…Our findings revealed impaired brain perfusion in offspring from preeclampsia, particularly dysfunctional brain perfusion signals with inadequate perfusion signal vasoreactivity to thermal physical stimuli. …”
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Analysis of ventricular repolarization parameters and heart rate variability in obesity: a comparative study by Akash Tomar, Himani Ahluwalia, H. S. Isser, Sameer Gulati, Puneet Kumar, Indrajeet Yadav

“…Abstract Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. …”
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Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide by César O. Lara, Carlos F. Burgos, Katherine Fariña-Oliva, Ana M. Marileo, Victoria P. San Martín, David Flaig, Paul Soto-Ortega, Omayra V. Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A. Castro, Luis G. Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E. Yévenes

“…Alterations to glycinergic inhibition and the generation of dysfunctional GlyRs have been linked to chronic pain, a widely prevalent disease. …”
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Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses by Yinan Du, Aozhuo Zhang, Zhiwei Li, Yukui Zhao, Shuyi Liu, Chunling Wei, Qiaohua Zheng, Yanning Qiao, Yihui Liu, Wei Ren, Jing Han, Zhiqiang Liu, Fei Gao

“…The present study provides a theoretical basis for treating emotional dysfunctions during MOR-targeted management.…”
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The Proangiogenic Potential of Rat Adipose-Derived Stromal Cells with and without Cell-Sheet Induction: A Comparative Study by Xiaoru Xu, Shuang Song, Xiangdong Liu, Yuchao Zhou, Shaojie Shi, Guoqiang Zhao, Xingxing Wang, Xutao Chen, Wenshuang Zhao, Sijia Zhang, Wei Ma, Yingliang Song

“…Utilizing mesenchymal stromal cells (MSCs) to alleviate tissue ischemia and repair dysfunctional or damaged endothelium is a promising strategy. …”
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The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway by Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao

“…Abstract Colorectal cancer is the second most common cause of cancer mortality worldwide, and liver metastasis is the major cause of death of patients with colorectal cancer. Dysfunctional E3 ligase activity has recently been shown to be associated with colorectal cancer. …”
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Lipopolysaccharide-induced intestinal mucosal injury disrupts proteostasis in broiler chickens by Aijuan Zheng, Wayne Bryden, Xing Chen, Zhimin Chen, Peilong Yang, Kun Meng, Guohua Liu

“…This experiment investigated the effects of immune stress on the intestinal mucosa proteome of Arbour Acres (AA) broilers challenged with Escherichia coli lipopolysaccharide (LPS). …”
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Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension by Dongxu Hua, Wanlin Huang, Qiyang Xie, Wenna Xu, Lu Tang, Mingwei Liu, Xiaoguang Wu, Qiaodong Zhang, Xu Cao, Peng Li, Yanhui Sheng

“…GPR39 KO and the small molecule ligand Z1780628919 potentially downregulates Nlrp3, thereby mitigating vascular fibrosis, endothelial inflammation, oxidative stress, and apoptosis. This effect contributes to the alleviation of Ang II-induced hypertension and the rectification of vascular dysfunctions. …”
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A neural network-based programming paradigm for heat transport of Eyring-Powell fluid with physiological blood flow applications by Abaker A. Hassaballa, Ali Imran, Ines Hilali Jaghdam, Jongsuk Ro

“…This study presents a novel investigation into the effects of electroosmosis in a non-uniform channel lined with cilia for an Eyring-Powell model fluid. …”
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CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment by Klaudia Bonowicz, Dominika Jerka, Klaudia Piekarska, Janet Olagbaju, Laura Stapleton, Munirat Shobowale, Andrzej Bartosiński, Magdalena Łapot, Yidong Bai, Maciej Gagat

“…Despite its promise, significant challenges remain, including off-target effects, ethical concerns, and limitations in delivery methods, which hinder its translation into clinical practice. …”
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Psychosocial and cognitive risk factors for orthorexia nervosa: an integrative review of recent literature by Vitória Morelli Guerrazzi, Isadora Paiva Abbondanza, Leticia Bragalia Passarella, Emily Godoi Pereira, Thiago Bonafé, Maíra Pieri Ribeiro

“… Introduction: Orthorexia nervosa (ON) is a dysfunctional eating behavior characterized by an obsession with healthy eating. …”
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Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints by Derek Madden, Tressie M. Stephens, Jim Scott, Christen O’Neal Swann, Kiana Prather, Jordan Hoffmeister, Lei Ding, Lei Ding, Ian F. Dunn, Andrew K. Conner, Han Yuan, Han Yuan, Han Yuan

