Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS by Katherine Dyke, Sophia E. Pépés, Ben Babourina-Brooks, Chen Chen, Soyoung Kim, Hilmar P. Sigurdsson, Amelia Draper, Masud Husain, Parashkev Nachev, Penny Gowland, Peter G. Morris, Stephen R. Jackson

“…These findings are important as they run counter to previous work, and suggest that the effect of an acute dose of GBP is likely to be subject to substantial individual variation, with timing of measures particularly likely to impact observed effects. …”
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Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways by Yu Yuefeng, Lin Zhiqi, Chen Yi, Zhu Keyu, Wan Heng, Wang Yuying, Wang Ningjian, Yu Yuetian, Gu Xinjie, Zhang Yihao, Lu Yingli, Xia Fangzhen

“…Our objective was to investigate the effects of testosterone deficiency on cholesterol metabolism and the corresponding molecular changes in vivo and in vitro. …”
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The EmpkinS-EKSpression Reappraisal Training Augmented With Kinesthesia in Depression: One-Armed Feasibility Study by Marie Keinert, Lena Schindler-Gmelch, Lydia Helene Rupp, Misha Sadeghi, Robert Richer, Klara Capito, Bjoern M Eskofier, Matthias Berking

“…However, relatively low remission rates and high dropout rates in CBT demonstrate the need for further improvement. Potentially, the effects of CBT could be enhanced by addressing not only dysfunctional depressogenic cognitions but also body states associated with depression. …”
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Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: Implications for developing novel anti-ageing foods by Rohit Sharma, Anamika Sharma

“…However, the mechanistic understanding of the anti-ageing effects of PSM vis-à-vis the modern hallmarks of ageing i.e., cellular senescence, chronic inflammation, gut dysbiosis, telomere attrition, genome instability, proteostasis and autophagy, epigenetic alterations, nutrient sensing pathways, and stem cells dysfunctions, is limited. …”
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Musical hallucination associated with hearing loss by T G Sanchez, S C M Rocha, K A B Knobel, M A Kii, R M R Santos, C B Pereira

“…Some researchers agree on a combination of peripheral and central dysfunctions as the mechanism that causes hallucination. …”
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Defatted hickory meal hydrolysate’s impact on memory impairment induced by D-galactose in mice by Fanping Qin, Ruiling Liu, Qi Kong, Hangjun Chen, Xiangjun Fang, Huizhi Chen, Weijie Wu, Haiyan Gao

“…Moreover, DHMH treatment effectively prevented histological alterations in neurons within the hippocampal CA1 area induced by D-gal. …”
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2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv... by Wei Dong, Yujia Peng, Guijie Chen, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan

“…Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions in animals and humans, including neuroinflammation and cognitive function decline. …”
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Transcutaneous auricular vagus nerve stimulation prevents postoperative delirium in elderly patients (VNSTAR): protocol for a multicentre, randomised controlled trial by Anxin Wang, Bo Wang, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Tianyuan Wang

“…However, its applicability in ameliorating neurocognitive dysfunctions that arise during the perioperative period remains unclear. …”
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Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylat... by Xin Cui, Yueming Zhu, Lidan Zeng, Mengyuan Zhang, Amad Uddin, Theresa W. Gillespie, Lauren E. McCullough, Shaying Zhao, Mylin A. Torres, Yong Wan

“…In preclinical models of obese TNBC, Retatrutide downregulates HBP, decreases YAP protein levels, and consequently decreases tumor size and enhances chemotherapy efficacy. This effect is particularly pronounced in obese mice bearing TNBC tumors. …”
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Combined anti-PD-L1 and anti-VEGFR2 therapy promotes the antitumor immune response in GBM by reprogramming tumor microenvironment by Lin Yao, Hao Wang, Yongsheng Liu, Ming Feng, Yanyan Li, Zuopeng Su, Wen Li, Yun Xiong, Heyang Gao, Youxin Zhou

