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8441
γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders
Published 2025-06-01“…We investigate how monitoring dynamic features of γ oscillations allows for detailed evaluations of neuromodulation effectiveness. By targeting γ oscillatory patterns and restoring healthy cross-frequency coupling, interventions may alleviate cognitive and behavioral symptoms linked to disrupted communication. …”
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8442
Morphine mediated neutrophil infiltration in intestinal tissue play essential role in histological damage and microbial dysbiosis
Published 2022-12-01“…Our findings implicate that inhibition of neutrophil infiltration may provide therapeutic benefits against gastrointestinal dysfunctions associated with opioid use.…”
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8443
Neuroprotective Potential of Peroxisome Proliferator Activated Receptor-α Agonist in Cognitive Impairment in Parkinson’s Disease: Behavioral, Biochemical, and PBPK Profile
Published 2014-01-01“…In this study, we have investigated the effect of fenofibrate, a PPAR-α agonist in cognitive impairment model in PD. …”
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8444
The COVID-19 Pandemic Increased the Risk of Eating Disorders and Emotional Eating Symptoms: A Review of the Current Clinical Evidence
Published 2024-10-01“…This narrative literature review aims to comprehensively analyze and scrutinize the existing clinical studies regarding the effects of the COVID-19 pandemic on people with EDs or EE. …”
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8445
Exploring the Impact of Semaglutide on Cognitive Function and Anxiety-Related Behaviors in a Murine Model of Alzheimer’s Disease
Published 2024-11-01“…This study investigates the effects of semaglutide (SEM), a glucagon-like peptide-1 analog, on cognitive function and anxiety-like behavior in a transgenic murine model of AD. …”
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8446
A Meta-Analysis of Task-Based fMRI Studies on Alcohol Use Disorder
Published 2025-06-01“…<b>Conclusions:</b> These findings support prior research indicating a motivational imbalance and persistent executive dysfunctions in AUD. Standardizing consumption metrics and expanding task diversity in future research is essential to further refine our understanding of the neural effects of AUD.…”
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8447
Protocol for a Randomized Controlled Trial to Enhance Executive Function via Brief Mindfulness Training in Individuals with Internet Gaming Disorder.
Published 2025-01-01“…It is anticipated that the findings will contribute to more targeted intervention strategies for executive function research, offering novel insights into the treatment of IGD and related cognitive dysfunctions. This study is expected to explore the effectiveness of brief mindfulness intervention on IGD and its underlying brain functional mechanisms, particularly providing more targeted intervention strategies for improving executive functions in this population.…”
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8448
Machado-Joseph disease op azorean ancestry in Brazil: the Catarina kindred neurological, neuroimaging, psychiatric and neuropsychological findings in the largest known family, the...
Published 1993-03-01“…Fully established MJD in this family seemed to exert a protective effect from depression.…”
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8449
Sweroside: unveiling broad therapeutic potential—from mechanistic insights to clinical potential
Published 2025-07-01“…Challenges in its clinical translation were also evaluated, with proposed strategies to enhance bioavailability.ResultsSweroside modulates critical signaling pathways, such as NF-κB, mTOR, MAPK, and PI3K/Akt, and their molecular substrates, contributing to its therapeutic effects across various pathological conditions. Preclinical studies demonstrate its efficacy in treating hepatic disorders, osteoporosis, cardiovascular diseases, and neurological dysfunctions. …”
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8450
Quality of life and objective functional impairment in lumbar spinal stenosis: a protocol for a systematic review and meta-analysis of moderators
Published 2019-11-01“…Independent reviewers will search published/unpublished studies through electronic databases and additional sources, will extract the data and assess the methodological quality. Random-effects meta-analysis will be carried out by calculating effect sizes as Cohen’s d indices. …”
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8451
The Sudden Cardiac Death Continuum. Message 2
Published 2025-04-01“…The formation of SCD can occur from a risk factor from any peripheral point of the SCD continuum and depends on the set of risk factors, the proximity of the trigger to the outcome, its independent effect and (or) interaction with other risk factors. …”
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8452
The Sudden Cardiac Death Continuum. Message 1
Published 2025-01-01“…The formation of SCD is determined by the proximity of the predictor to the outcome, its independent effect and (or) interaction with other risk factors. …”
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8453
Coping, meaning in life, and quality of life during ongoing conflict: insights from Israeli populations
Published 2025-01-01“…Aims include exploring effects of trauma and socio-demographics on HRQoL and MIL, analyzing mediating roles of psychological symptoms and coping, and evaluating if evacuation status moderates these relationships during ongoing conflict. …”
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8454
Exercise is medicine for patients with major depressive disorders : but only if the &ldquo;pill&rdquo; is taken!
Published 2016-08-01“…Meanwhile, the positive effects of exercise training on the treatment of MDDs are well documented, while compelling evidence exists that exercise interventions can improve cardiorespiratory fitness in clinically meaningful ways. …”
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8455
Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults
Published 2025-06-01“…., Campobasso, 86100, Italy, Tel + 39 0874 404771, Fax +39 0874 404 778, Email giovanni.scapagnini@unimol.itAbstract: Quercetin, a flavonol abundant in fruits and vegetables, has attracted significant attention for its senotherapeutic effects, which involve the selective elimination of senescent cells and the modulation of pro-inflammatory phenotypes that contribute to age-related dysfunctions. …”
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8456
Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator
Published 2017-02-01“…Based on the experimental data on the aging changes in the activity of SIRT1 and the level of NAD+, we attempted to study the effect of these age-related changes on the functioning of the circadian oscillator. …”
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8457
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis
Published 2023-01-01“…Deficiencies in klotho are implicated in various kidney dysfunctions including diabetic nephropathy (DN) related to inflammatory responses. …”
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8458
Efficacy of osmotic laxative polyethylene glycol 4000 in treatment of constipation in pediatrics
Published 2011-12-01“…In no patients drug side effects were not observed.Conclusions. The osmotic laxative polyethylene glycol 4000 has high clinical effect at treatment of constipation in children.…”
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8459
Relationship Between Peritraumatic Dissociation, Beliefs About Losing Control, Resilience, and PTSD on Earthquake Survivors in Turkey
Published 2025-04-01“…It has been suggested that peritraumatic dissociation and dysfunctional beliefs also play a role in the emergence and maintenance of PTSD, and resilience is one of the most important protective factors for PTSD. …”
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8460
Associative learning impairments in rats lacking dopamine transporter
Published 2022-07-01“…DAT knockout rats are a promising model of frontostriatal dysfunctions involved in adapting learning processes to current organism's needs, motivation, and experience.The objective was to evaluate the effect of DAT disruption on the interaction of classical and instrumental conditioning processes (associative learning).Methods and materials. …”
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