“…While patients with severe COVID have a higher prevalence of neurologic symptoms, as many as one in five patients with mild COVID may also be affected, exhibiting impaired memory as well as other cognitive dysfunctions.MethodsTo characterize the effect of COVID on the brain, the current study recruited a group of adults with post-COVID cognitive complaints but with mild, non-hospitalized cases. …”
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Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT by Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye

“…Morphological and functional alteration in the aging brain elicits age‐associated neuronal dysfunctions. However, the primary mechanism deteriorating the brain functions to regulate the aging process remains incompletely understood. …”
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Galectin‐1‐Induced Tumor Associated Macrophages Repress Antitumor Immunity in Hepatocellular Carcinoma Through Recruitment of Tregs by Xizhi Yu, Junjie Qian, Limin Ding, Caixu Pan, Xi Liu, Qinchuan Wu, Shuai Wang, Jianpeng Liu, Mingge Shang, Rong Su, Danjing Guo, Haiyang Xie, Shengyong Yin, Lin Zhou, Shusen Zheng

“…Inhibition of Gal1 improves the effectiveness of anti‐PD1 therapy, shedding important new light on the combination immunotherapy of HCC.…”
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Enhancing Communication and Swallowing Skills in Children with Cri Du Chat Syndrome: A Comprehensive Speech Therapy Guide by Soultana Papadopoulou, Areti Anagnostopoulou, Dimitra V. Katsarou, Kalliopi Megari, Efthymia Efthymiou, Alexandros Argyriadis, Georgios Kougioumtzis, Maria Theodoratou, Maria Sofologi, Agathi Argyriadi, Efterpi Pavlidou, Eugenia I. Toki

“…These arise from characteristic laryngeal abnormalities and oral–motor dysfunctions. <b>Objective:</b> This study aims to investigate the effectiveness of speech and language intervention in addressing the multifaceted challenges of CdCS, including speech and language impairments, feeding difficulties, and social communication deficits. …”
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Supernatants from Newly Isolated <i>Lacticaseibacillus paracasei</i> P4 Ameliorate Adipocyte Metabolism in Differentiated 3T3-L1 Cells by Natalia Grigorova, Zhenya Ivanova, Valeria Petrova, Ekaterina Vachkova, Georgi Beev

“…Two newly isolated <i>L. paracasei</i> strains, M2.1 and P4, were yielded from <i>Formica rufa</i> anthills in Sinite Kamani National Park, Bulgaria. Their metabolic effects on mature 3T3-L1 adipocytes were investigated. …”
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Application of the <italic>International Classification of Functioning, Disability and Health Rehabilitation Set</italic> in Rehabilitation of Patients with Knee Osteoarthritis in... by YAO Dong, HE Yiqi, ZHANG Qin, LIU Changhua, LI Taibiao, YAO Caiming, WANG Xiangfeng, WANG Qinfeng, HU Hongjun

“…ObjectiveTo explore the feasibility of the <italic>International Classification of Functioning, Disability and Health Rehabilitation Set</italic> (ICF-RS) in evaluating the overall functional level, rehabilitation treatment effects, and the relationship between rehabilitation efficacy and cost-effectiveness of patients with knee osteoarthritis (KOA) in the northwest Gobi region.MethodsA total of 50 patients with KOA who were hospitalized in the Acupuncture and Moxibustion Department of Jimsar County Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were selected. …”
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C60 fullerene helps restore muscle soleus contraction dynamics after achillotomy-induced atrophy by Dmytro Nozdrenko, Kateryna Bogutska, Іhor Pampuha, Mykola Petrovsky, Yuriy Prylutskyy

“…Previously, the positive effect of water-soluble C60 fullerenes, as strong antioxidants, was established on the background of muscle ischemia, mechanical muscle injury, and other muscle dysfunctions. …”
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Electroneuromyography for early diagnosis of diabetic distal polyneuropathy by Elena S. Mazurenko, Lyudmila A. Ruyatkina, Igor A. Pakhomov, Elena V. Chesheva, Larisa O. Gavrilova

“…AIM: To investigate the effectiveness and suitability of electroneuromyography (ENMG) for early DDPN diagnosis. …”
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Tablet-based sensorimotor home-training system for amnestic mild cognitive impairments in the elderly: design of a randomised clinical trial by Robin Bekrater-Bodmann, Annette Löffler, Stefano Silvoni, Lutz Frölich, Lucrezia Hausner, Simon Desch, Dieter Kleinböhl, Herta Flor

“…A mechanistic treatment targeting dysfunctional plastic changes associated with ageing should be efficacious in delaying AD. …”
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