“…GBM has significant immunosuppressive properties, and there are many immunosuppressive cells and dysfunctional effector T cells in the tumor microenvironment (TME), which is one of the important reasons for the failure of clinical treatment of GBM. …”
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Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity by Carolin Ector, Jeff Didier, Sébastien De Landtsheer, Malthe S Nordentoft, Christoph Schmal, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Thomas Sauter, Adrián E Granada

“…Circadian-based therapeutic strategies optimize treatment timing to enhance drug efficacy and minimize side effects, offering potential for precision cancer treatment. …”
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The signature of the small intestinal epithelial and immune cells in health and diseases by Xiang Gao, Cuiping Yang, Zhongsheng Feng, Ping Liu, Zhanju Liu, Yuanyuan Ji

“…Disruptions in this balance contribute to chronic inflammation, microbial dysbiosis, and compromised barrier function—key features of inflammatory bowel disease, celiac disease, and metabolic syndromes. Furthermore, dysfunctions in the small intestine and immune cells are linked to systemic diseases like obesity, diabetes, and autoimmune disorders. …”
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Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients by Guang-chun Wang, Jun-hua Zheng, Long-gen Xu, Zhi-lian Min, You-hua Zhu, Jun Qi, Qiang-lin Duan

“…Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.…”
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Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induc... by Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou

“…The daily pre-treatments of No.1, No.6, and No.7 for 10-days (40 mg/kg/day) showed to improve learning dysfunctions in scopolamine-induced ICR mice by passive avoidance tests. …”
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Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress by Ilaria Capolupo, Maria Rosaria Miranda, Simona Musella, Veronica Di Sarno, Michele Manfra, Carmine Ostacolo, Alessia Bertamino, Pietro Campiglia, Tania Ciaglia

“…ER-dependent defects or dysfunctions are associated with the genesis/progression of several pathological conditions, including cancer, inflammation, and neurodegenerative disorders, that are directly or indirectly correlated to a wide set of events collectively named under the term “ER stress”. …”
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The safety and efficacy of low-dose oral contraceptives by E. van der Westhuizen, E. van der Merwe

“…Higher-dose OC preparations are recommended in patients taking these concomitant drugs. The effectiveness of OCs with typical use is largely dependent on compliance, which is influenced by bleeding patterns and side-effects. …”
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Pharmacological and non-pharmacological interventions for adults with ADHD: protocol for a systematic review and network meta-analysis by Andrea Cipriani, Alexandra Philipsen, Susan Young, Cinzia Del Giovane, Samuel Chamberlain, Andrea Bilbow

“…Secondary outcomes will include tolerability (drop-out due to side effects) and change in the severity of emotional dysregulation, executive dysfunctions and quality of life. …”
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Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis. by Bolajoko O Olusanya, Folasade B Osibanjo, Tina M Slusher

“…We included only studies that controlled for the effects of confounding variables in determining maternal and infant risk factors for severe hyperbilirubinemia. …”
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The Mediating Role of Misinterpretations and Neutralizing Responses to Unwanted Intrusive Thoughts in Obsessive-Compulsive Spectrum Disorders by Belén Pascual-Vera, Guy Doron, Mujgan Inozu, Fernando García, Amparo Belloch

“…The IAD model accounted for a smaller proportion of variance than the OCD model. No mediating effects were found for BDD symptoms. <b>Conclusions</b>. …”
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Applying a mobile intervention for chronic insomnia in routine care: Study protocol for a multicenter randomized controlled trial by Daa Un Moon, Jeonghun Kim, Jeyoung Hannah Sun, Yujin Lee

“…Digital CBT-I (dCBT-I) offers a scalable solution to bridge this treatment gap, yet real-world evidence of its effectiveness remains limited. This study aims to examine the effectiveness of a mobile dCBT-I intervention, “SleepQ,” in a routine clinical setting. …”
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